TAp73 modifies metabolism and positively regulates growth of cancer stem-like cells in a redox-sensitive manner.

CONCLUSION: Collectively, we reveal a clinically relevant aspect of cancer cell growth and stemness regulation through TAp73-mediated redox-sensitive metabolic reprogramming.
PMID: 30593514 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - December 28, 2018 Category: Cancer & Oncology Authors: Sharif T, Dai C, Martell E, Saleh M, Hanes M, Murphy P, Kennedy B, Venugopal C, Subapanditha MK, Giacomantonio CA, Marcato P, Singh SK, Gujar S Tags: Clin Cancer Res Source Type: research