Primary Diffuse Large B-Cell CNS Lymphoma over 80 Years: An Analysis of 110 Patients from the French Oculo-Cerebral Lymphoma (LOC) Network

Conclusions: to the best of our knowledge, this is the largest series of consecutive PCNSL pts aged of 80y or over prospectively recorded in a national database. This study showed that the prognosis remains poor with major toxicity under conventional treatment. No clinical predictor of survival was highlighted in our series but patients initially treated with MTX-based CT in combination with rituximab had an improved outcome. The development of target and innovative therapies is needed for this category of patients representing 8% of all PCNSL in the database of the LOC network.DisclosuresHouot: Celgene: Honoraria; BMS: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Janssen: Honoraria; Novartis: Honoraria.

Source: Blood - November 21, 2018 Category: Hematology Authors: Maarek, A., Maucort-Boulch, D., Houillier, C., Chinot, O., Bijou, F., Taillandier, L., Agape, P., Houot, R., Boyle, E., Molucon-Chabrot, C., Rey, P., Choquet, S., Tamburini Bonnefoy, J., Jaccard, A., Ahle, G., Fabbro, M., Gac, A.-C., Meniane, J.-C., Le Co Tags: 627. Aggressive Lymphoma (Diffuse Large B-Cell and Other Aggressive B-Cell Non-Hodgkin Lymphomas)-Results from Retrospective/Observational Studies: Poster III Source Type: research