Early Intensive Therapy in Multiple Myeloma Using Tandem Transplantation with Novel Conditioning and Two Years Maintenance: A Single Institution Experience

ConclusionAccording to our results, patients with high risk cytogenetics did not have an inferior PFS and OS. These results suggest that in newly diagnosed MM patients, upfront treatment using novel conditioning regimen and tandem ASCT followed by intensive maintenance therapy can result in a very high CR rates, particularly in patients with high risk cytogenetics. Infections and peripheral neuropathies were the most common non-hematologic toxicities during maintenance. Longer follow up will determine further impact of maintenance therapy.DisclosuresNo relevant conflicts of interest to declare.

Source: Blood - November 21, 2018 Category: Hematology Authors: Nadiminti, K., Strouse, C., Vikas, P., Dozeman, L., Schultz, A., Mott, S. L., Claus, J., Farooq, U., Silverman, M., Tomasson, M., Zhan, F., Jethava, Y., Tricot, G. J. Tags: 731. Clinical Autologous Transplantation: Results: Poster I Source Type: research