Surprising New Pain Relief Methods

If you are one of the more than 100 million Americans suffering with chronic pain, you know how desperate you can get searching for relief. For constant or chronic pain, sometimes knowing that you can only get temporary relief from medications sits at the back of your brain and sets up pain anticipation. Shouldn’t there be a better way, an approach or approaches that don’t rely on pharmaceutical drugs to combat pain? According to new research, there are some new pain relief methods that look very promising to do just that. Treatment from Strangers Mat Provide Unexpected Pain Relief It may seem counter-intuitive, yet a study conducted by researchers from the University of Wuerzburg, Amsterdam and Zurich found that participants treated for pain by strangers (medical professionals from a different social group) experienced stronger pain relief than when they received pain treatment by someone from their own social group. Participants rated their pain “less intense” after being treated by strangers, and the reactions were reductions in both subjective and pain-related activation areas of the brain corresponding to the pain. Researchers call this “prediction error learning,” otherwise known as the analgesic effect of surprise. Patients didn’t expect to experience pain relief from strangers, and the less they expected to receive pain relief, the greater their surprise and the more pronounced their actual pain relief afterward. Higher Mindf...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Chronic Pain Health-related Mental Health and Wellness Mindfulness Psychology Research Treatment Source Type: blogs

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Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01858A, CommunicationJulie E. Laudenschlager, Logan A. Combee, Michael K. Hilinski Sc(OTf)3-promoted [5 + 1] cycloaddition of vinylcyclopropanes with PhINTs is reported, enabling the regioselective preparation of a range of 1,2,3,6-tetrahydropyridine scaffolds under mild conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Publication date: Available online 22 October 2019Source: Life SciencesAuthor(s): Pollyana S. Siqueira-Lima, Jullyana S.S. Quintans, Luana Heimfarth, Fabiolla R.S. Passos, Erik W.M. Pereira, Marilia M. Rezende, José E.R. Menezes-Filho, Rosana S.S. Barreto, Henrique D.M. Coutinho, Adriano A.S. Araújo, Aline S. Medrado, Ligia A. Naves, Horácio F. Bomfim, Angélica M. Lucchese, Sathiyabama Rajiv Gandhi, Lucindo J. Quintans-JúniorAbstractNeuropathic pain (NP) is a difficult condition to treat because of the modest efficacy of available drugs. New treatments are required. In the study we aimed ...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 22 October 2019Source: Journal of Bioscience and BioengineeringAuthor(s): Qingshan Shen, Hang Wang, Chunhui Zhang, Xiaojie Qin, Wei Jia, Xiong Xu, Aurore Richel, Qiankun ZhengInstant catapult steam explosion (ICSE) was proposed as a method to liquefy porcine hoof shell (PHS) and prepare a peptone substitute for fermentation culture, achieving environmentally friendly animal by-product recycling. The liquefaction of PHS was conducted at various pressures (0.5–2.3 MPa) for 5–30 min. As evidenced by the scanning electron microscopy analysis, ICSE caused randomly cracks ...
Source: Journal of Bioscience and Bioengineering - Category: Biomedical Science Source Type: research
Publication date: February 2020Source: Biomedical Signal Processing and Control, Volume 56Author(s): Gabriella Olmo, Francesca Farolfi, Federica Miola, Stefano Giorgi, Alessia Di Sapio, Antonio BertolottoAbstractFatigue is one of the most distressing symptoms of Multiple Sclerosis, impairing quality of life, work performance and social interactions. Moreover, it is difficult to objectively assess, and is often evaluated via subjective questionnaire; however, objective metrics are highly desirable.Objective of this paper is to implement a differential fatigue measure based on evoked potentials, and assess its reliability an...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
In this study, a series of deletion mutants or point mutants of horPDPN were produced for analyzing the PMab-219 epitope using flow cytometry. The analysis of deletion mutants showed that N-terminus of PMab-219 epitope exists between 55th amino acid (aa) and 60th aa of horPDPN. Furthermore, the analysis of point mutants demonstrated that the critical epitope of PMab-219, which was developed by CBIS method, could include Val59, Arg61, Ser62, and Thr63 of horPDPN, indicating that PMab-219 epitope is independent of PLAG domain or PLD of horPDPN. PMID: 31638470 [PubMed - as supplied by publisher]
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research
Publication date: Available online 22 October 2019Source: Plant Physiology and BiochemistryAuthor(s): Elena V. Pradedova, Oksana D. Nimaeva, Alexander L. Rakevich, Rurik K. SalyaevAbstractThe role of glutathione in the plant vacuole is still being debated. In the present paper, the redox state of glutathione and the activity of glutathione S-transferase (GST, E 2.5.1.18) in the vacuole compared to those in leucoplast have been studied. Organelles were isolated from dormant red beet (Beta vulgaris L.) taproots. Two generally used approaches have been applied to quantitatively assess the content of glutathione. Initially, le...
Source: Plant Physiology and Biochemistry - Category: Biochemistry Source Type: research
Publication date: Available online 22 October 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Steven Wesley Beckwith, Cristine Lynn CzachowskiAbstractIncreased subjective discounting of delayed rewards is associated with substance abuse, and individuals tend to discount their drug of choice at a greater rate compared to monetary rewards. While there is evidence indicating that increased delay discounting (DD) is a risk factor for substance abuse, some results suggest that exposure to drugs of abuse also increases DD, but effects are mixed. The current study examined whether ethanol pre-exposure increases DD an...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
In this study, we characterized in vitro and in vivo profiles of a novel highly selective OX2R agonist, TAK-925 [methyl (2R,3S)-3-[(methylsulfonyl)amino]-2-{[(cis-4-phenylcyclohexyl)oxy]methyl}piperidine-1-carboxylate]. TAK-925 activated human recombinant OX2R with 50% effective concentration value of 5.5 nM, and showed>5000-fold selectivity over OX1R in calcium mobilization assays. TAK-925 induced OX2R-downstream signals similar to those displayed by orexin peptides in Chinese hamster ovary cells stably expressing human OX2R. In an electrophysiological study, TAK-925 activated physiological OX2R on histaminergic neur...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
In this study, a poly (ε–caprolactone) grafted graphene quantum dots–based dispersive solid phase extraction coupled with dispersive liquid–liquid microextraction has been developed to extract nine pesticides including penconazole, chlorpyrifos, haloxyfop–R–methyl, oxadiazon, clodinafop–propargyl, diniconazole, fenazaquin, fenpropathrin, and fenoxaprop–P–ethyl from different packed fruit juice samples (pomegranate, watermelon, apricot, grape, sour cherry, apple, and orange juices). In the first step, the analytes are adsorbed onto the sorbent and after that the sorben...
Source: Microchemical Journal - Category: Chemistry Source Type: research
In this study, a facile stepwise sol-gel coating approach was utilized to synthesize Pt decorated oxygen-deficient mesoporous titania microspheres with core-shell structure and convenient magnetic separability (denoted as Fe3O4@SiO2@Pt/mTiO2-x). These photocatalysts consist of magnetic Fe3O4 cores, nonporous insulating SiO2 middle layer and mesoporous anatase TiO2-x shell decorated by Pt nanoparticles (∼ 3.5 nm) through wet impregnation and H2 reduction. As a result of high activity of oxygen-deficiency of black TiO2-x by H2 reduction and efficient inhibition of electron-hole recombination by Pt nanoparticles, t...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
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