DSPP-MMP20 gene silencing downregulates cancer stem cell markers in human oral cancer cells.
Conclusions: We conclude that the downregulation of OCSC markers may signal a reduction in OCSC population following MMP20/DSPP silencing in OSCC cells, while also increasing their sensitivity to cisplatin. Thus, our findings suggest a potential role for DSPP and MMP20 in sustaining OCSC population in OSCCs, possibly, through mechanism(s) that alter OCSC sensitivity to treatment with chemotherapeutic agents such as cisplatin.
PMID: 30002682 [PubMed - in process]
Source: Cellular and Molecular Biology Letters - Category: Biochemistry Authors: Nikitakis NG, Gkouveris I, Aseervatham J, Barahona K, Ogbureke KUE Tags: Cell Mol Biol Lett Source Type: research
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