Parasite Drug Shows Effectiveness Against Mesothelioma

Dr. Antonio Giordano believes his team has cleared the path to the next breakthrough in the treatment of malignant pleural mesothelioma. The advancement involves a new use for an old drug, pyrvinium pamoate, which doctors have successfully used for more than 50 years to treat infections of pinworm parasite. “This drug that no one expected to be involved with mesothelioma is potentially a new weapon against this aggressive type of tumor,” Giordano told “Our findings are exciting, very exciting. This one can move forward.” Giordano is the founder and director of the Sbarro Health Research Organization (SHRO) at Temple University in Philadelphia. He also is an internationally renowned professor of pathology and oncology at the University of Sienna in Italy. His expertise involves identifying novel targets and therapies at the molecular level. This particular drug has shown promise with mesothelioma as well as pancreatic and breast cancer. Better Mesothelioma Treatments Needed The findings have been published in the latest issue of Journal of Cell Physiology. A summary is available on the SHRO website. “This should trigger interest and attention of oncologists all over the world to work on it,” Giordano said. “It’s now about taking the initiative to bring this drug to the clinical bedside, to the patients.” Pleural mesothelioma, which is caused by exposure to asbestos, is a rare and aggressive cancer with no defi...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news

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Publication date: Available online 18 October 2018Source: Journal of Molecular LiquidsAuthor(s): H. Abramczyk, A. Imiela, A. ƚliwiƄskaAbstractLipids play an important role in many cellular processes. Raman-driven microscopy is one of the most powerful technique for analyzing the properties of lipids in cellular compartments offering lipid compositional mapping and more precise, faster, simpler, and nondestructive measurements. Recent advances in Raman imaging (RI) have greatly progressed lipidomic analysis, such as lipid droplet content, lipid phenotype, fatty acid composition, spatial distribution and drug treatment res...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Publication date: Available online 18 October 2018Source: Journal of Molecular LiquidsAuthor(s): Mostafa Zamani, Ehsan Naderi, Mozhgan Aghajanzadeh, Mahmoud Naseri, Ali Sharafi, Hossein DanafarAbstractThe present paper aimed to synthesize, using thermal-treatment method, a variety of Co1-XZnxFe2O4-based nanocarriers (NCs) as Dual-controlled and targeted drug delivery systems (DDS) and provide a new structure as NCs suitable for the loading and pH-responsive characteristics of the chemotherapeutic curcumin (CUR). To study the structure, surface morphology, surface charge and magnetic properties of NCs, X-ray diffraction (XR...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
This study examined the role of H2S in drug resistance in liver cancer cells.Materials and methodsHuman primary hepatocellular carcinoma cell line (HepG2) and doxorubicin (Dox)-resistant cells were used in this study. Cell survival was analyzed by MTT, Annexin V-FITC/propidium iodide staining and clonogenic assay. Western blotting was used for analysis of protein expression, and immunoprecipitation was used to determine interactions of LXR/RXR.Key findingsThe expression of H2S-generating enzyme cystathionine gamma-lyase (CSE) was inhibited by doxorubicin treatment in HepG2 cells, and H2S sensitized Dox-inhibited cell survi...
Source: Life Sciences - Category: Biology Source Type: research
This study was based on the fact that, overall mass, charge and size of a protein changes after interaction with charged ligands such as metal ions, which affects the electrophoretic movement of the analyte protein under the influence of electroosmotic flow. This alteration in electrophoretic mobility of the analyte is proportional to the strength of interaction between the two species and is utilized to calculate the binding results. The mobility ratio (R) of an EOF marker (injected in same run) and the analyte enzyme was determined and the binding result was expressed as the normalized difference of the mobility ratios o...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Publication date: Available online 18 October 2018Source: Genes &DiseasesAuthor(s): Xingxing Zang
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
Switching to a better, lower fat diet can reduce the risk of death by 20 percent for colorectal cancer patients, a new American Cancer Society study found. Western diets high in fat raise death risks.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
An Oregon teenager’s innovation could change the way doctors treat pancreatic cancer, a deadly form of the disease that has just a 7% five-year survival rate. Rishab Jain, a 13-year-old from Stoller Middle School in Portland, on Tuesday won the Discovery Education 3M Young Scientist Challenge with an algorithm that uses machine learning to help doctors zero in on the pancreas during cancer treatment. Doing so can be difficult, since the pancreas is often obscured by other organs, and since breathing and other bodily processes can cause it to move around the abdominal area. As a result, doctors sometimes need to deplo...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer healthytime onetime Source Type: news
One of the more interesting aspects of the various epigenetic clocks that have been developed in recent years is that it is still largely unknown as to what exactly it is that they are assessing in our aging biochemistry. These clocks are weighted measures of epigenetic markers, such as DNA methylation, over a comparatively small number of genes. The resulting number certainly reflects chronological age, with the best clocks having a margin or error of a few years when assessed over a group of people. There is also sound evidence for it to reflect biological age, the burden of damage and dysfunction, which varies between i...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Ken and Jane Gremling have shared everything since they got married in 1971, just three weeks after they started dating. But they never expected to receive identical breast cancer diagnoses.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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