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Genes on Y chromosome protect against pulmonary hypertension, study suggests

This study is the first to examine the involvement of sex chromosomes in the disease's development in the absence of sex hormones. In humans, females typically have two copies of the X chromosome, while males typically have one X and one Y chromosome.METHODIn the lab, the researchers engineered mice with different chromosomal makeups and measured their development of pulmonary hypertension in an environment with 10 percent oxygen, which is a well-established setting for inducing the disease.One group of mice was engineered with sex chromosomes that were independent of their gonadal sex, or sex based on their genitalia, so that the researchers could isolate the impact of sex chromosomes. The other group of mice in the experiment had different variants of sex chromosomes in order for the researchers to determine the impact of the presence of a Y chromosome versus varying numbers of X chromosomes. All the mice had their gonads removed so that the researchers could eliminate the potential effects of sex hormones.The researchers then placed the mice in the 10 percent oxygen environment for three weeks. At the end of the experiment, the researchers examined the hearts and lungs of the mice. Mice with a Y chromosome experienced significantly less severe pulmonary hypertension and were protected against the development of the disease.IMPACTThese findings identify a new avenue for research into effective ways to treat pulmonary hypertension. In the future, determining which genes on t...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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 >>>Available Here with Free Look Inside Option Correct answer: 3. Both 1 and 2 In domino heart transplantation, the donor receives heart lung transplantation. The excised heart is transplanted to another recipient so that the donor for recipient of domino heart transplantation is alive, unlike the conventional donor who is brain dead. In one report of 10 cases of domino heart transplantation, one year survival of donor was 60% while that of recipient was 90% [1]. It worthwhile noting that donors had terminal cardio pneumopathy (mostly primary pulmonary hypertension, one case of Eisenmenger syndrome and ...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Pulmonary hypertension (PH) refers to increased pressure in the pulmonary circulation. It develops when pulmonary vessels become constricted and/or obstructed, which can occur in a wide variety of conditions. The increase in pressure is measured by right catheterization, and is defined as a mean pulmonary arterial pressure ≥ 25 mm Hg at rest. PH leads to right ventricular hypertrophy and enlargement as the ventricle pumps against increased resistance. Right-sided heart failure (cor pulmonale) can eventually develop. Signs and symptoms of PH include dyspnea on exertion, fatigue, substernal chest pain, syncope, hepatomega...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Pulmonology Source Type: blogs
To the Editor:
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Primary graft dysfunction (PGD), a form of severe acute lung injury, is the main cause of early morbidity and mortality after lung transplantation. Pulmonary hypertension (PH), either World Health Organization (WHO) Group I or III, is a significant risk factor for PGD.1 We previously demonstrated that genetic variation in long pentraxin-3 (PTX3), a phylogenetically conserved acute-phase reactant that modulates inflammatory responses, and elevated post-transplant plasma PTX3 levels were associated with an increased risk of PGD after lung transplantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Research Correspondence Source Type: research
In this study we examined changes in N-terminal pro –B-type natriuretic peptide (NT-proBNP) in patients undergoing BPA for inoperable CTEPH and related them to peri-procedural success.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
This study examined changes in N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients undergoing BPA for inoperable CTEPH and related them to periprocedural success.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Nowadays, noninvasive imaging plays an essential role in diagnosis, prognosis and management of pulmonary arterial hypertension. The Fifth World Symposium on Pulmonary Hypertension (PH) highlighted the importance of right heart failure in pulmonary hypertension. It is defined as “a complex clinical syndrome due to suboptimal delivery of blood or elevated systemic venous pressure at rest or exercise as a consequence of elevated right ventricular afterload”, taking into account physiological demands, and both systolic and diastolic function of the ventricle-arterial coupl ing.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Introduction: Cardiovascular disease (CD) has an impact on the evolution and prognosis in patients with COPD. The aim of our study was to determine the prevalence of cardiovascular comorbidities in severe COPD patients.Methods: We included patients with COPD evaluated for lung transplant (LT) at the Hospital Universitari Vall DHebron Barcelona Spain, from January 2015 to September 2016. All patients underwent echocardiogram, blood analysis, respiratory lung function tests, and cardiac catheterism (CC) as part of the LT protocol.Results: Ninety-two patients with COPD were evaluated for LT during that period. 60.9% were men ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring Airway Disease Source Type: research
Conclusion: CT-derived measures of dPA and dPA/dAo should not be used to screen for PH in this population.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research
Introduction: Pulmonary hypertension is a malignant prognostic factor in ILD. Prognostic tools are required to help prioritise lung transplant allocation and have not been validated in PH-ILD. We hypothesised that the composite physiological index (CPI) would reliably predict prognosis in PH-ILD, as it reflects both the morphological extent of pulmonary fibrosis and pulmonary vascular disease.Methods: Demographics, ILD subtype, pulmonary function tests, and echocardiograms were collected in consecutive patients undergoing right heart catheterisation (RHC) for suspected PH-ILD. Predictors of prognosis were evaluated in thei...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research
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