Genes on Y chromosome protect against pulmonary hypertension, study suggests

This study is the first to examine the involvement of sex chromosomes in the disease's development in the absence of sex hormones. In humans, females typically have two copies of the X chromosome, while males typically have one X and one Y chromosome.METHODIn the lab, the researchers engineered mice with different chromosomal makeups and measured their development of pulmonary hypertension in an environment with 10 percent oxygen, which is a well-established setting for inducing the disease.One group of mice was engineered with sex chromosomes that were independent of their gonadal sex, or sex based on their genitalia, so that the researchers could isolate the impact of sex chromosomes. The other group of mice in the experiment had different variants of sex chromosomes in order for the researchers to determine the impact of the presence of a Y chromosome versus varying numbers of X chromosomes. All the mice had their gonads removed so that the researchers could eliminate the potential effects of sex hormones.The researchers then placed the mice in the 10 percent oxygen environment for three weeks. At the end of the experiment, the researchers examined the hearts and lungs of the mice. Mice with a Y chromosome experienced significantly less severe pulmonary hypertension and were protected against the development of the disease.IMPACTThese findings identify a new avenue for research into effective ways to treat pulmonary hypertension. In the future, determining which genes on t...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

Related Links:

This article reports a rare coexistence of aberrant right subclavian artery with other congenital anomalies of the heart and great vessels in living men.
Source: Surgical and Radiologic Anatomy - Category: Anatomy Source Type: research
Idiopathic pulmonary hypertension (IPH) is an indication for lung transplantation (LTx) or combined heart ‒lung transplantation (HLTx) in the pediatric population. Overall, pulmonary vascular disease is the primary diagnosis for a large minority of children listed for lung transplant, especially those
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: RESEARCH CORRESPONDENCE Source Type: research
Idiopathic pulmonary hypertension (IPH) is an indication for lung transplantation (LTx) or combined heart-lung transplantation (HLTx) in the pediatric population. Overall, pulmonary vascular disease is the primary diagnosis for a large minority of children listed for lung transplant, especially those less than 6 years of age.1 However, the relatively low numbers of these surgical procedures performed in children limits accurate outcome data. Previously published work has included study cohorts ranging from 5 to 23 children, severely restricting the ability to predict post-thoracic transplant outcomes based on clinical characteristics.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Research Correspondence Source Type: research
Abstract Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension (PH). The prognosis of PVOD patients remains poor, since no effective medical therapy is yet available. Imatinib is a tyrosine kinase inhibitor specific for platelet-derived growth factor receptor and is expected as a treatment option for pulmonary arterial hypertension (PAH). Recently, it has been reported that imatinib improved functional capacity of a patient with PVOD. We here report a patient with suspected PVOD who has been successfully treated with imatinib and is alive for 6 years after diagnosis. A 57-year-old woman ...
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
The number of heart and lung transplantations has risen over the years, and they remain the mainstay of treatment for end-stage heart failure and end-stage lung diseases. From the assessment of the donor's heart to intraoperative management during separation from cardiopulmonary bypass (CPB) to the postoperative follow-up of heart transplant patients, echocardiography plays a vital role throughout this process. Patients with chronic lung diseases also may have cardiovascular compromise secondary to pulmonary hypertension, pre-existing coronary artery disease, or valvular heart disease.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Review Article Source Type: research
Tedford RJ, Beaty CA, Mathai SC, Kolb TM, Damico R, Hassoun PM, Leary PJ, Kass DA, Shah AS.   Prognostic value of the pre-transplant diastolic pulmonary artery pressure–to–pulmonary capillary wedge pressure gradient in cardiac transplant recipients with pulmonary hypertension.  J Heart Lung Transplant 2014;33(3):289-97.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Source Type: research
Intensive care of patients with pulmonary hypertension (PH) and right-sided heart failure includes treatment of factors causing or contributing to heart failure, careful fluid management, and strategies to reduce ventricular afterload and improve cardiac function. Extracorporeal membrane oxygenation (ECMO) should be considered in distinct situations, especially in candidates for lung transplantation (bridge to transplant) or, occasionally, in patients with a reversible cause of right-sided heart failure (bridge to recovery). ECMO should not be used in patients with end-stage disease without a realistic chance for recovery ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: World Symposium on Pulmonary Hypertension Source Type: research
European J Pediatr Surg Rep 2018; 06: e100-e103 DOI: 10.1055/s-0038-1675377Lung hypoplasia and pulmonary hypertension (PH) in association with congenital diaphragmatic hernia (CDH) may cause fatal respiratory failure. Lung transplantation (Ltx) may represent an option for CDH-related end-stage pulmonary failure. The aim of this study is to report a patient with CDH who underwent Ltx or combined heart-lung transplantation (H-Ltx). Our patient was born at 33 weeks of gestation, with a prenatally diagnosed isolated left CDH. Twenty-four hours after birth, she underwent surgical repair of a type D defect (according to the CDH ...
Source: European Journal of Pediatric Surgery Reports - Category: Surgery Authors: Tags: Case Report Source Type: research
This article aims to increase awareness of IPF among cardiologists, providing an overview for cardiologists on the differenti al diagnosis of IPF from HF, and describing the signs and symptoms that would warrant referral to a pulmonologist with expertise in ILD. Once patients with IPF have received a diagnosis, cardiologists can have an important role in managing patients who are candidates for a lung transplant or those w ho develop pulmonary hypertension (PH). Group 3 PH is one of the most common cardiovascular complications diagnosed in patients with IPF, its prevalence varying between reports but most often cited as be...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
Right ventricular failure (RVF) is still associated with an increased mortality in patients with pulmonary hypertension (PH) or congenital heart disease. Transition from right ventricular dysfunction to RVF is not predictable and has not been well understood so far. Several studies in rodents and in piglets showed that impairment of capillary density (CD) in the right ventricle (RV) is associated with right ventricular failure (1, 2). Some evidence suggested that the RV of patients with Eisenmenger Syndrome (ES) has remarkable adaptive capacities to high pulmonary pressures (3), leading to a longer survival in these patien...
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Research Correspondence Source Type: research
More News: Cardiology | Environmental Health | Genetics | Heart | Heart Transplant | Hormones | Hypertension | Lung Transplant | National Institutes of Health (NIH) | Pulmonary Hypertension | Respiratory Medicine | Study | Transplant Surgery | Transplants | Universities & Medical Training | USA Health | Women