Age, vascular health, and Alzheimer disease biomarkers in an elderly sample

ObjectiveTo investigate the associations between age, vascular health, and Alzheimer disease (AD) imaging biomarkers in an elderly sample. MethodsWe identified 430 individuals along the cognitive continuum aged>60 years with amyloid positron emission tomography (PET), tau PET, and magnetic resonance imaging (MRI) scans from the population‐based Mayo Clinic Study of Aging. A subset of 329 individuals had fluorodeoxyglucose (FDG) PET. We ascertained presently existing cardiovascular and metabolic conditions (CMC) from health care records and used the summation of presence/absence of hypertension, hyperlipidemia, cardiac arrhythmias, coronary artery disease, congestive heart failure, diabetes mellitus, and stroke as a surrogate for vascular health. We used global amyloid from Pittsburgh compound B PET, entorhinal cortex tau uptake (ERC‐tau) from tau‐PET, and neurodegeneration in AD signature regions from MRI and FDG‐PET as surrogates for AD pathophysiology. We dichotomized participants into CMC = 0 (CMC−) versus CMC> 0 (CMC+) and tested for age‐adjusted group differences in AD biomarkers. Using structural equation models (SEMs), we assessed the impact of vascular health on AD biomarker cascade (amyloid leads to tau leads to neurodegeneration) after considering the direct and indirect age, sex, and apolipoprotein E effects. ResultsCMC+ participants had significantly greater neurodegeneration than CMC− participants but did not differ by amyloid or ERC...
Source: Annals of Neurology - Category: Neurology Authors: Tags: Research Article Source Type: research

Related Links:

ConclusionsPatients with CMS were more likely to present with increased comorbidities. Patients with CMS undergoing CABG were at risk for worse short ‐term secondary postoperative outcomes and reduced long‐term survival. The data supports the need for further investigation for risk reduction surrounding operative revascularization.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
We present two cases of a left ventricular diverticulum causing cardiac arrhythmia which led to furth er surgical treatment.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CASE REPORT Source Type: research
Publication date: Available online 17 February 2020Source: Zoologischer AnzeigerAuthor(s): Iago Bueno da Silva, Sandra Daruiche Buganeme, Ana Maria Costa-LeonardoAbstractNeocapritermes opacus is a Neotropical termite, which feeds on a variety of food sources, including highly decayed wood and humus. Similar to many Termitidae, this species contains a mixed segment in the intestine, an anatomic distinct region composed of both mesenteric and proctodeal tissues. In Neocapritermes spp., a pair of intestinal protrusions referred to as mesenteric sacs are associated with the mixed segment. In the present study, with the aid of ...
Source: A Journal of Comparative Zoology - Category: Zoology Source Type: research
Publication date: Available online 17 February 2020Source: Inorganic Chemistry CommunicationsAuthor(s): M. Eid, M.B. El-Arnaouty, M. Salah, El-Sayed Soliman, El-Sayed A. HegazyAbstractGamma radiation synthesis of Polyaniline/glycidyl methacrylate [P(ANI/GMA)] and Polyaniline/glycidyl methacrylate/Ag2O (P(ANI/GMA)-Ag2O were prepared by adding different concentrations of AgNO3 to the prepared Polyaniline/glycidyl methacrylate. The formation of the function groups of P(ANI/GMA) and P(ANI/GMA)-Ag2O nanocomposites have been investigated by FT-IR. The X-ray patterns of P(ANI/GMA)-Ag2O nanocomposites showed more than crystalline ...
Source: Inorganic Chemistry Communications - Category: Chemistry Source Type: research
Conclusion: the patients gave the highest health-related quality of life ratings in regard to mental domains and the lowest ratings for the physical domains.RESUMEN Objetivo: evaluar la calidad de vida relacionada con la salud de pacientes con marcapaso card íaco definitivo. Método: estudio observacional descriptivo, transversal, realizado en el ambulatorio de arritmia de un hospital universitario del interior del estado de Sao Paulo. La muestra consecutiva y no probabilística estuvo constituida de pacientes de los dos sexos, mayores de 18 años, co n marcapaso hace, por lo menos, un mes. Fueron ...
Source: Texto e Contexto - Enfermagem - Category: International Medicine & Public Health Source Type: research
This study built on existing research by exploring the consequences of sexual violence...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Jurisprudence, Laws, Legislation, Policies, Rules Source Type: news
Balance and ambulation are the result of a multicomponent control process through the interaction of the sensory and motor information. Despite the clinical relevance of the somatosensory system, its role has not drawn much attention from clinical research...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
In the present experiment, we examined preschoolers' disclosures of a secret as a function of rapport building strategies used in Scandinavian field settings (verbal rapport building vs. prop rapport building), age in months (33-75  months) and question ty...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Condition:   Diabetes Mellitus Interventions:   Other: Administration of standardized questionnaires;   Device: Physical activity tracker;   Other: Dietary log Sponsor:   McGill University Health Centre/Research Institute of the McGill University Health Centre Recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Stroke Interventions:   Device: WBPC;   Device: Without WBPC Sponsor:   Changhua Christian Hospital Completed
Source: - Category: Research Source Type: clinical trials
More News: Alzheimer's | Arrhythmia | Brain | Cardiac Arrhythmia | Cardiology | Cardiovascular | Congestive Heart Failure | Diabetes | Diabetes Mellitus | Endocrinology | Health Management | Heart | Heart Failure | Hypertension | MRI Scan | Neurology | PET Scan | Stroke | Study