WHO issues warning about rise of drug-resistant gonorrhoea

Conclusion The increase in antimicrobial resistance towards drugs used to treat gonorrhoea is reaching a critical stage, especially given how common the infection is worldwide, with an estimated 78 million new cases in 2012. This study raises concerns around an important topic while also proposing strategies to help address the slow pace of research and development of new drugs. The prevention of gonorrhoea is equally, if not more, important. The most effective way to prevent gonorrhoea is to always use a condom during sex, including anal and oral sex. Read more advice about sexually transmitted infections and how to prevent them. Links To The Headlines Gonorrhoea fast becoming 'untreatable', WHO experts warn. Sky News, July 7 2017 Oral sex spreading unstoppable bacteria. BBC News, July 7 2017 Gonorrhoea becoming 'untreatable', experts warn. ITV News, July 7 2017 Untreatable gonorrhoea 'superbug' spreading around world, WHO warns. The Guardian, July 7 2017 Links To Science Global Antibiotics Research and Development Partnership. Multi-drug-resistant gonorrhoea: a research and development roadmap to discover new medicines. July 2017 (PDF, 230kb)
Source: NHS News Feed - Category: Consumer Health News Tags: Medication QA articles Source Type: news

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Source: Molecular Phylogenetics and Evolution - Category: Molecular Biology Source Type: research
Publication date: Available online 21 March 2019Source: Chinese Journal of Chemical EngineeringAuthor(s): Marija R. Miladinović, Ivan J. Stojković, Ana V. Veličković, Olivera S. Stamenković, Ivana B. Banković-Ilić, Vlada B. VeljkovićAbstractContinuous biodiesel production from a waste pig-roasting lard, methanol and KOH was carried out in a reciprocating plate reactor (RPR) using a factorial design containing three process factors, namely methanol/lard molar ratio, catalyst loading, and normalized height of the reactor. The main goals were to optimize the influential process factors with respect to biodiesel purity...
Source: Chinese Journal of Chemical Engineering - Category: Chemistry Source Type: research
Publication date: Available online 21 March 2019Source: Chinese Chemical LettersAuthor(s): Qiong Yan, Cheng Wang, Ji Wang, Liangjun Pan, Zhiling ZhangAbstractVirus spread is closely related to pathogenesis. Traditional research methods of virus spread do not distinguish cell-to-cell spread from cell-free spread. The uncertainty of virus induced plaque and virus spread direction makes it difficult to track the spread of virus in situ. Herein, the cellular network was fabricated on the basis of PEG modification and soft lithography. Therein, cell numbers and spatial distributions were precisely controlled, e.g., cellular net...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
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Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
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Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
In this study, we reported a dual HDAC and DNMT inhibitor 208 and found it induced G1 cell cycle arrest and apoptosis in U937 cells. Proteome and bioinformatic analyses revealed that the combined inhibition of DNMT1 and HDAC by 208 affected the expression of a series of proteins involved in many biological processes. We observed that several proteins associated with G1 cell cycle arrest and apoptosis were down regulated after 208 treatment, including p85α, MEK, and CDK4, suggesting that 208 induces cell cycle arrest and apoptosis through the p85α/MEK-mediated pathway in U937 cells. Moreover, biological function...
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Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
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