Bone metabolism in non alcoholic fatty liver disease: vitamin D status and bone mineral density.

This study aimed to review current evidences supporting the association between bone metabolism including low BMD and serum vitamin D level in patients with NAFLD. Epidemiolocal studies indicating lower BMD and vitamin D in patients with NAFLD have been reviewed. The main pathophysiological mechanisms including association of insulin resistance, serum adiponectin, ghrelin, osteopontin, osteoprotegerin, and osteocalcin with NAFLD and low BMD have been briefly reviewed and summarized. Results of current clinical trials investigating the role of vitamin D supplementation for treatment of hepatic steatosis and non alcoholic steatohepoatitis (NASH) have been also summarized. As a conclusion, increasing evidences are now available suggesting low BMD in patients with NAFLD. Some of these studies showed association of NAFLD severity with low vitamin D and BMD. Screening and surveillance of skeletal system regarding osteoporosis/ osteomalacia in patients with NAFLD may be considered in future strategies and guidelines for NAFLD management. PMID: 27973461 [PubMed - as supplied by publisher]
Source: Minerva Endocrinologica - Category: Endocrinology Tags: Minerva Endocrinol Source Type: research