A close look at our cases with parathyroidectomy: 11 years of experience.
CONCLUSIONS: Parathyroid neoplasm with uncertain malignant potential defines cases with suspicious histopathological features of carcinoma but doesn't meet the criteria for parathyroid carcinoma. In our series, these cases are identified as atypical parathyroid adenoma. We present clinical and morphological features of our parathyroidectomy cases in an 11-year period and aim to raise concern about borderline cases in between adenoma and carcinoma. We think that such tumors, similar to the thyroid neoplasm classification, should be defined as parathyroid neoplasms with uncertain malignant potential and should be followed cl...
Source: Minerva Endocrinologica - October 27, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Untargeted metabolomics analysis of serum and follicular fluid samples from women with polycystic ovary syndrome.
CONCLUSIONS: Our findings would provide a resource for further investigations on metabolic disturbance in PCOS patients. PMID: 33103870 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 27, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Normocalcemic primary hyperparathyroidism: an update.
Authors: Salcuni AS, Battista C, Pugliese F, Columbu C, Guarnieri V, Carnevale V, Scillitani A Abstract Normocalcemic primary hyperparathyroidism (NPHPT) is diagnosed in the setting of elevated PTH concentrations with consistently normal albumin-adjusted and ionized serum calcium levels, in absence of secondary causes for elevated PTH concentrations. In order to confirm persistence of the hyperparathyroid state, PTH levels should be elevated on at least two occasions over a 3 to 6 months period. The prevalence of NPHPT depends on the population studied. Data from different studies are often not comparable; indeed, ...
Source: Minerva Endocrinologica - October 27, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Codon bias analyses on thyroid carcinoma genes.
CONCLUSIONS: This is the first study that analyzed the codon bias in thyroid cancer genes based also on synonymous mutations. The study provided different hints that should be further investigated by wet-lab validation and that it could open new scenarios in the understanding the molecular mechanisms involved in thyroid cancer development based on codon bias. PMID: 33103872 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 27, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The relation between sociosexual orientation, muscle performance and disgust sensitivity. A preliminary correlational study.
CONCLUSIONS: Higher MP is associated with a greater tendency to have occasional relationships and multiple sexual partners, in both genders. MP-related self-esteem and perceived vulnerability may be involved in mating behaviors. We speculate that the sexual hormones might mediate the relationship among these variables. Future studies are warranted to explore this hypothesis. PMID: 33103873 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 27, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Increased serum IL-18 levels and IL-18R expression in newly diagnosed type 2 diabetes mellitus.
CONCLUSIONS: Both serum IL-18 and its receptor IL-18R is significantly higher in newly diagnosed T2DM patients. PMID: 33103874 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 27, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Differentiated thyroid cancer: new perspectives from genetics to the clinic.
Authors: Colombo C, Cirello V, Muzza M, Pogliaghi G, Karapanou O, Giancola N, Fugazzola L PMID: 33103875 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 27, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

New perspectives in neuroendocrine neoplasms research from tumor xenografts in zebrafish embryos.
Authors: Carra S, Gaudenzi G PMID: 33103876 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 27, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The role of molecular genetics in the pre-surgical management of thyroid nodules.
CONCLUSIONS: Next Generation Sequencing NGS) development and incorporation of other genetic markers such as miRNA can improve diagnostic accuracy of molecular tests. PMID: 33045818 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 14, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The clonal origin of multifocal papillary thyroid cancer (MPTC): intrathyroid spread or independent tumors?
In conclusion, data available in the literature indicated that multifocal papillary thyroid cancer may derived from both intraglandular spread and independent tumor foci. The understanding of the clonal origin of multifocal papillary thyroid tumors might represent an important issue in patient treatment. PMID: 33045819 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 14, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Familial non-medullary thyroid carcinoma: clinico-pathological features, current knowledge and novelty regarding genetic risk factors.
Authors: Cirello V Abstract Familial non-medullary thyroid cancer (FNMTC) constitutes 3-9% of all thyroid cancers and occur in two or more first-degree relatives in the absence of predisposing environmental factors. Out of all FNMTC cases, only 5% are represented by syndromic forms (Gardner's syndrome, familial adenomatous polyposis, Cowden's syndrome, Carney complex 1, Werner's syndrome and DICER1 syndrome), in which thyroid cancer occurs as a minor component and the genetic alterations are wellknown. The non-syndromic forms represent the majority of all FNMTCs (95%), and the thyroid cancer is the predominant feat...
Source: Minerva Endocrinologica - October 14, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Sex difference in the association between malnutrition and hypoglycemia in hospitalized patients.
Authors: Gur Arieh N, Adler H, Khanimov I, Giryes S, Ditch M, Felner Burg N, Boaz M, Shimonov M, Leibovitz E Abstract OBJECTIVE: To examine the difference between males and females regarding association between malnutrition risk and hypoglycemia. DESIGN: Sub-analysis of a cross-sectional study of newly admitted patients to internal medicine departments. METHODS: Malnutrition risk, assessed with Nutritional Risk Screening 2002 (NRS2002), and serum albumin were measured upon admission. Logistic regression was applied to men and women separately, to test the effect of malnutrition and hypoalbuminemia on incide...
Source: Minerva Endocrinologica - October 4, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Insulin resistance and hepatic steatosis in type 1 diabetes mellitus and their association with diabetic chronic complications.
Authors: Popa SG, Simion AM, Soare M, Arcomita D Abstract AIMS: To evaluate insulin resistance and hepatic steatosis and their association with diabetes duration, control and chronic complications in patients with type 1 diabetes. METHODS: We studied medical records of 181 consecutive hospitalized adults patients with type 1 diabetes. Estimated glucose disposal rate (eGDR), insulin sensitivity score (ISS), fatty liver index (FLI) and hepatic steatosis index (HSI) were calculated. RESULTS: Patients in the 1st tertile of eGDR (
Source: Minerva Endocrinologica - October 4, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Vitamin D3 deficiency is associated with more severe insulin resistance and metformin use in patients with type 2 diabetes.
Authors: Aludwan M, Kobyliak N, Abenavoli L, Kyriienko D, Fagoonee S, Pellicano R, Komisarenko I Abstract BACKGROUND: Vitamin D3 (vit. D3) deficiency is considered as one of the main factors involved in the development of type 2 diabetes (T2D). We assessed insulin resistance (IR), β-cell functional activity and metabolic profile according to 25(OH) vit. D3 status in patients with T2D. METHODS: The study included 109 patients with T2D, divided in 3 groups: group 1 (N.=11) with normal levels of vit. D3 (>30 ng/mL); group 2 (N.=38) with vit. D3 insufficiency (21-29 ng/mL); and group 3 (N.=60) with vit. D3 deficiency (
Source: Minerva Endocrinologica - October 3, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Male hypogonadism: therapeutic choices and pharmacological management.
Authors: La Vignera S, Izzo G, Emerenziani GP, Cannarella R, Condorelli RA, Calogero AE, Aversa A Abstract Male hypogonadism, defined as an inadequate testosterone production, recognizes a testicular (primary hypogonadism) or a hypothalamic-pituitary dysfunction (central hypogonadism), although combined forms can also occur. Moreover, it has been known that intensive exercise training might be a cause of functional hypogonadism. Many therapeutic choices are currently available, depending on the timing of hypogonadism onset and fertility issue. The aim of this review was to comprehensively supply therapeutic options...
Source: Minerva Endocrinologica - October 3, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The possible role of endocrine dysfunction of adipose tissue in gestational diabetes mellitus.
Authors: Šimják P, Anderlová K, Cinkajzlová A, Pařízek A, Kršek M, Haluzík M Abstract Gestational diabetes mellitus (GDM) is diabetes that is first diagnosed in the second or third trimester of pregnancy in patients who did not have a history of diabetes before pregnancy. Consequences of GDM include increased risk of macrosomia and birth complications in the infant and an increased risk of maternal type 2 diabetes mellitus (T2DM) after pregnancy. There is also a longer-term risk of obesity, T2DM, and cardiovascular diseases in the child. GDM is the result of impaire...
Source: Minerva Endocrinologica - October 3, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Is hemithyroidectomy sufficient in unilateral benign nodular goitre?
CONCLUSIONS: Due to low reoperation risk and acceptable permanent hypothyroidism rates, hemithyroidectomy is a viable option for benign goitre cases. The patients should be on follow-up for possible complications, especially hypothyroidism, for at least a year. PMID: 32969625 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 25, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Subclinical male hypogonadism.
CONCLUSIONS: Although available evidence suggests that in aging populations SHG can be considered a particular condition associated with an increased CV risk, it is still unknown if treatment with T can improve any outcomes in these subjects. Hence, further interventional studies are advisable in order to better understand the characteristics of SHG and the possible advantages of an early TRT. PMID: 32969626 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 25, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

A favorable effect on nutritional status of 12-week tailored texture-modified sous-vide cooking meals in institutionalized elderly women with oropharyngeal dysphagia: an intervention study.
CONCLUSIONS: This study demonstrated that elderly dysphagic women at long-term care facilities can eat better and increase nutritional status by eating 12-week tailored appealing TTMSVC. PMID: 32969627 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 25, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

A new breakfast brioche containing bergamot fiber prevents insulin and glucose increase in healthy volunteers: a pilot study.
CONCLUSIONS: The association of wheat bran and bergamot fiber significantly influences glucose metabolism and may exert insulin-like effects on healthy volunteers. If confirmed, Bergabrioche would be a useful tool in preventing diabetes and controlling the glycometabolic status of Type 2 diabetic patients. PMID: 32969628 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 25, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Endocrinological disorders and inflammatory skin diseases during COVID-19 outbreak. A review of the literature.
CONCLUSIONS: Our study pays attention on medium-long term effects of COVID-19 outbreak on inflammatory skin disorders, due to the lifestyle changes. In such context this review considers how a multidisciplinary approach, involving dermatologists, nutritionists and endocrinologists, may lead to a better management of dermatologic patients. PMID: 32969629 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 25, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Mediterranean diet and breast cancer risk: a narrative review.
Authors: Laudisio D, Castellucci B, Barrea L, Pugliese G, Savastano S, Colao A, Muscogiuri G Abstract Breast cancer is the second most frequent type of cancer worldwide and the most commonly occurring malignancy in women, and its incidence is increasing in most developed and developing countries. There is growing evidence that lifestyle factors, in particular diet may be associated with higher Breast Cancer risk. Some evidence exists regarding the benefit of Mediterranean Diet on reduced risk of Breast Cancer in premenopausal and postmenopausal women. The protective effect of the Mediterranean Diet against the risk...
Source: Minerva Endocrinologica - September 25, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Oxidative stress as a key feature of autoimmune thyroiditis: an update.
CONCLUSIONS: Oxidant/antioxidant imbalance represent a key feature of thyroid autoimmunity. Oxidative stress parameters could be used as biochemical markers of chronic inflammation, to better predict the disease evolution along its natural history. Dietary habits and antioxidant supplements may provide protection from autoimmunity, opening new perspectives in the development of more tailored therapies. PMID: 32969631 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 25, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Evaluation of vitamin D receptor gene polymorphisms in patients with differentiated thyroid carcinomas and nodular goiter.
CONCLUSIONS: This is the first study in the literature evaluating the role of VDR gene SNPs in nodular goiter. We can suggest that SNP distribution in the VDR gene is not associated with malignancy but may cause some alterations in thyrocyte morphology and functions. PMID: 32744437 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - August 5, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Thyroid papillary carcinoma arising in ectopic thyroid tissue within sternocleidomastoid muscle: case report and review of current literature.
Authors: Barrea L, Fonderico F, Di Somma C, Pugliese G, De Alteriis G, Mascolo M, Colao A, Savastano S Abstract The prevalence of ectopic thyroid tissue as consequence of an aberrant migration of thyroid during embryogenesis ranges up to 10% in autopsy studies. The differential diagnosis between the relatively rare occurrence of a primary carcinoma arising in ectopic thyroid tissue and the more frequent presence of cervical lymph node metastasis from papillary thyroid carcinoma (PTC) might represent a difficult challenge in the clinical practice. The clinical relevance of these lesions lies in their risk of hidden ...
Source: Minerva Endocrinologica - August 5, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Early and delayed puberty among Iranian children with obesity.
CONCLUSIONS: Our study demonstrated no association between obesity and early puberty in girls; however, boys with obesity had delayed puberty. We also found higher birth weight is associated with earlier onset of obesity, putting light on the importance of preventive interventions. PMID: 32744439 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - August 5, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Subclinical hypothyroidism.
Authors: Chbat J, Ezzat S, Papi G Abstract Subclinical hypothyroidism - i.e., a condition characterized by serum TSH concentrations above the normal reference range in the presence of normal serum T4 levels - affects 4 to 20% of the population living in iodine-sufficient areas. The present work reviews the clinical challenges regarding, on the one hand, the signs and symptoms possibly related to subclinical hypothyroidism, and on the other hand, the most recent guideline recommendations to treatment. PMID: 32744440 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - August 5, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Association of cardio-metabolic risk factors with elevated basal heart rate in South African Asian Indians.
Authors: Prakaschandra R, Prakesh D Abstract BACKGROUND: The aim of this study was to determine the association of increasing basal heart rate (BHR) with cardio-metabolic risk in a community sample of Asian Indians from South Africa, due to lack of population-based data on the interaction between heart rate and cardiovascular factors. METHODS: Data drawn from 1349 randomly selected participants was collected using the WHO STEPS questionnaire. Anthropometry, blood pressure, physical examination and laboratory analyses of venous blood samples and definition of cardiometabolic derangements were performed according...
Source: Minerva Endocrinologica - August 5, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Electrocardiography in euthyroid individuals: a Danish general population study.
Authors: Isaksen JL, Skov MW, Graff C, Ellervik C, Kanters JK Abstract BACKGROUND: Thyroid hormones within the euthyroid range have been linked to mortality and differences in heart rate. However, some relations between thyroid hormone concentration and various electrocardiographic measurements remain unassessed. We aimed to investigate the association between thyroid hormone concentrations within the euthyroid range and different electrocardiographic markers in people free of thyroid disease. METHODS: We obtained electrocardiograms (ECG) and blood samples of free T4, total T3, and thyrotropin (TSH) in 20,852 s...
Source: Minerva Endocrinologica - July 29, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Identification of an immune-related key gene, PPARGC1A, in the development of Anaplastic Thyroid Carcinoma: in silico study and in vitro evaluation.
CONCLUSIONS: An immune-related gene, PPARGC1A, was filtered out as the key gene that might play critical roles in the initiation and progression of ATC. It might affect the prognosis by inhibiting immune cell infiltrations. Future experimental studies are needed to confirm the results. PMID: 32720497 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 29, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Lights and darks of neuroendocrine tumors of the appendix.
CONCLUSIONS: There are some persisting "grey areas" with regard to the characterization and the clinical management of neuroendocrine tumors of the appendix. An increasing awareness of the biological and clinical aspects of this disease and new, ideally prospective, focused studies might help and clarify some relevant issues that are not fully elucidated yet and could increase the solidity of the guidance for the management and the follow-up of the patients. PMID: 32720498 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 29, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Nutrition knowledge is associated with greater weight loss in obese patients following a multidisciplinary rehabilitaiton program.
Authors: Gilardini L, Cancello R, Caffetto K, Cottafava R, Gironi I, Invitti C Abstract BACKGROUND: A major objective of the metabolic-nutritional-psychological multidisciplinary rehabilitation of obese subjects is providing a nutritional education aimed at achieving a weight loss and the improvement of obesity-related cardio-metabolic diseases. The impact of nutrition knowledge in healthy eating patterns and weight loss is still debated. The aim of this study was to identify whether the increase in nutrition knowledge is associated with weight loss. METHODS: 256 obese patients (80% women, mean age 57.5±...
Source: Minerva Endocrinologica - July 29, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Pancreatitis and pancreatic cancer in patients with type 2 diabetes treated with glucagon-like peptide-1 receptor agonists: an updated meta-analysis of randomized controlled trials.
CONCLUSIONS: No clear evidence of risk for pancreatitis was observed, whereas data on pancreatic cancer are too scarce to draw any conclusion. PMID: 32720500 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 29, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Differential diagnosis between constitutional delay of growth and puberty, idiopathic growth hormone deficiency and congenital hypoogonadotropic hypogonadism: a clinical challenge for the pediatric endocrinologist.
CONCLUSIONS: Only a step-by-step diagnostic process based on appropriate endocrine and genetic markers together with LDSS treatment can help achieving the correct diagnosis and optimizing outcomes. PMID: 32720501 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 29, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Procalcitonin as a marker of medullary thyroid carcinoma.
Authors: Cancela-Nieto MG, Sánchez-Sobrino P, Velogarcía A PMID: 32720502 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 29, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Impact of current anti-psoriatic systemic treatments on male and female fertility: what the endocrinologist needs to know.
Authors: Cacciapuoti S, Scala E, Megna M, Gallo L, Fontanella G, Ruggiero A, Savastano S, Fabbrocini G Abstract Fertility is a function of the body that often is overlooked as a site for the expression of the side effects of certain drugs. With the approval of new drugs with a totally innovative mechanism of action, the risk assessment on fertility both in male and female is more difficult. This is particularly true in psoriasis, an invalidating inflammatory skin disease. The estimated prevalence of psoriasis in adults ranged from 0.51% to 11.43%, and in children from 0% to 1.37%, with frequent diagnosis in young p...
Source: Minerva Endocrinologica - July 29, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The osteopontin expression and microvascular density in thyroid cancer, comparison of CT and ultrasound in diagnosis of thyroid cancer and correlations of CT features and thyroid cancer.
Authors: Wang F, Ding H, Wang Q, Wen P Abstract BACKGROUND: The aim of this study was to explore the osteopontin expression and microvascular density in thyroid cancer, compare computed tomography (CT) and ultrasound in diagnosis of thyroid cancer and investigate the correlations of CT Features and thyroid cancer. METHODS: A total of 80 patients with thyroid masses admitted to our hospital from April 2017 to August 2019 were selected, of which there were 40 with benign tumor and 40 with malignant tumor. All patients with thyroid cancer confirmed by pathological tissue biopsy were examined by ultrasound (ultraso...
Source: Minerva Endocrinologica - July 22, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Sensitivity and specificity of anthropometric measures during early pregnancy for prediction of development of gestational Diabetes Mellitus.
Authors: Todorovic J, Terzic-Supic Z, Gojnic-Dugalic M, Dugalic S, Piperac P PMID: 32672435 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 18, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

New-generation anti-obesity drugs: naltrexone/bupropion and liraglutide. An update for endocrinologists and nutritionists.
Authors: Barrea L, Pugliese G, Muscogiuri G, Laudisio D, Colao A, Savastano S Abstract The prevalence of obesity increases worldwide and has a significant economic impact on health care systems. A comprehensive program of lifestyle modification, including diet, exercise, and behavior therapy is considered the first option for achieving the significant weight loss. However, the intrinsic difficulties associated with maintenance of lifestyle changes contribute to the unsatisfactory long-term outcomes reported and weight regain in the obesity management. In this context, pharmacological approaches are useful to maximi...
Source: Minerva Endocrinologica - July 11, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Ovarian responsiveness in ART after CO2 fiber laser vaporization for endometrioma treatment: preliminary data.
CONCLUSIONS: CO2 laser-treated endometrioma is associated with favorable reproductive assisted reproductive technology outcomes. PMID: 32638581 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 9, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Relationships between microvascular complications of diabetes mellitus and levels of macro and trace elements.
CONCLUSIONS: This study showed an association between especially low Mg and Cr levels measured via ICP-MS and microvascular complications in patients with T2DM. PMID: 32623842 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 8, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Turner syndrome for successful treatment it is necessary to diagnose it early.
CONCLUSIONS: Based on the results of this research, TS is increasingly diagnosed at a later age. The effect of rhGH therapy was favorable and resulted in a greater height gain in the treated patients. PMID: 32623843 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 8, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Assessment of RANKL/RANK/osteoprotegerin system expression in patients with hepatocellular carcinoma.
Authors: Cabiati M, Gaggini M, De Simone P, Basta G, Gastaldelli A, Del Ry S PMID: 32623844 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 8, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Management and follow-up of differentiated thyroid cancer not submitted to radioiodine treatment: a systematic review.
CONCLUSIONS: Management of DTC treated with lobectomy or TTx but without 131I is worldwide changing. The evidences suggest that in this setting of patients with LR or IR of recurrences, a relaxed surveillance could represent the most reasonable choice. PMID: 32623845 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 8, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

COVID-19: The Endocrine opportunity in a pandemic.
Authors: Chatterjee S, Ghosh R, Biswas P, Dubey S, Guria RT, Sharma CB, Kalra S Abstract The 2019 Coronavirus disease (COVID-19) pandemic has disrupted the social, economical and medical system worldwide. Although it is strictly an infectious disease, its intricate bidirectional relationship with various non-communicable metabolic diseases and endocrinological factors has been observed. While diabetes, hypertension, obesity have been found to be independent risk factors for COVID-19 disease severity and mortality, more inclination towards sedentary lifestyle, psychosocial stress at this critical time may be the har...
Source: Minerva Endocrinologica - June 19, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Covid-19 infection in kidney transplant recipients: endocrine and metabolic issues.
Authors: Sarno G, Montalti R PMID: 32408731 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - May 17, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Serum cystatin C levels are decreased in type 1 diabetes mellitus patients with diabetic ketoacidosis.
Authors: Cheng Y, Xu C, Wang S, Hou L, Guan Q, Zhou X Abstract BACKGROUND: Cystatin C is a marker of renal function and risk factor for cardiovascular disease. Patients with acute myocardial infarction showed a significant decrease in cystatin C levels. It is unknown whether reduced serum cystatin C levels are connected to acute events or represent a negative acute phase response. The current study aimed to assess the association between cystatin C and the existence of diabetic ketoacidosis (DKA), an acute event in individuals with type 1 diabetes mellitus (T1DM). METHODS: Cystatin C was measured in the control...
Source: Minerva Endocrinologica - April 30, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Positive effect of nutraceuticals on sperm DNA damage in selected infertile patients with idiopathic high sperm DNA fragmentation.
Authors: Delbarba A, Arrighi N, Facondo P, Cappelli C, Ferlin A Abstract BACKGROUND: The use of nutraceuticals to improve sperm parameters and male fertility is debatable, even if evidence suggests that selected infertile patients might benefit from their use. In particular, oxidative stress might play a role in idiopathic male infertility, leading to sperm membrane damage and high sperm DNA fragmentation (SDF). The aim of this study was to evaluate, in selected idiopathic infertile men with high SDF, the effect on sperm DNA damage and on standard semen parameters of a nutraceutical formulation containing myoinosit...
Source: Minerva Endocrinologica - April 30, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Vitamin D and psoriasis: an update for dermatologists and nutritionists.
Authors: Megna M, Ferrillo M, Barrea L, Patruno C, Muscogiuri G, Savastano S, Fabbrocini G, Napolitano M Abstract Psoriasis is a common chronic immune-mediated inflammatory skin disease, now considered a systemic inflammatory process with several comorbidities. The skin produces vitamin D by the action of ultraviolet light. Vitamin D performs various immunomodulatory, anti-inflammatory, antioxidant and anti-fibrotic actions. The immunomodulatory effects of vitamin D offer opportunities to improve the treatment of several autoimmune diseases, such as psoriasis. In the literature, several significant associations are...
Source: Minerva Endocrinologica - April 30, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

A pilot study on the epidemiology of hyperuricemia in Chinese adult population based on big data from EMR (Electronic Medical Records), 2014-2018.
Authors: Liu Y, Yan L, Lu J, Wang J, Ma H Abstract OBJECTIVES: We performed this study based on big data from Electronic Medical Records (EMR) of outpatients and inpatients from 52 hospitals in China to investigate the prevalence of hyperuricemia in Chinese adults. METHODS: In this retrospective, descriptive study, a total of 3,363,016 subjects from 52 hospitals in 13 provinces and municipalities in China were enrolled. Eligible subjects were 18 years and older performing serum uric acid test between 2014 and 2018. Subjects were divided into the total group (including the subjects from all the clinic department...
Source: Minerva Endocrinologica - April 12, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research