Serum cystatin C levels are decreased in type 1 diabetes mellitus patients with diabetic ketoacidosis.
Authors: Cheng Y, Xu C, Wang S, Hou L, Guan Q, Zhou X Abstract BACKGROUND: Cystatin C is a marker of renal function and risk factor for cardiovascular disease. Patients with acute myocardial infarction showed a significant decrease in cystatin C levels. It is unknown whether reduced serum cystatin C levels are connected to acute events or represent a negative acute phase response. The current study aimed to assess the association between cystatin C and the existence of diabetic ketoacidosis (DKA), an acute event in individuals with type 1 diabetes mellitus (T1DM). METHODS: Cystatin C was measured in the control...
Source: Minerva Endocrinologica - April 30, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Positive effect of nutraceuticals on sperm DNA damage in selected infertile patients with idiopathic high sperm DNA fragmentation.
Authors: Delbarba A, Arrighi N, Facondo P, Cappelli C, Ferlin A Abstract BACKGROUND: The use of nutraceuticals to improve sperm parameters and male fertility is debatable, even if evidence suggests that selected infertile patients might benefit from their use. In particular, oxidative stress might play a role in idiopathic male infertility, leading to sperm membrane damage and high sperm DNA fragmentation (SDF). The aim of this study was to evaluate, in selected idiopathic infertile men with high SDF, the effect on sperm DNA damage and on standard semen parameters of a nutraceutical formulation containing myoinosit...
Source: Minerva Endocrinologica - April 30, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Vitamin D and psoriasis: an update for dermatologists and nutritionists.
Authors: Megna M, Ferrillo M, Barrea L, Patruno C, Muscogiuri G, Savastano S, Fabbrocini G, Napolitano M Abstract Psoriasis is a common chronic immune-mediated inflammatory skin disease, now considered a systemic inflammatory process with several comorbidities. The skin produces vitamin D by the action of ultraviolet light. Vitamin D performs various immunomodulatory, anti-inflammatory, antioxidant and anti-fibrotic actions. The immunomodulatory effects of vitamin D offer opportunities to improve the treatment of several autoimmune diseases, such as psoriasis. In the literature, several significant associations are...
Source: Minerva Endocrinologica - April 30, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

A pilot study on the epidemiology of hyperuricemia in Chinese adult population based on big data from EMR (Electronic Medical Records), 2014-2018.
Authors: Liu Y, Yan L, Lu J, Wang J, Ma H Abstract OBJECTIVES: We performed this study based on big data from Electronic Medical Records (EMR) of outpatients and inpatients from 52 hospitals in China to investigate the prevalence of hyperuricemia in Chinese adults. METHODS: In this retrospective, descriptive study, a total of 3,363,016 subjects from 52 hospitals in 13 provinces and municipalities in China were enrolled. Eligible subjects were 18 years and older performing serum uric acid test between 2014 and 2018. Subjects were divided into the total group (including the subjects from all the clinic department...
Source: Minerva Endocrinologica - April 12, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Tolvaptan efficacy and drug-drug interactions.
Authors: Piccica M, Basile G, Bartalesi F, Parenti G, Farese A, Buci L, Corti G, Bartoloni A, Peri A PMID: 32272825 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - April 12, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

COVID-19, or the triumph of monogamy?
Authors: Aversa A, Jannini EA PMID: 32270992 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - April 10, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Nappy rash ointments and Cushing Syndrome: a cause for concern.
Authors: Khalid M, Khalid H, Bhimani S, Ochani RK PMID: 32221276 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - March 31, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Specific cut-off for the 25-OH vitamin D levels to predict the highest body mass index and fat mass: a sex prospective in patients with obesity.
Authors: Barrea L, Colao A, Savastano S, Muscogiuri G PMID: 32221277 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - March 31, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Suboptimal medication adherence may favor the progression of vertebral fractures in women with post-menopausal osteoporosis under treatment with denosumab: a real-life observational study.
CONCLUSIONS: In post-menopausal women at high risk of fractures, the small delay in the administration of denosumab (i.e., not uncommon in clinical practice) was associated with a significant increase of incidence of VFs. Preservation of standard dosing schedule appears to be an important determinant of denosumab effectiveness in the real-life clinical practice. PMID: 32186164 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - March 20, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

A message from the new Chief Editor.
Authors: Vitale G PMID: 32162506 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - March 14, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Metformin, MCL-1 and cancer: more players for a single goal?
Authors: Mormile R PMID: 32162507 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - March 14, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Sitagliptin relieves diabetic nephropathy fibrosis via the MAPK/ERK signaling pathway.
Authors: Cheng S, Li L, Song C, Jin H, Ma S, Kang P PMID: 32077673 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - February 22, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Plasma kisspeptin levels in boys with hypogonadotropic delayed puberty.
Authors: Nikitina IL, Yukhlina YN, Vasilieva E, Nagornaya II, Grineva EN, Kelmanson IA Abstract BACKGROUND: In hypogonadotropic forms of delayed puberty (DP), hypophyseal follicle-stimulating (FSH) and luteinizing (LH) hormones, normally released with GnRH stimulation, are detected low. Since kisspeptin (KP) is a strong stimulant of GnRH neurons, it is considered to have a role in DP etiology. It may be hypothesized that abnormal plasma levels of KP are indicative of DP. The study aimed at evaluation and comparison of plasma KP levels in boys of pre-pubertal age, with normal puberty and diagnosed primary hypogonado...
Source: Minerva Endocrinologica - January 31, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Effects of alendronate and calcifediol compared to alendronate and cholecalciferol in osteoporotic patients.
The objective of this study was to examine efficacy and safety of calcifediol (25(OH)D) compared to cholecalciferol (vitamin D3) and also the relationship between different formulations of alendronate and adverse reactions. METHODS: We observed a population of women diagnosed with postmenopausal osteoporosis or osteopenia treated with alendronate 70 mg weekly associated to vitamin D3 or 25(OH)D at monthly total dose of 625 µg. Data collected both at baseline (T0) and at follow-up after at least 12 months of therapy (T1) were: demographic characteristics, BMI, full medical history, lumbar T-score, femur T-score, c...
Source: Minerva Endocrinologica - January 24, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Association of insulin resistance with breast cancer: miR26b behind the scenes pulling autophagy strings?
Authors: Mormile R PMID: 31971358 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - January 24, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Effects of random urinary albumin creatinine ratio on perinatal infants in puerpera with hypertensive disorders.
Authors: Zhang X, Sun Y, Yu Y, Lu H, Zhang R PMID: 31797651 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 7, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

MiR-124 promotes proliferation and differentiation of osteoblasts via BMP/TGF- β signaling pathway.
MiR-124 promotes proliferation and differentiation of osteoblasts via BMP/TGF-β signaling pathway. Minerva Endocrinol. 2019 Dec 03;: Authors: Xu X, Zhu L PMID: 31797652 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 7, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

CTRP9 alleviates inflammation to ameliorate myocardial infarction in rats by activating Nrf2.
Authors: Liu T, Xu B, Liu Z PMID: 31797653 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 7, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Correlations between postoperative recurrence of ovarian cancer and immune function, inflammatory factors and glucose metabolism.
Authors: Wang J, Wang P, Liu X, Wang H, Wu X PMID: 31797654 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 7, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

MicroRNA-197 inhibits the progression of osteosarcoma through targeting FOXM1.
Authors: Sun C, Dai J, Ma S, Pan Y, Liu F, Wang Y PMID: 31797655 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 7, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Alprostadil alleviates myocardial fibrosis in rats with diabetes mellitus through TGF- β1/smad signaling pathway.
Alprostadil alleviates myocardial fibrosis in rats with diabetes mellitus through TGF-β1/smad signaling pathway. Minerva Endocrinol. 2019 Dec 03;: Authors: Li R, Qi C, Feng Q, Ding P, Kang L, Chi J PMID: 31797656 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 7, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Persistence of 'non-dipping' pattern in blood pressure after curative parathyroidectomy in apparently normotensive patients with symptomatic primary hyperparathyroidism.
CONCLUSIONS: AMBP can help detect hypertension in patients with PHPT that remains unrecognized with routine office-based blood pressure measurement. In addition, AMBP detects loss of normal dipping pattern in BP that persists in almost half of the patients even after successful parathyroidectomy, perhaps because of permanent vascular damage induced by PHPT. PMID: 31789012 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 5, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Selected adipocytokines in patients with an incidentally discovered pheochromocytoma.
Authors: Babinska A, Kaszubowski M, Kmieć P, Sworczak K Abstract BACKGROUND: Adipose tissue secretes many adipokines and cytokines, which may be an additional risk factor of cardiovascular and metabolic diseases in patients with an incidentally discovered pheochromocytoma (PHEO). The aim of the study was to investigate levels of selected adipocytokines in these patients. METHODS: This prospective study included 12 patients with an incidentally discovered PHEO and 18 healthy participants. In all participants plasma/serum concentrations of triglycerides, HDL and LDL cholesterol, insulin, glucose, adipocytokines ...
Source: Minerva Endocrinologica - November 20, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Rodent models of obesity.
Authors: Doulberis M, Papaefthymiou A, Polyzos SA, Katsinelos P, Grigoriadis N, Srivastava DS, Kountouras J Abstract Obese or overweight people exceed one-third of the global population and obesity along with diabetes mellitus consist basic components of metabolic syndrome, both of which are known cardio-cerebrovascular risk factors with detrimental consequences. These data signify the pandemic character of obesity and the necessity for effective treatments. Substantial advances have been accomplished in preclinical research of obesity by using animal models, which mimic the human disease. In particular, rodent mod...
Source: Minerva Endocrinologica - November 20, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Ipriflavone inhibits the differentiation of RAW 264.7 cells into osteoclasts via Foxo1.
Authors: Sun J, Zhang G, Hu Z PMID: 31738034 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 20, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Evaluation of the early endocrinological sequelae after hadron therapy on anterior skull base lesions in the adult population: a preliminary study.
Authors: Zoia C, Lombardi F, Custodi VM, Lovati E, Lucotti P, Iannalfi A, D'ippolito E, Valvo F, Bongetta D PMID: 31738035 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 20, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

A study on correlations of trefoil factor 3 with pathological characteristics and prognosis of papillary thyroid carcinoma.
Authors: Sun L, Wang S, Zhang S, Wang X, Li Y PMID: 31738036 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 20, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

MiR-132 relieves vascular endothelial inflammation and improve endothelial function in atherosclerosis rats by regulating SIRT1.
Authors: Wang W, Li X, Ren L, Yuan C, Han Y, Wang Z PMID: 31738037 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 20, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

MicroRNA-489 suppresses osteosarcoma invasion, migration and epithelial-to-mesenchymal transition by directly targeting NAA10.
Authors: Wang Y, Lin S, Chen L, Qiu H, Wang J PMID: 31738038 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 20, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Combined use of sonographic and elastosonographic parameters can improve the diagnostic accuracy in thyroid nodules at risk of malignancy at cytological examination.
CONCLUSIONS: A novel combined sonographic and elastosonographic parameter evaluation improved diagnostic accuracy for identifying thyroid nodules suspicious of malignancy. PMID: 31625708 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 19, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The clearance rate of day 7 peripheral blood blasts (D7PBBs) can predict therapeutic effect for AML.
Authors: Wu H, Zhao X, Cao H, Liu X, Xia X, Dong L, Fu G PMID: 31625709 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 19, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Aspirin reduces the incidence of postmenopausal osteoporosis in rats through OPG-RANKL-RANK signaling pathway.
Authors: Ma L, Liu X, Sun G Abstract PMID: 31625710 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 19, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

MiR-26b suppressed cervical cancer cell proliferation and apoptosis by targeting ATF2 through MAPK1/ERK2 pathway.
Authors: Xiao Y, Wang L, Yang L, Yu X, Cheng S, Ma F, Cheng H Abstract PMID: 31625711 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 19, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Effect of MiR-16 on behaviors of depression model mice through regulating NF- κB pathway.
Effect of MiR-16 on behaviors of depression model mice through regulating NF-κB pathway. Minerva Endocrinol. 2019 Sep 06;: Authors: Liu Q, Zhou J Abstract PMID: 31502809 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 12, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

miR-20a enhanced cell migration and invasion via ATG5 in osteosarcoma.
Authors: Wang H, Yin J, Huang J, Liu Z, Pei S Abstract PMID: 31359746 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - August 1, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

IL-10 suppress vascular smooth muscle cell apoptosis via JAK2/STAT3 signaling pathway and its mechanism of action in atherosclerosis.
Authors: Ma L, Zheng H, Zhang T Abstract PMID: 31359747 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - August 1, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

MiRNA-494 inhibits apoptosis and promotes autophagy of acute myeloid leukemia cells by downregulating FGFR2.
Authors: Liu Z, Hua Y, Liu C, Cheng S Abstract PMID: 31359748 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - August 1, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

MiR-29 alleviates renal fibrosis in hypertension rats through inhibiting AKT signaling pathway.
Authors: Ou J, Yu G, Tan X, Zhang H, Hu B, Hunag D, Li Y, Yin L Abstract PMID: 31359749 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - August 1, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Oral insulin: an update.
Authors: Chatterjee S, Sharma CB, Lavie CJ, Adhikari A, Deedwania P, O'keefe JH Abstract Insulin, either in its intravenous or subcutaneous forms, remains the standard therapy for virtually all type-1 diabetes and many of the type-2 diabetes patients in its advanced stages. With advancement of injection techniques, insulin therapy has become much more patient- friendly than ever. Still there is vast area of unmet needs regarding current practice of insulin therapy. Insulin injections are associated with poor compliance, weight gain, fears of hypoglycemia and adverse effects of systemic hyperinsulinemia. So, a searc...
Source: Minerva Endocrinologica - July 29, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Hyperchloremic normal gap metabolic acidosis.
Authors: Palmer BF, Clegg DJ Abstract Metabolic acidosis is defined as a pathologic process that, when unopposed, increases the concentration of hydrogen ions (H+) in the body and reduces the bicarbonate (HCO3-) concentration. Metabolic acidosis can be of a kidney origin or an extrarenal cause. Assessment of urinary ammonium excretion by calculating the urine anion gap or osmolal gap is a useful method to distinguish between these two causes. Extrarenal processes include increased endogenous acid production and accelerated loss of bicarbonate from the body. Metabolic acidosis of renal origin is due to a primary def...
Source: Minerva Endocrinologica - July 29, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Expression of HOXA10 gene in women with polycystic ovarian syndrome and its correlation analysis with lipid metabolism.
Authors: Liu Z, Guo Y, Lian F, Wang K, Sun Z, Wang Y, Zhang Z Abstract PMID: 31347345 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 29, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Helicobacter pylori and diabetes mellitus: a controversial relationship.
Authors: Valenzano M, Bisio A, Grassi G Abstract Research on Helicobacter pylori (H. pylori), a pathogenic bacterium that is widespread among humans, is investigating the medical implications of the infection in many fields beyond gastroenterology. Because of the ubiquitous presence of the infection, there is an increasing interest in finding a relationship between this bacterium and diabetes mellitus (DM). It is not clear whether a significant relation between H. pylori and DM exists, whether the infection influences diabetes or vice versa, and the mechanisms underlying such a relationship. This review provides an...
Source: Minerva Endocrinologica - July 17, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

A new perspective on the prevalence of metabolic disturbances in Polish young adults.
Authors: Płaczkowska S, Pawlik-Sobecka L, Kokot I, Piwowar A Abstract PMID: 31304728 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 17, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Diabetes mellitus and susceptibility to hemorrhagic stroke: a MiR126 affair?
Authors: Mormile R PMID: 31304729 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 17, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Type 1 diabetes mellitus and thyroid diseases: relationship between glycometabolism and thyroid function.
Authors: Tromba V, Silvestri F, Costantino F Abstract PMID: 31286754 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 12, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Coping strategies in people with type 1 diabetes on insulin pump treatment.
CONCLUSIONS: Assessing coping strategies preferably used by PWD is useful to select PWD in need of counseling and empowerment-oriented training in order to improve glycemic outcomes and decrease severe hypo/hyperglycemic events. PMID: 31240899 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - June 27, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Diabetes mellitus and osteoporosis.
Authors: Paschou SΑ, Vryonidou A Abstract PMID: 31240900 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - June 27, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Management of diabetes mellitus in chronic kidney disease: an overview.
Authors: Garla VV, Kanduri S, Yanes-Cardozo L, Lien LF Abstract Diabetes mellitus (DM) and Chronic Kidney Disease (CKD) are two chronic diseases whose prevalence and co-prevalence are on the rise. CKD is also the most debilitating and expensive complication of DM while management of DM in CKD is most challenging. CKD is developing in much younger patients with DM, and its presentation is also changing. Various methods of glycemic assessment are affected by CKD and dosage of DM medications needs to be adjusted according to the kidney function. One of the significant barriers to glycemic control in DM patients with C...
Source: Minerva Endocrinologica - May 23, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Pycnogenol ® prevents oxidative stress and side effects in patients with hypothyroidism during levothyroxine treatment.
In this study we aimed to evaluate the efficacy of Pycnogenol® supplementation in controlling oxidative stress levels and in reducing the frequency and severity of side effects of levothyroxine (LT4) treatment in patients who had recently started this therapy. METHODS: The registry included 60 females affected by primary hypothyroidism with multi-nodular goiter. LT4 was administered at the dosage of 100 μg/day.The registry study included only subjects under initial treatment, and followed up for a period of at least 30 days. A group took 150 mg Pycnogenol® daily and another served as control. RESULTS: Th...
Source: Minerva Endocrinologica - May 18, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Emerging incretin hormones actions: focus on bone metabolism.
Authors: Grammatiki M, Antonopoulou V, Kotsa K Abstract Incretin hormones, namely glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are gastro-intestinal hormones released from different enteroendocrine cells after nutrient intake. Incretins exert their actions though binding to and activation of specific GIP and GLP-1 receptors which are present in several target tissues. Incretin receptor activation in the pancreas leads to the incretin effect and other significant non-insulinotropic effects. Extra-pancreatic effects of incretin hormones in several other target tissues, such a...
Source: Minerva Endocrinologica - April 18, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research