Management of diabetes mellitus in chronic kidney disease: an overview.
Authors: Garla VV, Kanduri S, Yanes-Cardozo L, Lien LF Abstract Diabetes mellitus (DM) and Chronic Kidney Disease (CKD) are two chronic diseases whose prevalence and co-prevalence are on the rise. CKD is also the most debilitating and expensive complication of DM while management of DM in CKD is most challenging. CKD is developing in much younger patients with DM, and its presentation is also changing. Various methods of glycemic assessment are affected by CKD and dosage of DM medications needs to be adjusted according to the kidney function. One of the significant barriers to glycemic control in DM patients with C...
Source: Minerva Endocrinologica - May 23, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Pycnogenol ® prevents oxidative stress and side effects in patients with hypothyroidism during levothyroxine treatment.
In this study we aimed to evaluate the efficacy of Pycnogenol® supplementation in controlling oxidative stress levels and in reducing the frequency and severity of side effects of levothyroxine (LT4) treatment in patients who had recently started this therapy. METHODS: The registry included 60 females affected by primary hypothyroidism with multi-nodular goiter. LT4 was administered at the dosage of 100 μg/day.The registry study included only subjects under initial treatment, and followed up for a period of at least 30 days. A group took 150 mg Pycnogenol® daily and another served as control. RESULTS: Th...
Source: Minerva Endocrinologica - May 18, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Emerging incretin hormones actions: focus on bone metabolism.
Authors: Grammatiki M, Antonopoulou V, Kotsa K Abstract Incretin hormones, namely glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are gastro-intestinal hormones released from different enteroendocrine cells after nutrient intake. Incretins exert their actions though binding to and activation of specific GIP and GLP-1 receptors which are present in several target tissues. Incretin receptor activation in the pancreas leads to the incretin effect and other significant non-insulinotropic effects. Extra-pancreatic effects of incretin hormones in several other target tissues, such a...
Source: Minerva Endocrinologica - April 18, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Current concepts in the diagnosis and management of neuroendocrine neoplasms of unknown primary.
Authors: Alexandraki KI, Tsoli M, Kyriakopoulos G, Angelousi A, Nikolopoulos G, Kolomodi D, Kaltsas GA Abstract Neuroendocrine neoplams (NENs) of unknowm primary origin (UPO-NENs) are advanced neoplasms constituting 11%-22% of all NENs that by definition their primary tissue of origin has not been identified with standard diagnostic work-up. Delineating the primary site of origin of UPO-NENs has important implications for selecting the appropriate treatment and overall prognosis. The small bowel, followed by the lung and pancreas are the most prevalent primary sites of origin of UPO-NENs that are uncovered during a...
Source: Minerva Endocrinologica - April 18, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Endocrine dysfunctions associated with Hodgkin lymphoma treatment. Experience from an endocrine late effects clinic of a single centre.
Authors: Dias D, Simões-Pereira J, Donato S, Pereira MC Abstract PMID: 30942565 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - April 4, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Ghrelin combined with sodium tanshinone IIA sulfonate pretreatment reduces apoptosis and fractalkine expression induced by high-dose glucose in human umbilical vein endothelial cells.
CONCLUSIONS: Pretreatment of ghrelin combined with STS reduces the apoptosis rate of HUVECs induced by high glucose environment and inhibits the expression of FKN via β-catenin/Wnt signaling pathway. PMID: 30848111 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - March 9, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Adrenal biopsy: performance and use.
Authors: Zhang CD, Delivanis DA, Eiken PW, Atwell TD, Bancos I Abstract The widespread use of cross-sectioning abdominal imaging in recent years has led to the increased detection of adrenal masses. In each case, determining whether a newly identified adrenal mass is benign or malignant is essential for management, but can be challenging. A significant proportion of adrenal lesions remain indeterminate after initial evaluation due to limitations of current imaging modalities. Adrenal biopsy can be considered for further diagnostic workup in select cases, particularly in patients with an active or previously diagnos...
Source: Minerva Endocrinologica - February 9, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Acromegaly in the era of precision medicine.
Authors: Pico A Abstract PMID: 30732428 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - February 9, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Molecular determinants of the response to medical treatment of growth hormone secreting pituitary neuroendocrine tumors.
Authors: Fuentes-Fayos AC, García-Martínez A, Herrera-Martínez AD, Jiménez-Vacas JM, Vazquez-Borrego MC, Castaño JP, Picó A, Gahete MD, Luque RM Abstract Acromegaly is a chronic systemic disease mainly caused by a growth hormone (GH)- secreting pituitary neuroendocrine tumor (PitNETs), which is associated with many health complications and increased mortality when not adequately treated. Transsphenoidal surgery is considered the treatment of choice in GH-secreting PitNETs, but patients in whom surgery cannot be considered or with persistent disease after surgery require med...
Source: Minerva Endocrinologica - January 19, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Pycnogenol ®: supplementary management of symptomatic osteoarthritis with a patch. An observational registry study.
CONCLUSIONS: Pycnogenol® patch was effective in controlling mild to moderate pain and inflammations and its related symptoms in subjects with knee OA over a period of three weeks. PMID: 30561176 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 20, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Cardioprotection by metformin in type 2 diabetes: what is the truth?
Authors: Mormile R Abstract PMID: 30561177 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 20, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Improving effect of vitamin D supplementation on obesity-related diabetes in rats.
CONCLUSIONS: These suggested the beneficial effects of vitamin D supplementation in obesity-related diabetes rat, which may through VDR, IRS-1/p-IRS-1, and GluT4 signaling activation. PMID: 30531693 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 13, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Pathological markers of somatotroph pituitary neuroendocrine tumors (PitNET)s predicting the response to medical treatment.
In conclusion, the SSTR expression profile and morphological subtypes of the somatotroph tumor may help predict the response to medical treatment. Such pathological profiling could become a useful decision-making tool for clinicians in the context of a multidisciplinary approach, after surgery failure. PMID: 30531694 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 13, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Precision medicine in the treatment of acromegaly.
Authors: Puig-Domingo M, Marazuela M Abstract Acromegaly is a chronic disorder usually diagnosed late in the disease evolution, leading to substantial morbidity and mortality related to this long period of undiagnosed state as well as the difficulty in achieving normalization of GH hypersecretion and controlling tumour mass. First generation somatostatin analogues (SSA) are accepted as the first-line medical therapy or as second-line therapy in patients undergoing unsuccessful surgery. However, because a high percentage of patients experience SSA treatment failure, the inclusion of biomarkers associated with a succ...
Source: Minerva Endocrinologica - December 13, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Silent somatotropinomas.
Authors: Lamas C, García-Martínez A, Cámara R, Fajardo-Montanana C, Viguera L, Aranda I Abstract Silent somatotroph pituitary neuroendocrine tumors (or silent growth hormone pituitary neuroendocrine tumors, SGH-PitNET) are neoplasias with positive immunostaining for growth hormone (GH), in patients with no signs and symptoms of acromegaly nor biochemical evidence of GH hypersecretion. From a clinical stand-point they are considered and managed as non-functioning pituitary tumors, since they usually come to evidence due to mass-effects (headache, visual impairment, hypopituitarism) or as asympto...
Source: Minerva Endocrinologica - December 13, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Monitoring of treament adherence with easypodTM in 6 Italian centres: a real-world experience.
Authors: Cardinale G, Pesce S, Ingletto D, Mariano M, Catucci A, Corciulo N, Fidotti E Abstract BACKGROUND: A poor adherence to r-hGH therapy is associated to a low growth rate in patients with growth deficiency. For this reason, the choice of an objective method, such as an electronic device, for monitoring treatment adherence is very important. This retrospective study evaluated the r-hGH treatment adherence of patients with growth deficiency, monitored through the easypodTM device. METHODS: Data from 90 patients (52 males; mean age at the end of the study: 11.9 years) enrolled in 6 Italian centres, was colle...
Source: Minerva Endocrinologica - December 1, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Bone health among patients with primary aldosteronism: a systematic review and meta-analysis.
CONCLUSIONS: PA is associated with hypercalciuria with subsequent secondary hyperparathyroidism. This potentially affects bone health. We recommend this to be part of complication screening among patients with PA. PMID: 30482008 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 1, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Heterogeneous clinical features of ketosis-prone type 2 diabetes mellitus patients: gender, age, loss of weight and HbA1c.
Authors: Wang J, Zhang M, Liu Z, Wang X, Pang Y, Lu Y, Liu Z Abstract BACKGROUND: To observe the clinical features of type 2 diabetes mellitus (T2DM) patients with ketosis as the initial symptom, and investigate its differences from clinical features of non-ketotic T2DM patients. METHODS: A total of 385 T2DM patients treated in our hospital from 2014 to 2017 were selected and divided into ketosis-prone T2DM group and non-ketotic T2DM group. Ketosis-prone T2DM patients refer to DM patients with the urine ketone body++ or above or the blood ketone body ≥1.0 mmol/L when treated. Fasting venous blood was collect...
Source: Minerva Endocrinologica - December 1, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Sleep apnea and cardiovascular complications of the acromegaly. Response to the medical treatment.
Authors: García-Alvarez M, Climent V Abstract Acromegaly is a rare disease characterized by high levels of growth hormone (GH) and insulin- like growth factor 1 (IGF-1). The excess of GH leads to the development of different manifestations in different organs, from subtle signs in the bones and soft tissues to the development of respiratory and cardiac insufficiency. In the cardiovascular system, the GH/IGF-1 axis exerts its influence on three major aspects: myocyte growth and structure, cardiac contractility and vascular function. In this article, we review the different cardiovascular and respiratory compl...
Source: Minerva Endocrinologica - December 1, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

A multistep approach for the stratification of the risk of severe hypoglycemia in patients with type 2 diabetes.
CONCLUSIONS: The process led to the identification of relevant factors, to be used for the development of a hypoglycemia risk score. An ad-hoc study will be performed to assess the contribution of these risk factors and their relative weight. If the risk score will confirm its ability to correctly stratify patients according to their risk of hypoglycemia, it will represent a useful support to optimize the care of people with T2DM. PMID: 30463398 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 24, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Biochemical following-up of treated acromegaly. Limitations of the current determinations of IGF-1 and perspective.
CONCLUSIONS: We will focus on the issues regarding the measurement and interpretation of IGF-I concentrations in the management of acromegaly patients. PMID: 30311754 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 14, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The main predictors of the enlargement of ascending aorta in Turner syndrome: a cross-sectional contrast-enhanced magnetic resonance angiography study.
CONCLUSIONS: The main factors associated with the enlargement of ascending aorta in Turner syndrome were age, body surface area and bicuspid aortic valve, the relation between diameter of ascending aorta and bone mineral density was not identified. PMID: 30290692 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 8, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Correlation between cytological and histological findings in patients who underwent thyroidectomy. Predictive value and confounders. Our experience.
CONCLUSIONS: These findings suggest that we need more studies to evaluate real BSRTC predictive value in single centers. Meanwhile we found out that thyroiditis may be a confounding factor in cytological examination wich would lead to an overstating of thyroid nodules. PMID: 30256073 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 28, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Performance of low-dose cosyntropin stimulation test in the afternoon.
Authors: Abu-Ahmad A, Shechner C, Sheikh-Ahmad M, Reut M, Chen-Konak L, Jiries N, Saiegh L Abstract BACKGROUND: Earlier research on 1 μg low-dose test (LDT) performed using 20.3 cm plastic IV tubing on healthy volunteers, has shown that afternoon testing was associated with a sevenfold increased likelihood of failing the test. Nevertheless, it has been claimed that subnormal cortisol response using plastic tubes might have resulted from cosyntropin adherence to the tube and, thus, loss of the delivered dosage. Following from our previous study, which showed that using a short (2.5 cm) plastic tube does not alter...
Source: Minerva Endocrinologica - September 28, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Clinical and molecular prognostic factors in adrenocortical carcinomas.
CONCLUSIONS: Individualizing patients' prognosis and tumor biology appears as a necessary step for personalized medicine. In addition to tumor stage and tumor grade, the genomic classification may precise the risk stratification and thus help defining therapeutic strategy. PMID: 30221891 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 18, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Adrenocortical tumours: challenges and recent advances in diagnosis and treatment.
Authors: Ronchi CL PMID: 30221892 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 18, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Retrospective clinical analysis of glucose metabolism in acromegaly patients.
Authors: Zhou X, Gong Y, Tian J, Yang G, Li F, Li L, Ba J, Dou J, Mu Y PMID: 30037183 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 26, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Clinical diagnosis of endocrine diseases.
Authors: Giovanella L PMID: 29991210 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 13, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Obesity and breast cancer risk: implications of MiR-126.
Authors: Mormile R PMID: 29991211 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 13, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Weight gain increase plasma levels of uric acid in adults in China.
Authors: Liu M, Zhang M, Chen X, Zhang X PMID: 29991212 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 13, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Polycystic ovary syndrome and vitamin D serum levels.
Authors: Cetkovic N, Pellicano R, Bjelica A, Abenavoli L PMID: 29991213 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 13, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Pathogenesis of benign unilateral adrenocortical tumours: focus on cAMP/PKA pathway.
Authors: Weigand I Abstract Somatic mutations affecting genes in the cAMP/PKA (Protein Kinase A) signaling pathway have been described as causative for the pathogenesis of benign unilateral adrenocortical adenomas associated with cortisol over secretion. These include predominantly somatic mutations in the PRKACA gene which encodes the catalytic subunit α of PKA. In addition, mutations in the GNAS gene, coding for the stimulatory G protein α, have been observed in approximately 10 % of cortisol producing adenomas (CPAs). The mutations render PKA signaling constitutively active and are therefore involved...
Source: Minerva Endocrinologica - July 3, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The role of Insulin-like Growth Factor (IGF) system in the adrenocortical tumors.
CONCLUSIONS: Nowadays, predictive markers for the response of target-IGF therapy are missing and further studies which investigate new molecular markers and evaluate the entire IGF receptors, including the IR, are urgently needed. PMID: 29963827 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 3, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Autonomous hypercortisolism: definition and clinical implications.
Authors: Reimondo G, Puglisi S, Pia A, Terzolo M Abstract In current practice, an adrenal adenoma usually comes as an unexpected byproduct of an imaging study performed for unrelated reasons, without any prior suspect of adrenal disease. Therefore, these tumors currently represent a public health challenge because they are increasingly recognized due to the widespread use of high-resolution cross-sectional imaging for diagnostic purposes. In radiology series, the prevalence of adrenal adenomas increases steeply with age, from around 3% below the age of 50 years up to 10% in the ageing population. These tumors may h...
Source: Minerva Endocrinologica - July 3, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The role of steroid metabolome analysis for the diagnosis and follow-up of adrenocortical tumours.
Authors: Chortis V Abstract The diagnostic work up of adrenal tumours, often incidentally discovered, has emerged as an ever-increasing diagnostic problem for clinical endocrinologists. No imaging modality has sufficiently high sensitivity and specificity at differentiating benign from malignant adrenal lesions. It has long been observed that adrenocortical carcinomas (ACCs) present an immature pattern of steroidogenesis, dominated by steroid hormone precursors. Modern mass spectrometry-based assays can generate multi-steroid metabolite profiles in urine collections, which can detect differences between ACCs and be...
Source: Minerva Endocrinologica - June 16, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The beta-cell death in long-term type 2 diabetes mellitus: never say never again.
Authors: Koufakis T, Ioannidis I, Zebekakis P, Kotsa K PMID: 29808640 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - May 30, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

New targeted therapies for adrenocortical carcinomas.
Authors: Manso J, Pezzani R Abstract Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis. It has been undergone to in-depth clinical and laboratory investigations, with the help of the most important research groups of all over the world. Nonetheless the cure for this kind of neoplasia is not right around the corner, given its complexity and multi-faceted feature, that lead researchers to think at "one person one ACC". Currently total resection is the most concrete option for ACC patients, whenever possible. Although years are still necessary for an effective treatment, indubitably the...
Source: Minerva Endocrinologica - May 30, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Unilateral non-aldosterone producing adrenocortical tumors.
Authors: Morelli V, Palmieri S Abstract Adrenal incidentaloma is a frequent clinical finding. Once an adrenal mass is detected, is mandatory to determine whether the lesion is malignant or benign and whether it is hormonally active or non- functioning, to estabilish an adequate treatement or follow-up. The European Society and ENSAT Guidelines recently provided the best recommendation based on the available literature. However, due to the retrospective design of the majority of the studies, the small number of patients included and the inadequate follow-up, some issues are still unresolved. In particular, there is ...
Source: Minerva Endocrinologica - May 30, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Women with type 2 diabetes in pregnancy remain a high-risk group.
Authors: Mcgrath RT, Gunton JE, Hocking SL, Glastras SJ, Fulcher GR PMID: 29761685 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - May 17, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Etiology and patterns of presentation of short stature in Eastern Cape of South Africa.
Authors: Ekpebegh C PMID: 29761686 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - May 17, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Correlation between changes in inflammatory cytokines and the combination with hypertension in patients with type 2 diabetes mellitus.
Authors: He Q, Dong M, Pan Q, Wang X, Guo L Abstract BACKGROUND: We aimed to analyze the relationship between the combination with hypertension and the level of inflammatory cytokines in peripheral serum in patients with type 2 diabetes mellitus (DM), and to explore the value of inflammatory cytokines in predicting type 2 DM combined with hypertension. METHODS: A total of 120 patients diagnosed with type 2 DM in our hospital from March 2014 to September 2016 were selected. The clinical data were retrospectively analyzed. These patients were divided into the combination with hypertension group (n=56) and the non...
Source: Minerva Endocrinologica - April 26, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Associations between vitamin D levels and polycystic ovary syndrome (PCOS) phenotypes.
CONCLUSIONS: Vitamin D deficiency occurred more frequently in PCOS cases with androgen excess, but associations were attenuated after adjusting for BMI and race/ethnicity. Combining etiologically distinct PCOS subgroups may obscure associations with lower vitamin D levels and other potential risk factors. PMID: 29652114 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - April 14, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Analysis on influencing factors of abnormal renal function in elderly patients with type 2 diabetes mellitus.
Authors: Chai T, Zhang D, Li Z Abstract BACKGROUND: To investigate the related influencing factors of abnormal renal function in elderly in patients with type 2 diabetes mellitus (T2DM) and their clinical significance. METHODS: The clinical data of elderly T2DM patients hospitalized in Beijing Luhe Hospital from January 2013 to June2016 were retrospectively analyzed. According to their glomerular filtration rate (GFR) levels, these patients were divided into GFR ≥90 mL/min/1.73m2 group (Group A), GFR =60-90 mL/min/1.73m2 group (Group B), and GFR
Source: Minerva Endocrinologica - April 14, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Exploring patients' experiences with thyroid hormones' replacement therapy: gaining a better insight into drivers and barriers.
Authors: Fattori A, Neri L, Lania A PMID: 29633820 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - April 12, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Anorexia nervosa and alcohol use disorders: a change is necessary.
Authors: Testino G, Leone S, Balbinot P, Pellicano R PMID: 29600836 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - March 31, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Routine intra-operative neuromonitoring during thyroidectomy. A UK single institution experience.
Authors: Cvasciuc T, Lansdown M, Fraser SM PMID: 29546741 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - March 23, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

How to handle pituitary disease during pregnancy?
Authors: Petersenn S PMID: 29546742 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - March 23, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Secondary adrenal insufficiency in pregnancy: any differences?
Authors: Petersenn S Abstract Secondary adrenal insufficiency may pose specific challenges during pregnancy. The interpretation of diagnostic tests is hindered by physiological adaptations of the HPA axis. Due the relevant increases in CBG, measurement of salivary cortisol may be preferable, but lacks sufficiently established cut-offs both for early-morning evaluation and during dynamic testing. Hydrocortisone should be used for replacement to avoid overexposure of the fetus, with dose adjustments according to clinical judgement. To account for increased free cortisol levels during the course of pregnancy, hydrocor...
Source: Minerva Endocrinologica - March 23, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Growth hormone deficiency and pregnancy: any role for substitution?
Authors: Vila G, Luger A Abstract Growth hormone (GH) is not approved for use during conception and pregnancy. Nevertheless, data from the clinical care practice reveal that most women concieve on GH replacement therapy (GHRT), and more than half continue on GHRT also during pregnancy. GH stimulates the hypothalamic-pituitary-gonadal axis at all levels, and there is evidence that GH deficiency impacts the morphology of reproductive organs, onset of puberty, ovarian function and fertility. Patients with hypopituitarism often conceive using assisted reproductive techniques and several studies support the benefit of G...
Source: Minerva Endocrinologica - March 11, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Diabetes insipidus in pregnancy: how to advice the patient?
Authors: Refardt J, Christ-Crain M Abstract Diabetes insipidus, characterized by polyuria and polydipsia, is a rare disease during pregnancy. Nevertheless, its recognition is important to avoid complications due to dehydration and hypernatremia. Its manifestation during pregnancy ranges from exacerbation of pre-existing central or nephrogenic diabetes insipidus to transient pregnancy-induced diabetes insipidus due to the increased metabolism of the antidiuretic hormone vasopressin by the placental vasopressinase. Diagnosis can be challenging, as urinary frequency is common during pregnancy and primary polydipsia al...
Source: Minerva Endocrinologica - February 26, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research