The level of the neudesin in Type-2 Diabetic patients and the relationship between the metabolic parameters and carotid intima-media thickness.
CONCLUSIONS: Serum neudesin increased in new diagnosis Type-2 DM patients. This increase seems to be related to obesity and insulin resistance. However, more extensive research is needed to clarify this issue. PMID: 33435641 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - January 15, 2021 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Clinical management of low-risk papillary thyroid microcarcinoma.
Authors: Masaki C, Sugino K, Ito K Abstract Papillary thyroid microcarcinoma (PTMC) is well known to have an indolent nature with an excellent prognosis. Surgery has been the standard treatment during the past several decades, with metastasis or recurrence being exceedingly rare. Active surveillance (AS) is a new risk-adapted approach alternative to surgery that involves just watching, but not giving any treatment unless needed, not addressing the tumor itself. The patients for whom AS is adopted spend their time "with tumors". In follow-up, it is possible that alarming factors such as tumor progression a...
Source: Minerva Endocrinologica - January 15, 2021 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Pubertal induction in girls with Turner syndrome.
Authors: Aversa T, Corica D, Pepe G, Pajno GB, Valenzise M, Messina MF, Wasniewska M Abstract Turner syndrome (TS) is the most common female sex chromosome aneuploidy in females, and patients may present with hypergonadotropic hypogonadism due to gonadal dysgenesis. Timing and modalities of pubertal induction in these patients is still a matter of debate. Aim of this review is to focus on the latest update on pubertal induction in TS. Based on literature data, the following practical approach to this issue is recommended. Pubertal induction should begin between 11 and 12 years of age, starting with low doses of est...
Source: Minerva Endocrinologica - January 15, 2021 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Endocrine dysfunction and cognitive impairment.
Authors: Calsolaro V, Bottari M, Coppini G, Lemmi B, Monzani F Abstract Dementia is a highly prevalent chronic disease among the older population, affecting more than 50 million people worldwide and representing a huge healthcare, social and economic burden. Dementia, and in particular Alzheimer's disease, prevalence is expected to raise within the next few years. Unfortunately, no disease-modifying therapies are available so far, despite a plethora of clinical trials targeting the hallmarks of Alzheimer's disease. Given these premises, it appears crucial to address not only the neuropathological correlates of the ...
Source: Minerva Endocrinologica - January 15, 2021 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Ethnic differences in the impact of gestational diabetes on macrosomia.
CONCLUSIONS: GDM is an independent predictor of macrosomia in Latin-American, South-Central Asian and Moroccan women but not in Caucasian or East-Asian women in whom other factors play a more important role. PMID: 33435645 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - January 15, 2021 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Normal thyroid volume in subjects evaluated in a primary ambulatory setting in Liguria.
Authors: Giusti M, Sidoti M Abstract BACKGROUND: Ultrasonography (US) is the simplest method of evaluating thyroid volume (TV). The current normal TV in Liguria is not known. The aim of this study was to obtain normative data on TV in Liguria. MATERIALS AND METHODS: From 3552 files of endocrine evaluations registered in a primary outpatient setting, we selected 483 files on euthyroid subjects (383 females and 100 males) with a normal echoic pattern on US. The inclusion criterion was the absence of thyroperoxidase autoantibodies and drugs known to interfere with thyroid hormone secretion or metabolism. TV was ca...
Source: Minerva Endocrinologica - January 15, 2021 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

A retrospective comparison between intensive and non-intensive insulin regimens in type 2 diabetes mellitus.
CONCLUSIONS: Both intensive and non-intensive insulin therapies improved the baseline glycemic parameters, but being overweight or obese and/or being reluctant to dietary recommendations led to treatment failures regardless of the insulin regimen. PMID: 33435647 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - January 15, 2021 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Does Abelmoschus Esculentus act as anti-diabetic? A systematic review with updated evidence.
CONCLUSIONS: This review can highlight the current evidence of the particular topic, useful for a reader to gain knowledge, application in clinical practice in a community setting, or planning for new human experiment in depth. PMID: 33435648 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - January 15, 2021 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Clinicopathological significance of epidermal growth factor receptor expression in papillary thyroid carcinoma: a meta-analysis.
CONCLUSIONS: The results in the expression of EGFR is frequent and cancer-specific event in PTC. Besides, the expression of EGFR was involved in the progression and metastasis of PTC. PMID: 33435649 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - January 15, 2021 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Obesity and COVID-19: 2 The ominous duet affecting the renin-angiotensin system.
Authors: Luzi L, Bucciarelli L, Ferrulli A, Terruzzi I, Massarini S Abstract The World population is facing a health challenge never seen since the Spanish influenza of one hundred years ago. During the last months, the scientific community has been debating on the potential harmful effect of Angiotensin-converting-enzyme inhibitors (ACEi) or Angiotensin II receptor Type 1 receptor blockers (AT1-Receptor blockers, ARBs) during the COVID-19 pandemic. That is because the S spike protein of SARS8 CoV viruses utilizes the angiotensin-converting enzyme 2 (ACE2) as a receptor to enter alveolar epithelial cells. Obesity, ...
Source: Minerva Endocrinologica - January 15, 2021 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The endocrinology of sarcopenia and frailty.
CONCLUSIONS: A life-course approach to improving 'health-span' is advocated. Lifestyle factors such as nutrition and physical activity have important interactions with body composition, physical function and metabolic outcomes. Large-scale clinical trials will determine the efficacy and long-term safety of hormone supplementation in the management of sarcopenia and frailty. PMID: 33331737 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 19, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

New risk factors in diabetic nephropathy: microRNA-196-3p and microRNA-203.
CONCLUSIONS: Increased serum levels of miR-203 and miR-196a-3p are independent risk factors of UAE which is a marker of DN. PMID: 33331738 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 19, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Recent advances in small cell lung cancer: the future is now?
Authors: Luciani A, Blasi M, Provenzano L, Zonato S, Ferrari D Abstract Small cell lung cancer is a relevant clinical issue as it is a highly malignant cancer, often diagnosed in advanced stage. Similarly to non-small cell lung cancer, tobacco smoking is currently the main risk factor. Its incidence, at least in males, has declined over the past decades, due to the worldwide decreased percentage of active smokers. The typical small cells of this tumor type are characterized by a high proliferation index, chromosomal deletions such as 3p(14-23) involving the tumor-suppressor gene FHIT, alterations of the MYC or Notc...
Source: Minerva Endocrinologica - December 19, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

A paradigm shift in preventing diabetic heart failure? A review of SGLT2 inhibitors.
Authors: Khadke S, Jawaid H, Yasmin F, Binte Ali M, Rehman A Abstract Recent trials have reported sodium-glucose co-transporter 2 (SGLT2) inhibitors to decrease cardiac morbidity and hospitalization in diabetic patients. They have a remarkable ability to modify the cardio-renal axis and have a safer metabolic profile among the existing pharmacotherapy in diabetes. There are multiple proposed mechanisms postulated behind the cardioprotection offered by these drugs as seen in CANVAS and EMPA-REG OUTCOME trial. The pathophysiological evidence which directly contributes to improved cardiac mechanics remains elusive. We...
Source: Minerva Endocrinologica - December 19, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Rubrometabolic syndrome.
Authors: Kalra S, Coetzee A, Kalra PA, Saldaña JR, Kilov G Abstract Metabolic syndrome (MS), a conglomeration of several conditions including obesity, type 2 diabetes mellitus (T2DM), insulin resistance, elevated blood pressure, and dyslipidemia is reaching epidemic proportions. Anemia is caused by iron deficiency or dysregulation of iron homeostasis, leading to tissue hypoxia. Coexistence of anemia and MS or its components has been reported in the literature. The term "rubrometabolic syndrome" acts as a unifying entity linking the importance of blood in health and anemia in MS; it justifies two pr...
Source: Minerva Endocrinologica - December 19, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

GPR56 gene down-regulation in patients with Klinefelter syndrome: a candidate for infertility?
Authors: Salemi M, Cannarella R, Cimino L, Condorelli RA, Giurato G, Marchese G, Cordella A, Santa Paola S, Romano C, La Vignera S, Calogero AE Abstract PURPOSE: The etiology of azoospermia in patients with Klinefelter syndrome (KS) is still unknown. The protein codified by the G protein-couple receptor 56 (GPR56) belongs to the adhesion family of G protein-coupled receptors (GPRs). Its mutations are involved in the pathogenesis of intellectual disability and, according to animal studies, infertility. As the expression of GPR56 in patients with KS has not been investigated so far, this study was undertaken with the...
Source: Minerva Endocrinologica - December 19, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The triglyceride glucose index (TyG) and CDKAL1 gene rs10946398 SNP are associated with NAFLD in Chinese adults.
CONCLUSIONS: We identified an association between the rs10946398 genotypes of CDKAL1 and NAFLD and the TyG index, and the TyG index was related to the risk of NAFLD. PMID: 33269568 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 5, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Analysis of defects in GNAS and STX16 genes in a Chinese family with pseudohypoparathyroidism.
Authors: Zhao P, Liu J, Cheng J, Li Q, Fu S, Wang Y, Yang X, Ma X PMID: 33269569 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 5, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Continuous glucose monitoring in diabetes patients with chronic kidney disease on dialysis: a meta-analysis.
CONCLUSIONS: CGM is an efficient method of glycemic monitoring in diabetes patients on dialysis. CGM had similar correlations with HbA1c and glycated albumin. PMID: 33269570 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 5, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Evaluation of management of patients with postoperative permanent hypoparathyroidism. How close are we to the targets?
CONCLUSIONS: Our study shows that the management of the patients with PO-HypoPT is suboptimal with active vitamin D and cholecalciferol treatment. PMID: 33269571 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 5, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Hormonal therapy potentiates the effect of surgery on gene expression profile of peripheral blood mononuclear cells in patients affected by endometriosis.
CONCLUSIONS: Results support the concept that a systemic chronic inflammatory status is among the mechanisms underlying endometriosis. Moreover, they shed light into the mechanisms of action of COCs and strength the rationale for their use to improve quality of life of women affected by the disease. PMID: 33269572 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 5, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Downregulation of plasma microRNA-29c-3p expression may be a new risk factor for diabetic retinopathy.
CONCLUSIONS: Plasma miR-29c-3p expression is downregulated in diabetic patients with and without retinopathy, and changes in this miRNA are an independent risk factor for the development of DR. PMID: 33213115 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 22, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Vitamin D in obesity and obesity-related diseases: an overview.
Authors: Barrea L, Frias-Toral E, Pugliese G, Garcia-Velasquez E, De Los Angeles Carignano M, Savastano S, Colao A, Muscogiuri G Abstract Hypovitaminosis D and obesity represent two pandemic conditions sometimes associated with each other. Although it is known that there is a close relationship between these two health problems, the underlying pathophysiological mechanism has not yet been fully clarified. In fact, on the one hand, obesity per se seems to involve low circulating levels of vitamin D due to low sun exposure, physical activity, and intake of foods rich in vitamin D, volumetric dilution and sequestratio...
Source: Minerva Endocrinologica - November 22, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

TSH modulation in advanced differentiated thyroid cancer: a continuous walk on the tightrope between prognostic stratification, adverse events, and levothyroxine bioavailability.
Authors: Marotta V, Botti G, Ionna F, Pezzullo L PMID: 33213117 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 22, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Liquid biopsy in thyroid cancer: from circulating biomarkers to a new prospective of tumor monitoring and therapy.
The objective of this monography is to describe the main components studied in liquid biopsy (circulating tumor nucleic acids, circulating tumor cells and extracellular vesicles) and how they have been explored in thyroid cancer, through an in-depth scientific literature review. While circulating tumor cells are the most represented component in the literature of liquid biopsy in thyroid cancer, circulating tumor nucleic acids and extracellular vesicles have also been recently explored. One important challenge in this field of research, especially for differentiated thyroid cancer, has been the low quantity of circulating ...
Source: Minerva Endocrinologica - November 22, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Personalized treatment for thyroid cancer: current data and new perspectives.
Authors: Colombo C, Giancola N, Fugazzola L Abstract More conservative and personalized treatment options have been developed in recent years to face the rising diagnosis of low-risk differentiated thyroid carcinoma (DTC). The present review describes the changes in the direction toward a more risk-adapted management either in the treatment or in the follow-up of DTC. Particular attention is given to the innovations introduced by the latest guidelines for low-risk tumors, starting from the most appropriate extension of surgery up to the post-operative management. The emerging role of active surveillance for lowrisk...
Source: Minerva Endocrinologica - November 22, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Very-low-calorie ketogenic diet for the management of obesity, overweight and related disorders.
Authors: Castellana M, Biacchi E, Procino F, Casanueva FF, Trimboli P Abstract Very-low-calorie ketogenic diet (VLCKD) is a promising lifestyle intervention for the management of overweight and obesity. It is characterized by a restriction of both calories and carbohydrates, while assuring the adequate proteins, fats and micronutrients intake. Significant results in terms of excess body weight loss have been reported and this strategy considered also in the preoperative settings, accordingly. Improvements in hypertension, type 2 diabetes and dyslipidemia follows. The present narrative review discusses available evi...
Source: Minerva Endocrinologica - November 22, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Obesity and physical exercise.
Authors: Celik O, Yildiz BO Abstract Obesity represents a major health problem worldwide and is associated with increased prevalance of numerous health-related conditions, including diabetes, hypertension, cardiovascular disease, some forms of cancer and musculoskeletal disorders among others. Studies that have examined the impact of physical exercise combined with energy restriction diets on weight have shown greater weight loss compared to interventions of exercise-only. Accodingly, the most effective approach to achieve significant weigt loss includes a combination of diet, exercise and behavioral strategies. Cu...
Source: Minerva Endocrinologica - November 22, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Obesity and GLP-1.
Authors: Perez-Montes De Oca A, Pellitero S, Puig-Domingo M Abstract Obesity is an important public health issue that has been on the rise over the last decades. It calls for effective prevention and treatment. Bariatric surgery is the most effective medical therapy for weight loss in morbid obesity but we are in need for less aggressive treatments. Glucagon-likepeptide-1 receptor agonists are a group of incretin based drugs that have proven to be productive for obesity treatment. Through activation of the GLP-1 receptor they not only have an important role stimulating insulin secretion after meals, but with their ...
Source: Minerva Endocrinologica - November 22, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Next-generation of strain specific probiotics in diabetes treatment: the case of Prevotella copri.
Authors: Abenavoli L, Falalyeyeva T, Pellicano R, Fagoonee S, Kobyliak N PMID: 33213123 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 22, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The southern European atlantic diet, a review.
Authors: Tejera-Pérez C, Sánchez-Bao A, Bellido-Guerrero D, Casanueva FF Abstract The Southern Europe Atlantic Diet (SEAD) is the traditional diet consumed in the northwestern region of the Iberian peninsula: Galicia (Spain) and North of Portugal. These regions have geographical, climatic and cultural characteristics that had led them to develop their own dietary pattern. This dietary pattern integrated into its environment is based on fresh, local and seasonal products intake. In this diet there is a high intake of fish, seafood, cereals, potatoes, legumes, fruits, dairy products and vegetables. Meat...
Source: Minerva Endocrinologica - November 22, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

A close look at our cases with parathyroidectomy: 11 years of experience.
CONCLUSIONS: Parathyroid neoplasm with uncertain malignant potential defines cases with suspicious histopathological features of carcinoma but doesn't meet the criteria for parathyroid carcinoma. In our series, these cases are identified as atypical parathyroid adenoma. We present clinical and morphological features of our parathyroidectomy cases in an 11-year period and aim to raise concern about borderline cases in between adenoma and carcinoma. We think that such tumors, similar to the thyroid neoplasm classification, should be defined as parathyroid neoplasms with uncertain malignant potential and should be followed cl...
Source: Minerva Endocrinologica - October 27, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Untargeted metabolomics analysis of serum and follicular fluid samples from women with polycystic ovary syndrome.
CONCLUSIONS: Our findings would provide a resource for further investigations on metabolic disturbance in PCOS patients. PMID: 33103870 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 27, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Normocalcemic primary hyperparathyroidism: an update.
Authors: Salcuni AS, Battista C, Pugliese F, Columbu C, Guarnieri V, Carnevale V, Scillitani A Abstract Normocalcemic primary hyperparathyroidism (NPHPT) is diagnosed in the setting of elevated PTH concentrations with consistently normal albumin-adjusted and ionized serum calcium levels, in absence of secondary causes for elevated PTH concentrations. In order to confirm persistence of the hyperparathyroid state, PTH levels should be elevated on at least two occasions over a 3 to 6 months period. The prevalence of NPHPT depends on the population studied. Data from different studies are often not comparable; indeed, ...
Source: Minerva Endocrinologica - October 27, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Codon bias analyses on thyroid carcinoma genes.
CONCLUSIONS: This is the first study that analyzed the codon bias in thyroid cancer genes based also on synonymous mutations. The study provided different hints that should be further investigated by wet-lab validation and that it could open new scenarios in the understanding the molecular mechanisms involved in thyroid cancer development based on codon bias. PMID: 33103872 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 27, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The relation between sociosexual orientation, muscle performance and disgust sensitivity. A preliminary correlational study.
CONCLUSIONS: Higher MP is associated with a greater tendency to have occasional relationships and multiple sexual partners, in both genders. MP-related self-esteem and perceived vulnerability may be involved in mating behaviors. We speculate that the sexual hormones might mediate the relationship among these variables. Future studies are warranted to explore this hypothesis. PMID: 33103873 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 27, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Increased serum IL-18 levels and IL-18R expression in newly diagnosed type 2 diabetes mellitus.
CONCLUSIONS: Both serum IL-18 and its receptor IL-18R is significantly higher in newly diagnosed T2DM patients. PMID: 33103874 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 27, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Differentiated thyroid cancer: new perspectives from genetics to the clinic.
Authors: Colombo C, Cirello V, Muzza M, Pogliaghi G, Karapanou O, Giancola N, Fugazzola L PMID: 33103875 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 27, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

New perspectives in neuroendocrine neoplasms research from tumor xenografts in zebrafish embryos.
Authors: Carra S, Gaudenzi G PMID: 33103876 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 27, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The role of molecular genetics in the pre-surgical management of thyroid nodules.
CONCLUSIONS: Next Generation Sequencing NGS) development and incorporation of other genetic markers such as miRNA can improve diagnostic accuracy of molecular tests. PMID: 33045818 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 14, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The clonal origin of multifocal papillary thyroid cancer (MPTC): intrathyroid spread or independent tumors?
In conclusion, data available in the literature indicated that multifocal papillary thyroid cancer may derived from both intraglandular spread and independent tumor foci. The understanding of the clonal origin of multifocal papillary thyroid tumors might represent an important issue in patient treatment. PMID: 33045819 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 14, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Familial non-medullary thyroid carcinoma: clinico-pathological features, current knowledge and novelty regarding genetic risk factors.
Authors: Cirello V Abstract Familial non-medullary thyroid cancer (FNMTC) constitutes 3-9% of all thyroid cancers and occur in two or more first-degree relatives in the absence of predisposing environmental factors. Out of all FNMTC cases, only 5% are represented by syndromic forms (Gardner's syndrome, familial adenomatous polyposis, Cowden's syndrome, Carney complex 1, Werner's syndrome and DICER1 syndrome), in which thyroid cancer occurs as a minor component and the genetic alterations are wellknown. The non-syndromic forms represent the majority of all FNMTCs (95%), and the thyroid cancer is the predominant feat...
Source: Minerva Endocrinologica - October 14, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Sex difference in the association between malnutrition and hypoglycemia in hospitalized patients.
Authors: Gur Arieh N, Adler H, Khanimov I, Giryes S, Ditch M, Felner Burg N, Boaz M, Shimonov M, Leibovitz E Abstract OBJECTIVE: To examine the difference between males and females regarding association between malnutrition risk and hypoglycemia. DESIGN: Sub-analysis of a cross-sectional study of newly admitted patients to internal medicine departments. METHODS: Malnutrition risk, assessed with Nutritional Risk Screening 2002 (NRS2002), and serum albumin were measured upon admission. Logistic regression was applied to men and women separately, to test the effect of malnutrition and hypoalbuminemia on incide...
Source: Minerva Endocrinologica - October 4, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Insulin resistance and hepatic steatosis in type 1 diabetes mellitus and their association with diabetic chronic complications.
Authors: Popa SG, Simion AM, Soare M, Arcomita D Abstract AIMS: To evaluate insulin resistance and hepatic steatosis and their association with diabetes duration, control and chronic complications in patients with type 1 diabetes. METHODS: We studied medical records of 181 consecutive hospitalized adults patients with type 1 diabetes. Estimated glucose disposal rate (eGDR), insulin sensitivity score (ISS), fatty liver index (FLI) and hepatic steatosis index (HSI) were calculated. RESULTS: Patients in the 1st tertile of eGDR (
Source: Minerva Endocrinologica - October 4, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Vitamin D3 deficiency is associated with more severe insulin resistance and metformin use in patients with type 2 diabetes.
Authors: Aludwan M, Kobyliak N, Abenavoli L, Kyriienko D, Fagoonee S, Pellicano R, Komisarenko I Abstract BACKGROUND: Vitamin D3 (vit. D3) deficiency is considered as one of the main factors involved in the development of type 2 diabetes (T2D). We assessed insulin resistance (IR), β-cell functional activity and metabolic profile according to 25(OH) vit. D3 status in patients with T2D. METHODS: The study included 109 patients with T2D, divided in 3 groups: group 1 (N.=11) with normal levels of vit. D3 (>30 ng/mL); group 2 (N.=38) with vit. D3 insufficiency (21-29 ng/mL); and group 3 (N.=60) with vit. D3 deficiency (
Source: Minerva Endocrinologica - October 3, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Male hypogonadism: therapeutic choices and pharmacological management.
Authors: La Vignera S, Izzo G, Emerenziani GP, Cannarella R, Condorelli RA, Calogero AE, Aversa A Abstract Male hypogonadism, defined as an inadequate testosterone production, recognizes a testicular (primary hypogonadism) or a hypothalamic-pituitary dysfunction (central hypogonadism), although combined forms can also occur. Moreover, it has been known that intensive exercise training might be a cause of functional hypogonadism. Many therapeutic choices are currently available, depending on the timing of hypogonadism onset and fertility issue. The aim of this review was to comprehensively supply therapeutic options...
Source: Minerva Endocrinologica - October 3, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The possible role of endocrine dysfunction of adipose tissue in gestational diabetes mellitus.
Authors: Šimják P, Anderlová K, Cinkajzlová A, Pařízek A, Kršek M, Haluzík M Abstract Gestational diabetes mellitus (GDM) is diabetes that is first diagnosed in the second or third trimester of pregnancy in patients who did not have a history of diabetes before pregnancy. Consequences of GDM include increased risk of macrosomia and birth complications in the infant and an increased risk of maternal type 2 diabetes mellitus (T2DM) after pregnancy. There is also a longer-term risk of obesity, T2DM, and cardiovascular diseases in the child. GDM is the result of impaire...
Source: Minerva Endocrinologica - October 3, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Is hemithyroidectomy sufficient in unilateral benign nodular goitre?
CONCLUSIONS: Due to low reoperation risk and acceptable permanent hypothyroidism rates, hemithyroidectomy is a viable option for benign goitre cases. The patients should be on follow-up for possible complications, especially hypothyroidism, for at least a year. PMID: 32969625 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 25, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Subclinical male hypogonadism.
CONCLUSIONS: Although available evidence suggests that in aging populations SHG can be considered a particular condition associated with an increased CV risk, it is still unknown if treatment with T can improve any outcomes in these subjects. Hence, further interventional studies are advisable in order to better understand the characteristics of SHG and the possible advantages of an early TRT. PMID: 32969626 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 25, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

A favorable effect on nutritional status of 12-week tailored texture-modified sous-vide cooking meals in institutionalized elderly women with oropharyngeal dysphagia: an intervention study.
CONCLUSIONS: This study demonstrated that elderly dysphagic women at long-term care facilities can eat better and increase nutritional status by eating 12-week tailored appealing TTMSVC. PMID: 32969627 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 25, 2020 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research