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Women with type 2 diabetes in pregnancy remain a high-risk group.
Authors: Mcgrath RT, Gunton JE, Hocking SL, Glastras SJ, Fulcher GR PMID: 29761685 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - May 17, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Etiology and patterns of presentation of short stature in Eastern Cape of South Africa.
Authors: Ekpebegh C PMID: 29761686 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - May 17, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Correlation between changes in inflammatory cytokines and the combination with hypertension in patients with type 2 diabetes mellitus.
Authors: He Q, Dong M, Pan Q, Wang X, Guo L Abstract BACKGROUND: We aimed to analyze the relationship between the combination with hypertension and the level of inflammatory cytokines in peripheral serum in patients with type 2 diabetes mellitus (DM), and to explore the value of inflammatory cytokines in predicting type 2 DM combined with hypertension. METHODS: A total of 120 patients diagnosed with type 2 DM in our hospital from March 2014 to September 2016 were selected. The clinical data were retrospectively analyzed. These patients were divided into the combination with hypertension group (n=56) and the non...
Source: Minerva Endocrinologica - April 26, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Associations between vitamin D levels and polycystic ovary syndrome (PCOS) phenotypes.
CONCLUSIONS: Vitamin D deficiency occurred more frequently in PCOS cases with androgen excess, but associations were attenuated after adjusting for BMI and race/ethnicity. Combining etiologically distinct PCOS subgroups may obscure associations with lower vitamin D levels and other potential risk factors. PMID: 29652114 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - April 14, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Analysis on influencing factors of abnormal renal function in elderly patients with type 2 diabetes mellitus.
Authors: Chai T, Zhang D, Li Z Abstract BACKGROUND: To investigate the related influencing factors of abnormal renal function in elderly in patients with type 2 diabetes mellitus (T2DM) and their clinical significance. METHODS: The clinical data of elderly T2DM patients hospitalized in Beijing Luhe Hospital from January 2013 to June2016 were retrospectively analyzed. According to their glomerular filtration rate (GFR) levels, these patients were divided into GFR ≥90 mL/min/1.73m2 group (Group A), GFR =60-90 mL/min/1.73m2 group (Group B), and GFR
Source: Minerva Endocrinologica - April 14, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Exploring patients' experiences with thyroid hormones' replacement therapy: gaining a better insight into drivers and barriers.
Authors: Fattori A, Neri L, Lania A PMID: 29633820 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - April 11, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Anorexia nervosa and alcohol use disorders: a change is necessary.
Authors: Testino G, Leone S, Balbinot P, Pellicano R PMID: 29600836 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - March 31, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Routine intra-operative neuromonitoring during thyroidectomy. A UK single institution experience.
Authors: Cvasciuc T, Lansdown M, Fraser SM PMID: 29546741 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - March 23, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

How to handle pituitary disease during pregnancy?
Authors: Petersenn S PMID: 29546742 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - March 23, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Secondary adrenal insufficiency in pregnancy: any differences?
Authors: Petersenn S Abstract Secondary adrenal insufficiency may pose specific challenges during pregnancy. The interpretation of diagnostic tests is hindered by physiological adaptations of the HPA axis. Due the relevant increases in CBG, measurement of salivary cortisol may be preferable, but lacks sufficiently established cut-offs both for early-morning evaluation and during dynamic testing. Hydrocortisone should be used for replacement to avoid overexposure of the fetus, with dose adjustments according to clinical judgement. To account for increased free cortisol levels during the course of pregnancy, hydrocor...
Source: Minerva Endocrinologica - March 23, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Growth hormone deficiency and pregnancy: any role for substitution?
Authors: Vila G, Luger A Abstract Growth hormone (GH) is not approved for use during conception and pregnancy. Nevertheless, data from the clinical care practice reveal that most women concieve on GH replacement therapy (GHRT), and more than half continue on GHRT also during pregnancy. GH stimulates the hypothalamic-pituitary-gonadal axis at all levels, and there is evidence that GH deficiency impacts the morphology of reproductive organs, onset of puberty, ovarian function and fertility. Patients with hypopituitarism often conceive using assisted reproductive techniques and several studies support the benefit of G...
Source: Minerva Endocrinologica - March 11, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Diabetes insipidus in pregnancy: how to advice the patient?
Authors: Refardt J, Christ-Crain M Abstract Diabetes insipidus, characterized by polyuria and polydipsia, is a rare disease during pregnancy. Nevertheless, its recognition is important to avoid complications due to dehydration and hypernatremia. Its manifestation during pregnancy ranges from exacerbation of pre-existing central or nephrogenic diabetes insipidus to transient pregnancy-induced diabetes insipidus due to the increased metabolism of the antidiuretic hormone vasopressin by the placental vasopressinase. Diagnosis can be challenging, as urinary frequency is common during pregnancy and primary polydipsia al...
Source: Minerva Endocrinologica - February 26, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Adverse effects of doping with anabolic androgenic steroids (AAS) in competitive athletics, recreational sports and bodybuilding.
Authors: Vorona E, Nieschlag E Abstract Despite the fact that sports organizations and legislators have introduced various mechanisms to discourage athletes from using performance and appearance enhancing substances a high percentage of athletes admits to their unabated application. In competitive athletics, bodybuilding and in recreational sports anabolic androgenic steroids (AAS) continue to be the substances most abused. This review summarizes the side effects of AAS abuse on organs and system functions in both sexes. High doses of AAS cause a significant increase of erythrocytes und haemoglobin concentration, w...
Source: Minerva Endocrinologica - February 26, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Acute pituitary disease in pregnancy: how to handle hypophysitis and Sheehan's syndrome?
Authors: Honegger J, Giese S Abstract Pregnancy-related hypophysitis (PR-Hy) that typically occurs during late pregnancy and the early postpartum period is considered an autoimmune disorder. Knowledge and awareness of characteristic clinical symptoms and specific endocrine and neuroradiological features mostly enables a correct diagnosis and guarantees best possible management. In the presence of mild clinical symptoms, a "wait and watch" policy is recommended. Transsphenoidal surgery or glucocorticoid therapy is indicated if progressive clinical signs or severe visual symptoms are observed. Reported case...
Source: Minerva Endocrinologica - February 26, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Association of heterogeneity of the thyroid gland with matrix metalloproteinase-3 in rheumatoid arthritis patients with Hashimoto's thyroiditis.
Authors: Nagasaki T, Nagata Y, Wakita Y, Yamada S, Goto H, Imanishi Y, Onoda N, Emoto M, Inaba M Abstract PURPOSE: Hashimoto's thyroiditis (HT) is highly prevalent in patients with rheumatoid arthritis (RA). The aim is to determine their relation, focusing on matrix metalloproteinase-3 (MMP-3), a marker predicting joint destruction and RA activity. METHODS: Fifty three consecutive RA patients were prospectively separated into two groups on the basis of the presence or absence of HT; those with and without TPO-Ab or Tg-Ab (34.0% and 66.0%, respectively). To estimate the extent of inflammation and destruction of ...
Source: Minerva Endocrinologica - February 16, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Analysis of the correlation of gestational diabetes mellitus and peripheral ferritin with iron levels in early pregnancy.
Authors: Guo W, Wang H, Liu Q, Yuan Y, Jing Y, Yang X Abstract BACKGROUND: To investigate the relationship of serum iron and ferritin concentrations in early pregnancy with gestational diabetes mellitus (GDM) complicated in pregnant metaphase through detecting the serum iron and ferritin concentrations in early pregnancy of normal pregnant women, so as to provide new ideas for the early detection and prevention of GDM. METHODS: Spontaneously pregnant women with single fetus receiving prenatal routine examination in our hospital from December 2014 to October 2016 were selected. They were in good health before wi...
Source: Minerva Endocrinologica - February 16, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Role of thyroid ultrasound combined with thyroglobulin in the diagnosis of postoperative recurrence of thyroid cancer.
CONCLUSIONS: Thyroid ultrasound combined with Tg is of high clinical value in the diagnosis of postoperative recurrence of thyroid cancer, which can significantly improve the sensitivity, specificity and accuracy of clinical diagnosis. The TgAb level can be detected when Tg is used to monitor the postoperative recurrence and metastasis of thyroid cancer, providing a reference for the clinical prevention and treatment. PMID: 29442477 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - February 16, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

A clinical Audit: diagnostic and epidemiological evaluation of the Adrenal Incidentaloma (AI).
Authors: Nuzzo V, Attardo T, Augello G, Brancato D, Camerlingo S, Canale C, Coretti F, Franco A, Giacometti F, Gambacorta M, Loreno M, Maffettone A, Provenzano V, Zuccoli A Abstract Audit is a clinical instrument of government characterized by a whole process of evaluation inter pares to improve medical behaviors in the clinical practice. Different endocrinopathies are underestimated in the clinical and diagnostics practice but they can be a real problem in patients admitted in the departments of Internal Medicine. The Adrenal Incidentaloma (AI) is an accidental discovery with an incidence equal to 4% in radiologic...
Source: Minerva Endocrinologica - February 16, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Adrenocortical carcinoma: where we stand.
Authors: Pezzani R PMID: 29442479 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - February 16, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Cushing's disease: major difficulties in diagnosis and management during pregnancy.
Authors: Caimari F, Corcoy R, Webb SM Abstract Pregnancy in women with a diagnosis of Cushing' syndrome (CS) is an extremely rare event and its diagnosis and treatment are a real medical challenge. During pregnancy, the hypothalamus-pituitary-adrenal axis undergoes major changes leading to a significant increase in plasma cortisol levels throughout gestation. The difficulties in diagnosis are related to the resemblance of symptoms of CS and those of pregnancy, and to the complex interpretation of the screening tests. Moreover, the diagnostic work up in the postnatal period may be difficult in the first weeks postpa...
Source: Minerva Endocrinologica - February 16, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Quality of semen: a 6-year single experience study on 5680 patients.
Authors: Cozzolino M, Coccia ME, Picone R, Troiano G Abstract BACKGROUND: The aim of our study was to evaluate the quality of semen of a large sample from general healthy population living in Italy, in order to identify possible variables that could influence several parameters of spermiogram. METHODS: We conducted a cross-sectional study from February 2010 to March 2015, collecting semen samples from the general population. Semen analysis was performed according to the WHO guidelines. The collected data were inserted in a database and processed using the software Stata 12. The Mann - Whitney test was used to a...
Source: Minerva Endocrinologica - February 11, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Clinicopathological significance of chemokine receptor CXCR4 expression in papillary thyroid carcinoma: a meta-analysis.
Authors: Wu Z, Cao Y, Jiang X, Li M, Wang G, Yang Y, Lu K Abstract INTRODUCTION: Emerging evidence indicates that C-X-C chemokine receptor type 4(CXCR 4) is a candidate oncogene in several types of human tumors including papillary thyroid carcinoma (PTC). To investigate its expression impact on clinicopathological features, a meta-analysis was performed. EVIDENCE ACQUISITION: A comprehensive search in the PubMed, Embase and The Cochrane Library (up to March 14, 2017) was performed for relevant studies using multiple search strategies. Methodological quality of the studies was also evaluated. Odds ratios (ORs) w...
Source: Minerva Endocrinologica - February 11, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Relation between change in treatment for central diabetes insipidus and body weight loss.
CONCLUSIONS: Switching the treatment from nasal to oral desmopressin may cause weight loss in patients with CDI who seemed to have polydipsia-associated weight gain. PMID: 29424204 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - February 11, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The impact of assisted reproductive technologies in the human experience.
Authors: Brezina PR PMID: 29397678 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - February 6, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Non-functioning pituitary tumors: any special considerations during pregnancy?
Authors: Flitsch J, Burkhardt T Abstract New clinical symptoms from pituitary tumors during pregnancy are rare. Either the patient becomes symptomatic from a known lesion prior to conception during pregnancy, or it is a de-novo diagnosis due to acute symptoms. Non-functioning pituitary tumors can be subdivided into non-functioning pituitary adenomas and other pathologies. This review aims at giving a general overview as well as therapeutical considerations, taking into account that no specific recommendations/guidelines are available for this rare clinical problem. PMID: 29265782 [PubMed - as supplied by publis...
Source: Minerva Endocrinologica - December 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

TSH-receptor autoantibodies: pathophysiology, assay methods, and clinical applications.
Authors: Ehlers M, Allelein S, Schott M Abstract TSH receptor antibodies (TRAbs) are characteristic indicators for the common autoimmune thyroid disease Graves' disease (GD). In almost all patients stimulating TRAbs are found leading to hyperthyroidism as these antibodies act in an agonistic manner to TSH. Besides stimulating TRAbs, other TRAbs are also frequently found leading to inhibition of TSH receptor signaling (blocking TRAbs) or to the activation of different signaling cascades resulting in e.g. thyrocyte apoptosis (cleavage antibodies). Patients' sera may contain all three types of TRAbs. Dependent on the ...
Source: Minerva Endocrinologica - December 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Prolactinomas: how to handle prior to and during pregnancy?
Authors: Glezer A, Bronstein MD Abstract Prolactinomas are the most common cause of pathological hyperprolactinemia, leading to central hypogonadism and, therefore, a frequent etiology of infertility. Treatment, usually with dopamine agonist (DA), can reverse hyperprolactinemia and hypogonadism, allowing pregnancy in the majority of cases. Bromocriptine is still the DA of choice for such purpose. Important issues in DA-induced pregnancies include fetal exposition, both malformations and neuropsychological development and tumor size increase. Regarding microprolactinomas and intrasellar macroprolactinomas, DA should...
Source: Minerva Endocrinologica - December 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Effects of anesthesia methods on insulin, blood glucose, immune and postoperative infection of gastric cancer patients complicated with diabetes mellitus.
Authors: Yang L, Chen C, Li M, Qiu L, Shen J, Bu X PMID: 29249798 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 20, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Evaluation of the different surgical parathyroidectomieson secondary hyperparathyroidism in uremia patients.
Authors: Zhu L, Xiong F, Cui T PMID: 29205012 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 7, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Study on regulation of adipokines on body fat distribution and its correlation with metabolic syndrome in type 2 diabetes mellitus.
Authors: Liu X, Li X, Li C, Gong C, Liu S, Shi Y Abstract BACKGROUND: This paper aims to investigate the regulating role of adipokine expression level in body fat distribution of patients with type 2 diabetes mellitus (T2MD) as well as its correlation with metabolic syndrome (MS). METHODS: 140 patients with T2MD admitted in the Endocrinology Department of the First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from January 2017 to July 2017 were selected; their body height and weight were measured to calculate body mass index (BMI); patients with a BMI ≤23.9 kg/m2 were included i...
Source: Minerva Endocrinologica - December 7, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Effects of insulin intervention on the expression of VE-cadherin, β-catenin, Annexin A2, Annexin A5, and 14-3-3 protein in the placentas of patients with gestational diabetes mellitus.
Effects of insulin intervention on the expression of VE-cadherin, β-catenin, Annexin A2, Annexin A5, and 14-3-3 protein in the placentas of patients with gestational diabetes mellitus. Minerva Endocrinol. 2017 Nov 28;: Authors: Su J, Yang L, Chen W, Liu L, Xue Y PMID: 29185643 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 1, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Lower irisin levels in coronary artery disease: a meta-analysis.
Authors: Guo W, Zhang B, Wang X Abstract INTRODUCTION: Irisin is a newly discovered myokine, which is involved in energy metabolism and associated with "browning" of the white adipose tissue, obesity, diabetes mellitus and metabolic syndrome. It's still uncertain that whether irisin level is associated with coronary artery disease. The purpose of this study is to explore the relationship between irisin levels and coronary artery disease. EVIDENCE ACQUISITION: A search of PubMed, MEDLINE, Elsevier Science Direct, Springer, Web of Science and China National Knowledge Infrastructure (CNKI) for studies pu...
Source: Minerva Endocrinologica - November 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Study on clinical indicators of diabetic retinopathy.
Authors: Jiao X, Li G, Yin X PMID: 29160050 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Irisin as a regulator of bone and glucose metabolism: a narrative review.
Authors: Briganti SI, Gaspa G, Tabacco G, Naciu AM, Cesareo R, Manfrini S, Palermo A Abstract In humans, irisin is produced mainly by skeletal muscle in response to physical activity. It has been demonstrated that irisin plays a pivotal role in inducing fat browning and regulating energy expenditure. New findings from various studies conducted in both animals and humans suggest that irisin can affect bone and glucose metabolism. In particular, irisin is able to increase bone cortical mass by stimulating the osteoblast pathways, and irisin levels are inversely correlated with the incidence of fragility fractures amo...
Source: Minerva Endocrinologica - November 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

An update on disorders of calcium, phosphate and bone.
Authors: Schalin-Jäntti C PMID: 29160052 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The relationship between the hormone levels before transplantation and outcomes of hormone replacement therapy-frozen embryo transfer.
Authors: Liu YF, Wang F, Huang GY, Mao XG Abstract OBJECTIVE: To analyze the relationship between outcomes of hormone replacement therapy-frozen embryo transfer (HRT-FET) and serum estradiol and progesterone levels on the day of endometrial transformation and before transplantation. METHODS: Clinical datas of patients who underwent 426 cycles of FET were retrospectively analyzed and were divided into groups according to estradiol and progesterone levels. Differences in embryo implantation rate and clinical pregnancy rate were compared, and relationship between estradiol levels and outcome of transplantation was...
Source: Minerva Endocrinologica - November 11, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Expression and clinical significance of EGF and TGF- Α in chronic pancreatitis and pancreatic cancer.
CONCLUSIONS: EGF and TGF-α have important research value as indicators to assess the progression of these conditions and provide a new basis for the clinical diagnosis. PMID: 29125273 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 11, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Pseudohypoparathyroidism.
Authors: Cianferotti L, Brandi ML Abstract The term pseudohypoparathyroidism (PHP) refers to a spectrum of rare disorders of mineral metabolism, characterized by features due to end-organ resistance to PTH. The phenotypes of Albright hereditary osteodystrophy (AHO), originally described as associated to the disease, and progressive osseous heteroplasia, can be associated to the endocrine manifestations of hormonal resistance. Genetic or epigenetic alterations in the complex imprinted GNAS locus, encoding the alpha-subunit of the stimulatory G protein (GSα) and several other transcripts, give rise to the diffe...
Source: Minerva Endocrinologica - November 11, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Different therapeutic options in patients with Cushing's syndrome due to bilateral macronodular adrenal hyperplasia.
Authors: Albiger NM, Regazzo D, Iacobone M, Scaroni C Abstract Bilateral macronodular adrenal hyperplasia (BMAH) is a relatively rare cause of Cushing's syndrome (CS). In recent years, growing evidence has shown that steroidogenesis is regulated by aberrant G-protein-coupled receptors (GPCR) expression and their ligands, in a significant proportion of patients with BMAH. The screening of patients with overt or subclinical CS demonstrate the frequent expression of several GPCR that opened the option to potential therapeutic applications. Thus, several studies have demonstrated that targeting the involved receptor wi...
Source: Minerva Endocrinologica - November 8, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Clinical endocrinology and hormones quantitation: the increasing role of mass spectrometry.
Authors: D'Aurizio F, Cantù M Abstract Clinical endocrinology has always had a close relationship with laboratory medicine. In fact, the quantification of hormones is of great importance for diagnosis, treatment, recurrence and patient's prognosis of endocrine disorders. This review dealt with the role of the laboratory in diagnosing endocrine pathologies related to adrenal gland, pituitary, gonads and thyroid. The measurements of the main hormones (17- hydroxyprogesterone, androstenedione, dehydroepiandrosterone sulphate, testosterone, estradiol, cortisol, aldosterone, metanephrines, thyroglobulin and insul...
Source: Minerva Endocrinologica - November 1, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Post-transplant diabetes: diagnosis and management.
Authors: Boerner BP, Shivaswamy V, Wolatz E, Larsen J Abstract Post-transplant diabetes mellitus (PTDM) is common after most types of solid organ transplantation, though the actual incidence is as yet unknown because of the use of different diagnostic criteria. PTDM is the result of individual risk factors as well as risk factors associated with the transplant itself, particularly immunosuppressants. Previously called New Onset Diabetes, in many cases inadequate screening for diabetes before transplant cannot assure that the diabetes is new after transplant. The most recent international consensus guidelines sugges...
Source: Minerva Endocrinologica - October 12, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Autoimmune endocrine diseases.
Authors: Ruggeri RM, Giuffrida G, Campennì A Abstract The endocrine system is interested by several autoimmune diseases, characterized by different impact and severity, according to the organs involved. Autoimmune thyroid disorders (i.e. Hashimoto's thyroiditis and Graves' disease) and type 1 diabetes mellitus are the most common autoimmune endocrine disorders, while hypophysitis, adrenalitis (90% of cases of primary hypocortisolism or Addison's disease), premature ovarian failure and hypoparathyroidism represent quite rare conditions. Autoimmune endocrine diseases can also coexist in the same individuals an...
Source: Minerva Endocrinologica - October 12, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Parathyroid carcinoma: a clinical and genetic perspective.
Authors: Cetani F, Pardi E, Marcocci C Abstract Parathyroid carcinoma (PC) is a rare neoplasia difficult to diagnose preoperatively. It mainly occurs as a sporadic disease but also as part of familial PHPT. At variance with patients with the benign counterpart, the phenotype of these patients is characterized by a severe primary hyperparathyroidism (PHPT). The clinical features are mostly due to the effects of the excessive secretion of PTH by the functioning tumor and hypercalcemia rather than to the tumor burden. The prognosis is poor and unmanageable hypercalcemia accounts for death in the majority of cases. The...
Source: Minerva Endocrinologica - September 28, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Role of positron emission tomography in thyroid and neuroendocrine tumours.
CONCLUSIONS: PET imaging with different radiotracers is a useful functional imaging technique in the work-up of several endocrine tumours. PMID: 28949122 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 28, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Endocrine and neuroendocrine cytopathology.
Authors: Bongiovanni M, LA Rosa S, Sykiotis GP Abstract Cytology is an easily accessible, cost-effective and safe procedure for the initial evaluation of most endocrine/neuroendocrine lesions. Both fine-needle aspiration cytology and exfoliative cytology have shown good sensitivity and specificity in detecting endocrine/neuroendocrine benign proliferations and malignancies. Thanks to its utility for early diagnosis, cytology has contributed to the decline in mortality of endocrine/neuroendocrine neoplasms. The endocrine system comprises different endocrine organs, such as the thyroid, adrenal glands, paraganglia, p...
Source: Minerva Endocrinologica - September 28, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Diagnosis and management of Zollinger-Ellison syndrome in 2017.
Authors: DE Angelis C, Cortegoso Valdivia P, Venezia L, Bruno M, Pellicano R Abstract Zollinger-Ellison Syndrome (ZES) is a clinical syndrome characterized by gastric acid hypersecretion due to the ectopic secretion of gastrin by a gastrinoma, a neuroendocrine tumor (NET) which mostly develops in the duodenum and in the pancreas. This syndrome was first described by Zollinger and Ellison in 1964; if left untreated, ZES can lead to multiple complications mainly due to gastric hypersecretion and some patients can suffer from the complications of an advanced metastatic disease. Although its clinical features are consi...
Source: Minerva Endocrinologica - September 28, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Decrease in size and activity of parathyroid adenoma after ultrasound guided biopsy.
Authors: Ogrin C PMID: 28914043 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 17, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

How many patients with TIR3 FNA really have a thyroid neoplasm?
Authors: Pezzolla A, Lattarulo S, Madaro A, Docimo G, Lacalendola E, Prete F, Marzaioli R PMID: 28914044 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 17, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

How to complete gastroduodenal protection in patients with bleeding risk?
Authors: Durazzo M, Fagoonee S PMID: 28895681 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 14, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Ultrasound and ultrasound-related techniques in endocrine diseases.
Authors: Trimboli P, Dietrich CF, David E, Mastroeni G, Ventura Spagnolo O, Sidhu PS, Letizia C, Messineo D, D'Ambrosio F, Radzina M, Cantisani V Abstract Ultrasound examination has become essential to evaluate morphology and size of several endocrine glands and detect the presence of lesions within these organs. Nevertheless, with the recent advances of ultrasound technology, we have opportunity to correlate the echostructure of thyroid, ovary, testis, parathyroids, etc. to their function. Thus, the ultrasound systems are in-office essential instruments for many clinical specialists. Herein we presented the most u...
Source: Minerva Endocrinologica - September 8, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research