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Non-functioning pituitary tumors: any special considerations during pregnancy?
Authors: Flitsch J, Burkhardt T Abstract New clinical symptoms from pituitary tumors during pregnancy are rare. Either the patient becomes symptomatic from a known lesion prior to conception during pregnancy, or it is a de-novo diagnosis due to acute symptoms. Non-functioning pituitary tumors can be subdivided into non-functioning pituitary adenomas and other pathologies. This review aims at giving a general overview as well as therapeutical considerations, taking into account that no specific recommendations/guidelines are available for this rare clinical problem. PMID: 29265782 [PubMed - as supplied by publis...
Source: Minerva Endocrinologica - December 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

TSH-receptor autoantibodies: pathophysiology, assay methods, and clinical applications.
Authors: Ehlers M, Allelein S, Schott M Abstract TSH receptor antibodies (TRAbs) are characteristic indicators for the common autoimmune thyroid disease Graves' disease (GD). In almost all patients stimulating TRAbs are found leading to hyperthyroidism as these antibodies act in an agonistic manner to TSH. Besides stimulating TRAbs, other TRAbs are also frequently found leading to inhibition of TSH receptor signaling (blocking TRAbs) or to the activation of different signaling cascades resulting in e.g. thyrocyte apoptosis (cleavage antibodies). Patients' sera may contain all three types of TRAbs. Dependent on the ...
Source: Minerva Endocrinologica - December 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Prolactinomas: how to handle prior to and during pregnancy?
Authors: Glezer A, Bronstein MD Abstract Prolactinomas are the most common cause of pathological hyperprolactinemia, leading to central hypogonadism and, therefore, a frequent etiology of infertility. Treatment, usually with dopamine agonist (DA), can reverse hyperprolactinemia and hypogonadism, allowing pregnancy in the majority of cases. Bromocriptine is still the DA of choice for such purpose. Important issues in DA-induced pregnancies include fetal exposition, both malformations and neuropsychological development and tumor size increase. Regarding microprolactinomas and intrasellar macroprolactinomas, DA should...
Source: Minerva Endocrinologica - December 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Effects of anesthesia methods on insulin, blood glucose, immune and postoperative infection of gastric cancer patients complicated with diabetes mellitus.
Authors: Yang L, Chen C, Li M, Qiu L, Shen J, Bu X PMID: 29249798 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 20, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Evaluation of the different surgical parathyroidectomieson secondary hyperparathyroidism in uremia patients.
Authors: Zhu L, Xiong F, Cui T PMID: 29205012 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 7, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Study on regulation of adipokines on body fat distribution and its correlation with metabolic syndrome in type 2 diabetes mellitus.
Authors: Liu X, Li X, Li C, Gong C, Liu S, Shi Y Abstract BACKGROUND: This paper aims to investigate the regulating role of adipokine expression level in body fat distribution of patients with type 2 diabetes mellitus (T2MD) as well as its correlation with metabolic syndrome (MS). METHODS: 140 patients with T2MD admitted in the Endocrinology Department of the First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from January 2017 to July 2017 were selected; their body height and weight were measured to calculate body mass index (BMI); patients with a BMI ≤23.9 kg/m2 were included i...
Source: Minerva Endocrinologica - December 7, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Effects of insulin intervention on the expression of VE-cadherin, β-catenin, Annexin A2, Annexin A5, and 14-3-3 protein in the placentas of patients with gestational diabetes mellitus.
Effects of insulin intervention on the expression of VE-cadherin, β-catenin, Annexin A2, Annexin A5, and 14-3-3 protein in the placentas of patients with gestational diabetes mellitus. Minerva Endocrinol. 2017 Nov 28;: Authors: Su J, Yang L, Chen W, Liu L, Xue Y PMID: 29185643 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 1, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Lower irisin levels in coronary artery disease: a meta-analysis.
Authors: Guo W, Zhang B, Wang X Abstract INTRODUCTION: Irisin is a newly discovered myokine, which is involved in energy metabolism and associated with "browning" of the white adipose tissue, obesity, diabetes mellitus and metabolic syndrome. It's still uncertain that whether irisin level is associated with coronary artery disease. The purpose of this study is to explore the relationship between irisin levels and coronary artery disease. EVIDENCE ACQUISITION: A search of PubMed, MEDLINE, Elsevier Science Direct, Springer, Web of Science and China National Knowledge Infrastructure (CNKI) for studies pu...
Source: Minerva Endocrinologica - November 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Study on clinical indicators of diabetic retinopathy.
Authors: Jiao X, Li G, Yin X PMID: 29160050 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Irisin as a regulator of bone and glucose metabolism: a narrative review.
Authors: Briganti SI, Gaspa G, Tabacco G, Naciu AM, Cesareo R, Manfrini S, Palermo A Abstract In humans, irisin is produced mainly by skeletal muscle in response to physical activity. It has been demonstrated that irisin plays a pivotal role in inducing fat browning and regulating energy expenditure. New findings from various studies conducted in both animals and humans suggest that irisin can affect bone and glucose metabolism. In particular, irisin is able to increase bone cortical mass by stimulating the osteoblast pathways, and irisin levels are inversely correlated with the incidence of fragility fractures amo...
Source: Minerva Endocrinologica - November 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

An update on disorders of calcium, phosphate and bone.
Authors: Schalin-Jäntti C PMID: 29160052 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The relationship between the hormone levels before transplantation and outcomes of hormone replacement therapy-frozen embryo transfer.
Authors: Liu YF, Wang F, Huang GY, Mao XG Abstract OBJECTIVE: To analyze the relationship between outcomes of hormone replacement therapy-frozen embryo transfer (HRT-FET) and serum estradiol and progesterone levels on the day of endometrial transformation and before transplantation. METHODS: Clinical datas of patients who underwent 426 cycles of FET were retrospectively analyzed and were divided into groups according to estradiol and progesterone levels. Differences in embryo implantation rate and clinical pregnancy rate were compared, and relationship between estradiol levels and outcome of transplantation was...
Source: Minerva Endocrinologica - November 11, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Expression and clinical significance of EGF and TGF- Α in chronic pancreatitis and pancreatic cancer.
CONCLUSIONS: EGF and TGF-α have important research value as indicators to assess the progression of these conditions and provide a new basis for the clinical diagnosis. PMID: 29125273 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 11, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Pseudohypoparathyroidism.
Authors: Cianferotti L, Brandi ML Abstract The term pseudohypoparathyroidism (PHP) refers to a spectrum of rare disorders of mineral metabolism, characterized by features due to end-organ resistance to PTH. The phenotypes of Albright hereditary osteodystrophy (AHO), originally described as associated to the disease, and progressive osseous heteroplasia, can be associated to the endocrine manifestations of hormonal resistance. Genetic or epigenetic alterations in the complex imprinted GNAS locus, encoding the alpha-subunit of the stimulatory G protein (GSα) and several other transcripts, give rise to the diffe...
Source: Minerva Endocrinologica - November 11, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Different therapeutic options in patients with Cushing's syndrome due to bilateral macronodular adrenal hyperplasia.
Authors: Albiger NM, Regazzo D, Iacobone M, Scaroni C Abstract Bilateral macronodular adrenal hyperplasia (BMAH) is a relatively rare cause of Cushing's syndrome (CS). In recent years, growing evidence has shown that steroidogenesis is regulated by aberrant G-protein-coupled receptors (GPCR) expression and their ligands, in a significant proportion of patients with BMAH. The screening of patients with overt or subclinical CS demonstrate the frequent expression of several GPCR that opened the option to potential therapeutic applications. Thus, several studies have demonstrated that targeting the involved receptor wi...
Source: Minerva Endocrinologica - November 8, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Clinical endocrinology and hormones quantitation: the increasing role of mass spectrometry.
Authors: D'Aurizio F, Cantù M Abstract Clinical endocrinology has always had a close relationship with laboratory medicine. In fact, the quantification of hormones is of great importance for diagnosis, treatment, recurrence and patient's prognosis of endocrine disorders. This review dealt with the role of the laboratory in diagnosing endocrine pathologies related to adrenal gland, pituitary, gonads and thyroid. The measurements of the main hormones (17- hydroxyprogesterone, androstenedione, dehydroepiandrosterone sulphate, testosterone, estradiol, cortisol, aldosterone, metanephrines, thyroglobulin and insul...
Source: Minerva Endocrinologica - November 1, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Post-transplant diabetes: diagnosis and management.
Authors: Boerner BP, Shivaswamy V, Wolatz E, Larsen J Abstract Post-transplant diabetes mellitus (PTDM) is common after most types of solid organ transplantation, though the actual incidence is as yet unknown because of the use of different diagnostic criteria. PTDM is the result of individual risk factors as well as risk factors associated with the transplant itself, particularly immunosuppressants. Previously called New Onset Diabetes, in many cases inadequate screening for diabetes before transplant cannot assure that the diabetes is new after transplant. The most recent international consensus guidelines sugges...
Source: Minerva Endocrinologica - October 12, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Autoimmune endocrine diseases.
Authors: Ruggeri RM, Giuffrida G, Campennì A Abstract The endocrine system is interested by several autoimmune diseases, characterized by different impact and severity, according to the organs involved. Autoimmune thyroid disorders (i.e. Hashimoto's thyroiditis and Graves' disease) and type 1 diabetes mellitus are the most common autoimmune endocrine disorders, while hypophysitis, adrenalitis (90% of cases of primary hypocortisolism or Addison's disease), premature ovarian failure and hypoparathyroidism represent quite rare conditions. Autoimmune endocrine diseases can also coexist in the same individuals an...
Source: Minerva Endocrinologica - October 12, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Parathyroid carcinoma: a clinical and genetic perspective.
Authors: Cetani F, Pardi E, Marcocci C Abstract Parathyroid carcinoma (PC) is a rare neoplasia difficult to diagnose preoperatively. It mainly occurs as a sporadic disease but also as part of familial PHPT. At variance with patients with the benign counterpart, the phenotype of these patients is characterized by a severe primary hyperparathyroidism (PHPT). The clinical features are mostly due to the effects of the excessive secretion of PTH by the functioning tumor and hypercalcemia rather than to the tumor burden. The prognosis is poor and unmanageable hypercalcemia accounts for death in the majority of cases. The...
Source: Minerva Endocrinologica - September 28, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Role of positron emission tomography in thyroid and neuroendocrine tumours.
CONCLUSIONS: PET imaging with different radiotracers is a useful functional imaging technique in the work-up of several endocrine tumours. PMID: 28949122 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 28, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Endocrine and neuroendocrine cytopathology.
Authors: Bongiovanni M, LA Rosa S, Sykiotis GP Abstract Cytology is an easily accessible, cost-effective and safe procedure for the initial evaluation of most endocrine/neuroendocrine lesions. Both fine-needle aspiration cytology and exfoliative cytology have shown good sensitivity and specificity in detecting endocrine/neuroendocrine benign proliferations and malignancies. Thanks to its utility for early diagnosis, cytology has contributed to the decline in mortality of endocrine/neuroendocrine neoplasms. The endocrine system comprises different endocrine organs, such as the thyroid, adrenal glands, paraganglia, p...
Source: Minerva Endocrinologica - September 28, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Diagnosis and management of Zollinger-Ellison syndrome in 2017.
Authors: DE Angelis C, Cortegoso Valdivia P, Venezia L, Bruno M, Pellicano R Abstract Zollinger-Ellison Syndrome (ZES) is a clinical syndrome characterized by gastric acid hypersecretion due to the ectopic secretion of gastrin by a gastrinoma, a neuroendocrine tumor (NET) which mostly develops in the duodenum and in the pancreas. This syndrome was first described by Zollinger and Ellison in 1964; if left untreated, ZES can lead to multiple complications mainly due to gastric hypersecretion and some patients can suffer from the complications of an advanced metastatic disease. Although its clinical features are consi...
Source: Minerva Endocrinologica - September 28, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Decrease in size and activity of parathyroid adenoma after ultrasound guided biopsy.
Authors: Ogrin C PMID: 28914043 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 17, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

How many patients with TIR3 FNA really have a thyroid neoplasm?
Authors: Pezzolla A, Lattarulo S, Madaro A, Docimo G, Lacalendola E, Prete F, Marzaioli R PMID: 28914044 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 17, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

How to complete gastroduodenal protection in patients with bleeding risk?
Authors: Durazzo M, Fagoonee S PMID: 28895681 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 14, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Ultrasound and ultrasound-related techniques in endocrine diseases.
Authors: Trimboli P, Dietrich CF, David E, Mastroeni G, Ventura Spagnolo O, Sidhu PS, Letizia C, Messineo D, D'Ambrosio F, Radzina M, Cantisani V Abstract Ultrasound examination has become essential to evaluate morphology and size of several endocrine glands and detect the presence of lesions within these organs. Nevertheless, with the recent advances of ultrasound technology, we have opportunity to correlate the echostructure of thyroid, ovary, testis, parathyroids, etc. to their function. Thus, the ultrasound systems are in-office essential instruments for many clinical specialists. Herein we presented the most u...
Source: Minerva Endocrinologica - September 8, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

A comparative study of the levels of thyroid hormones and antithyroid antibodies in patients with gestational diabetes mellitus and pregnant patients with diabetes.
Authors: Xu C, Zhang Z Abstract BACKGROUND: To investigate the levels of thyroid hormone and antithyroid antibodies and their relationship with pregnancy outcome in patients with gestational diabetes mellitus (GDM) and diabetic patients. METHODS: Fifty patients with GDM and 50 pregnant patients with diabetes were selected. Their levels of fasting blood glucose (FBG), glycosylated hemoglobin, FT3, FT4, TGab, TSH, TPOab were measured until parturition. RESULTS: There were no statistically significant differences in the age, gestational age, weight, FBG and glycosylated hemoglobin between the two groups (P>...
Source: Minerva Endocrinologica - September 8, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Acromegaly and bone.
CONCLUSIONS: In this article, we summarize the pathophysiology, clinical aspects and the new diagnostic tools to better understand bone impairment in acromegaly. PMID: 28880058 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 8, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Evaluation of somatic genomic imbalances in thyroid carcinomas of follicular origin by CGH-based approaches.
CONCLUSIONS: Though a quite heterogeneous picture arises from results so far available, CGH array, combined with other methodologies as well as an accurate clinical management, may offer novel opportunities for a better stratification of thyroid cancer patients. PMID: 28880059 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 8, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Secondary adrenal insufficiency: from the physiopathology to the possible role of modified-release hydrocortisone treatment.
Authors: Paragliola RM, Corsello SM Abstract Central adrenal insufficiency represents a life-threatening disorder that results from a reduced cortisol production due to an impairment production of adrenocorticotropic hormone. In particular, secondary AI results from pituitary disease that impedes the release of ACTH, while tertiary adrenal insufficiency is caused from an impaired synthesis of corticotropin-releasing hormone. Central adrenal insufficiency has an estimated prevalence of 150-280 per million, resulting more common than primary AI. Prompt diagnosis and management of this condition is crucial, but the di...
Source: Minerva Endocrinologica - July 30, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Imaging in primary hyperparathyroidism: focus on the evidence-based diagnostic performance of different methods.
CONCLUSIONS: Patients with PHPT who are candidates for parathyroidectomy should be referred to an expert clinician to decide which imaging studies to perform based on regional imaging capabilities. The imaging techniques with higher diagnostic performance in detecting and localizing HP seems to be 99mTc-MIBI SPECT/CT and 4D-CT. Taking into account several data beyond the diagnostic performance, the combination of cervical US performed by an experienced parathyroid sonographer and 99mTc-MIBI SPECT or SPECT//CT seems to be an optimal first-line strategy in the preoperative planning of patients with PHPT. PMID: 28650133 [...
Source: Minerva Endocrinologica - June 27, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The value of color Doppler ultrasound in the diagnosis of lower extremity vascular disease in type 2 diabetes and an analysis of related factors.
Authors: Jiang L, Zhao Y Abstract BACKGROUND: The aim of this paper is to explore the application and clinical significance of color Doppler ultrasound (CDU) in diagnosing lower extremity vascular disease in type 2 diabetes mellitus (T2DM) patients. METHODS: The lower extremity arteries of 81 patients with T2DM and 50 control patients were examined by CDU for blood vessel diameter, intima-media thickness, plaque on the vessel wall, lumen stenosis and filling defect in blood flow. The occurrence of diabetes mellitus was investigated in additional T2DM patients of various ages. RESULTS: Left popliteal artery,...
Source: Minerva Endocrinologica - June 20, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Cardiovascular disease in PCOS is related to severe insulin resistance, not mild.
Authors: Dahan MH, Abbasi F, Reaven GM PMID: 28627866 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - June 20, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Role of adipokines and inflammatory markers in postmenopausal hypertension.
Authors: July M, Faiz S, Yaqub A, Santhanam P, Douglas J, Stanek R, Gress T, Olajide O, Driscoll H, Santanam N Abstract BACKGROUND: The role of inflammatory markers and adipokines contributing to the development of postmenopausal hypertension, has not been established. The aim of our study was to assess the complex association between blood pressure, obesity, menopausal status, adipokines and inflammatory mediators in postmenopausal women. METHODS: We recruited 38 women seen at our Endocrinology Clinic and collected anthropometric measures and blood pressure and obtained serum samples for inflammatory markers a...
Source: Minerva Endocrinologica - June 3, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Renal function markers and metformin eligibility.
CONCLUSIONS: Metformin is the first line pharmacological agent in type 2 Diabetes Mellitus patients, being associated with significant HbA1c reductions and improvements in both micro and macrovascular outcomes. Avoiding its use due to imprecise renal function markers would potentially render the patient deprived of optimal pharmacological therapy for T2D. Creatinine contraindication criteria alone are associated with unnecessary underprescription of metformin. PMID: 28565889 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - June 3, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The 100 most-cited articles focused on thyroid research: a bibliometric analysis.
CONCLUSIONS: Our study presents a detailed list and analysis of the 100 most-cited thyroid research articles, which provides a unique insight into the historical development in this field. PMID: 28548477 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - May 28, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Influencing of antioxidants' gene variants on risk of diabetes mellitus and its complications: a systematic review.
CONCLUSIONS: Finding gene polymorphisms involved in diabetes and its complications might be helpful in discovering new therapeutic approaches, as well as prevention which is currently as a main focus in personalized medicine. PMID: 28548478 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - May 28, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Ethical considerations in the field of assisted reproductive technology.
Authors: Cobb LN, Ke RW Abstract Human reproduction has always generated more than its share of emotion that exceeds the life and death issues of medicine. For patients that are unable to conceive naturally, medical advances have greatly expanded treatment options. Assisted reproductive technology (ART) is a highly evolving, complex, and controversial field of medicine in which ethical principles play a large role in decision-making. The following highlights ethical considerations regarding ART, specifically in vitro fertilization (IVF), that practicing obstetricians and indeed all physicians may encounter. The aim...
Source: Minerva Endocrinologica - May 12, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Fertility preservation for social and oncofertility indications.
This articles attempts to summarize the current state of the art technologies regarding fertility preservation for both social and oncofertility indications. PMID: 28490170 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - May 12, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Ameliorating dyslipidemia in type 2 diabetic patients by femoropopliteal artery plaque resection under acute inflammation response.
Authors: Guo J, Cai Z, Zhang S, Liu Y, Gu Y PMID: 28462578 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - May 5, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Pharmacological management of obesity.
Authors: Velazquez A, Apovian CM Abstract Current management of obesity includes three main arms: behavioral modification, pharmacologic therapy, and bariatric surgery. Decades prior, the only pharmacological agents available to treat obesity were approved only for short-term use (≤ 12 weeks) by the Food and Drug Administration (FDA). However, in the last several years, the FDA has approved several medications for longer term treatment of obesity. This highlights the important progression that we, as a society, better appreciate now the chronicity and complexity of obesity as a disease. Also, availability of mor...
Source: Minerva Endocrinologica - May 5, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Embryo transfer: a review of timing and techniques.
Authors: Bortoletto P, Bakkensen J, Anchan RM Abstract Since the first successful human in vitro fertilization (IVF) pregnancy nearly 40 years ago, remarkable progress has been made in assisted reproductive technology (ART). Improvements in oocyte retrieval, embryo culture, genetic screening, and embryo selection have contributed to dramatic improvements in IVF outcomes. A more robust understanding of embryologic development has driven innovation in not only the timing of embryo transfer but also the number of embryos to transfer. Additionally, overcoming the technical hurdle of embryo vitrification has given both ...
Source: Minerva Endocrinologica - April 8, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

What is new in 2017? Update on fertility preservation in cancer patients.
Authors: Winkler-Crepaz K, Böttcher B, Toth B, Wildt L, Hofer-Tollinger S Abstract Prevention of fertility loss due to cancer treatment as well as non-malignant causes has gained importance during the last decades. Clinically applied modalities for fertility preservation in cancer patients include cryopreservation of oocytes and embryos, the application of GnRH agonists, ovarian tissue banking, and cryopreservation of ejaculated or surgically extracted sperm. In addition, several new possibilities to restore fertility are currently being investigated, such as the establishment of in vitro culture systems for g...
Source: Minerva Endocrinologica - March 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Controlled ovarian stimulation and triggers in in vitro fertilization: protocol personalization key to optimize outcomes.
Authors: Maher JY, Christianson MS Abstract The past four decades have delivered many advancements to improve in vitro fertilization (IVF) outcomes. These include a delicate balance of controlled ovarian hyperstimulation (COH) without causing ovarian hyperstimulation syndrome (OHSS), a safe oocyte retrieval, fertilization and embryo culture, endometrial growth and receptivity to promote implantation, and luteal support to maintain the pregnancy. Contemporary IVF practice includes both the classic COH protocols as well as protocols for poor responders and those for specific patient populations. An assortment of agen...
Source: Minerva Endocrinologica - March 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

A review on ovarian hyperstimulation syndrome (OHSS) management strategies.
Authors: Eskew AM, Omurtag KR Abstract Ovarian hyperstimulation syndrome (OHSS) is one of the most frequent, serious and potentially lethal iatrogenic complications of controlled ovarian stimulation. Despite extensive research, the exact pathogenesis of this syndrome remains less clear, but there appears to be a relationship of increased vascular permeability mediated by HCG and other downstream mediators. Adequate experience with ovulation induction therapy and identifying patients with known risk factors are essential in preventing OHSS. As this is a completely iatrogenic disease numerous strategies have been inv...
Source: Minerva Endocrinologica - March 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Effect of Vitamin D replacement in Primary Hyperparathyroidism with concurrent Vitamin D deficiency: a systematic review and meta-analysis.
Authors: Loh HH, Lim LL, Yee A, Loh HS, Vethakkan SR Abstract INTRODUCTION: We conducted a meta-analysis to assess the effects of vitamin D replacement on biochemical and skeletal parameters in subjects with mild primary hyperparathyroidism (PHPT) and coexistent vitamin D deficiency. EVIDENCE ACQUISITION: A systematic search of all English-language medical literature published from 1980 till May 2016 using Pubmed, Embase and Ovid was performed. Nine observational studies were evaluated after fulfilling the inclusion and exclusion criteria. EVIDENCE SYNTHESIS: A total of 547 patients were examined. All studi...
Source: Minerva Endocrinologica - March 18, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

The anti-inflammatory protein kallistatin is associated with carotid intima media thickness in women with polycystic ovary syndrome.
Authors: Calan M, Guler A, Unal Kocabas G, Alarslan P, Bicer M, Imamoglu C, Yuksel A, Bozkaya G, Bilgir O Abstract BACKGROUND: Kallistatin is a secreted protein that acts as a tissue kallikrein inhibitor. It has antiinflammatory, antioxidant and vasoprotective properties. Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disease associated with low-grade chronic inflammation and multiple risk factors for cardiovascular diseases. The aims of this study were to ascertain whether circulating kallistatin levels are altered in women with PCOS, and whether there is an association between kallistatin and ca...
Source: Minerva Endocrinologica - March 18, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Pancreatic beta cell function is preserved in the short term in patients with type 2 diabetes undergoing non-urgent surgery.
CONCLUSIONS: The pancreatic beta reserve of patients with T2DM was not affected a month after the non-urgent surgery. The direct measurement of pancreatic function by dynamic assessment with glucagon did not change, nor did we find alterations in the indirect calculation of insulin secretion using the HOMA-B. None of these parameters reached statistical significance. Non-urgent surgical procedures included in our study are safe for patients with short lasting, properly controlled T2DM, from the point of view of glucose metabolism assessed by pancreatic insulin secretion. We can consider non-urgent surgical procedures safe ...
Source: Minerva Endocrinologica - March 8, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Comparison of curative effect of 131I and antithyroid drugs in Graves' disease: a meta analysis.
Authors: Yuan J, Lu X, Yue Y Abstract BACKGROUND: Radioactive 131I is currently reported to be a potential effective intervention for Graves' Disease treatment in China. Whether 131I treatment was associated with effective outcome or reduced risk of side effects, reccurence rate remained unknown. EVIDENCE ACQUISITION: Eligible studies were selected from Chinese VIP, Wangfang, CNKI databases using the keywords "Iodine" and "Graves Disease". Finally, 13 clinical trials met the inclusion criterion and were included this meta-analysis. EVIDENCE SYNTHESIS: Our meta-analysis included 1355 pati...
Source: Minerva Endocrinologica - March 4, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Laparoscopic roux-en-y gastric bypass vs. laparoscopic sleeve gastrectomy for morbid obesity: a systematic review and meta-analysis of lipid effects at one year post-surgery.
Conclusions cannot be drawn from hypertriglyceridaemia and low HDL remission rates based on this meta-analysis. PMID: 28206728 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - February 18, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research