Effectiveness of Tamiflu and Relenza questioned
ConclusionThis major review is particularly significant for its use of unpublished, previously confidential data from both the drug manufacturers and regulators, to verify the information in published trials. As the researchers point out, much of the trial data is unreliable for various reasons, which makes it difficult to draw firm conclusions.While it appears that these drugs have a modest benefit, there is no solid evidence that either drug can protect people from the more serious complications of influenza. Paracetamol or ibuprofen would seem to be a far more cost-effective method of relieving the symptoms of influenza. Analysis by Bazian. Edited by NHS Choices. Follow Behind the Headlines on Twitter. Join the Healthy Evidence forum. Links To The Headlines Tamiflu: Millions wasted on flu drug, claims major report. BBC News, April 10 2014Scientists say UK wasted £560m on flu drugs that are not proven. The Guardian, April 10 2014Ministers blew £650 MILLION on useless anti-flu drugs: Cash spent on stockpiling treatments that 'worked no better than paracetamol'. Mail Online, April 10 2014The drugs don't work: Britain wasted £600m of taxpayers' money on useless flu pills stockpiled by Government in case of pandemic. The Independent, April 10 2014Tamiflu: drugs given for swine flu 'were waste of £500m'. The Daily Telegraph, April 10 2014Half A Billion Pounds 'Wasted' On Anti-Flu Drugs. Sky News, April 10 2014 Links To Science Jefferson T, Jones...
This article is the first systematic review of the effects of biosynthesized nanoparticles on both malaria parasites (Plasmodium spp.) and relevant vectors.Graphical Abstract
In this study, aqueous suspensions of various active ingredients (A.I.s) were utilized to generate Engineered Water Nanostructures (EWNS) nano-sanitizers, containing the A.I. utilized to produced them (termed iEWNS). These iEWNS had nanoscale size, were loaded with ROS and contained the A.I. utilized to produce them. They were challenged with Influenza H1N1/PR/8 and Acinetobacter baumannii on surfaces and in air. The results indicate that a nanogram dose of A.I. is effective in producing significant inactivation in Influenza H1N1/PR/8 and Acinetobacter baumannii.
Migraine is a common, disruptive, and often debilitating neurological disorder that the World Health Organization classifies in the highest disability category. Migraine is up to three times more common in women than men. Attacks are commonly triggered by stress, and many migraineurs show signs of sympathetic dysregulation. While the vascular hypothesis for migraine has largely fallen from favor, there are still several lines of evidence to suggest that dysregulation of the dural vasculature may contribute to the initiation of a migraine attack.
Approximately 90% of individuals with headache believe there is at least one trigger, or causal factor, of their headache attacks. The list of headache triggers is extensive, but little is known about how individuals develop such beliefs. The aim of this secondary analysis was to evaluate the degree of information, measured using Shannon entropy, that headache triggers contain and to examine the relationship between joint entropy (i.e., triggers and headache activity) and trigger beliefs. We hypothesized that as information about a headache trigger increased (i.e., an individual was exposed to more states of the trigger), ...
Comparative effectiveness studies can provide clinically meaningful and useful evidence of drug performance. The comparative effectiveness of ibuprofen and CL-108 (hydro-codone 7.5 mg/acetaminophen 325 mg/low-dose promethazine 12.5 mg) for acute postoperative pain was examined post hoc when it was noted that all patients in the placebo treatment group in a randomized controlled trial1 had used multiple doses of ibuprofen as needed throughout the 48-hour treatment evaluation period. Pharmacologically, these were ibuprofen-treated patients.
Pain catastrophizing plays a key role in shaping the experience of acute and chronic pain, adverse pain-related outcomes and amplified pain perception. Mindfulness-based stress reduction (MBSR) is an evidence-based program designed to focus attention on the present moment in order to decrease stress, and enhance overall wellbeing. MBSR is believed to benefit patients with chronic pain by increasing pain acceptance and potentially interrupting the link between cognitive and emotional experiences, such as catastrophizing, and the experience of pain.
Erenumab is a calcitonin gene-related peptide (CGRP) monoclonal antibody, approved recently for prevention of episodic and chronic migraine. CGRP is involved in the pathogenesis of migraine, and erenumab works by blocking the CGRP receptors. Common side effects include injection site reactions and constipation. Here we present a patient with hemicrania continua (HC) who responded well to erenumab, while the medication additionally treated her debilitating diarrhea. A 61-year-old female with history of intractable, refractory, chronic, daily, left hemicranial headaches with migrainous features associated with restlessness, ...
A 25-year-old female presented to our clinic with one-year history of retro-orbital orthostatic headaches associated with nausea, vomiting and rare binocular diplopia exacerbated by valsalva, work, and exercise and relieved by lying down. She denied headache upon awakening, photophobia and phonophobia. Her headaches started after returning from a trip to Haiti where she participated in a 30-foot waterfall dive. While there she also developed E. coli diarrheal illness. Two weeks after returning she started having daily headaches which was subsequently evaluated by an otolaryngologist, family medicine practitioner and neurologist.
Post-traumatic headache (PTH) after traumatic brain injury (TBI) is debilitating and hard to diagnose. Unfortunately, PTH is highly prevalent in active duty personnel, Veterans, as well as in sport athletes. The high incidence and chronic nature of PTH underscores the need to study these problems in animal models in order to develop new and effective treatments. The foundation of our study is the fact that PTH has many symptoms of chronic migraine. We proposed to evaluate photosensitivity and tactile hypersensitivity in two mouse models of mild TBI: the blast-induced TBI model and the closed-head injury (mCHI) model induced by weight drop.
Migraine is commonly reported among individuals with temporomandibular disorders (TMDs), especially in the patients with myogenic TMDs. This relationship can potentially add to the significant burden already experienced by migraineurs. Despite the prevalence of this comorbidity, most of previous studies focus on its epidemiological statistics. To date, the pathophysiologic mechanisms related to the comorbidity of these two conditions remain elusive. To better address this issue, an animal model that represents the comorbidity of migraine-like pain and TMDs in a clinical population is needed.
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