The first case report of cerebral cyst infection due to Helicobacter cinaedi.

We report the first case of cerebral cyst infection of H. cinaedi, a fastidious spiral-shaped gram-negative rod bacterium.A 70-year-old man visited our hospital with a fever persisting for 2 weeks. He had received surgery and radiotherapy for parapharyngeal space squamous cell carcinoma 10 years ago. The radiotherapy had resulted in a cerebral cyst as a side effect, and an Ommaya reservoir had been inserted into the cyst. Blood culture and analysis of the brain cyst fluid revealed the presence of spiral-shaped gram-negative rod bacteria, which were identified as Helicobacter cinaedi by polymerase chain reaction.We first administered clarithromycin (400 mg per day). After H. cinaedi infection was confirmed, the treatment was changed to meropenem (6 g per day). The patient was treated for 43 days in hospital with intravenous administration of meropenem, and his course was satisfactory. On the forty-fourth day, he was discharged with daily oral minocycline (200 mg per day). After his discharge, our patient's H. cinaedi infection has never recurred.Our case showed the wide range of clinical spectrum of H. cinaedi as well as the effectiveness of antibiotic therapy by meropenem and minomycine for central nervous system infection of this organism. PMID: 27357987 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research