Making Sense of Carcinogens: A New Method for Navigating Mechanistic Data

Carol Potera, based in Montana, also writes for Microbe, Genetic Engineering News, and the American Journal of Nursing. About This Article open Citation: Potera C. 2016. Making sense of carcinogens: a new method for navigating mechanistic data. Environ Health Perspect 124:A113; http://dx.doi.org/10.1289/ehp.124-A113 Published: 1 June 2016 PDF Version (143 KB) Related EHP Article Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis Martyn T. Smith, Kathryn Z. Guyton, Catherine F. Gibbons, Jason M. Fritz, Christopher J. Portier, Ivan Rusyn, David M. DeMarini, Jane C. Caldwell, Robert J. Kavlock, Paul F. Lambert, Stephen S. Hecht, John R. Bucher, Bernard W. Stewart, Robert A. Baan, Vincent J. Cogliano, and Kurt Straif There’s no shortage of scientific studies that link specific environmental chemicals to human cancer. Yet until recently there was no broadly accepted method to systematically organize and evaluate mechanistic data on human carcinogens, data that are key to assessing the potential carcinogenicity of unstudied chemicals. In a review published this month in EHP, researchers apply a new method to create order among a sprawling body of mechanistic data, based on 10 key characteristics of human carcinogens.1 As part of two 2012 workshops organized by the International Agency for Research on Cancer (IARC), several of the authors evaluated about 100 substances classified by IARC as Group 1 carcinogens, mea...
Source: EHP Research - Category: Environmental Health Authors: Tags: Featured News Science Selection June 2016 Source Type: research