Three-quarters of people with flu have no symptoms

ConclusionThis large, community-based study found that most people with influenza in England don’t have symptoms, and even if they do, only a small proportion go to a doctor.Approximately 20% of people had an increase in antibodies against influenza in their blood after an influenza “season”. However, about three-quarters of infections were symptom-free, or so mild they weren't identified through weekly questioning about whether participants had a cough, cold, sore throat, or a “flu-like illness”.People who reported being ill were asked to take a nasal swab to test for the influenza virus. Among those with illnesses and with confirmed influenza, only 17% went to see their doctor; among those that did, influenza or influenza-like illnesses were rarely recorded in medical notes. This information is important, as it indicates that current surveillance systems that rely on people visiting their doctor underestimate the extent of infection and illness in the community. This, somewhat counterintuitively, can lead to overestimates of the severity of the disease (only people with the most severe symptoms are identified as being infected).There is also the worry that people unaware they are infected may pass it on to people more vulnerable to infection, such as those with weakened immune systems. Find out if you are in a "vulnerable group". If you are, get the annual flu jab.Analysis by Bazian. Edited by NHS Choices.  Follow Behind the...
Source: NHS News Feed - Category: Consumer Health News Tags: Swine flu Medical practice Source Type: news

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Publication date: Available online 21 May 2019Source: Journal of Hospital InfectionAuthor(s): George Hills, Matthew Kennedy, Osama Ahmed, Julian W. Tang
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
AbstractA longitudinal study was performed in three Danish farrow to grower (30 kilos) herds over a 4-month period to investigate the dynamics and clinical impacts of influenza A virus (IAV) infections. In each herd, four batches consisting of four sows each with five ear-tagged piglets were included. Nasal swabs and/or blood were sampled from the sows and/or the piglets prior to farrowing and at weeks 1, 3, and 5 and at the end of the nursery period. Clinical examinations were performed at each sampling time. The sows and piglets were tested for IAV and IAV antibodies in nasal swabs and blood samples, respectively. The re...
Source: Veterinary Research - Category: Veterinary Research Source Type: research
ConclusionsA high seroconversion rate (73%) for EV-D68 was found among kindergarten attendees, which indicates preschool-aged children are highly susceptible to EV-D68 infection and that the disease burden may be extremely underestimated. Once EV-D 68 circulates, preventive measures may be advocated, especially within kindergartens or daycares, to reduce transmission and subsequent development of severe cases.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Avian malaria parasites (genus Plasmodium) are cosmopolitan and some species cause severe pathologies or even mortality in birds, yet their virulence remains fragmentally investigated. Understanding mechanisms an...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Publication date: Available online 20 May 2019Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Yasunori Watanabe, Thomas A. Bowden, Ian A. Wilson, Max CrispinAbstractGlycosylation is a ubiquitous post-translational modification responsible for a multitude of crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to glycosylate their own proteins during replication. Viral envelope proteins from a variety of human pathogens including HIV-1, influenza virus, Lassa virus, SARS, Zika virus, dengue virus, and Ebola virus have evolved to be extensively glycosylated. These host...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
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Source: Photochemistry and Photobiology - Category: Science Authors: Tags: Research Article Source Type: research
This report finds that attitudes of older adults to influenza immunisation are a significant factor in influencing the vaccination rates amongst this group. It argues that efforts to increase the vaccination coverage rates among the older population needs to move beyond associating age with vulnerability and towards presenting immunisation as a positive and healthy lifestyle choice.Report
Source: Health Management Specialist Library - Category: UK Health Authors: Tags: Local authorities, public health and health inequalities Source Type: blogs
Recently, the evolution of H7N9 AIVs has been widely studied in this journal.1, 2 The six internal genes (PB2, PB1, PA, NP, M, and NS) of H7N9 are from chicken H9N2 avian influenza viruses.3 Genotypic analysis of these six internal genes revealed that the most frequent genotypes of H9N2 genotypes did not become the major genotypes in H7N9, thus it appears that H7N9 prefer some genotypes for these genes.4 The cause for this preference remains unknown, as is whether this preference helped H7N9 become a successful AIV subtype.
Source: Journal of Infection - Category: Infectious Diseases Authors: Tags: Letter to the Editor Source Type: research
We examined the clinical and serologic features of Guillain-Barré syndrome (GBS)-related diseases (GBSRDs), including GBS, Fisher syndrome (FS), and Bickerstaff brainstem encephalitis (BBE), after influenza virus infection (GBSRD-I) to reveal potential underlying autoimmune mechanisms. Methods We retrospectively investigated the presence of antiglycolipid antibodies against 11 glycolipids and the clinical features of 63 patients with GBSRD-I. Autoantibody profiles and clinical features were compared with those of 82 patients with GBSRDs after Campylobacter jejuni infection (GBSRD-C). Results The anti-GQ1b seroposi...
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Guillain-Barre syndrome Article Source Type: research
The dissemination of Influenza A virus (IAV) throughout the world has become one of the main concerns for the health of both animals and human beings. An efficient and sensitive diagnostic tool is thus needed for the early detection of IAV. Here, we developed a wash-free magnetic bioassay and further integrated it with a handheld platform based on giant-magnetoresistance (GMR) sensors. The wash-free magnetic bioassay significantly accelerates and simplifies the detection process. This brand-new system was successful in detecting both IAV nucleoprotein and IAV-contained nasal swab samples from pigs on the farm. The extrapol...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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