UCLA scientists unravel the genetic evolution of Zika virus

How does a formerly innocuous and obscure virus like Zika transform itself into a feared pathogen inflicting a devastating impact on global health? A new UCLA study suggests that the virus possesses the ability to mutate rapidly, allowing the current outbreak to spread swiftly around the world. The Cell Press journal, Cell Host & Microbe, published the findings today in its advance online edition. “The Zika virus has undergone significant genetic changes in the past 70 years,” explained senior author Genhong Cheng, a professor of microbiology, immunology and molecular genetics at the David Geffen School of Medicine at UCLA. “By tracing its genetic mutations, we aimed to understand how the virus is transmitted from person to person and how it causes different types of disease.” First isolated in 1947, the Zika virus only sporadically caused disease in Africa and Asia until the 2007 Micronesia and 2013 French Polynesia outbreaks. Scientists previously believed that infection was spread solely by mosquitoes and caused only mild illnesses.  The latest epidemic has linked the virus to fetal brain-development disorders and Guillain-Barre syndrome. New modes of transmission, including infection through sexual contact and from mother to  fetus, have also surfaced. “We don’t know why Zika infection was not associated with serious human disease, especially in newborns, until recently,” said co-author Dr. Stephanie Valderramos, a fellow in obstetrics-gynecology at...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news