Abstract A194: PEGylated human IL-10 (AM0010) in advanced solid tumors

ConclusionIn Monotherapy, AM0010 has a well-tolerated safety profile and leads to sustained and systemic immune stimulation. The pharmacodynamics and clinical activity observed support the ongoing monotherapy expansions and combination regimens with checkpoint inhibitors as well as cytotoxic chemotherapies.Trial registration: www.clinicaltrials.gov NCT02009449Citation Format: Jeffrey R. Infante, Aung Naing, Kyriakos P. Papadopoulos, Karen A. Autio, Patrick A. Ott, Deborah J. Wong, Gerald S. Falchook, Manish Patel, Shubham Pant, Melinda Whiteside, Johanna C. Bendell, Todd M. Bauer, Filip Janku, Milind Javle, Rivka Colen, Nizar Tannir, Martin Oft. PEGylated human IL-10 (AM0010) in advanced solid tumors. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2015 Nov 5-9; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr A194.
Source: Molecular Cancer Therapeutics - Category: Cancer & Oncology Authors: Tags: Tumor Immunology Targets: Poster Presentations - Proffered Abstracts Source Type: research

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In this study, five population databases plus the Catalog of Somatic Mutations in Cancer was employed to demonstrate the impact of changing the PF cut-off on assignment of variants as germline versus somatic. The 1% to 2% PF cut-offs widely used in bioinformatic pipelines result in high sensitivity for classification of somatic variants, but unnecessarily reduced sensitivity for germline variants. Using optimized PF cut-offs, the source of variants in TCGA data could be predicted with>95% accuracy. Further exploration of four TCGA cancer datasets indicated that the optimal cut-off is influenced by both cancer type and t...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
Publication date: Available online 25 June 2019Source: The Journal of Molecular DiagnosticsAuthor(s): Paolo A. Ascierto, Carlo Bifulco, Giuseppe Palmieri, Solange Peters, Nikoletta SidiropoulosAn enduring goal of personalized medicine in cancer is the ability to identify patients who are likely to respond to specific therapies. Our growing understanding of the biology and molecular signatures of individual tumor types has facilitated the identification of predictive biomarkers and has led to an increasing number of diagnostic tests to be performed, often as serial and distinct assays on limited tumor specimens. The biomark...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
Objective The aim of this study was to use an electronic tablet–based education module to increase patient knowledge about human papillomavirus (HPV). Methods Patients presenting to an academic colposcopy clinic were first queried as to whether they had been infected with HPV. A quality improvement project was then conducted using a 4-question pretest assessing baseline knowledge about HPV and cancer, followed by a tablet-based education module and a 5-question posttest. Results Between June 2017 and January 2018, 119 patients participated in the tablet education. At their initial visit, only 50 (42.0%) of pa...
Source: Journal of Lower Genital Tract Disease - Category: OBGYN Tags: Original Research Articles: Cervix and HPV Source Type: research
Conclusions Both methods of sampling were found to be acceptable to women. Self-sampling is cost-effective and could increase the screening coverage among underscreened populations. However, more information about the quality, reliability, and accuracy of self-sampling is needed to increase women's confidence about using to this method.
Source: Journal of Lower Genital Tract Disease - Category: OBGYN Tags: Original Research Articles: Cervix and HPV Source Type: research
No abstract available
Source: Journal of Lower Genital Tract Disease - Category: OBGYN Tags: Forum Source Type: research
Conclusions We reviewed and discussed unusual benign and malignant dermatopathology conditions that can affect the foreskin.
Source: Journal of Lower Genital Tract Disease - Category: OBGYN Tags: Review Source Type: research
Publication date: Available online 26 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): David Baker, Benjamin M. Jacobs, Sharmilee Gnanapavan, Klaus Schmierer, Gavin GiovannoniABSTRACTThere is increasing evidence that agents that target peripheral B cells and in some instances plasma cells can exhibit marked effects on relapsing multiple sclerosis. In addition, B cells, including plasma cells, within the central nervous system compartment are likely to play an important role in disease progression in both relapsing and progressive MS. However, current B cell-targeting antibodies may not inhibit these, bec...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Nashville-based E+CancerCare (stylized e+CancerCare) has been sold to a Newport Beach, California, company, according to a news release. Integrated Oncology Network LLC, a portfolio company of Silver Oak Services Partners LLC, announced Wednesday it has bought E+CancerCare. Terms of the deal were not disclosed. Founded in 2002, E+CancerCare operates 21 outpatient cancer treatment centers in 21 states, according to the release. The company’s centers provide diagnostic testing, radiation oncology…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
ConclusionIt seems that human breast cancer and BLV infection in cattle could be associated using nested PCR technique.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
ConclusionsMore research is necessary to understand why cervical cancer screenings are not associated with receipt of an AFV.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
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