Nanodiamonds might prevent tooth loss after root canals

People undergoing root canals may have gained a powerful, if tiny, new ally. Researchers from the UCLA School of Dentistry have found that using nanodiamonds to fortify a material used in the procedure could significantly improve outcomes for patients.   A paper on their research is published in the current issue of the peer-reviewed journal ACS Nano. Nanodiamonds are tiny particles formed as byproducts of diamond refining and mining. Thousands of times smaller than the width of a human hair, they have been widely explored for use in dentistry, cancer therapy, imaging and regenerative medicine, among other applications. Each year, more than 15 million root canal procedures are performed in the United States. Dentists’ goal is to save their patients’ teeth from infected dental “pulp” — the part of the tooth that includes blood vessels and nerve tissue. During a root canal, inflamed dental pulp is removed and the empty space is then filled in with a polymer called gutta percha, which is used in part because it does not react within the body. But some root canals don’t entirely remove the infection, and residual infection after root canals can lead to tooth loss. In addition, traditional gutta percha has certain shortcomings, including a limited capacity to ward off infection and less-than-optimal rigidity. To overcome those issues, the UCLA team developed and tested two types of reinforced gutta percha: One strengthened with nanodia...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Publication date: April 2019Source: Biomedicine &Pharmacotherapy, Volume 112Author(s): Yingjuan Lu, Yingru Li, Zhangsong Wang, Shule Xie, Qing Wang, Xinyuan Lei, Yi Ruan, Jinsong LiAbstractRepulsive guidance molecules comprise a group of proteins that play an important role in carcinogenesis through interactions with their receptors, but their function in oral squamous cell carcinoma (OSCC) is unclear. Here, we investigated the potential role of the RGM family members in oral cancer pathogenesis. Our study showed that only RGMA was significantly downregulated in the OSCC tissues analyzed by TCGA and validated this find...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Conditions:   Prostate Cancer Metastatic;   Castration-resistant Prostate Cancer Interventions:   Drug: HC-1119;   Drug: Enzalutamide Sponsor:   Hinova Pharmaceuticals USA, Inc. Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Sexual intercourse is regarded as the primary route of human papillomavirus (HPV) transmission. Reported rates of the genotype-specific genital concordance of HPV infection among heterosexual partners vary. Most studies have evaluated only male/female genital transmission, but lately, the oral region has gained interest because of a rising trend of HPV-associated oropharyngeal cancer. Risk factors for type-specific concordance have been reported as an increasing number of younger couples, persistent HPV infection, higher frequency of sexual intercourse, rising number of spouse ’s lifetime sexual partners, and sexual ...
Source: Acta Cytologica - Category: Cytology Source Type: research
When it comes to low-calorie sweeteners, you have a lot of choices. There’s the blue one, the pink one, the yellow one, or the green one. Whichever one you choose, know that scientists have probably studied it extensively. What they’ve found may surprise you. Artificial and other non-caloric sweeteners: The major players The marketers for artificial sweeteners have color-coded their products, but they differ in some important ways beyond their packaging. In the US, the most popular FDA-approved non-sugar sweeteners (NSSs) and their most common packaging color are: aspartame (blue): examples include Nutrasweet ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Diet and Weight Loss Health Healthy Eating Source Type: blogs
CANCER symptoms vary depending on which part of the body is affected by a tumour. You could be at risk of deadly tumour signs if you notice this feeling in your teeth. It could be a warning sign of deadly mouth cancer. Should you see a doctor?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
In this study, the role of Thymoquinone (TQ) in OSCC cells was studied. It was confirmed that TQ can inhibit the proliferation, migration and invasion of KB cells, and can also achieve apoptosis by inhibiting the activation of PI3K/Akt pathway. Therefore, TQ is an effective candidate for the treatment of OSCC. PMID: 30782296 [PubMed - in process]
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
To evaluate incontinence severity and patient reported outcomes (PROs) of women undergoing concomitant surgical treatment of early stage endometrial cancer and stress urinary incontinence (SUI) compared to women who chose cancer surgery with non-surgical treatment of incontinence, and to women choosing cancer surgery alone.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Oral Presentation Source Type: research
The most common occult malignancy in gynecologic surgery is uterine cancer. Unintentional spillage of cells can occur during morcellation and subtotal hysterectomy performed with supportive repair. While available screening for endometrial cancer may reduce the risk of occult malignancy, it is not cost effective in the asymptomatic patient. One diagnostic method that has not been explored for the uterine body, but has shown promise in cervical, breast, prostate, and skin cancer is bioimpedance analysis.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Non-Oral Poster Source Type: research
ConclusionThe method was effective in the identification of precancerous lesions for the purpose of secondary prevention, but equally important against upper aerodigestive tract cancer, since in the present study the chance of finding the latter was increased by 22.7, showing it is an alternative for future campaigns against the disease.ResumoIntroduçãoO câncer do trato aerodigestivo superior configura-se entre os mais frequentes e apresenta-se com importância epidemiológica no mundo. A maior parte apresenta-se avançada ao diagnóstico, com forte impacto negativo na sobrevida e...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
Fengxue Geng, Qingxuan Wang, Chen Li, Junchao Liu, Dongmei Zhang, Shuwei Zhang, Yaping Pan
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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