Nanodiamonds might prevent tooth loss after root canals

People undergoing root canals may have gained a powerful, if tiny, new ally. Researchers from the UCLA School of Dentistry have found that using nanodiamonds to fortify a material used in the procedure could significantly improve outcomes for patients.   A paper on their research is published in the current issue of the peer-reviewed journal ACS Nano. Nanodiamonds are tiny particles formed as byproducts of diamond refining and mining. Thousands of times smaller than the width of a human hair, they have been widely explored for use in dentistry, cancer therapy, imaging and regenerative medicine, among other applications. Each year, more than 15 million root canal procedures are performed in the United States. Dentists’ goal is to save their patients’ teeth from infected dental “pulp” — the part of the tooth that includes blood vessels and nerve tissue. During a root canal, inflamed dental pulp is removed and the empty space is then filled in with a polymer called gutta percha, which is used in part because it does not react within the body. But some root canals don’t entirely remove the infection, and residual infection after root canals can lead to tooth loss. In addition, traditional gutta percha has certain shortcomings, including a limited capacity to ward off infection and less-than-optimal rigidity. To overcome those issues, the UCLA team developed and tested two types of reinforced gutta percha: One strengthened with nanodia...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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In this study, the hollow structure of MOF-5 was synthesized. Its drug loading and drug release capacity were studied. The human ovarian cancer SK-OV-3 cell line was selected to study the drug loading system, cytotoxicity, and cellular uptake. We concluded that a hollow MOF with an excellent morphology was successfully fabricated in the experiment; it increased the drug loading capacity, achieved a more ideal sustained-release effect, improved the treatment efficiency of the hydrophobic Chinese medicine component, and provided a relatively efficient drug loading material.Graphical abstract
Source: Inorganic Chemistry Communications - Category: Chemistry Source Type: research
SummaryRolapitant is a neurokinin-1 receptor antagonist that is approved in combination with other antiemetic agents in adults for the prevention of delayed nausea and vomiting (CINV) associated with initial and repeat courses of emetogenic cancer chemotherapy, including but not limited to highly emetogenic chemotherapy. Here, we assessed the absorption, metabolism, and excretion of14C-labeled rolapitant in healthy male subjects. Rolapitant was administered as a single 180-mg oral dose containing approximately 100  μCi of total radioactivity, with plasma, urine, and fecal samples collected at defined intervals afte...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
AbstractThe purpose of the present study was to examine the educational needs of patients regarding early detection of oral cancer. A total of 790 patients without cancer were interviewed and shown a set of validated clinical images of various oral lesions including early oral cancer. Participants were asked about their perception of cancer and the action that they would take if they notice a similar lesion. Lower risk lesions (e.g., lumps) were more likely to be perceived as cancer (52.4%), while higher risk lesions (e.g., red patches) were least likely to be perceived as cancer (8.8%). The perceived appearance of the les...
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
I took our cat, Peekaboo, to the vet two days ago, around lunchtime. When her new CAT scan results came in, my vet told me that, even though the melanoma had spread a bit in the past two weeks, the cancer hadn’t gone into the jawbone yet. She recommended that we do the surgery. After asking a few obvious but almost-impossible-to-answer questions (will the surgery PROLONG HER LIFE without impacting her QUALITY OF LIFE, blablabla), I called Stefano, and we both agreed it was our only choice at this point, even though there really aren’t any guarantees: this sort of cancer is very aggressive, so it may come back a...
Source: Margaret's Corner - Category: Cancer & Oncology Authors: Tags: Blogroll cat surgery feline oral cancer feline oral melanoma Source Type: blogs
(Natural News) Aside from contributing to bad breath, it looks like drinking alcohol can disrupt the balance of both “good” and “bad” bacteria in your mouth. The results of a study determined that regular alcohol consumption can also increase an individual’s chance of developing cavities and gum disease, along with cancer and heart disease. Alcohol, mouth...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
The objective of this study was to characterize OSCC-associated inflammation and to determine the molecular mechanisms underlying inflammation-mediated OSCC invasion. Our results showed a significant increase in neutrophil infiltration, the neutrophil-to-lymphocyte ratio in the OSCC microenvironment and increased inflammatory markers, particularly TNFα in saliva. We performed next-generation sequencing of the TNFα-treated OSCC cells and showed marked overexpression of over 180 genes distributed among clusters related to neutrophil recruitment, invasion, and invadopodia. At the molecular level, TNFα treatm...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
This study was conducted to compare histological margins and duration of surgery between ultrasonic coagulation device and electrodiathermy in the resection of oral tongue tumours. A retrospective analysis was performed comprising patients undergoing wide excision for squamous cell carcinoma of the lateral tongue, with either ultrasonic coagulation device or conventional electrodiathermy at Our Institute in Mumbai, India, from October 2015 to December 2016. Single factor ANOVA with the level of significance set at 95% and alpha value of 0.05. Patients who underwent excision with ultrasonic coagulation devicebetter histolog...
Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research
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Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research
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Source: Drugs - Category: Drugs & Pharmacology Source Type: research
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