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Nanodiamonds might prevent tooth loss after root canals

People undergoing root canals may have gained a powerful, if tiny, new ally. Researchers from the UCLA School of Dentistry have found that using nanodiamonds to fortify a material used in the procedure could significantly improve outcomes for patients.   A paper on their research is published in the current issue of the peer-reviewed journal ACS Nano. Nanodiamonds are tiny particles formed as byproducts of diamond refining and mining. Thousands of times smaller than the width of a human hair, they have been widely explored for use in dentistry, cancer therapy, imaging and regenerative medicine, among other applications. Each year, more than 15 million root canal procedures are performed in the United States. Dentists’ goal is to save their patients’ teeth from infected dental “pulp” — the part of the tooth that includes blood vessels and nerve tissue. During a root canal, inflamed dental pulp is removed and the empty space is then filled in with a polymer called gutta percha, which is used in part because it does not react within the body. But some root canals don’t entirely remove the infection, and residual infection after root canals can lead to tooth loss. In addition, traditional gutta percha has certain shortcomings, including a limited capacity to ward off infection and less-than-optimal rigidity. To overcome those issues, the UCLA team developed and tested two types of reinforced gutta percha: One strengthened with nanodia...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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This study investigates the ability of a novel combined therapy of radioprotective amifostine (AMF) and angiogenic deferoxamine (DFO) to mitigate XRT-induced bone injury in a murine model of DO.
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research
Conditions:   Oral Cavity Squamous Cell Carcinoma;   Saliva Altered;   Precancerous Lesions Interventions:   Diagnostic Test: Oral Cancer group;   Diagnostic Test: PMOD group;   Diagnostic Test: Control Sponsors:   University of Zagreb;   Croatian Science Foundation Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Cheng CY, Liu CJ, Huang YC, Wu SH, Fang HW, Chen YJ Abstract BI2536 has been developed as a potential therapeutic agent for various cancers but not in oral cancer cells. Since BI2536 exhibits mitosis-regulating activity which are the most radiosensitive, we hypothesized that BI2536 might modulate the radiosensitivity of oral cancer cells. Human normal fibroblasts, oral cancer SAS, and OECM1 cells were treated with BI2536 (0-50 nM) and/or radiation (0-4 Gy). MTT assay, Liu's staining, flow cytometry, clonogenic assay, Annexin V/propidium iodide (PI) staining, western blot analysis, and small interfering RNA...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
This study also deals with the effect of E. triaculeata on the standard drug cyclophosphamide (CP) treatment in mice. Three different doses 250, 500 and 1000 mg/kg body weight were selected. In micronucleus assay, single oral dose administration of Euphorbia triaculeata extract at the three doses did not increase the number of micronucleated polychromatic erythrocytes. Similarly, a single oral administration of Euphorbia triaculeata extract showed no significant changes on mitotic indices or in induction of chromosomal aberrations in mice bone marrow cells. Pretreatment with E. triaculeata extract significantly reduced t...
Source: Toxicology Reports - Category: Toxicology Source Type: research
This study evaluated parameters of toxicity and antiproliferative effects of (+)-N(1)-4-fluorobenzaldehyde-N(4)-{1-methyl-1-[(1R)-4-methylcyclohexene-3-il]-ethyl}-thiossemicarbazone (4-FTSC) in PC-3 adenocarcinoma prostate cells. Main methods Cytotoxicity of 4-FTSC in PC-3 cells was evaluated using MTT assay. Morphology examination of PC-3 cells treated with 4-FTSC was also performed as well as the cell death mechanisms induced were investigated using flow cytometry. Parameters of toxicity of 4-FTSC was conducted by the investigation of its potential myelotoxicity and lymphotoxicity, hemolytic activity and acute oral toxic...
Source: Life Sciences - Category: Biology Source Type: research
This study examined the impact of emulsifier type on the formation and stability of curcumin-loaded oil-in-water emulsions: sodium caseinate; Tween 80; quillaja saponin; gum arabic. The effectiveness of these food-grade emulsifiers at forming emulsions by microfluidization was characterized in terms of their surface load, i.e., the mass of emulsifier per unit surface area. The surface loads decreased in the following order: gum arabic (55.3 mg/m2) > > saponins (2.0 mg/m2) > Tween 80 (1.6 mg/m2) > caseinate (1.5 mg/m2), which indicated that much more gum arabic was required to form emulsion...
Source: Food Research International - Category: Food Science Source Type: research
Conclusions Approximately two-thirds of patients who undergo treatment with radium-223 will experience an improvement in pain and, if it occurs, it will most likely occur within the first two cycles. Patients should be counseled about this timeline and, if pain improvement isn't achieved, palliative radiation and oral analgesic readjustment should be considered. Pain response is not associated with survival and should not be used to evaluate the effectiveness of treatment.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
There are more than 1 million firefighters throughout the USA and Canada who are exposed to multiple dangers as they perform their vital duties protecting our communities. The current virtual issue inOccupational Medicine highlights selected firefighter research published over the last 6 years in the journal. These papers reflect the three highest priority health concerns of the current North American Fire Service: cardiovascular disease (CVD), cancer and behavioural health issues. While each of these three issues seems discrete and disconnected, there are important ways in which these very different problems interrelate. ...
Source: Occupational Medicine - Category: Respiratory Medicine Source Type: research
This study protocol is the first to test the effects of the modified DCS regimen for metastatic SCCE.Oncology
Source: Oncology - Category: Cancer & Oncology Source Type: research
Auris Health, previously known as Auris Surgical Robotics, said today it inked a cooperative development and commercialization deal with Johnson &Johnson (NYSE:JNJ) division Ethicon’s NeuWave Medical subsidiary looking to develop systems for the robotically-assisted bronchoscopic ablation of lung lesions. Through the agreement, both companies will help develop an integrated system for robotic control, navigation and application of bronchoscope-delivered microwave ablation. The bronchoscope in development will be equipped with a small camera and accessory channel to allow tools to enter the lungs through the ...
Source: Mass Device - Category: Medical Devices Authors: Tags: Business/Financial News Endoscopic / Arthroscopic Respiratory Robotics aurishealth Ethicon johnsonandjohnson NeuWave Medical Inc. Source Type: news
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