Nanodiamonds might prevent tooth loss after root canals

People undergoing root canals may have gained a powerful, if tiny, new ally. Researchers from the UCLA School of Dentistry have found that using nanodiamonds to fortify a material used in the procedure could significantly improve outcomes for patients.   A paper on their research is published in the current issue of the peer-reviewed journal ACS Nano. Nanodiamonds are tiny particles formed as byproducts of diamond refining and mining. Thousands of times smaller than the width of a human hair, they have been widely explored for use in dentistry, cancer therapy, imaging and regenerative medicine, among other applications. Each year, more than 15 million root canal procedures are performed in the United States. Dentists’ goal is to save their patients’ teeth from infected dental “pulp” — the part of the tooth that includes blood vessels and nerve tissue. During a root canal, inflamed dental pulp is removed and the empty space is then filled in with a polymer called gutta percha, which is used in part because it does not react within the body. But some root canals don’t entirely remove the infection, and residual infection after root canals can lead to tooth loss. In addition, traditional gutta percha has certain shortcomings, including a limited capacity to ward off infection and less-than-optimal rigidity. To overcome those issues, the UCLA team developed and tested two types of reinforced gutta percha: One strengthened with nanodia...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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This study aimed to determine the oral health knowledge (OHK) of Hispanic adults in Iowa to identify potential gaps in knowledge. METHODS: This cross-sectional study included a convenience sample of self-identifying Hispanic adults. Data pertaining to oral health literacy and demographic, cultural, and dental characteristics were collected. OHK was assessed with the Conceptual Measure of Oral Health Knowledge, and it was categorized as low or high. Bivariate analyses and multiple logistic regression models were conducted to identify the variables related to OHK (P
Source: Journal of the American Dental Association - Category: Dentistry Tags: J Am Dent Assoc Source Type: research
Conclusions: Dermatologic or mucosal conditions that might affect barrier integrity and use of corticosteroids and intravenous antibiotics prior to chemotherapy may increase risk of FN and should be considered in prophylaxis use and FN prediction modeling. PMID: 30323090 [PubMed - in process]
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
Oral cancer pain level at the primary site may help doctors identify which patients with occult metastases will benefit from neck dissection, according to results of a study by researchers at New York University in New York City.Reuters Health Information
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Hematology-Oncology News Source Type: news
ConclusionsIt is possible that the lesion that progressively and very slowly eroded the splanchnocranial structures of Freud was not a bona-fide cancerous malignancy, but rather, the necrotizing effect of cocaine use that has been previously reported to be responsible for some massive facial destructive lesions.
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
Authors: Ríos González E, Martínez-Piñeiro L Abstract Androgen deprivation therapy is part of the initial treatment of patients with metastatic prostate cancer. Nevertheless, after an initial response and despite maintaining an effective testosterone suppression, the tumor is able to continue growing.Enzalutamide is an oral second generation pure antiandrogen that acts at various levels in the signal activation cascade of the androgen receptor and has demonstrated being effective in this phase of the disease. In the clinical trials completed, it has demonstrated benefits in overall patie...
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
CONCLUSIONS: Abiraterone acetate is a new hormonal treatment for metastatic castration resistant prostate cancer both before and after chemotherapy. The results of the available studies demonstrate a significant improvement in terms of efficacy, with a tolerability profile generally acceptable, predictable and manageable, and an improvement in patient's perceived quality of life. PMID: 30319125 [PubMed - in process]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
Purpose of review To review the recent literature regarding treatment of gastric cancer. Recent findings Addition of postoperative radiation therapy to perioperative chemotherapy offers no survival benefit. Fluoropyrimidines, in particular 5-fluorouracil (5-FU), are the backbone for gastric cancer chemotherapy. S-1, an oral prodrug of 5-FU, has become the mainstay for gastric cancer chemotherapy in Japan. In a Japanese adjuvant chemotherapy trial, addition of docetaxel to standard S-1 chemotherapy improved disease-free survival; this regimen will become their new standard for adjuvant therapy. Microsatellite instabili...
Source: Current Opinion in Gastroenterology - Category: Gastroenterology Tags: STOMACH AND DUODENUM: Edited by Mitchell L. Schubert Source Type: research
ConclusionThe deep learning system produced diagnostic outcomes similar to those of the radiologists, which suggests that it may be valuable for diagnostic support.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Publication date: Available online 15 October 2018Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): E. Marttila, H. Thorén, J. Törnwall, A. Viitikko, T. WilkmanAbstractThe aim of this retrospective study was to analyse the incidence of complications and loss of flaps after primary reconstructions for oral cancer in 191 patients at our hospital over the five years 2005–2010. The patients’ clinical and personal details, characteristics of the tumours, types of microvascular flap, complications, and outcomes were recorded. The soft tissue flaps used most often were the fasciocutaneous...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Licochalcone H induces the apoptosis of human oral squamous cell carcinoma cells via regulation of matrin 3. Oncol Rep. 2018 Oct 11;: Authors: Nho SH, Yoon G, Seo JH, Oh HN, Cho SS, Kim H, Choi HW, Shim JH, Chae JI Abstract Licochalcone H (LCH) is a chemical compound that is a positional isomer of licochalcone C (LCC), a chalconoid isolated from the root of Glycyrrhiza inflata, which has various pharmacological properties including anti‑inflammatory, antioxidant, antitumor, and anticancer effects. However, the efficacy of LCH on cancer cells has not been investigated. The present ...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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