Macrophage-Derived GSDMD Plays an Essential Role in Atherosclerosis and Cross Talk Between Macrophages via the Mitochondria-STING-IRF3/NF- κB Axis

CONCLUSIONS: Our study has provided a novel macrophage-derived GSDMD mechanism in the promotion of atherosclerosis and demonstrated that GSDMD can be a potential therapeutic target for atherosclerosis.PMID:38695170 | DOI:10.1161/ATVBAHA.123.320612

Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 2, 2024 Category: Cardiology Authors: Xiaoxi Fan Jibo Han Lingfeng Zhong Wenyuan Zheng Ruiyin Shao Yucong Zhang Si Shi Shuang Lin Zhouqing Huang Weijian Huang Xueli Cai Bozhi Ye Source Type: research