Consideration for alpha-gal syndrome in two critically ill persons with group O blood who received group B plasma

CONCLUSION: Two patients with O-positive blood and no known allergies experience danaphyl axis after transfusion with group B FFP. The symptoms cannot definitively be imputed to an allergic transfusion reaction, but the presence of IgE against alpha-gal supports an association. Medicating patients with antihistamines and IV steroids pre-transfusion may prevent allergic reactions. Restricting group B plasma-containing products (plasma, platelets, cryoprecipitate) for patients who experience AGS-like symptoms may be considered.PMID:38566573 | DOI:10.1111/trf.17811

Source: Transfusion - April 3, 2024 Category: Hematology Authors: Maureen J Miller Patricia Lee Brian G Lee Willy A Flegel Kamille West-Mitchell Kathleen Conry-Cantilena Valeria De Giorgi Source Type: research