Metabolic and cardiovascular benefits and risks of 4-hydroxy guanabenz hydrochloride: α < sub > 2 < /sub > -adrenoceptor and trace amine-associated receptor 1 ligand

CONCLUSIONS: The precise sequence of molecular events within the organism, linking the impact of 4-OH-Guanabenz on α2A-adrenoceptor and TAAR1 with weight reduction and the amelioration of metabolic disturbances, remains an unresolved matter necessitating further investigation. Undoubtedly, the fact that 4-OH-Guanabenz is a metabolite of a well-known drug has considerable importance, which is beneficial from an economic point of view and towards its further development as a drug candidate.PMID:37624466 | DOI:10.1007/s43440-023-00518-9
Source: Pharmacological Reports - Category: Drugs & Pharmacology Authors: Source Type: research