An Update on Impacts of Epigallocatechin Gallate Co-administration in Modulating Pharmacokinetics of Statins, Calcium Channel Blockers, and Beta-blockers
Planta Med DOI: 10.1055/a-2111-7319Brewed green tea, green tea extract, and its primary active compound, epigallocatechin gallate, may interact with drugs and alter the drugʼs therapeutic effectiveness, ultimately leading to
therapeutic failure or drug overdose. Several isolated reports have claimed that epigallocatechin gallate is the main active ingredient that causes these effects. While a few studies aimed
to uncover evidence of epigallocatechin gallate-drug interactions, no study has thoroughly and collectively reviewed them. Epigallocatechin gallate is a potential cardioprotective agent used
by many patients with cardiovascular diseases as a complementary medicine alongside conventional modern medications, either with or without the knowledge of their physicians. Therefore, this
review focuses on the impact of concurrent epigallocatechin gallate supplementation on pharmacokinetics and pharmacodynamics of several commonly used cardiovascular drugs (statins,
beta-blockers, and calcium channel blockers). The PubMed index was searched for key words related to this review, without year limit, and the results were analyzed for interactions of
cardiovascular drugs with epigallocatechin gallate. This review concludes that epigallocatechin gallate increases systemic circulation of several statins (simvastatin, fluvastatin,
rosuvastatin) and calcium channel blockers (verapamil), but decreases the bioavailability of beta-blockers (nadolol, ateno...
Source: Planta Medica - Category: Drugs & Pharmacology Authors: Siew-Keah, Lee Jie, Tan Hong Ang-Lim, Chua Bin, Liew Kai Yik-Ling, Chew Tags: Reviews Source Type: research
More News: Alternative and Complementary Therapies | Atenolol | Beta-Blockers | Bisoprolol | Calcium | Cardiology | Cardiovascular | Cholesterol | Complementary Medicine | Crestor | Drugs & Pharmacology | Fluvastatin | Green Tea | Heart | Nadolol | Overdose | Rosuvastatin | Simvastatin | Statin Therapy | Study | Verapamil | Zocor