Gastrodin protects porcine sertoli cells from zearalenone-induced abnormal secretion of glial cell line-derived neurotrophic factor through the NOTCH signaling pathway

In conclusion, the present study demonstrates that ZEA disrupts pSSCs self-renewal by affecting the function of porcine Sertoli cell, and highlights the protective mechanism of GAS through the regulation of the NOTCH signaling pathway. These findings may offer a novel strategy for alleviating ZEA-induced male reproductive dysfunction in animal production.PMID:37285694 | DOI:10.1016/j.repbio.2023.100781

Source: Reproductive Biology - June 7, 2023 Category: Reproduction Medicine Authors: Yulu Cao Jingjing Wang Xiaoxiao Li Biyun Liu Chongjun Li Yijin Sun Kang Zou Source Type: research