Direct and indirect effects of alcohol and its toxic metabolite acetaldehyde on human esophageal myofibroblasts and epithelial cells

CONCLUSIONS: Alcohol and acetaldehyde doses in which the majority of HEMFs and epithelial cells are healthy, elicit production of paracrine mediators with pro-proliferative effects on neighboring cells. Understanding the effect of alcohol and acetaldehyde on HEMFs and HEMF-epithelial interactions may help identify the molecular basis by which alcohol increases risk for esophageal cancer.PMID:37128647 | DOI:10.1111/acer.15093
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Source Type: research