Cochrane study finds stool transplants more effective than antibiotics for treating recurring, life-threatening gut infections

A new Cochrane Review has found that, compared with standard antibiotic treatment, stool transplantation can increase the number of people recovering from Clostridioides difficile (C. diff) infection, a condition which causes potentially life-threatening diarrhea. 77 percent of people who received a stool transplant did not experience reinfection within eight weeks, compared to 40 percent of those who received antibiotics alone.C. diff is a bacterium that can cause life-threatening diarrheal illness in individuals with an unhealthy mixture of gut bacteria, known as dysbiosis. The most common cause of dysbiosis is treatment with antibiotics, and while antibiotics can be very effective against bacterial infections, they can also harm the beneficial bacteria colonizing the gut, known as the intestinal microbiome. Usually this ecosystem of “good” bacteria recovers quickly, but occasionally “bad” species like C. diff take over and cause serious diarrhea.The standard treatment of C. diff infection includes antibiotics, which may further exacerbate dysbiosis. This can lead to a vicious cycle of brief treatment effect followed by a recurrent infection. This happens in nearly a third of infected individuals.According to the CDC, every year there are around a quarter of a million C. diff infections in the US alone, causing approximately 12,000 fatalities.Transplanting healthy donor stool into a gut with dysbiosis is intended to balance the gut microbes and reestablish a healthy...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news