Therapeutic Molecular Phenotype of {beta}-Blocker-Associated Reverse-Remodeling in Nonischemic Dilated Cardiomyopathy [Original Articles]
Conclusions—
In addition to known gene expression changes, additional calcium-handling, sarcomeric, adrenergic signaling, and metabolic genes were associated with reverse-remodeling. The pattern suggests a fetal–adult paradigm but may be because of reversal of gene expression controlled by a β1-adrenergic receptor gene network.
Clinical Trial Registration—
URL: www.clinicaltrials.gov. Unique Identifier: NCT01798992.
Source: Circulation: Cardiovascular Genetics - Category: Cardiology Authors: Kao, D. P., Lowes, B. D., Gilbert, E. M., Minobe, W., Epperson, L. E., Meyer, L. K., Ferguson, D. A., Volkman, A. K., Zolty, R., Borg, C. D., Quaife, R. A., Bristow, M. R. Tags: Congestive, Remodeling, Physiological and pathological control of gene expression, Receptor pharmacology Original Articles Source Type: research
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