Therapeutic Molecular Phenotype of {beta}-Blocker-Associated Reverse-Remodeling in Nonischemic Dilated Cardiomyopathy [Original Articles]

Conclusions— In addition to known gene expression changes, additional calcium-handling, sarcomeric, adrenergic signaling, and metabolic genes were associated with reverse-remodeling. The pattern suggests a fetal–adult paradigm but may be because of reversal of gene expression controlled by a β1-adrenergic receptor gene network. Clinical Trial Registration— URL: www.clinicaltrials.gov. Unique Identifier: NCT01798992.
Source: Circulation: Cardiovascular Genetics - Category: Cardiology Authors: Tags: Congestive, Remodeling, Physiological and pathological control of gene expression, Receptor pharmacology Original Articles Source Type: research