BMP4 in human endometrial stromal cells can affect decidualization by regulating FOXO1 expression
CONCLUSIONS: Our findings highlighted the downregulation of BMP4 in both RSA patients and mice. BMP4 in human endometrial stromal cells was shown to modulate decidualization by regulating FOXO1 expression. Loss of BMP4 may contribute to the pathogenesis of RSA, suggesting potential avenues for abortion prevention strategies.PMID:38679470 | DOI:10.1210/endocr/bqae049 (Source: Endocrinology)
Source: Endocrinology - April 28, 2024 Category: Endocrinology Authors: Yanjie Huang Fangfang Dai Liping Chen Zhidian Li Hua Liu Yanxiang Cheng Source Type: research
Glycoprotein-glycoprotein receptor binding detection using bioluminescence resonance energy transfer
Endocrinology. 2024 Apr 29:bqae052. doi: 10.1210/endocr/bqae052. Online ahead of print.ABSTRACTThe glycoprotein receptors, members of the large G protein-coupled receptors (GPCRs) family, are characterized by a large extracellular domains responsible of binding their glycoprotein hormones. Hormone-receptor interactions are traditionally analyzed by ligand-binding assays most often using radiolabeling but also by thermal shift assays. Despite their high sensitivity, these assays require appropriate laboratory conditions and, often, purified plasma cell membranes, which do not provide information on receptor localization or ...
Source: Endocrinology - April 28, 2024 Category: Endocrinology Authors: Kamila Adamczuk Thu Ha Ngo Jakub Czapinski Adolfo Rivero-M üller Source Type: research
BMP4 in human endometrial stromal cells can affect decidualization by regulating FOXO1 expression
CONCLUSIONS: Our findings highlighted the downregulation of BMP4 in both RSA patients and mice. BMP4 in human endometrial stromal cells was shown to modulate decidualization by regulating FOXO1 expression. Loss of BMP4 may contribute to the pathogenesis of RSA, suggesting potential avenues for abortion prevention strategies.PMID:38679470 | DOI:10.1210/endocr/bqae049 (Source: Endocrinology)
Source: Endocrinology - April 28, 2024 Category: Endocrinology Authors: Yanjie Huang Fangfang Dai Liping Chen Zhidian Li Hua Liu Yanxiang Cheng Source Type: research
Glycoprotein-glycoprotein receptor binding detection using bioluminescence resonance energy transfer
Endocrinology. 2024 Apr 29:bqae052. doi: 10.1210/endocr/bqae052. Online ahead of print.ABSTRACTThe glycoprotein receptors, members of the large G protein-coupled receptors (GPCRs) family, are characterized by a large extracellular domains responsible of binding their glycoprotein hormones. Hormone-receptor interactions are traditionally analyzed by ligand-binding assays most often using radiolabeling but also by thermal shift assays. Despite their high sensitivity, these assays require appropriate laboratory conditions and, often, purified plasma cell membranes, which do not provide information on receptor localization or ...
Source: Endocrinology - April 28, 2024 Category: Endocrinology Authors: Kamila Adamczuk Thu Ha Ngo Jakub Czapinski Adolfo Rivero-M üller Source Type: research
BMP4 in human endometrial stromal cells can affect decidualization by regulating FOXO1 expression
CONCLUSIONS: Our findings highlighted the downregulation of BMP4 in both RSA patients and mice. BMP4 in human endometrial stromal cells was shown to modulate decidualization by regulating FOXO1 expression. Loss of BMP4 may contribute to the pathogenesis of RSA, suggesting potential avenues for abortion prevention strategies.PMID:38679470 | DOI:10.1210/endocr/bqae049 (Source: Endocrinology)
Source: Endocrinology - April 28, 2024 Category: Endocrinology Authors: Yanjie Huang Fangfang Dai Liping Chen Zhidian Li Hua Liu Yanxiang Cheng Source Type: research
Glycoprotein-glycoprotein receptor binding detection using bioluminescence resonance energy transfer
Endocrinology. 2024 Apr 29:bqae052. doi: 10.1210/endocr/bqae052. Online ahead of print.ABSTRACTThe glycoprotein receptors, members of the large G protein-coupled receptors (GPCRs) family, are characterized by a large extracellular domains responsible of binding their glycoprotein hormones. Hormone-receptor interactions are traditionally analyzed by ligand-binding assays most often using radiolabeling but also by thermal shift assays. Despite their high sensitivity, these assays require appropriate laboratory conditions and, often, purified plasma cell membranes, which do not provide information on receptor localization or ...
Source: Endocrinology - April 28, 2024 Category: Endocrinology Authors: Kamila Adamczuk Thu Ha Ngo Jakub Czapinski Adolfo Rivero-M üller Source Type: research
Correction to: "The Role of GLP-1 in the Metabolic Success of Bariatric Surgery"
Endocrinology. 2024 Mar 29;165(5):bqae042. doi: 10.1210/endocr/bqae042.NO ABSTRACTPMID:38651299 | DOI:10.1210/endocr/bqae042 (Source: Endocrinology)
Source: Endocrinology - April 23, 2024 Category: Endocrinology Source Type: research
Correction to: "The Role of GLP-1 in the Metabolic Success of Bariatric Surgery"
Endocrinology. 2024 Mar 29;165(5):bqae042. doi: 10.1210/endocr/bqae042.NO ABSTRACTPMID:38651299 | DOI:10.1210/endocr/bqae042 (Source: Endocrinology)
Source: Endocrinology - April 23, 2024 Category: Endocrinology Source Type: research
Correction to: "The Role of GLP-1 in the Metabolic Success of Bariatric Surgery"
Endocrinology. 2024 Mar 29;165(5):bqae042. doi: 10.1210/endocr/bqae042.NO ABSTRACTPMID:38651299 | DOI:10.1210/endocr/bqae042 (Source: Endocrinology)
Source: Endocrinology - April 23, 2024 Category: Endocrinology Source Type: research
Correction to: "The Role of GLP-1 in the Metabolic Success of Bariatric Surgery"
Endocrinology. 2024 Mar 29;165(5):bqae042. doi: 10.1210/endocr/bqae042.NO ABSTRACTPMID:38651299 | DOI:10.1210/endocr/bqae042 (Source: Endocrinology)
Source: Endocrinology - April 23, 2024 Category: Endocrinology Source Type: research
Correction to: "The Role of GLP-1 in the Metabolic Success of Bariatric Surgery"
Endocrinology. 2024 Mar 29;165(5):bqae042. doi: 10.1210/endocr/bqae042.NO ABSTRACTPMID:38651299 | DOI:10.1210/endocr/bqae042 (Source: Endocrinology)
Source: Endocrinology - April 23, 2024 Category: Endocrinology Source Type: research
Molecular Assessment of Pro-Adipogenic Effects for Common-Use Contraceptives and their Mixtures
In conclusion, this research provides valuable insights into the complex interactions between hormonal contraceptives and adipocyte development. The results suggest that both progestins and estrogens within these contraceptives can influence adipogenesis, and the specific effects may vary based on the receptor activation profiles. Further research is warranted to establish translation of these findings to in vivo models and to further assess causal mechanisms underlying these effects.PMID:38648498 | DOI:10.1210/endocr/bqae050 (Source: Endocrinology)
Source: Endocrinology - April 22, 2024 Category: Endocrinology Authors: Yu-Ting Tiffany Chiang Christopher D Kassotis Source Type: research
Estrogen receptor alpha mutations, truncations, heterodimers, and therapies
Endocrinology. 2024 Apr 21:bqae051. doi: 10.1210/endocr/bqae051. Online ahead of print.ABSTRACTAnnual breast cancer (BCa) deaths have declined since its apex in 1989 concomitant with widespread adoption of hormone therapies that target estrogen receptor alpha (ERα), the prominent nuclear receptor expressed in ∼80% of BCa. However, up to ∼50% of ER + patients with high-risk disease experience post endocrine therapy relapse and metastasis to distant organs. The vast majority of BCa mortality occurs in this setting, highlighting the inadequacy of current therapies. Genomic abnormalities to ESR1, the gene encoding ERα, e...
Source: Endocrinology - April 21, 2024 Category: Endocrinology Authors: Govinda R Hancock Jason Gertz Rinath Jeselsohn Sean W Fanning Source Type: research
Impact of ghrelin on islet size in non-pregnant and pregnant female mice
Endocrinology. 2024 Apr 16:bqae048. doi: 10.1210/endocr/bqae048. Online ahead of print.ABSTRACTReducing ghrelin by ghrelin gene knockout (GKO), ghrelin-cell ablation, or high-fat diet feeding increases islet size and β-cell mass in male mice. Here, we determined if reducing ghrelin also enlarges islets in females, and if pregnancy-associated changes in islet size are related to reduced ghrelin. Islet size and β-cell mass were larger (P=0.057 for β-cell mass) in female GKO mice. Pregnancy was associated with reduced ghrelin and increased LEAP2 [a ghrelin receptor (GHSR) antagonist] in WT mice. Ghrelin deletion and pregna...
Source: Endocrinology - April 16, 2024 Category: Endocrinology Authors: Deepali Gupta Avi W Burstein Kripa Shankar Salil Varshney Omprakash Singh Sherri Osborne-Lawrence Corine P Richard Jeffrey M Zigman Source Type: research
Impact of ghrelin on islet size in non-pregnant and pregnant female mice
Endocrinology. 2024 Apr 16:bqae048. doi: 10.1210/endocr/bqae048. Online ahead of print.ABSTRACTReducing ghrelin by ghrelin gene knockout (GKO), ghrelin-cell ablation, or high-fat diet feeding increases islet size and β-cell mass in male mice. Here, we determined if reducing ghrelin also enlarges islets in females, and if pregnancy-associated changes in islet size are related to reduced ghrelin. Islet size and β-cell mass were larger (P=0.057 for β-cell mass) in female GKO mice. Pregnancy was associated with reduced ghrelin and increased LEAP2 [a ghrelin receptor (GHSR) antagonist] in WT mice. Ghrelin deletion and pregna...
Source: Endocrinology - April 16, 2024 Category: Endocrinology Authors: Deepali Gupta Avi W Burstein Kripa Shankar Salil Varshney Omprakash Singh Sherri Osborne-Lawrence Corine P Richard Jeffrey M Zigman Source Type: research
