Genetic diversity and natural selection of plasmodium vivax Merozoite surface protein 8 in global populations
This study delves into the genetic characteristics of the Pvmsp8 gene, specifically focusing on samples from the China-Myanmar border (CMB) region, and contrasts these findings with broader global patterns. The study uncovers that Pvmsp8 exhibits a notable level of conservation across different populations, with limited polymorphisms and relatively low nucleotide diversity (0.00023-0.0012). This conservation contrasts starkly with the high polymorphisms found in other P. vivax antigens such as msp1. A total of 25 haplotypes and 14 amino acid mutation sites were identified in the global samples, and all mutation sites were ...
Source: Infection, Genetics and Evolution - May 17, 2024 Category: Genetics & Stem Cells Authors: Man Zhang Yue Wang Hai-Mo Shen Shen-Bo Chen Tian-Yu Wang Kokouvi Kassegne Jun-Hu Chen Source Type: research
Brno loanvirus (BRNV) in bats inhabiting the urban area of Brno, Czech Republic
Infect Genet Evol. 2024 May 14:105604. doi: 10.1016/j.meegid.2024.105604. Online ahead of print.ABSTRACTBats are known reservoirs of various emerging pathogens, and have recently been found to host a novel hantavirus, named Brno loanvirus (BRNV), from the Mammantavirinae subfamily (family Hantaviridae, order Bunyavirales). Here we report BRNV detection in bats from the urban area of Brno, Czech Republic in March 2022. Specifically, we uncovered a high prevalence of BRNV (8.8%, 5/57) among hibernating bats (Nyctalus noctula) in urban area, which poses a risk of human exposure. The positive bats included adult females (3/9 p...
Source: Infection, Genetics and Evolution - May 16, 2024 Category: Genetics & Stem Cells Authors: Andrea Fo řtová Petra Strakov á Jan Haviernik Pavel Svoboda Tom áš Bartonička Jana Kvi čerová Daniel R ůžek Ji ří Salát Source Type: research
Brno loanvirus (BRNV) in bats inhabiting the urban area of Brno, Czech Republic
Infect Genet Evol. 2024 May 14:105604. doi: 10.1016/j.meegid.2024.105604. Online ahead of print.ABSTRACTBats are known reservoirs of various emerging pathogens, and have recently been found to host a novel hantavirus, named Brno loanvirus (BRNV), from the Mammantavirinae subfamily (family Hantaviridae, order Bunyavirales). Here we report BRNV detection in bats from the urban area of Brno, Czech Republic in March 2022. Specifically, we uncovered a high prevalence of BRNV (8.8%, 5/57) among hibernating bats (Nyctalus noctula) in urban area, which poses a risk of human exposure. The positive bats included adult females (3/9 p...
Source: Infection, Genetics and Evolution - May 16, 2024 Category: Genetics & Stem Cells Authors: Andrea Fo řtová Petra Strakov á Jan Haviernik Pavel Svoboda Tom áš Bartonička Jana Kvi čerová Daniel R ůžek Ji ří Salát Source Type: research
Prevalence and molecular characterization of hepatitis E virus (HEV) from wild rodents in Hubei Province, China
Infect Genet Evol. 2024 May 9:105602. doi: 10.1016/j.meegid.2024.105602. Online ahead of print.ABSTRACTHepatitis E, caused by the hepatitis E virus (HEV), is a global public health issue. Low similarity between the gene sequences of mouse and human HEV led to the belief that the risk of human infection was low. Recent reports of chronic and acute hepatitis E caused by murine HEV infection in humans in Hong Kong have raised global concerns. Therefore, it is crucial to investigate the epidemiology and prevalence of HEV in China. We comprehensively analyzed different rodent HEV strains to understand rocahepevirus occurrence i...
Source: Infection, Genetics and Evolution - May 11, 2024 Category: Genetics & Stem Cells Authors: Qingwen Ding Bing Hu Xuan Yao Min Gan Dan Chen Nailou Zhang Jinbo Wei Kun Cai Zhenhua Zheng Source Type: research
Prevalence and molecular characterization of hepatitis E virus (HEV) from wild rodents in Hubei Province, China
Infect Genet Evol. 2024 May 9:105602. doi: 10.1016/j.meegid.2024.105602. Online ahead of print.ABSTRACTHepatitis E, caused by the hepatitis E virus (HEV), is a global public health issue. Low similarity between the gene sequences of mouse and human HEV led to the belief that the risk of human infection was low. Recent reports of chronic and acute hepatitis E caused by murine HEV infection in humans in Hong Kong have raised global concerns. Therefore, it is crucial to investigate the epidemiology and prevalence of HEV in China. We comprehensively analyzed different rodent HEV strains to understand rocahepevirus occurrence i...
Source: Infection, Genetics and Evolution - May 11, 2024 Category: Genetics & Stem Cells Authors: Qingwen Ding Bing Hu Xuan Yao Min Gan Dan Chen Nailou Zhang Jinbo Wei Kun Cai Zhenhua Zheng Source Type: research
Prevalence and molecular characterization of hepatitis E virus (HEV) from wild rodents in Hubei Province, China
Infect Genet Evol. 2024 May 9:105602. doi: 10.1016/j.meegid.2024.105602. Online ahead of print.ABSTRACTHepatitis E, caused by the hepatitis E virus (HEV), is a global public health issue. Low similarity between the gene sequences of mouse and human HEV led to the belief that the risk of human infection was low. Recent reports of chronic and acute hepatitis E caused by murine HEV infection in humans in Hong Kong have raised global concerns. Therefore, it is crucial to investigate the epidemiology and prevalence of HEV in China. We comprehensively analyzed different rodent HEV strains to understand rocahepevirus occurrence i...
Source: Infection, Genetics and Evolution - May 11, 2024 Category: Genetics & Stem Cells Authors: Qingwen Ding Bing Hu Xuan Yao Min Gan Dan Chen Nailou Zhang Jinbo Wei Kun Cai Zhenhua Zheng Source Type: research
Prevalence and molecular characterization of hepatitis E virus (HEV) from wild rodents in Hubei Province, China
Infect Genet Evol. 2024 May 9:105602. doi: 10.1016/j.meegid.2024.105602. Online ahead of print.ABSTRACTHepatitis E, caused by the hepatitis E virus (HEV), is a global public health issue. Low similarity between the gene sequences of mouse and human HEV led to the belief that the risk of human infection was low. Recent reports of chronic and acute hepatitis E caused by murine HEV infection in humans in Hong Kong have raised global concerns. Therefore, it is crucial to investigate the epidemiology and prevalence of HEV in China. We comprehensively analyzed different rodent HEV strains to understand rocahepevirus occurrence i...
Source: Infection, Genetics and Evolution - May 11, 2024 Category: Genetics & Stem Cells Authors: Qingwen Ding Bing Hu Xuan Yao Min Gan Dan Chen Nailou Zhang Jinbo Wei Kun Cai Zhenhua Zheng Source Type: research
Genomic and spatial analysis reveal the transmission dynamics of tuberculosis in areas with high incidence of Zhejiang, China: A prospective cohort study
This study aimed to investigate molecular and spatial epidemiology of TB in two mountainous, rural counties of Zhejiang Province, China, from 2015 to 2021, to elucidate the recent transmission and drug-resistance profiles. The predominant Lineage 2 (L2) Beijing family accounted for 80.1% of total 532 sequenced Mycobacterium tuberculosis (Mtb) strains, showing consistent prevalence over seven years. Gene mutations associated with drug resistance were identified in 19.4% (103/532) of strains, including 47 rifampicin or isoniazid-resistant strains, eight multi-drug-resistant (MDR) strains, and five pre-extensively drug-resist...
Source: Infection, Genetics and Evolution - May 9, 2024 Category: Genetics & Stem Cells Authors: Zhengwei Liu Xiangchen Li Haiyan Xiong Qingrong Zhou Huaiming Yi Kunyang Wu Zonglei Zhou Yewei Lu Yelei Zhu Lin Zhou Mingwu Zhang Junshun Gao Junli Gao Songhua Chen Xiaomeng Wang Weibing Wang Source Type: research
Genomic and spatial analysis reveal the transmission dynamics of tuberculosis in areas with high incidence of Zhejiang, China: A prospective cohort study
This study aimed to investigate molecular and spatial epidemiology of TB in two mountainous, rural counties of Zhejiang Province, China, from 2015 to 2021, to elucidate the recent transmission and drug-resistance profiles. The predominant Lineage 2 (L2) Beijing family accounted for 80.1% of total 532 sequenced Mycobacterium tuberculosis (Mtb) strains, showing consistent prevalence over seven years. Gene mutations associated with drug resistance were identified in 19.4% (103/532) of strains, including 47 rifampicin or isoniazid-resistant strains, eight multi-drug-resistant (MDR) strains, and five pre-extensively drug-resist...
Source: Infection, Genetics and Evolution - May 9, 2024 Category: Genetics & Stem Cells Authors: Zhengwei Liu Xiangchen Li Haiyan Xiong Qingrong Zhou Huaiming Yi Kunyang Wu Zonglei Zhou Yewei Lu Yelei Zhu Lin Zhou Mingwu Zhang Junshun Gao Junli Gao Songhua Chen Xiaomeng Wang Weibing Wang Source Type: research
Genomic and spatial analysis reveal the transmission dynamics of tuberculosis in areas with high incidence of Zhejiang, China: A prospective cohort study
This study aimed to investigate molecular and spatial epidemiology of TB in two mountainous, rural counties of Zhejiang Province, China, from 2015 to 2021, to elucidate the recent transmission and drug-resistance profiles. The predominant Lineage 2 (L2) Beijing family accounted for 80.1% of total 532 sequenced Mycobacterium tuberculosis (Mtb) strains, showing consistent prevalence over seven years. Gene mutations associated with drug resistance were identified in 19.4% (103/532) of strains, including 47 rifampicin or isoniazid-resistant strains, eight multi-drug-resistant (MDR) strains, and five pre-extensively drug-resist...
Source: Infection, Genetics and Evolution - May 9, 2024 Category: Genetics & Stem Cells Authors: Zhengwei Liu Xiangchen Li Haiyan Xiong Qingrong Zhou Huaiming Yi Kunyang Wu Zonglei Zhou Yewei Lu Yelei Zhu Lin Zhou Mingwu Zhang Junshun Gao Junli Gao Songhua Chen Xiaomeng Wang Weibing Wang Source Type: research
Whole genome sequencing of uropathogenic E. coli from Ireland reveals diverse resistance mechanisms and strong correlation with phenotypic (EUCAST) susceptibility testing
In this study, we analysed 57 UPEC isolates from different UTI patients following EUCAST guidelines. A selection of 17 representative strains underwent WGS, phylotyping, MLST, and comparative analysis to connect laboratory susceptibility data with predictive genomics based on key resistance genes and chromosomal mutations in antimicrobial targets. Trimethoprim resistance consistently correlated with dfr genes, with six different alleles detected among the isolates. These dfr genes often coexisted with class 1 integrons, with the most common gene cassette combining dfr and aadA. Furthermore, 52.9% of isolates harboured the ...
Source: Infection, Genetics and Evolution - May 1, 2024 Category: Genetics & Stem Cells Authors: Shane Whelan Francesca Bottacini Colin Buttimer Karen Finn Brigid Lucey Source Type: research
Whole genome sequencing of uropathogenic E. coli from Ireland reveals diverse resistance mechanisms and strong correlation with phenotypic (EUCAST) susceptibility testing
In this study, we analysed 57 UPEC isolates from different UTI patients following EUCAST guidelines. A selection of 17 representative strains underwent WGS, phylotyping, MLST, and comparative analysis to connect laboratory susceptibility data with predictive genomics based on key resistance genes and chromosomal mutations in antimicrobial targets. Trimethoprim resistance consistently correlated with dfr genes, with six different alleles detected among the isolates. These dfr genes often coexisted with class 1 integrons, with the most common gene cassette combining dfr and aadA. Furthermore, 52.9% of isolates harboured the ...
Source: Infection, Genetics and Evolution - May 1, 2024 Category: Genetics & Stem Cells Authors: Shane Whelan Francesca Bottacini Colin Buttimer Karen Finn Brigid Lucey Source Type: research
Whole genome sequencing of uropathogenic E. coli from Ireland reveals diverse resistance mechanisms and strong correlation with phenotypic (EUCAST) susceptibility testing
In this study, we analysed 57 UPEC isolates from different UTI patients following EUCAST guidelines. A selection of 17 representative strains underwent WGS, phylotyping, MLST, and comparative analysis to connect laboratory susceptibility data with predictive genomics based on key resistance genes and chromosomal mutations in antimicrobial targets. Trimethoprim resistance consistently correlated with dfr genes, with six different alleles detected among the isolates. These dfr genes often coexisted with class 1 integrons, with the most common gene cassette combining dfr and aadA. Furthermore, 52.9% of isolates harboured the ...
Source: Infection, Genetics and Evolution - May 1, 2024 Category: Genetics & Stem Cells Authors: Shane Whelan Francesca Bottacini Colin Buttimer Karen Finn Brigid Lucey Source Type: research
Whole genome sequencing of uropathogenic E. coli from Ireland reveals diverse resistance mechanisms and strong correlation with phenotypic (EUCAST) susceptibility testing
In this study, we analysed 57 UPEC isolates from different UTI patients following EUCAST guidelines. A selection of 17 representative strains underwent WGS, phylotyping, MLST, and comparative analysis to connect laboratory susceptibility data with predictive genomics based on key resistance genes and chromosomal mutations in antimicrobial targets. Trimethoprim resistance consistently correlated with dfr genes, with six different alleles detected among the isolates. These dfr genes often coexisted with class 1 integrons, with the most common gene cassette combining dfr and aadA. Furthermore, 52.9% of isolates harboured the ...
Source: Infection, Genetics and Evolution - May 1, 2024 Category: Genetics & Stem Cells Authors: Shane Whelan Francesca Bottacini Colin Buttimer Karen Finn Brigid Lucey Source Type: research
Whole genome sequencing of uropathogenic E. coli from Ireland reveals diverse resistance mechanisms and strong correlation with phenotypic (EUCAST) susceptibility testing
In this study, we analysed 57 UPEC isolates from different UTI patients following EUCAST guidelines. A selection of 17 representative strains underwent WGS, phylotyping, MLST, and comparative analysis to connect laboratory susceptibility data with predictive genomics based on key resistance genes and chromosomal mutations in antimicrobial targets. Trimethoprim resistance consistently correlated with dfr genes, with six different alleles detected among the isolates. These dfr genes often coexisted with class 1 integrons, with the most common gene cassette combining dfr and aadA. Furthermore, 52.9% of isolates harboured the ...
Source: Infection, Genetics and Evolution - May 1, 2024 Category: Genetics & Stem Cells Authors: Shane Whelan Francesca Bottacini Colin Buttimer Karen Finn Brigid Lucey Source Type: research
