Ex vivo expansion and activation of V γ9Vδ2 T cells by CELMoDs in combination with zoledronic acid
Int J Hematol. 2024 Apr 6. doi: 10.1007/s12185-024-03763-7. Online ahead of print.ABSTRACTAs multiple myeloma (MM) progresses, immune effector cells decrease in number and function and become exhausted. This remains an insurmountable clinical issue that must be addressed by development of novel modalities to revitalize anti-MM immunity. Human Vγ9Vδ2 T (Vδ2+ γδ T) cells serve as the first line of defense against pathogens as well as tumors and can be expanded ex vivo from peripheral blood mononuclear cells (PBMCs) upon treatment with amino-bisphosphonates in combination with IL-2. Here, we demonstrated that next-genera...
Source: International Journal of Hematology - April 6, 2024 Category: Hematology Authors: Yusuke Inoue Asuka Oda Yusaku Maeda Ryohei Sumitani Masahiro Oura Kimiko Sogabe Tomoko Maruhashi Mamiko Takahashi Shiro Fujii Shingen Nakamura Hirokazu Miki Masahiro Hiasa Jumpei Teramachi Takeshi Harada Masahiro Abe Source Type: research
Ex vivo expansion and activation of V γ9Vδ2 T cells by CELMoDs in combination with zoledronic acid
Int J Hematol. 2024 Apr 6. doi: 10.1007/s12185-024-03763-7. Online ahead of print.ABSTRACTAs multiple myeloma (MM) progresses, immune effector cells decrease in number and function and become exhausted. This remains an insurmountable clinical issue that must be addressed by development of novel modalities to revitalize anti-MM immunity. Human Vγ9Vδ2 T (Vδ2+ γδ T) cells serve as the first line of defense against pathogens as well as tumors and can be expanded ex vivo from peripheral blood mononuclear cells (PBMCs) upon treatment with amino-bisphosphonates in combination with IL-2. Here, we demonstrated that next-genera...
Source: International Journal of Hematology - April 6, 2024 Category: Hematology Authors: Yusuke Inoue Asuka Oda Yusaku Maeda Ryohei Sumitani Masahiro Oura Kimiko Sogabe Tomoko Maruhashi Mamiko Takahashi Shiro Fujii Shingen Nakamura Hirokazu Miki Masahiro Hiasa Jumpei Teramachi Takeshi Harada Masahiro Abe Source Type: research
GSE263181 Exercise-induced beta2 adrenergic receptor activation enhances the anti-leukemic activity of expanded gamma-delta T-Cells via DNAM-1 upregulation and PVR-Nectin-2 recognition
Contributors : Forrest L Baker ; Kyle A Smith ; Preetesh L Mylabathula ; Tiffany M Zuniga ; Douglass M Diak ; Helena Batatinha ; Grace M Niemiro ; Michael D Seckeler ; Charles R Pedlar ; Danie P O'Connor ; Jamie Colombo ; Emmanual Katsanis ; Richard J SimpsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensExercise mobilizes cytotoxic lymphocytes to blood which may allow superior cell products to be manufactured for cancer therapy. Gamma-delta T-cells have shown promise for treating solid tumors, but there is a need to increase their potency against hematologic malignancies. Here, w...
Source: GEO: Gene Expression Omnibus - April 4, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
The Dutch multidisciplinary guideline osteoporosis and fracture prevention, taking a local guideline to the international arena
ConclusionIn our new multidisciplinary guideline osteoporosis and fracture prevention, we developed 5 “relatively new statements” that are all a crucial step forward in the optimization of diagnosis and treatment for fracture prevention. We also developed 5 flowcharts, and we suppose that this may be helpful for individual doctors and their patients in daily practice and may facilitate implement ation. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - April 2, 2024 Category: Orthopaedics Source Type: research
The Dutch multidisciplinary guideline osteoporosis and fracture prevention, taking a local guideline to the international arena
ConclusionIn our new multidisciplinary guideline osteoporosis and fracture prevention, we developed 5 “relatively new statements” that are all a crucial step forward in the optimization of diagnosis and treatment for fracture prevention. We also developed 5 flowcharts, and we suppose that this may be helpful for individual doctors and their patients in daily practice and may facilitate implement ation. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - April 2, 2024 Category: Orthopaedics Source Type: research
Long-term effectiveness of zoledronic acid in patients with Paget ’s disease of bone – a retrospective cohort study
ConclusionThe majority of patients with PDB experience a mild disease course, marked by monostotic involvement and a low prevalence of fractures. Zoledronic acid effectively manages PDB, providing sustained biochemical response. The necessity for multiple zoledronic acid injections remains questionable, often implemented due to osteoporosis. (Source: Endocrine)
Source: Endocrine - March 30, 2024 Category: Endocrinology Source Type: research
Laser-assisted synthesis of nano-hydroxyapatite and functionalization with bone active molecules for bone regeneration
Colloids Surf B Biointerfaces. 2024 Mar 18;237:113859. doi: 10.1016/j.colsurfb.2024.113859. Online ahead of print.ABSTRACTThe main goal of bone tissue engineering research is to replace the allogenic and autologous bone graft substitutes that can promote bone repair. Owing to excellent biocompatibility and osteoconductivity, hydroxyapatite is in extensive research and high demand for both medical and non-medical applications. Although various methods have been developed for the synthesis of hydroxyapatite, in the present study we have shown the use of nanosecond laser energy in the wet precipitation method of nano-hydroxya...
Source: Colloids and Surfaces - March 28, 2024 Category: Biotechnology Authors: Shazia Shaikh Sneha Gupta Ankita Mishra Parvaiz A Sheikh Prerna Singh Ashok Kumar Source Type: research
Laser-assisted synthesis of nano-hydroxyapatite and functionalization with bone active molecules for bone regeneration
Colloids Surf B Biointerfaces. 2024 Mar 18;237:113859. doi: 10.1016/j.colsurfb.2024.113859. Online ahead of print.ABSTRACTThe main goal of bone tissue engineering research is to replace the allogenic and autologous bone graft substitutes that can promote bone repair. Owing to excellent biocompatibility and osteoconductivity, hydroxyapatite is in extensive research and high demand for both medical and non-medical applications. Although various methods have been developed for the synthesis of hydroxyapatite, in the present study we have shown the use of nanosecond laser energy in the wet precipitation method of nano-hydroxya...
Source: Colloids and Surfaces - March 28, 2024 Category: Biotechnology Authors: Shazia Shaikh Sneha Gupta Ankita Mishra Parvaiz A Sheikh Prerna Singh Ashok Kumar Source Type: research
Zoledronic Acid Accelerates ER Stress-Mediated Inflammation by Increasing PDE4B Expression in Bisphosphonate-Related Osteonecrosis of the Jaw
Appl Biochem Biotechnol. 2024 Mar 25. doi: 10.1007/s12010-024-04859-w. Online ahead of print.ABSTRACTLong-term administration of bisphosphonates can lead to a significant side effect known as bisphosphonate-related osteonecrosis of the jaw (BRONJ). Although macrophage-mediated inflammation has been established as an important factor in BRONJ, the underlying mechanism remains elusive. In the current study, the roles of endoplasmic reticulum (ER) stress in zoledronic acid (ZOL)-induced inflammation were analyzed in macrophages, and the regulatory mechanism of ER stress activation was next investigated. An in vitro model of B...
Source: Applied Biochemistry and Biotechnology - March 25, 2024 Category: Biochemistry Authors: Qu Xz Sun Zq Liu L Ong Hs Source Type: research
Real-World Evaluation of Primary Versus Secondary Prevention of Skeletal-Related Events in Metastatic Castration-Resistant Prostate Cancer
CONCLUSION: A majority of patients with mCRPC never receive BTAs prior to first SRE, despite universal access and availability of these agents in Ontario. These results highlight an opportunity to improve outcomes by emphasizing early introduction of BTA in patients with mCRPC being started on systemic therapy.PMID:38527096 | DOI:10.1093/oncolo/oyae036 (Source: The Oncologist)
Source: The Oncologist - March 25, 2024 Category: Cancer & Oncology Authors: William J Phillips Fred Saad Jennifer Leigh Alborz Jooya Colleen Webber Scott Morgan Robert MacRae Jean-Marc Bourque Peter Tanuseputro Michael Ong Source Type: research
Zoledronic Acid Accelerates ER Stress-Mediated Inflammation by Increasing PDE4B Expression in Bisphosphonate-Related Osteonecrosis of the Jaw
Appl Biochem Biotechnol. 2024 Mar 25. doi: 10.1007/s12010-024-04859-w. Online ahead of print.ABSTRACTLong-term administration of bisphosphonates can lead to a significant side effect known as bisphosphonate-related osteonecrosis of the jaw (BRONJ). Although macrophage-mediated inflammation has been established as an important factor in BRONJ, the underlying mechanism remains elusive. In the current study, the roles of endoplasmic reticulum (ER) stress in zoledronic acid (ZOL)-induced inflammation were analyzed in macrophages, and the regulatory mechanism of ER stress activation was next investigated. An in vitro model of B...
Source: Applied Biochemistry and Biotechnology - March 25, 2024 Category: Biochemistry Authors: Qu Xz Sun Zq Liu L Ong Hs Source Type: research
Reducing Re-fractures Post Percutaneous Kyphoplasty: The Impact of Zoledronic Acid with Calcium and Vitamin D3 in Osteoporotic Patients
CONCLUSIONS: Zoledronic acid in combination with calcium carbonate and vitamin D3 effectively enhances bone health in osteoporosis patients, warranting its clinical recommendation. This regimen shows promise for improving patient outcomes in osteoporosis management.PMID:38518159 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Weiqian Wu Wenbiao Zheng Weiwei Pan Fanghu Chen Langqing Jiang Source Type: research
Reducing Re-fractures Post Percutaneous Kyphoplasty: The Impact of Zoledronic Acid with Calcium and Vitamin D3 in Osteoporotic Patients
CONCLUSIONS: Zoledronic acid in combination with calcium carbonate and vitamin D3 effectively enhances bone health in osteoporosis patients, warranting its clinical recommendation. This regimen shows promise for improving patient outcomes in osteoporosis management.PMID:38518159 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Weiqian Wu Wenbiao Zheng Weiwei Pan Fanghu Chen Langqing Jiang Source Type: research
Reducing Re-fractures Post Percutaneous Kyphoplasty: The Impact of Zoledronic Acid with Calcium and Vitamin D3 in Osteoporotic Patients
CONCLUSIONS: Zoledronic acid in combination with calcium carbonate and vitamin D3 effectively enhances bone health in osteoporosis patients, warranting its clinical recommendation. This regimen shows promise for improving patient outcomes in osteoporosis management.PMID:38518159 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Weiqian Wu Wenbiao Zheng Weiwei Pan Fanghu Chen Langqing Jiang Source Type: research
Reducing Re-fractures Post Percutaneous Kyphoplasty: The Impact of Zoledronic Acid with Calcium and Vitamin D3 in Osteoporotic Patients
CONCLUSIONS: Zoledronic acid in combination with calcium carbonate and vitamin D3 effectively enhances bone health in osteoporosis patients, warranting its clinical recommendation. This regimen shows promise for improving patient outcomes in osteoporosis management.PMID:38518159 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Weiqian Wu Wenbiao Zheng Weiwei Pan Fanghu Chen Langqing Jiang Source Type: research
