Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis
Free Radic Biol Med. 2023 Jun 24:S0891-5849(23)00509-9. doi: 10.1016/j.freeradbiomed.2023.06.022. Online ahead of print.ABSTRACTLong-term usage of bisphosphonates, especially zoledronic acid (ZA), induces osteogenesis disorders and medication-related osteonecrosis of the jaw (MRONJ) in patients, thereby contributing to the destruction of bone remodeling and the continuous progression of osteonecrosis. Menaquinone-4 (MK-4), a specific vitamin K2 isoform converted by the mevalonate (MVA) pathway in vivo, exerts the promotion of bone formation, whereas ZA administration suppresses this pathway and results in endogenous MK-4 d...
Source: Free Radical Biology and Medicine - June 26, 2023 Category: Biology Authors: Yajun Cui Weidong Zhang Panpan Yang Siqi Zhu Shenglei Luo Minqi Li Source Type: research
Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis
Free Radic Biol Med. 2023 Jun 24:S0891-5849(23)00509-9. doi: 10.1016/j.freeradbiomed.2023.06.022. Online ahead of print.ABSTRACTLong-term usage of bisphosphonates, especially zoledronic acid (ZA), induces osteogenesis disorders and medication-related osteonecrosis of the jaw (MRONJ) in patients, thereby contributing to the destruction of bone remodeling and the continuous progression of osteonecrosis. Menaquinone-4 (MK-4), a specific vitamin K2 isoform converted by the mevalonate (MVA) pathway in vivo, exerts the promotion of bone formation, whereas ZA administration suppresses this pathway and results in endogenous MK-4 d...
Source: Free Radical Biology and Medicine - June 26, 2023 Category: Biology Authors: Yajun Cui Weidong Zhang Panpan Yang Siqi Zhu Shenglei Luo Minqi Li Source Type: research
A Case of Hypercalcemia from PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy
We report a case of PTHrP-induced hypercalcemia due to a malignancy —low grade fibromyxoid sarcoma—that responded to glucocorticoid treatment. This is the first report of glucocorticoids controlling PTHrP-mediated hypercalcemia of malignancy. Immunohistochemistry of the surgical pathology localized PTHrP staining to the vascular endothelial cells within the tumo r. Further studies are needed to elucidate the mechanism of glucocorticoid action in the treatment of PTHrP-mediated hypercalcemia of malignancy. (Source: Calcified Tissue International)
Source: Calcified Tissue International - June 26, 2023 Category: Orthopaedics Source Type: research
Cinacalcet increases renal calcium excretion in PTHrP-mediated hypercalcemia: a case report
In the acute setting, PTH-independent hypercalcemia is typically treated with anti-resorptive agents such as zoledronic acid or denosumab. When these agents are no longer able to control hypercalcemia, several... (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - June 16, 2023 Category: Endocrinology Authors: Samya Faiq, Kristen Lavelle, Tina Hu, Dolores Shoback and Gregory Ku Tags: Case report Source Type: research
Approach to the differential diagnosis between multiple myeloma or osteonecrosis: a case report
A 67-year-old female patient, diagnosed with multiple myeloma (MM), reported intense pain in the right-side mandible and hemi-face. She was undergoing third-line chemotherapy associated with the use of zoledronic acid. Clinical exams showed drainage of purulent secretion in the gingival sulcus and gingival edema in the peri-implant region. Computed tomography showed an osteolytic lesion in the right mandible, with bone sequestration adjacent to the base of a dental implant leading to MM lesion or osteonecrosis hypothesis. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - June 15, 2023 Category: ENT & OMF Authors: Julia Lopes FERIGATTO, Iara Zapparoli Gon çalves, Maurício Eiji de Almeida Santos Yamashita, Emilze Mafra de Lima, Victor Tieghi Neto, Fábio Luiz Coracin, Renata de Freitas Varanda Source Type: research
Jaw plasmocytoma leading to a multiple myeloma relapse diagnosis: a case report
A 46-year-old female patient was diagnosed with multiple myeloma and is undergoing treatment using the chemotherapy CTD protocol, followed by autologous stem cell transplantation and zoledronic acid use. Her complaints included paresthesia in the left mental region with increased volume. Physical examination revealed a 4.5cm rubbery nodule with intact epithelium. Cone-beam computed tomography revealed an osteolytic image of the medullary bone and cortical disruption in the lower left alveolar ridge. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - June 15, 2023 Category: ENT & OMF Authors: Pedro Henrique Cossu VALLEJO, Aline Pereira de MENEZES, Daniele Moraes LOSADA, Isabela Assis de SIQUEIRA, Victor Tieghi NETO, F ábio Luiz CORACIN, Renata Freitas VARANDA Source Type: research
Osteonecrosis in the jaw associated with the use of biphosphonate after dental implant installation
Bisphosphonates are recommended to treat bone metastasis, multiple myeloma, and other diseases of bone metabolism. They inhibit the action of osteoclasts, decreasing bone resorption and turnover, and endothelial growth factor. This led to osteonecrosis, characterized by osteolytic lesions and exposure of necrotic bone, appearing spontaneously or after surgical procedures. Osteonecrosis treatment is difficult and brings morbidity to the patient. A 68-year-old diabetic man, with prostate tumor, using zoledronic acid monthly since 2008, received implants in the mandible in April 2013. (Source: Oral Surgery, Oral Medicine, Ora...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - June 15, 2023 Category: ENT & OMF Authors: Ana Maria Ip ólito BARROS, Marco Murilo BUSO, Addah Regina da Silva FREIRE, Cleomar Donizeth RODRIGUES, Ana Paula Veras SOBRAL, Márcia Maria Fonseca da SILVEIRA Source Type: research
Zoledronic acid –induced severe lymphopenia
This article describes a case of severe lymphopenia following a 5 mg zoledronic acid infusion administered to treat osteoporosis. Zoledronic acid is used to treat osteoporosis, hypercalcemia, Paget ’s disease, and solid malignancies, including multiple myeloma, breast cancer, and prostate cancer. An acute phase response can be seen in 42% of patients after zoledronic acid treatment. Acute phase response may be accompanied by short-term spontaneously recovered anemia, thrombocytopenia, and se vere lymphopenia. (Source: Osteoporosis International)
Source: Osteoporosis International - June 15, 2023 Category: Orthopaedics Source Type: research
Correction to “Durability and Delayed Treatment Effects of Zoledronic Acid on Bone Loss after Spinal Cord Injury: A Randomized, Controlled Trial”
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 12, 2023 Category: Orthopaedics Tags: Erratum Source Type: research
Zoledronic acid after spinal cord injury mitigates losses in proximal femoral strength independent of ambulation ability
ConclusionThese findings demonstrate that treatment with zoledronic acid in acute SCI attenuates losses in proximal femoral strength, which may reduce the risk of hip fractures across patients with varying degrees of ambulatory abilities. (Source: Osteoporosis International)
Source: Osteoporosis International - June 8, 2023 Category: Orthopaedics Source Type: research
GSE233745 Transcriptional alteration in the treatment of MDA-MB-231 cells using BITC and/or ZA
We report differential gene expression changes by benzyl isothiocyanate (BITC) and/or zoledronic acid (ZA) in MDA-MB-231 human breast cancer cell line (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
