Retracted: Efficacy Evaluation of Zoledronic Acid Combined with Chemotherapy in the Treatment of Lung Cancer Spinal Metastases on Computed Tomography Images on Intelligent Algorithms
Comput Math Methods Med. 2023 Jul 12;2023:9797160. doi: 10.1155/2023/9797160. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2022/6431852.].PMID:37475951 | PMC:PMC10356340 | DOI:10.1155/2023/9797160 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - July 21, 2023 Category: Statistics Authors: Computational And Mathematical Methods In Medicine Source Type: research
Increased apoptosis of gingival epithelium is associated with impaired autophagic flux in medication-related osteonecrosis of the jaw
In this study, we aimed to explore the relationship between autophagy and apoptosis in MRONJ gingival epithelium and search for a method to prevent this disease. First, we examined clinical samples from patients diagnosed with MRONJ and healthy controls, finding that autophagy-related markers MAP1LC3/LC3 and SQSTM1/p62 synchronously increased, thus suggesting that autophagic flux was suppressed in MRONJ. Moreover, mRNA sequencing analysis and TUNEL assay showed that the process of apoptosis was upregulated in patients and animals with MRONJ, indicating autophagy and apoptosis participate in the development of MRONJ. Furthe...
Source: Autophagy - July 21, 2023 Category: Cytology Authors: Xian Dong Yang He Jingang An Linhai He Yi Zheng Xinyu Wang Jie Wang Shuo Chen Yi Zhang Source Type: research
Retracted: Efficacy Evaluation of Zoledronic Acid Combined with Chemotherapy in the Treatment of Lung Cancer Spinal Metastases on Computed Tomography Images on Intelligent Algorithms
Comput Math Methods Med. 2023 Jul 12;2023:9797160. doi: 10.1155/2023/9797160. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2022/6431852.].PMID:37475951 | PMC:PMC10356340 | DOI:10.1155/2023/9797160 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - July 21, 2023 Category: Statistics Authors: Computational And Mathematical Methods In Medicine Source Type: research
Increased apoptosis of gingival epithelium is associated with impaired autophagic flux in medication-related osteonecrosis of the jaw
In this study, we aimed to explore the relationship between autophagy and apoptosis in MRONJ gingival epithelium and search for a method to prevent this disease. First, we examined clinical samples from patients diagnosed with MRONJ and healthy controls, finding that autophagy-related markers MAP1LC3/LC3 and SQSTM1/p62 synchronously increased, thus suggesting that autophagic flux was suppressed in MRONJ. Moreover, mRNA sequencing analysis and TUNEL assay showed that the process of apoptosis was upregulated in patients and animals with MRONJ, indicating autophagy and apoptosis participate in the development of MRONJ. Furthe...
Source: Autophagy - July 21, 2023 Category: Cytology Authors: Xian Dong Yang He Jingang An Linhai He Yi Zheng Xinyu Wang Jie Wang Shuo Chen Yi Zhang Source Type: research
Retracted: Efficacy Evaluation of Zoledronic Acid Combined with Chemotherapy in the Treatment of Lung Cancer Spinal Metastases on Computed Tomography Images on Intelligent Algorithms
Comput Math Methods Med. 2023 Jul 12;2023:9797160. doi: 10.1155/2023/9797160. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2022/6431852.].PMID:37475951 | PMC:PMC10356340 | DOI:10.1155/2023/9797160 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - July 21, 2023 Category: Statistics Authors: Computational And Mathematical Methods In Medicine Source Type: research
Short-term efficacy of zoledronic acid in the treatment of 30 cases of SAPHO syndrome
Clin Exp Rheumatol. 2023 Jul 14. doi: 10.55563/clinexprheumatol/zpgyz9. Online ahead of print.NO ABSTRACTPMID:37470228 | DOI:10.55563/clinexprheumatol/zpgyz9 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 20, 2023 Category: Rheumatology Authors: Shengyan Liu Dan Yin Zhimin Lin Shufeng Wei Chen Li Source Type: research
A Patient with a History of Multiple Myeloma Presents for the Evaluation of Oral Lesion and Burning Sensation of the Mouth
Multiple myeloma (MM) is a hematologic malignancy belonging to a class of disorders known as plasma cell dyscrasias. Common oral manifestations of MM include osteolytic lesions in the mandible and maxilla that can present as painful bony swellings, epulis formation, or sudden teeth movement. MM treatment is coordinated by a multidisciplinary team and is dependent upon the age and physical fitness of the patient, as well as the staging of the disease. A large proportion will be treated with intravenous bisphosphonates, such as pamidronate and zoledronic acid, which places the patients at high risk for developing medication-...
Source: Dental Clinics of North America - July 6, 2023 Category: Dentistry Authors: Irene H. Kim, Walter W. Hong, Sophia Oak, Brad M. Hong, Mel Mupparapu Source Type: research
Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis
Free Radic Biol Med. 2023 Jun 24:S0891-5849(23)00509-9. doi: 10.1016/j.freeradbiomed.2023.06.022. Online ahead of print.ABSTRACTLong-term usage of bisphosphonates, especially zoledronic acid (ZA), induces osteogenesis disorders and medication-related osteonecrosis of the jaw (MRONJ) in patients, thereby contributing to the destruction of bone remodeling and the continuous progression of osteonecrosis. Menaquinone-4 (MK-4), a specific vitamin K2 isoform converted by the mevalonate (MVA) pathway in vivo, exerts the promotion of bone formation, whereas ZA administration suppresses this pathway and results in endogenous MK-4 d...
Source: Free Radical Biology and Medicine - June 26, 2023 Category: Biology Authors: Yajun Cui Weidong Zhang Panpan Yang Siqi Zhu Shenglei Luo Minqi Li Source Type: research
