Global Publication Trends and Research Hotspots of the Immune System and Osteoporosis: A Bibliometric and Visualization Analysis from 2012 to 2022
CONCLUSION: The influence of the immune system on OP has been widely studied, and the current research in this field focuses on the effect or mechanism of immune-related cytokines, signaling pathways and vitamin D on OP. Future research trends in this field should focus on the immune regulation mechanism and clinical transformation of zoledronic acid, chain fatty acids and the gut microbiota in OP.PMID:37881072 | DOI:10.2174/0118715303257269231011073100 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 26, 2023 Category: Drugs & Pharmacology Authors: Jinlong Zhao Yaoxing Dou Guihong Liang Hetao Huang Kunhao Hong Weiyi Yang Guanghui Zhou Bangxin Sha Jun Liu Lingfeng Zeng Source Type: research
Prediction of musculoskeletal pain after the first intravenous zoledronic acid injection in patients with primary osteoporosis: development and evaluation of a new nomogram
To construct a new prediction nomogram to predict the risk of musculoskeletal pain in patients with primary osteoporosis who receive zoledronic acid intravenously for the first time. (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - October 25, 2023 Category: Orthopaedics Authors: Xiaoxia Zheng, Jiangnan Ye, Qunzhang Zhan, Weifeng Zhao, Zhongqin Liao, Xiaolin Ye and Chongzheng Qu Tags: Research Source Type: research
Growth hormone and testosterone delay vertebral fractures in boys with muscular dystrophy on chronic glucocorticoids
ConclusionGH and testosterone each decreased VF risk in patients independent of or in combination with ZA, respectively. (Source: Osteoporosis International)
Source: Osteoporosis International - October 23, 2023 Category: Orthopaedics Source Type: research
Zoledronic acid add-on therapy for standard-risk Ewing sarcoma patients in the Ewing 2008R1 trial
CONCLUSION: In patients with standard-risk localized EWS, there is no additional benefit from maintenance treatment with ZOL.PMID:37843857 | DOI:10.1158/1078-0432.CCR-23-1966 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - October 16, 2023 Category: Cancer & Oncology Authors: Raphael Koch Lianne Haveman Ruth Ladenstein B énédicte Brichard Heribert Juergens So ňa Cyprová Henk van den Berg Wolf Hassenpflug Anna Raciborska Torben Ek Daniel Baumhoer Gerlinde Egerer Leo Kager Marleen Renard Peter Hauser Stefan Burdach Judith V Source Type: research
Zoledronic acid add-on therapy for standard-risk Ewing sarcoma patients in the Ewing 2008R1 trial
CONCLUSION: In patients with standard-risk localized EWS, there is no additional benefit from maintenance treatment with ZOL.PMID:37843857 | DOI:10.1158/1078-0432.CCR-23-1966 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - October 16, 2023 Category: Cancer & Oncology Authors: Raphael Koch Lianne Haveman Ruth Ladenstein B énédicte Brichard Heribert Juergens So ňa Cyprová Henk van den Berg Wolf Hassenpflug Anna Raciborska Torben Ek Daniel Baumhoer Gerlinde Egerer Leo Kager Marleen Renard Peter Hauser Stefan Burdach Judith V Source Type: research
M < sub > 4 < /sub > IDP stimulates ROS elevation through inhibition of mevalonate pathway and pentose phosphate pathway to inhibit colon cancer cells
This study revealed for the first time a possible mechanism of bisphosphonate-induced increase of ROS in malignant tumor cells. This is helpful for the development of new molecular therapeutic targets and can provide new ideas for the combined therapy of bisphosphonates in tumors.PMID:37838274 | DOI:10.1016/j.bcp.2023.115856 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - October 14, 2023 Category: Drugs & Pharmacology Authors: Ying Peng Qing-Zhu Liu Dong Xu Jia-Yu Fu Li-Xia Zhang Ling Qiu Jian-Guo Lin Source Type: research
M < sub > 4 < /sub > IDP stimulates ROS elevation through inhibition of mevalonate pathway and pentose phosphate pathway to inhibit colon cancer cells
This study revealed for the first time a possible mechanism of bisphosphonate-induced increase of ROS in malignant tumor cells. This is helpful for the development of new molecular therapeutic targets and can provide new ideas for the combined therapy of bisphosphonates in tumors.PMID:37838274 | DOI:10.1016/j.bcp.2023.115856 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - October 14, 2023 Category: Drugs & Pharmacology Authors: Ying Peng Qing-Zhu Liu Dong Xu Jia-Yu Fu Li-Xia Zhang Ling Qiu Jian-Guo Lin Source Type: research
Postoperative Anti-Osteoporotic Therapy with Zoledronic Acid Improves Rotator Cuff Healing but Not Ameliorates Outcomes in Female Patients with Postmenopausal Osteoporosis: A Prospective, Single-Blinded Randomized Study
To investigate the effect of the anti-osteoporotic agent zoledronic acid (ZA) on rotator cuff healing and clinical outcomes in patients with postmenopausal osteoporosis. (Source: Arthroscopy - Journal of Arthroscopic and Related Surgery)
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - October 10, 2023 Category: Surgery Authors: Mingjie Lei, Zhenglin Zhu, Xiaobo Hu, Dandong Wu, Wei Huang, Yong Zhang, Hong Chen Source Type: research
Postoperative Antiosteoporotic Treatment with Zoledronic Acid Improves Rotator Cuff Healing but Not Ameliorates Outcomes in Female Patients with Postmenopausal Osteoporosis: A Prospective, Single-Blinded Randomized Study
To investigate the effect of the antiosteoporotic agent zoledronic acid (ZA) on rotator cuff healing and clinical outcomes in patients with postmenopausal osteoporosis. (Source: Arthroscopy - Journal of Arthroscopic and Related Surgery)
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - October 10, 2023 Category: Surgery Authors: Mingjie Lei, Zhenglin Zhu, Xiaobo Hu, Dandong Wu, Wei Huang, Yong Zhang, Hong Chen Source Type: research
Postoperative Antiosteoporotic Treatment with Zoledronic Acid Improves Rotator Cuff Healing but Does Not Improve Outcomes in Female Patients with Postmenopausal Osteoporosis: A Prospective, Single-Blinded, Randomized Study
To investigate the effect of the antiosteoporotic agent zoledronic acid (ZA) on rotator cuff healing and clinical outcomes in patients with postmenopausal osteoporosis. (Source: Arthroscopy - Journal of Arthroscopic and Related Surgery)
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - October 10, 2023 Category: Surgery Authors: Mingjie Lei, Zhenglin Zhu, Xiaobo Hu, Dandong Wu, Wei Huang, Yong Zhang, Hong Chen Tags: Original Article Source Type: research
CREB1 alleviates the apoptosis and potentiates the osteogenic differentiation of zoledronic acid-treated human periodontal ligament stem cells via up-regulating VEGF
Tissue Cell. 2023 Sep 22;85:102223. doi: 10.1016/j.tice.2023.102223. Online ahead of print.ABSTRACTPeriodontitis represents a severe inflammatory illness in tooth supporting tissue. It has been supported that cAMP response element binding protein 1 (CREB1), a common transcription factor, extensively participates in osteogenic differentiation. Here, the current study was to look into the impacts of CREB1 on the process of periodontitis and its possible action mechanism. After human periodontal ligament stem cells (PDLSCs) were challenged with zoledronic acid (ZA), CREB1 expression was examined with RT-qPCR and western blott...
Source: Tissue and Cell - September 30, 2023 Category: Cytology Authors: Yao Duan Chanyuan Jin Yuwei Wu Yan Chen Minjuan Zhang Jun Qian Ting Shuai Jian Li Huimin Chen Dan Li Source Type: research
CREB1 alleviates the apoptosis and potentiates the osteogenic differentiation of zoledronic acid-treated human periodontal ligament stem cells via up-regulating VEGF
Tissue Cell. 2023 Sep 22;85:102223. doi: 10.1016/j.tice.2023.102223. Online ahead of print.ABSTRACTPeriodontitis represents a severe inflammatory illness in tooth supporting tissue. It has been supported that cAMP response element binding protein 1 (CREB1), a common transcription factor, extensively participates in osteogenic differentiation. Here, the current study was to look into the impacts of CREB1 on the process of periodontitis and its possible action mechanism. After human periodontal ligament stem cells (PDLSCs) were challenged with zoledronic acid (ZA), CREB1 expression was examined with RT-qPCR and western blott...
Source: Tissue and Cell - September 30, 2023 Category: Cytology Authors: Yao Duan Chanyuan Jin Yuwei Wu Yan Chen Minjuan Zhang Jun Qian Ting Shuai Jian Li Huimin Chen Dan Li Source Type: research
CREB1 alleviates the apoptosis and potentiates the osteogenic differentiation of zoledronic acid-treated human periodontal ligament stem cells via up-regulating VEGF
Tissue Cell. 2023 Sep 22;85:102223. doi: 10.1016/j.tice.2023.102223. Online ahead of print.ABSTRACTPeriodontitis represents a severe inflammatory illness in tooth supporting tissue. It has been supported that cAMP response element binding protein 1 (CREB1), a common transcription factor, extensively participates in osteogenic differentiation. Here, the current study was to look into the impacts of CREB1 on the process of periodontitis and its possible action mechanism. After human periodontal ligament stem cells (PDLSCs) were challenged with zoledronic acid (ZA), CREB1 expression was examined with RT-qPCR and western blott...
Source: Tissue and Cell - September 30, 2023 Category: Cytology Authors: Yao Duan Chanyuan Jin Yuwei Wu Yan Chen Minjuan Zhang Jun Qian Ting Shuai Jian Li Huimin Chen Dan Li Source Type: research
Blocking glycosphingolipid production alters autophagy in osteoclasts and improves myeloma bone disease
Autophagy. 2023 Sep 29:1-3. doi: 10.1080/15548627.2023.2208931. Online ahead of print.ABSTRACTGlycosphingolipids (GSLs) are key constituents of membrane bilayers playing a role in structural integrity, cell signalling in microdomains, endosomes and lysosomes, and cell death pathways. Conversion of ceramide into GSLs is controlled by GCS (glucosylceramide synthase) and inhibitors of this enzyme for the treatment of lipid storage disorders and specific cancers. With a diverse range of functions attributed to GSLs, the ability of the GSC inhibitor, eliglustat, to reduce myeloma bone disease was investigated. In pre-clinical m...
Source: Autophagy - September 29, 2023 Category: Cytology Authors: Houfu Leng Anna Katharina Simon Nicole J Horwood Source Type: research
Blocking glycosphingolipid production alters autophagy in osteoclasts and improves myeloma bone disease
Autophagy. 2023 Sep 29:1-3. doi: 10.1080/15548627.2023.2208931. Online ahead of print.ABSTRACTGlycosphingolipids (GSLs) are key constituents of membrane bilayers playing a role in structural integrity, cell signalling in microdomains, endosomes and lysosomes, and cell death pathways. Conversion of ceramide into GSLs is controlled by GCS (glucosylceramide synthase) and inhibitors of this enzyme for the treatment of lipid storage disorders and specific cancers. With a diverse range of functions attributed to GSLs, the ability of the GSC inhibitor, eliglustat, to reduce myeloma bone disease was investigated. In pre-clinical m...
Source: Autophagy - September 29, 2023 Category: Cytology Authors: Houfu Leng Anna Katharina Simon Nicole J Horwood Source Type: research
