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Bioavailability and daily requirement of vitamin B 12 in adult humans: an observational study of its colonic absorption and daily excretion as measured by [ 13 C]-cyanocobalamin kinetics
CONCLUSIONS: B12 is absorbed in the human colon. This observation confirms the potential contribution of the colon in daily B12 nutriture, and along with a possible lower requirement, could explain the absence of clinical deficiency in populations with marginal B12 intakes.TRIAL REGISTRATION NUMBER: This study was registered in Clinical Trials Registry of India (CTRI) with the registration number CTRI/2018/04/012957, available from https://ctri.nic.in/Clinicaltrials/showallp.php?mid1=49319&EncHid=&userName=029108.PMID:38044024 | DOI:10.1016/j.ajcnut.2023.08.020 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - December 3, 2023 Category: Nutrition Authors: Anura V Kurpad Roshni M Pasanna Shalini G Hegde Mallikarjun Patil Arpita Mukhopadhyay Harshpal S Sachdev Kishor G Bhat Ambily Sivadas Sarita Devi Source Type: research

Bioavailability and daily requirement of vitamin B 12 in adult humans: an observational study of its colonic absorption and daily excretion as measured by [ 13 C]-cyanocobalamin kinetics
CONCLUSIONS: B12 is absorbed in the human colon. This observation confirms the potential contribution of the colon in daily B12 nutriture, and along with a possible lower requirement, could explain the absence of clinical deficiency in populations with marginal B12 intakes.TRIAL REGISTRATION NUMBER: This study was registered in Clinical Trials Registry of India (CTRI) with the registration number CTRI/2018/04/012957, available from https://ctri.nic.in/Clinicaltrials/showallp.php?mid1=49319&EncHid=&userName=029108.PMID:38044024 | DOI:10.1016/j.ajcnut.2023.08.020 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - December 3, 2023 Category: Nutrition Authors: Anura V Kurpad Roshni M Pasanna Shalini G Hegde Mallikarjun Patil Arpita Mukhopadhyay Harshpal S Sachdev Kishor G Bhat Ambily Sivadas Sarita Devi Source Type: research

Treatment of refractory shock with vitamin B 12 : A narrative review
Nutr Clin Pract. 2023 Nov 29. doi: 10.1002/ncp.11095. Online ahead of print.ABSTRACTHigh-dose vitamin B12 is a potential treatment for patients with vasodilatory shock that is refractory to other therapies. Vasodilatory shock is characterized by low blood pressure and low systemic vascular resistance. Nitric oxide and hydrogen sulfide, two potential targets of high-dose vitamin B12 given as hydroxocobalamin, facilitate this syndrome. This review explores the relationship between high-dose vitamin B12 and hemodynamic outcomes in adults with vasodilatory shock and provides an update on the literature since a 2019 review on t...
Source: Nutrition in Clinical Practice - November 29, 2023 Category: Nutrition Authors: Courtney Wedemire Hamed Samavat Melanie Newkirk Anna Parker Source Type: research

Siderophore-producing bacteria mitigate cobalt stress in black gram (Vigna mungo L.), and the mitigation strategies are associated with iron concentration
In conclusion, CWTS 5 (Bacillus subtilis) and CWTS 10 (Bacillus albus) can be used to mitigate Co-stress and mobilize Co and Fe in plants.PMID:37993648 | DOI:10.1007/s11356-023-31106-2 (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - November 22, 2023 Category: Environmental Health Authors: Sapna Chandwani Natarajan Amaresan Source Type: research

Impact of vitamin B 12 on rhamnose metabolism, stress defense and in-vitro virulence of Listeria monocytogenes
In this study we investigated the impact of B12 and BMC activation on i) aerobic and anerobic growth of L. monocytogenes on rhamnose and ii) the level of virulence. We observed B12-induced pdu BMC activation and growth stimulation only in anaerobically grown cells. Comparative Caco-2 virulence assays showed that these pdu BMC-induced cells have significantly higher translocation efficiency compared to non-induced cells (anaerobic growth without B12; aerobic growth with or without B12), while adhesion and invasion capacity is similar for all cells. Comparative proteome analysis showed specific and overlapping responses link...
Source: International Journal of Food Microbiology - November 22, 2023 Category: Food Science Authors: Zhe Zeng Lucas M Wijnands Sjef Boeren Eddy J Smid Richard A Notebaart Tjakko Abee Source Type: research

Association between nutritional status and gait performance in Alzheimer's disease
CONCLUSIONS: AD patients at the dementia stage had worse nutritional status and gait performance than those at the MCI stage, which was associated with worse global cognition and activities of daily living. Poorer nutritional status was associated with higher gait variability in patients at the MCI stage and with poorer gait performance in patients at the dementia stage. Early identification and intervention of patients with nutritional risk or malnutrition may improve gait performance, thus reducing the risk of falling and cognitive decline, as well as the mortality.PMID:37950363 | DOI:10.1111/cns.14502 (Source: CNS Neuro...
Source: CNS Neuroscience and Therapeutics - November 11, 2023 Category: Neuroscience Authors: Mingyue He Tenghong Lian Peng Guo Yanan Zhang Yue Huang Jing Qi Jinghui Li Huiying Guan Dongmei Luo Zhan Liu Weijia Zhang Zijing Zheng Hao Yue Jing Li Wenjing Zhang Ruidan Wang Fan Zhang Xiaomin Wang Wei Zhang Source Type: research