Low level arsenic exposure, B-vitamins, and achievement among Uruguayan school children.
CONCLUSION: At low-levels of exposure, U-As does not appear to affect children's academic achievement. PMID: 31588016 [PubMed - as supplied by publisher] (Source: International Journal of Hygiene and Environmental health)
Source: International Journal of Hygiene and Environmental health - October 3, 2019 Category: Environmental Health Authors: Desai G, Barg G, Vahter M, Queirolo EI, Peregalli F, Mañay N, Millen AE, Yu J, Browne RW, Kordas K Tags: Int J Hyg Environ Health Source Type: research

A Narrative Review of Complementary Nutritional Supplements for Chemotherapy-induced Peripheral Neuropathy.
Conclusion: Nutritional therapists seem to recommend nutrient supplements as potential anti-inflammatory and neuroprotective agents for both the prevention and management of CIPN. An understanding of this evolving literature is useful in exploring these therapies with patients who are considering using them. However, their effects against CIPN are still controversial due to the undetermined neuropathic mechanisms of different antineoplastic agents and complex drug interactions. Further research on these agents is warranted. PMID: 31634876 [PubMed - as supplied by publisher] (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - October 1, 2019 Category: Complementary Medicine Tags: Altern Ther Health Med Source Type: research

Tryptophan catabolites as metabolic markers of vitamin B-6 status evaluated in cohorts of healthy adults and cardiovascular patients.
This study aimed to comprehensively evaluate the use of Kyns as potential markers of functional vitamin B-6 status across 2 large cohorts. METHODS: We measured circulating concentrations of the first 6 metabolites in the Trp catabolic pathway by LC-MS-MS in the community-based Hordaland Health Study (HUSK; n  = 7017) and cardiovascular patient-based Western Norway Coronary Angiography Cohort (WECAC; n = 4161). Cross-sectional and longitudinal associations of plasma PLP with Kyns were estimated using linear and nonlinear regression-based methods. RESULTS: 3'-Hydroxykynurenine (HK), a subst...
Source: The American Journal of Clinical Nutrition - September 26, 2019 Category: Nutrition Authors: Ulvik A, Midttun Ø, McCann A, Meyer K, Tell G, Nygård O, Ueland PM Tags: Am J Clin Nutr Source Type: research

Thiamin therapy for chronic heart failure: is there any future for this vitamin?
PMID: 31536119 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - September 19, 2019 Category: Nutrition Authors: Goel A, Kattoor AJ, Mehta JL Tags: Am J Clin Nutr Source Type: research

Vibrational spectra, hydrogen bonding interactions and chemical reactivity analysis of nicotinamide-citric acid cocrystal by an experimental and theoretical approach
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ03085A, PaperPRIYA VERMA, Anubha Srivastava, Anuradha Shukla, Poonam Tandon, Manishkumar Ramesh Shimpi Nicotinamide (NIC); vitamin B-3 is commonly known as pellagra preventive drug. The citric acid (CA) is a weak tribasic acid, generally used as flavouring and chelating agent. A combined experimental... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - September 11, 2019 Category: Chemistry Authors: PRIYA VERMA Source Type: research

Preoperative Gabapentin Administration Improves Acute Postoperative Analgesia in Patients Undergoing Craniotomy: A Randomized Controlled Trial
Background: Gabapentin is an adjuvant antiepileptic agent and helps to reduce acute postoperative pain in several surgery settings. However, the effect of gabapentin on postoperative pain from suboccipital or subtemporal craniotomy is not clear. Methods: The study was a single-center, randomized, placebo-controlled, and double-blinded trial. A total of 122 patients undergoing elective craniotomy by a suboccipital or subtemporal approach were randomly allocated to a placebo group and gabapentin group. The patients received gabapentin (600 mg, orally) the night before surgery and 2 hours before anesthesia inducti...
Source: Journal of Neurosurgical Anesthesiology - September 9, 2019 Category: Anesthesiology Tags: Clinical Investigations Source Type: research

Effect of micronutrient pack on micronutrient status and antioxidant capacities among institutional older adults in Shanghai, China.
This study aimed to investigate the effect of micronutrient pack on micronutrient status and oxidative/antioxidative biomarkers in institutional older adults. METHODS AND STUDY DESIGN: Subjects aged 65-100 years were randomly assigned to either intervention group or control group (n=49 each), providing a package of micronutrient pack or placebo daily for three months. The concentrations of micronutrients, malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were detected both at baseline and at the end of the study. RESULTS: The changes in concentrations of serum folate (21.1&plus...
Source: Asia Pacific Journal of Clinical Nutrition - August 30, 2019 Category: Nutrition Authors: Ren Q, Xie H, Chen YQ, Wu CF, Li H, Lu YW, Lin N, Li X, Yuan W, Yang YH, Jin HM, Sun JQ Tags: Asia Pac J Clin Nutr Source Type: research

Sex-Specific Linkages Between Taxonomic and Functional Profiles of Tick Gut Microbiomes
Ticks transmit the most diverse array of disease agents and harbor one of the most diverse microbial communities. Major progress has been made in the characterization of the taxonomic profiles of tick microbiota. However, the functional profiles of tick microbiome have been comparatively less studied. In this proof of concept we used state-of-the-art functional metagenomics analytical tools to explore previously reported datasets of bacteria found in male and female Ixodes ovatus, Ixodes persulcatus and Amblyomma variegatum. Results showed that both taxonomic and functional profiles have differences between sexes of the sa...
Source: Frontiers in cellular and infection microbiology - August 14, 2019 Category: Microbiology Source Type: research

Intermittent alien hand syndrome caused by Marchiafava–Bignami disease: A case report
We present a 57-year-old Chinese man who could not stop or turn himself around as he involuntarily and uncontrollably walked forward, which had happened frequently in the month prior to treatment. He had been a heavy drinker for thirty years before the onset of the disease, with an alcohol intake of 600 to 800 ml/day. Diagnoses: History of alcohol intake and the brain magnetic resonance imaging findings indicated a diagnosis of Marchiafava–Bignami disease. The patient was additionally diagnosed with Alien Hand Syndrome according to his clinical symptoms. Interventions: The patient was treated with high doses ...
Source: Medicine - August 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Genetics of hyperhomocysteinemia and 1-carbon metabolism: implications for retinal structure and eye functions.
Abstract Homocysteine (Hcy); a sulfur-containing non-proteinogenic amino acid is generated as a metabolic intermediate. Hcy constitutes an important part of the "1-carbon metabolism" during methionine turnover. Elevated levels of Hcy known as hyperhomocysteinemia (HHcy) results from vitamin B deficiency, lack of exercise, smoking, excessive alcohol intake, high fat and methionine rich diet, and the underlying genetic defects. These factors directly affect the "1-carbon metabolism (methionine-Hcy-folate)" of a given cell. In fact, the Hcy levels are determined primarily by dietary intake, vitami...
Source: Canadian Journal of Physiology and Pharmacology - August 1, 2019 Category: Drugs & Pharmacology Authors: George AK, Majumder A, Ice H, Homme RP, Eyob W, Tyagi SC, Singh M Tags: Can J Physiol Pharmacol Source Type: research

Effects Of Folic Acid And Vitamin B 12 , Alone and in Combination on Cognitive Function and inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-Blind Experimental Design.
CONCLUSIONS: The combination of oral folic acid plus vitamin B 12 in MCI elderly for six months can significantly improve cognitive performance and reduce the levels of inflammatory cytokines in human peripheral blood. The combination of folic acid and vitamin B 12 was significantly superior to either folic acid or vitamin B 12 alone. PMID: 31345146 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - July 25, 2019 Category: Neurology Authors: Ma F, Zhou X, Li Q, Zhao J, Song A, An P, Du Y, Xu W, Huang G Tags: Curr Alzheimer Res Source Type: research

Prevalence of Inappropriateness of Vitamin B 12 Administration in Ontario, Canada
This population-based cohort study evaluated how often intramuscular vitamin B12 was prescribed to Canadian elderly patients when not medically necessary. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - July 15, 2019 Category: Internal Medicine Source Type: research

The Critical Role of Nutrition in Facial Plastic Surgery.
er AJ Abstract Nutrition plays a key role in optimizing healing following surgery. The increased catabolic state postoperatively, coupled with a propensity for patients to be suffering from marginal nutritional deficiencies at baseline preoperatively, necessitates that the surgeon be attuned to the need for optimal perioperative nutritional support. This ensures the smoothest recovery and best possible outcomes in facial plastic surgery. Key nutrients include vitamin A, vitamin C, zinc, bromelain, arnica montana, arginine, glutamine, hydrolyzed collagen, vitamin B complex, and protein. The ability for patients to ...
Source: The Surgical Clinics of North America - July 11, 2019 Category: Surgery Authors: Laliberté F, Bloom I, Alexander AJ Tags: Facial Plast Surg Clin North Am Source Type: research

The Critical Role of Nutrition in Facial Plastic Surgery
Nutrition plays a key role in optimizing healing following surgery. The increased catabolic state postoperatively, coupled with a propensity for patients to be suffering from marginal nutritional deficiencies at baseline preoperatively, necessitates that the surgeon be attuned to the need for optimal perioperative nutritional support. This ensures the smoothest recovery and best possible outcomes in facial plastic surgery. Key nutrients include vitamin A, vitamin C, zinc, bromelain, arnica montana, arginine, glutamine, hydrolyzed collagen, vitamin B complex, and protein. The ability for patients to obtain this optimal supp...
Source: Facial Plastic Surgery Clinics of North America - July 5, 2019 Category: Cosmetic Surgery Authors: Fr édérick Laliberté, Ilan Bloom, Ashlin J. Alexander Source Type: research

A systematic review of the efficacy of alternative medicine in the treatment of nausea and vomiting of pregnancy.
Authors: Khorasani F, Aryan H, Sobhi A, Aryan R, Abavi-Sani A, Ghazanfarpour M, Saeid M, Rajab Dizavandi F Abstract To assess the efficacy alternative medicine in the treatment of nausea and vomiting of pregnancy (NVP), three major databases of PubMed, Cochrane Library and Scopus were systematically searched since inception until January 14 2019 to investigate the effects of herbal medicines on NVD. The quality assessment of studies was performed according to Jadad scale. All studies showed that ginger had a positive effect on nausea in pregnant women. Unlike others studies, one study reported that ginger was not b...
Source: Journal of Obstetrics and Gynaecology - June 21, 2019 Category: OBGYN Tags: J Obstet Gynaecol Source Type: research

MAIT Cells As Attractive Vaccine Targets
This article is protected by copyright. All rights reserved. (Source: FEBS Letters)
Source: FEBS Letters - June 17, 2019 Category: Biochemistry Authors: A. Michael Downey, Paulina Kap łonek, Peter H. Seeberger Tags: Review Source Type: research

Composition requirements of follow-up formula for 6-12-month-old infants: recommendations of a Chinese expert group.
CONCLUSIONS: These nutrient standard modifications based on recent evidence are expected to enhance feeding practices and further guarantee the health of 6-12-month-old infants in China. PMID: 31192564 [PubMed - in process] (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - June 14, 2019 Category: Nutrition Authors: Han J, Kang L, Liang D, Li H, Su Y, Zhang Y, Yang Y Tags: Asia Pac J Clin Nutr Source Type: research

[ASAP] Facilitation of < sc > l < /sc > -Lactic Acid Fermentation by Lignocellulose Biomass Rich in Vitamin B Compounds
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.9b02297 (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - June 14, 2019 Category: Food Science Authors: Xushen Han †, Li Li†, Chengxiang Wei, Jian Zhang, and Jie Bao* Source Type: research

Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals
ConclusionsWe identified novel epigenetic loci that are associated with folate and vitamin B-12 intake. Interestingly, we found a negative association between folate and DNA methylation. Replication of these methylation loci is necessary in future studies. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - June 5, 2019 Category: Nutrition Source Type: research

Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals.
CONCLUSIONS: We identified novel epigenetic loci that are associated with folate and vitamin B-12 intake. Interestingly, we found a negative association between folate and DNA methylation. Replication of these methylation loci is necessary in future studies. PMID: 31165884 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - June 5, 2019 Category: Nutrition Authors: Mandaviya PR, Joehanes R, Brody J, Castillo-Fernandez JE, Dekkers KF, Do AN, Graff M, Hänninen IK, Tanaka T, de Jonge EAL, Kiefte-de Jong JC, Absher DM, Aslibekyan S, de Rijke YB, Fornage M, Hernandez DG, Hurme MA, Ikram MA, Jacques PF, Justice AE, Kiel Tags: Am J Clin Nutr Source Type: research

Association between vitamin B group supplementation with changes in % flow-mediated dilatation and plasma homocysteine levels: a randomized controlled trial.
This study investigated whether low-dose B vitamin supplementation improves endothelial dysfunction in Japanese adults with one or more components of metabolic syndrome. A randomized, controlled, crossover trial, without a washout period or blinding of subjects, was conducted from May-September, 2010. The subjects were 127 Japanese men and women aged 40-65 years who had at least one component of metabolic syndrome without medication. Participants took a supplement drink for two months but were divided into early intervention or later intervention groups. The flow-mediated dilatation, plasma homocysteine level, serum B-vita...
Source: Journal of Clinical Biochemistry and Nutrition - May 31, 2019 Category: Nutrition Tags: J Clin Biochem Nutr Source Type: research

Dietary intake and cognitive function: evidence from the Bogalusa Heart Study.
Abstract BACKGROUND: Dementia and late-life cognitive decline are leading causes of death and disability in the United States. Prevention of these diseases, by maintaining brain health throughout the life course, is essential. Diet and lifestyle changes are the chief strategies aimed at primary prevention for many of the risk factors of cognitive decline. OBJECTIVE: The aim of this study was to examine the potential impact of dietary factors on cognitive function. METHODS: This prospective cohort study followed 516 young adults through midlife. The Youth/Adolescent Questionnaire was used to collect habit...
Source: The American Journal of Clinical Nutrition - May 30, 2019 Category: Nutrition Authors: Fortune NC, Harville EW, Guralnik JM, Gustat J, Chen W, Qi L, Bazzano LA Tags: Am J Clin Nutr Source Type: research

Nutrients in the US Diet: Naturally Occurring or Enriched/Fortified Food and Beverage Sources, Plus Dietary Supplements: NHANES 2009 –2012
ConclusionsFortification/enrichment constitutes a meaningful contribution to reducing the percentage of individuals with less than the EAR for their demographic. These data underscore the need to encourage better dietary patterns to improve the intake of nutrients at risk of low intake. (Source: Journal of Nutrition)
Source: Journal of Nutrition - May 27, 2019 Category: Nutrition Source Type: research

A genetic approach to examine the relationship between vitamin B 12 status and metabolic traits in a South Asian population
ConclusionOur findings suggest that a genetically lowered vitamin B12 concentration may have an impact on central obesity in the presence of a dietary influence; however, our study failed to provide evidence for an impact of metabolic-GRS on lowering B12 concentrations. Given that our study has a small sample size, further large studies are required to confirm our findings. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - May 27, 2019 Category: Endocrinology Source Type: research

Age-specific reference ranges are needed to interpret serum methylmalonic acid concentrations in the US population.
CONCLUSIONS: The higher serum MMA concentrations throughout the entire distribution in older persons (especially persons aged ≥70 y) who are vitamin B-12-replete and have normal renal function indicate the need for age-specific MMA reference intervals to better interpret vitamin B-12 status in epidemiologic research. PMID: 31127807 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - May 25, 2019 Category: Nutrition Authors: Mineva EM, Sternberg MR, Zhang M, Aoki Y, Storandt R, Bailey RL, Pfeiffer CM Tags: Am J Clin Nutr Source Type: research

[ASAP] Photochemical Spin Dynamics of the Vitamin B < sub > 12 < /sub > Derivative, Methylcobalamin
The Journal of Physical Chemistry BDOI: 10.1021/acs.jpcb.9b01969 (Source: Journal of Physical Chemistry B)
Source: Journal of Physical Chemistry B - May 23, 2019 Category: Chemistry Authors: Valentina Lukinovic ´, Jonathan R. Woodward, Teresa C. Marrafa, Muralidharan Shanmugam, Derren J. Heyes, Samantha J. O. Hardman, Nigel S. Scrutton, Sam Hay, Alistair J. Fielding, Alex R. Jones Source Type: research

Modulatory Effects of Single and Complex Vitamins on the In Vitro Growth of Murine Ovarian Follicles
Conclusion:Supplementation of vitamins duringin vitro maturation of murine follicles is an efficient strategy forin vitro expansion of follicular cells. These results could be customized to the sophisticated culture of follicles retrieved from aged or cancer-survived female that contain smaller number of follicles with reduced potential to develop into mature follicles. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - May 11, 2019 Category: Biotechnology Source Type: research

Fecal Metabolomics and Potential Biomarkers for Systemic Lupus Erythematosus
In this study, we analyzed the metabolic profiling of fecal samples from SLE patients and healthy controls based on ultra-high-performance liquid chromatography equipped with mass spectrometry for exploring the potential biomarkers of SLE. The results showed that 23 differential metabolites and 5 perturbed pathways were identified between the two groups, including aminoacyl-tRNA biosynthesis, thiamine metabolism, nitrogen metabolism, tryptophan metabolism, and cyanoamino acid metabolism. In addition, logistic regression and ROC analysis were used to establish a diagnostic model for distinguishing SLE patients from healthy ...
Source: Frontiers in Immunology - May 3, 2019 Category: Allergy & Immunology Source Type: research

Relationship between genetic polymorphisms MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) genes and multiple sclerosis: a  case-control study.
In this study, we aimed to investigate the association between MS and the following four DNA polymorphisms: MTR A[2756]G, MTHFR C[677]T, MTHFR A[1298]C and MTRR A[66]G. The DNA polymorphisms were genotyped in 80 patients with confirmed MS and 80 healthy control age- and gender-matched subjects using PCR-RFLP approach. Our results show that the frequency of the T/T genotype homozygotes for the MTHFR C[677]T polymorphism was significantly higher in patients than in controls (p = 0.04, OR: 3.16, 95% CI: 1.23-8.17). In turn, the A/A genotype of the MTHFR A[1298]C polymorphism was more frequent in controls than in patients...
Source: Folia Neuropathologica - May 1, 2019 Category: Pathology Authors: Cakina S, Ocak O, Ozkan A, Yucel S, Ozısık Karaman HI Tags: Folia Neuropathol Source Type: research

Nutrient Intake, Diet Quality, and Diet Diversity in Irritable Bowel Syndrome and the Impact of the Low FODMAP Diet
Publication date: Available online 24 April 2019Source: Journal of the Academy of Nutrition and DieteticsAuthor(s): Heidi M. Staudacher, Frances S.E. Ralph, Peter M. Irving, Kevin Whelan, Miranda C.E. LomerAbstractBackgroundIndividuals with irritable bowel syndrome (IBS) may modify their diet, which may pose nutritional risk. Further, some dietary approaches, such as a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs), are restrictive and may contribute to nutritional inadequacy.ObjectiveOur aim was to evaluate habitual nutrient intake, diet quality, and diversity in IBS and th...
Source: Journal of the Academy of Nutrition and Dietetics - April 25, 2019 Category: Nutrition Source Type: research

Inositol hexaphosphate plus inositol induced complete remission in stage IV melanoma: a case report
We present a case report of a patient with metastatic melanoma who declined traditional therapy and opted to try over the counter supplement IP6+inositol instead. To our surprise, the patient achieved a complete remission and remains in remission 3 years later. On the basis of this case and previous preclinical studies, we believe further research is indicated in exploring antiproliferative and potential immune stimulating effects of IP6+inositol in patients with metastatic melanoma. (Source: Melanoma Research)
Source: Melanoma Research - April 25, 2019 Category: Cancer & Oncology Tags: SHORT COMMUNICATIONS Source Type: research

Efficacy and Safety of Whey Protein Supplements on Vital Sign and Physical Performance Among Athletes: A Network Meta-Analysis
Conclusion: The findings of this review support the efficacy and safety of WPS as an ergogenic aid on athletes' sports performance and recovery. The overall quality of clinical evidence was found to be valid and reliable from the comprehensive search strategy and ROB assessment. Introduction Athletes train to be skilful and physically fit to compete and ensure success against their opponents. The effect of athletes' stamina, body structure and skill development are essential to able to do so, while an effective while an effective nutrition and diet plan to ensure good health and well-being of athletes...
Source: Frontiers in Pharmacology - April 24, 2019 Category: Drugs & Pharmacology Source Type: research

Vitamin B12 Enhances Nerve Repair and Improves Functional Recovery After Traumatic Brain Injury by Inhibiting ER Stress-Induced Neuron Injury
In this study, we explored the effect of vitamin B12 on nerve regeneration after TBI both in vivo and in vitro. Meanwhile, we investigated the role of ER stress during the vitamin B12 treatment for TBI by inspecting changes in neuronal apoptosis, microtubule, myelin regeneration, and axonal growth. Materials and Methods Animals Adult C57BL/6 male mice aged 6–8 weeks and weighing 20–26 g were purchased from the Animal Center of the Chinese Academy of Sciences (Shanghai, China). Animals were housed under a 12-h light/dark cycle at 21–23°C and provided access to food and water ad libitum. The care and...
Source: Frontiers in Pharmacology - April 24, 2019 Category: Drugs & Pharmacology Source Type: research

Elevated plasma cystathionine is associated with increased risk of mortality among patients with suspected or established coronary heart disease.
CONCLUSIONS: Elevated plasma cystathionine is associated with both cardiovascular and noncardiovascular mortality among patients with suspected or established CHD. The joint risk associations of high plasma cystathionine with lifestyle factors and impaired vitamin B-6 status on mortality need further investigation. This trial was registered at clinicaltrials.gov as NCT00354081 and NCT00266487. PMID: 31005968 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 21, 2019 Category: Nutrition Authors: Dhar I, Lysne V, Svingen GFT, Ueland PM, Gregory JF, Bønaa KH, Nygård OK Tags: Am J Clin Nutr Source Type: research

Defining the plasma folate concentration associated with the red blood cell folate concentration threshold for optimal neural tube defects prevention: a population-based, randomized trial of folic acid supplementation.
CONCLUSIONS: The relation between RBC and plasma folate concentrations was modified by BMI and genotype and substantially by low plasma vitamin B-12. This suggests that the threshold of 25.5 nmol/L for optimal NTD prevention may be appropriate in populations with similar characteristics, but it should not be used in vitamin B-12 insufficient populations. This trial was registered at clinicaltrials.gov as NCT00207558. PMID: 31005964 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 21, 2019 Category: Nutrition Authors: Chen MY, Rose CE, Qi YP, Williams JL, Yeung LF, Berry RJ, Hao L, Cannon MJ, Crider KS Tags: Am J Clin Nutr Source Type: research

Micronutrient status and leukocyte telomere length in school-age Colombian children
ConclusionsLTL is associated with vitamin B-12 status among girls. LTL is also associated with birth weight, height, and C-reactive protein in boys. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - April 20, 2019 Category: Nutrition Source Type: research

Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
In this study, herpes virus serological status and T cell, B cell, NK cell and monocyte populations were investigated in 251 ME/CFS patients, including 54 who were severely affected, and compared with those from 107 healthy participants and with 46 patients with Multiple Sclerosis. There were no differences in seroprevalence for six human herpes viruses between ME/CFS and healthy controls, although seroprevalence for the Epstein-Barr virus was higher in multiple sclerosis patients. Contrary to previous reports, no significant differences were observed in NK cell numbers, subtype proportions or in vitro responsiveness betwe...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Vitamin Status and Mineralized Tissue Formation
AbstractPurpose of the ReviewVitamins play important roles in bone health, and vitamin supplementation has been recommended to prevent osteoporosis and to reduce fracture risk in the elderly. However, the benefits of vitamin intake for bone health are still controversial. The aim of the review is to examine the relationship between vitamins and bone health and how vitamins function in osteoblasts and osteoclasts.Recent FindingsA broad literature search with the PubMed database was performed. The results of human clinical studies are inconsistent due to differences in the study design, race, genetic factors, and the populat...
Source: Current Oral Health Reports - April 16, 2019 Category: Dentistry Source Type: research

Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation.
Abstract Renal interstitial fibrosis is a common pathological feature in progressive kidney diseases currently lacking effective treatment. Nicotinamide (NAM), a member of water-soluble vitamin B family, was recently suggested to have a therapeutic potential for acute kidney injury (AKI) in mice and humans. The effect of NAM on chronic kidney pathologies, including renal fibrosis, is unknown. Here we have tested the effects of NAM on renal interstitial fibrosis using in vivo and in vitro models. In vivo, unilateral urethral obstruction (UUO) induced renal interstitial fibrosis as indicated Masson trichrome stainin...
Source: J Cell Mol Med - April 16, 2019 Category: Molecular Biology Authors: Zheng M, Cai J, Liu Z, Shu S, Wang Y, Tang C, Dong Z Tags: J Cell Mol Med Source Type: research

Astragalus and Ginseng Polysaccharides Improve Developmental, Intestinal Morphological, and Immune Functional Characters of Weaned Piglets
This study was carried out in accordance with the recommendations of the care and use of laboratory animals, Institutional Animal Care and Use Committee of Zhejiang Agricultural and Forestry University. The protocol was approved by the Ethics Committee of Zhejiang Agricultural and Forestry University, Hangzhou, China (SYXKzhe 2016-087). TABLE 1 Table 1. Composition and nutrient levels of the basal diet. Preparation of Aps and Gps The polysaccharide product had a purity of 80% and a molecular weight of 20,000–60,000. Aps was composed of hexanoic acid, glucose, fructose, rhamnose, arabinose, and galac...
Source: Frontiers in Physiology - April 12, 2019 Category: Physiology Source Type: research

Plasma B-vitamins and one-carbon metabolites and the risk of breast cancer in younger women
We examined the association of plasma B-vitamins and metabolites, and related genetic variants, with risk of breast cancer among predominantly premenopausal women.MethodsWe conducted a nested case –control study within the Nurses’ Health Study II. From blood samples collected in 1996–1999 and follow-up through 2007, plasma measures were available for 610 cases and 1207 controls. Unconditional multivariable logistic regression was used to estimate relative risks (RR) of breast cancer and 95% confidence intervals (CIs). We examined whether associations varied by methylenetetrahydrofolate reductase (MTHFR) a...
Source: Breast Cancer Research and Treatment - April 6, 2019 Category: Cancer & Oncology Source Type: research

Effect of Vitamin B Supplementation on Cognitive Function in the Elderly: A Systematic Review and Meta-Analysis
ConclusionsRaised total plasma homocysteine is associated with an increased risk of cognitive impairment and dementia, although available evidence from randomized controlled trials shows no obvious cognitive benefit of lowering homocysteine using B vitamins. Existing trials vary greatly in the type of supplementation, population sampled, study quality, and duration of treatment, thereby making it difficult to draw firm conclusions from existing data. Findings should therefore be viewed in the context of the limitations of the available data and the lack of evidence of effect should not necessarily be interpreted as evidenc...
Source: Drugs and Aging - April 4, 2019 Category: Geriatrics Source Type: research

Long non-coding RNA and mRNA analysis of Ang II-induced neuronal dysfunction.
This study assessed apoptosis and energy metabolism with Annexin V/PI staining and a Seahorse assay after Ang II exposure in SH-SY5Y cells. The expression of mRNA and lncRNA was investigated by transcriptome sequencing. The integrated analysis of mRNA and lncRNAs and the molecular mechanism of Ang II on neuronal injury was analysed by bioinformatics. Ang II increased the apoptosis rate and reduced the energy metabolism of SH-SY5Y cells. The data showed that 702 mRNAs and 821 lncRNAs were differentially expressed in response to Ang II exposure (244 mRNAs and 432 lncRNAs were upregulated, 458 mRNAs and 389 lncRNAs were downr...
Source: Molecular Biology Reports - April 3, 2019 Category: Molecular Biology Authors: Shao LL, Jiang YH, Jiang LY, Yang CH, Qi YZ Tags: Mol Biol Rep Source Type: research

Mitigating effect of biotin against irradiation-induced cerebral cortical and hippocampal damage in the rat brain tissue.
In conclusion, biotin treatment at high dose post-irradiation has efficiently neutralized the effect of free radicals in the hippocampal region of rats. Thus, it could be applicable as a radio-mitigator for reducing or delayed radiation-induced brain injury in patients post-radiotherapy. PMID: 30911963 [PubMed - as supplied by publisher] (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - March 25, 2019 Category: Environmental Health Authors: Abdel-Magied N, Shedid SM, Ahmed AG Tags: Environ Sci Pollut Res Int Source Type: research

Nutritional status of patients admitted to a metropolitan tertiary care vascular surgery unit.
CONCLUSIONS: Patients with vascular disease are a nutritionally vulnerable group. The MUST and PG-SGA did not identify the full extent of nutritional deficiencies. Further investigation is warranted to assess tool validity in this group. A number of micronutrients are crucial in these patients and hence a more comprehensive assessment that encompasses a wider range of parameters, including micronutrient status appears warranted. PMID: 30896416 [PubMed - in process] (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - March 22, 2019 Category: Nutrition Authors: Thomas J, Delaney C, Suen J, Miller M Tags: Asia Pac J Clin Nutr Source Type: research

Synergistic Effects of Combined Chlorine and Vitamin B 1 on the Reduction of Murine Norovirus-1 on the Oyster ( Crassostrea gigas ) Surface
This study investigated the synergistic effects of combined chlorine (200, 500, 700, and 1000  ppm) and vitamin B1 (1000, 2000, and 3000  ppm) on the murine norovirus-1 (MNV-1), a human norovirus (NoV) surrogate, on oyster surface. Vitamin B1 slightly reduced MNV-1 (0.04 –0.3 log-reduction), whereas chlorine significantly reduced MNV-1 (0.4–1.0 log-reduction). The combined chlorine and vitamin B1 resulted in a 0.52 –1.97 log-reduction of MNV-1. The synergistic reduction in the MNV titer was not dependent on the concentrations of chlorine and vitamin B1, and it ranged between 0.08 and 1.03 log10 ...
Source: Food and Environmental Virology - March 22, 2019 Category: Virology Source Type: research

Folate/Vitamin B Alleviates Hyperhomocysteinemia-Induced Alzheimer-Like Pathologies in Rat Retina
AbstractHyperhomocysteinemia (Hhcy) is an independent risk factor for Alzheimer ’s disease (AD). Visual dysfunction is commonly found and is positively correlated with the severity of cognitive defects in AD patients. Our previous study demonstrated that Hhcy induces memory deficits with AD-like tau and amyloid-β (Aβ) pathologies in the hippocampus, and supplementation with folate and vitamin B12 (FB) prevents the Hhcy-induced AD-like pathologies in the hippocampus. Here, we investigated whether Hhcy also induces AD-like pathologies in the retina and the effects of FB. An Hhcy rat model was produced by vena...
Source: Neuroscience Bulletin - March 20, 2019 Category: Neuroscience Source Type: research

Vitamin B-12 and liver activity and expression of methionine synthase are decreased in fetuses with neural tube defects.
CONCLUSIONS: The decreased vitamin B-12 in liver and cord blood and decreased expression and activity of MS in liver point out the impaired remethylation pathway as hallmarks associated with NTD risk. We suggest evaluating vitamin B-12 in the nutritional recommendations for prevention of NTD risk beside folate fortification or supplementation. PMID: 30848279 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - March 6, 2019 Category: Nutrition Authors: Fofou-Caillierez MB, Guéant-Rodriguez RM, Alberto JM, Chéry C, Josse T, Gérard P, Forges T, Foliguet B, Feillet F, Guéant JL Tags: Am J Clin Nutr Source Type: research

Chronic diarrhea: an unusual clinical presentation of vitamin B 12 deficiency?
(Source: Internal and Emergency Medicine)
Source: Internal and Emergency Medicine - March 5, 2019 Category: Emergency Medicine Source Type: research