[ASAP] Synthesis of Vitamin B < sub > 12 < /sub > -Antibiotic Conjugates with Greatly Improved Activity against Gram-Negative Bacteria
Organic LettersDOI: 10.1021/acs.orglett.0c02403 (Source: Organic Letters)
Source: Organic Letters - August 3, 2020 Category: Chemistry Authors: Sheng Zhao †, Zhi-Peng Wang‡, Xumei Wen†, Siyu Li†, Guoxing Wei†, Jian Guo*†, and Yun He*† Source Type: research

[ASAP] Ultrafast Excited State Dynamics and Fluorescence from Vitamin B < sub > 12 < /sub > and Organometallic [Co] –C=C–R Cobalamins
The Journal of Physical Chemistry BDOI: 10.1021/acs.jpcb.0c04886 (Source: Journal of Physical Chemistry B)
Source: Journal of Physical Chemistry B - July 21, 2020 Category: Chemistry Authors: Elvin V. Salerno †, Nicholas A. Miller†, Arkaprabha Konar‡, Yan Li†, Christoph Kieninger§, Bernhard Kra¨utler§, and Roseanne J. Sension*†‡ Source Type: research

Revised D-A-CH Reference Values for the Intake of Vitamin B < sub > 6 < /sub >
Background: The Nutrition Societies of Germany, Austria, and Switzerland as the joint editors of the “D-A-CH reference values for nutrient intake” have revised the reference values for vitamin B6 in summer 2019.Summary: For women, the average requirement (AR) for vitamin B6 intake was derived on the basis of balance studies using a pyridoxal-5 ′-phosphate (PLP) plasma concentration of ≥30 nmol/L as a biomarker of an adequate vitamin B6 status. The recommended intake (RI) was derived considering a coefficient of variation of 10%. The RIs of vitamin B6 for men, children, and adolescents were extrapolated...
Source: Annals of Nutrition and Metabolism - July 20, 2020 Category: Nutrition Source Type: research

Effects of consuming red furu (fermented bean curd) on serum vitamin B-12, homocysteine and other cardiometabolic risk factors in young healthy volunteers: A randomized controlled trial.
CONCLUSIONS: A breakfast meal with 50 g of red furu containing 0.096 μg of B-12 did not increase serum B-12 in healthy volunteers. These results suggested that one meal containing B-12 could be sufficient to reduce serum Hcy. PMID: 32674237 [PubMed - in process] (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - July 19, 2020 Category: Nutrition Authors: Tsheko T, Gu J, Tong W, Zhou R, Li D Tags: Asia Pac J Clin Nutr Source Type: research

High-dose vitamin B supplementation for persistent visual deficit in multiple sclerosis: a pilot study.
Authors: Mallone F, Lucchino L, Franzone F, Marenco M, Carlesimo SC, Moramarco A Abstract The aim of this study is to investigate the potential neuroprotective effect of high-doses vitamins B1, B6 and B12 in patients with relapsing-remitting multiple sclerosis (RRMS) and persistent visual loss after acute optic neuritis (AON). Sixteen patients (20 eyes) diagnosed with RRMS and visual permanent disability following AON were enrolled for the present open, pilot study. Each patient was treated with oral high-doses 300 mg of vitamin B1, 450 mg of vitamin B6 and 1,500 mcg of vitamin B12, as add-on treatment to concomita...
Source: Drug Discoveries and Therapeutics - July 18, 2020 Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research

Effect of Meat Sources on Nutritional Composition and Heavy Metal Profile of Suya (A West African Grilled Meat)
Conclusion: In conclusion, the suya samples from beef, goat, sheep and chickens meats are good sources of lysine, which is severely restricted in cereals, the most important staple food. (Source: Current Nutrition and Food Science)
Source: Current Nutrition and Food Science - July 14, 2020 Category: Nutrition Source Type: research

Assessment of Vitamin B 12 Deficiency and Risk Factors in Healthy Infants
ConclusionsThere is a high prevalence of vitamin B12 deficiency in infants and their mothers. There is urgent need to supplement our population with vitamin B12. (Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - July 4, 2020 Category: Pediatrics Source Type: research

Extracellular loops of BtuB facilitate transport of vitamin B < sub > 12 < /sub > through the outer membrane of < i > E. coli < /i >
by Tomasz Pie ńko, Joanna Trylska Vitamin B12 (or cobalamin) is an enzymatic cofactor essential both for mammals and bacteria. However, cobalamin can be synthesized only by few microorganisms so most bacteria need to take it up from the environment through the TonB-dependent transport system. The first stage of cobalamin import toE. coli cells occurs through the outer-membrane receptor called BtuB. Vitamin B12 binds with high affinity to the extracellular side of the BtuB protein. BtuB forms aβ-barrel with inner luminal domain and extracellular loops. To mechanically allow for cobalamin passage, the luminal domain n...
Source: PLoS Computational Biology - July 1, 2020 Category: Biology Authors: Tomasz Pie ńko Source Type: research

Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial.
Authors: PMID: 32607557 [PubMed - in process] (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - July 1, 2020 Category: Nutrition Tags: Am J Clin Nutr Source Type: research

The effect of rat nerve growth factor combined with vitamin B on peripheral neuropathy in multiple myeloma patients.
Authors: Yan M, Li Y, Zeng H, Zhao X, Wu H, Qian W, Guo X Abstract Background: Peripheral neuropathy can induce marked disability and negative effects on quality of life and is the most common therapy-related complication in multiple myeloma patients treated with bortezomib. Currently, there is no useful method to prevent or treat it. So, it is necessary to study the clinical efficacy of rat nerve growth factor combined with vitamin B for the treatment of peripheral neuropathy in multiple myeloma patients. Methods: Sixty multiple myeloma patients who developed peripheral neuropathy after bortezomib-based chemothera...
Source: Hematology - June 24, 2020 Category: Hematology Tags: Hematology Source Type: research

Association of antenatal vitamin B complex supplementation with neonatal vitamin B 12 status: evidence from a cluster randomized controlled trial
AbstractPurposeEvidence about the effect of maternal vitamin B12 supplementation on offspring ’s vitamin B12 status is limited. The present interventional study sought to evaluate the association of antenatal vitamin B complex supplementation with neonatal vitamin B12 status.MethodsIn an ongoing cluster randomized controlled trial conducted in three rural counties in northwest China, pregnant women  
Source: European Journal of Nutrition - June 23, 2020 Category: Nutrition Source Type: research

[ASAP] Resonance Raman Optical Activity Shows Unusual Structural Sensitivity for Systems in Resonance with Multiple Excited States: Vitamin B < sub > 12 < /sub > Case
The Journal of Physical Chemistry LettersDOI: 10.1021/acs.jpclett.0c01218 (Source: The Journal of Physical Chemistry Letters)
Source: The Journal of Physical Chemistry Letters - June 16, 2020 Category: Chemistry Authors: Ewa Machalska †‡, Grzegorz Zajac‡, Anna Gruca†‡, Fabio Zobi§, Malgorzata Baranska†‡, and Agnieszka Kaczor*†‡ Source Type: research

Prenatal Choline Supplements May Protect Offspring if Mother Contracts Viral Infection
Taking choline supplements during pregnancy may reduce the negative impact of viral respiratory infections on offspring, according to astudy published in theJournal of Psychiatric Research.“The new analysis may provide information relevant to potential COVID-19 effects on fetal brain development and their interaction with higher prenatal maternal choline levels,” wrote Robert Freedman, M.D., of the University of Colorado School of Medicine and colleagues.Previous studies showed that infection in pregnant women can affect fetal brain development and may increase the risk of attention-deficit/hyperactivity disord...
Source: Psychiatr News - June 9, 2020 Category: Psychiatry Tags: ADHD autism choline COVID-19 infant behavior Infant Behavior Questionnaire-Revised infections Journal of Psychiatric Research prenatal supplements Robert Freedman schizophrenia Source Type: research

Molecular interactions between Vitamin B12 and membrane models: A biophysical study for new insights into the bioavailability of Vitamin.
Abstract Vitamin B12 (VB12) deficiency is one of the most common malnutrition problems worldwide and is related to its poor bioavailability. The lipid composition of cell membranes and molecule-cell membrane lipid interactions are major factors affecting the bioavailability of nutrients. So, the study of these interactions may allow predicting the behavior of VB12 at cellular membranes and the effects on its activity. Thus, lipid vesicles with lipid composition similar to the majority of eukaryotic cell membranes were used as biomembrane models, and their interactions with VB12 molecules were evaluated. For that, ...
Source: Colloids and Surfaces - June 8, 2020 Category: Biotechnology Authors: Ramalho MJ, Andrade S, Coelho MAN, Loureiro JA, Pereira MC Tags: Colloids Surf B Biointerfaces Source Type: research

A water-stable MOF-AgClO4-abtz as fluorescent sensor for detection of folic acid based on inner filter effect.
Abstract Folic acid (FA, Vitamin B9), as a water-soluble chemical compound of the vitamin B groups, plays an important role to human health. Thus, it is of great significance to develop sensitive assays for detection of FA. Herein, we prepared a water-stable metal-organic frameworks {[Ag2(μ2-abtz)(μ3-abtz)(ClO4)]⋅(ClO4)}n (MOF-AgClO4-abtz; abtz = 1-(4-aminobenzyl)-1, 2, 4,-triazole) material, which exhibited a high fluorescent quantum yield of 78.97%, good water dispersibility and excellent chemical stability. Then MOF-AgClO4-abtz was developed as a "turn-off" fluorescent sensor for ...
Source: Talanta - June 7, 2020 Category: Chemistry Authors: Yang B, Li X, Wang L, An J, Wang T, Zhang F, Ding B, Li Y Tags: Talanta Source Type: research

Parenteral thiamine for prevention and treatment of delirium in critically ill adults: a systematic review protocol
DiscussionThis review will provide evidence for the effectiveness of parental thiamine in the prevention or treatment of delirium in critical care. Findings will contribute to establishing the need for a multicentre study of parenteral thiamine in the prevention and treatment of critical care delirium.Systematic review registrationPROSPERO CRD42019118808 (Source: Systematic Reviews)
Source: Systematic Reviews - June 5, 2020 Category: International Medicine & Public Health Source Type: research

Genes, Vol. 11, Pages 612: 3 ’-UTR Polymorphisms of Vitamin B-Related Genes Are Associated with Osteoporosis and Osteoporotic Vertebral Compression Fractures (OVCFs) in Postmenopausal Women
In this study, we investigated the genetic association of four single nucleotide polymorphisms (SNPs) within the 3&amp;rsquo;-untranslated regions of vitamin B-related genes, including TCN2 (encodes transcobalamin II), CD320 (encodes transcobalamin II receptor), SLC19A1 (encodes reduced folate carrier protein 1), and SLC19A2 (encodes thiamine carrier 1), with osteoporosis and osteoporotic vertebral compression fracture (OVCF). We recruited 301 postmenopausal women and performed genotyping of CD320 rs9426 C&amp;gt;T, TCN2 rs10418 C&amp;gt;T, SLC19A1 rs1051296 G&amp;gt;T, and SLC19A2 rs16862199 C&amp;gt;T...
Source: Genes - June 2, 2020 Category: Genetics & Stem Cells Authors: Tae-Keun Ahn Jung Oh Kim Hui Jeong An Han Sung Park Un Yong Choi Seil Sohn Kyoung-Tae Kim Nam Keun Kim In-Bo Han Tags: Article Source Type: research

Anticancer Effect of Amygdalin (Vitamin B-17) on Hepatocellular Carcinoma Cell Line (HepG2) in the Presence and Absence of Zinc
(Source: Anti-Cancer Agents in Medicinal Chemistry)
Source: Anti-Cancer Agents in Medicinal Chemistry - May 22, 2020 Category: Cancer & Oncology Authors: El-Desouky, Mohamed A. Fahmi, Abdelgawad A. Abdelkader, Ibrahim Y. Nasraldin, Karima M. Tags: Research article Source Type: research

Medications in COVID-19 patients: summarizing the current literature from an orthopaedic perspective
ConclusionEight main recommendations were derived from the review. Firstly, paracetamol remains the first line of analgesia and antipyretic. Secondly, there is no need to avoid NSAIDs for COVID-19 patients. Thirdly, opioids have the potential for immunosuppression in addition to respiratory depression and, therefore, should be prescribed with care in COVID-19 patients. Fourthly, patients with conditions where steroids are proven to be efficacious can continue to receive their steroids; otherwise, systemic steroids are not recommended for COVID-19 patients. Fifthly, orthopaedic surgeons following up on COVID-19 patients who...
Source: International Orthopaedics - May 22, 2020 Category: Orthopaedics Source Type: research

[ASAP] Mechanistic Studies on CysS – A Vitamin B < sub > 12 < /sub > -Dependent Radical SAM Methyltransferase Involved in the Biosynthesis of the < italic toggle="yes" > tert < /italic > -Butyl Group of Cystobactamid
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06454 (Source: Journal of the American Chemical Society)
Source: Journal of the American Chemical Society - May 21, 2020 Category: Chemistry Authors: Yuanyou Wang and Tadhg P. Begley* Source Type: research

Vitamin B —Can it prevent cognitive decline? A systematic review and meta-analysis
DiscussionWe found no overall evidence that oral vitamin B supplementation prevented cognitive decline. The isolated significant effects that were reported could be attributed to methodological issues. The results of this review do not provide evidence that population groups with certain risk factors would profit more from the intervention than others. Our findings do not apply to forms of administration other than oral supplementation nor do they offer information regarding the treatment of cognitively impaired individuals via the administration of vitamin B.Systematic review registrationPROSPERO CRD42017071692 (Source: Systematic Reviews)
Source: Systematic Reviews - May 15, 2020 Category: International Medicine & Public Health Source Type: research

Subacute combined degeneration induced by nitrous oxide inhalation: Two case reports
Rationale: Nitrous oxide (N2O), commonly known as “laughing gas,” is being increasingly abused by young people as a recreational drug; this can subsequently result in myelopathy and peripheral neuropathy, however, in China, few cases of neurologic deterioration by N2O abuse have been reported. Patient concerns: Herein, we present 2 patients who developed progressive limb weakness, numbness, and ataxia. Both of them had recreationally inhaled N2O intermittently for a long time. Diagnosis: Subacute combined degeneration (SCD) based on myelopathy and polyneuropathy after N2O abuse. Interventions: The 2 ...
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Comparative efficacy of vitamin supplements on prevention of major cardiovascular disease: Systematic review with network meta-analysis.
CONCLUSIONS: Vitamin B, D and E could reduce the incidence of cardiovascular events to varying degrees. At the same time, the combination of vitamins can not show improvement on the efficacy. PMID: 32379630 [PubMed - as supplied by publisher] (Source: Complementary Therapies in Clinical Practice)
Source: Complementary Therapies in Clinical Practice - May 1, 2020 Category: Complementary Medicine Authors: Han J, Zhao C, Cai J, Liang Y Tags: Complement Ther Clin Pract Source Type: research

Dietary patterns related to cardiovascular disease based on reduced rank regression analysis of healthy middle-aged Koreans: data from the community-based Korean Genome and Epidemiology Study (KoGES) cohort.
CONCLUSIONS: In this study, we identified DPs related to CVD, and a DP characterized by high intakes of eggs, fish, milk, and dairy products protected against incident CVD in women. PMID: 32338724 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 27, 2020 Category: Nutrition Authors: Lee HAH, An H, Lee E Tags: Am J Clin Nutr Source Type: research

Vitamin B and Vitamin C Affect DNA Methylation and Amino Acid Metabolism in Mycobacterium bovis BCG
Vitamins are essential nutrients and key cofactors of enzymes that regulate cellular metabolism, and also activate the immune system. Recent studies have shown that vitamin B1 (VB1) and vitamin C (Vc) can inhibit Mycobacterium tuberculosis growth, but the precise mechanism is still not well understood. In the present study, we have used RNA-sequencing (RNA-seq), liquid chromatography coupled to mass spectrometry (LC-MS) and single-molecule real-time (SMRT) sequencing to analyze the transcriptional, metabolic and methylation profiles of Mycobacterium bovis BCG when treated with VB1 and Vc. Our results show that, after vitam...
Source: Frontiers in Microbiology - April 22, 2020 Category: Microbiology Source Type: research

Vitamin B and vitamin D as modulators of gut microbiota in overweight individuals.
Authors: Jiang S, Zhu Q, Mai M, Yang W, Du G Abstract Growing evidence indicates that vitamin B (VB) and vitamin D (VD) are associated with the development of obesity. The effects of supplemental dietary VB and VD on the gut microbiota of obese individuals are still largely unknown. In the present study, 997 normoweight (NW) and 773 overweight (OW) samples were screened from the American Gut Project. The microbial α-diversity was not affected by VB, VD or VB combined with VD (VBD) supplementation in the normoweight population or the overweigh population. VD significantly modulated 20 gut microbial metabolic p...
Source: International Journal of Food Sciences and Nutrition - April 16, 2020 Category: Nutrition Tags: Int J Food Sci Nutr Source Type: research

Metabolic Infrastructure of Pregnant Women with Methylenetetrahydrofolate Reductase Polymorphisms: A Metabolomic Analysis.
Abstract The aim of this study is to demonstrate altered metabolic infrastructure of pregnant women with methylenetetrahydrofolate reductase (MTHFR) polymorphisms at first-trimester and during delivery. Eight singleton pregnant women with MTHFR polymorphisms were compared with 10 normal pregnant women. Maternal blood samples were withdrawn twice during their pregnancies (between the 11th and 14th gestational weeks and during delivery). Metabolomic analysis was performed by gas chromatography-mass spectrometry (GC-MS). The GC-MS-based metabolomics profile helped identify 95 metabolites in the plasma samples. In the...
Source: Biomedical Chromatography : BMC - April 8, 2020 Category: Biomedical Science Authors: Recber T, Orgul G, Aydın E, Tanacan A, Nemutlu E, Kır S, Beksac MS Tags: Biomed Chromatogr Source Type: research

Polyneuropathy is inadequately treated despite increasing symptom intensity in individuals with and without diabetes (PROTECT follow ‐up study)
ConclusionsThese findings point to insufficient care, inadequate treatment adherence, or limited efficacy of treatments in patients with polyneuropathy, suggesting that effective measures should be implemented to correct these health care deficits. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 8, 2020 Category: Endocrinology Authors: Dan Ziegler, R üdiger Landgraf, Ralf Lobmann, Karlheinz Reiners, Kristian Rett, Oliver Schnell, Alexander Strom Tags: ORIGINAL ARTICLE Source Type: research

"Efficacy and safety of Liangxue Jiedu decoction for the treatment of progressive psoriasis vulgaris: a multicenter, randomized, controlled study".
"Efficacy and safety of Liangxue Jiedu decoction for the treatment of progressive psoriasis vulgaris: a multicenter, randomized, controlled study". J Tradit Chin Med. 2020 Apr;40(2):296-304 Authors: Sun L, Zhou D, Wang P, Li T, Xu X, Yang X, Tian J, Zhao J, He Y, Liu F, Tong C, Chu X, Dai L, Zhu W Abstract OBJECTIVE: To determine the clinical efficacy and safety of Liangxue Jiedu decoction (LJD) for the treatment of progressive psoriasis vulgaris and to provide the basis for the development of a standardized treatment protocol for psoriasis vulgaris. METHODS: In this multicenter, random...
Source: Journal of Traditional Chinese Medicine - April 1, 2020 Category: Complementary Medicine Authors: Sun L, Zhou D, Wang P, Li T, Xu X, Yang X, Tian J, Zhao J, He Y, Liu F, Tong C, Chu X, Dai L, Zhu W Tags: J Tradit Chin Med Source Type: research

Vitamin B 12 deficiency as a cause of severe neurological symptoms in breast fed infant – a case report
ConclusionsVitamin B12 levels should be considered during differential diagnosis of neurological symptoms in exclusively breast-fed infants especially if they co-exist with megaloblastic anemia and psychomotor retardation. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 30, 2020 Category: Pediatrics Source Type: research

Biochemical characterisation and application of keratinase from Bacillus thuringiensis MT1 to enable valorisation of hair wastes through biosynthesis of vitamin B-complex.
This study reports on the exploitation of keratinous hydrolysate by keratinase enzymes to produce vitamin B-complex. Toward this end, keratinase enzyme was produced by Bacillus thuringiensis strain MT1, newly isolated from cattle-yard utilising donkey hairs. Scanning electron microscope (SEM) and Fourier transform infrared spectrophotometer (FTIR) analyses demonstrated hairs disintegration and the disruption of the disulphide bonds of the keratin structure, respectively. The biochemical characterisation of the produced enzyme exhibited optimal activity of 422 U/ml at 50 °C and pH 9 with a molecular mass of 80 k...
Source: International Journal of Biological Macromolecules - March 6, 2020 Category: Biochemistry Authors: Hassan MA, Taha TH, Hamad GM, Hashem M, Alamri S, Mostafa YS Tags: Int J Biol Macromol Source Type: research

Vitamin B 12 and diabetes risk —myth or reality
(Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 27, 2020 Category: Endocrinology Source Type: research

Is the gut microbiota dysbiotic in patients with classical homocystinuria?
Abstract Classical homocystinuria (HCU) is characterized by increased plasma levels of total homocysteine (tHcy) and methionine (Met). Treatment may involve supplementation of B vitamins and essential amino acids, as well as restricted Met intake. Dysbiosis has been described in some inborn errors of metabolism, but has not been investigated in HCU. The aim of this study was to investigate the gut microbiota of HCU patients on treatment. Six unrelated HCU patients (males= 5, median age= 25.5 years) and six age-and-sex-matched healthy controls (males= 5, median age= 24.5 years) had their fecal microbiota characteri...
Source: Biochimie - February 24, 2020 Category: Biochemistry Authors: Rizowy GM, Poloni S, Colonetti K, Donis KC, Dobbler PT, Leistner-Segal S, Roesch LFW, Schwartz IVD Tags: Biochimie Source Type: research

Efficient Prediction of Vitamin B Deficiencies via Machine-Learning Using Routine Blood Test Results in Patients With Intense Psychiatric Episode
This study demonstrates that machine-learning can efficiently predict some vitamin deficiencies in patients with active psychiatric symptoms, based on the largest cohort to date with intense psychiatric episode. The prediction method may expedite risk stratification and clinical decision-making regarding whether replacement therapy should be prescribed. Further research includes validating its external generalizability in other clinical situations and clarify whether interventions based on this method could improve patient care and cost-effectiveness. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - February 20, 2020 Category: Psychiatry Source Type: research

Association of multiple mineral and vitamin B group intake with blood glucose using quantile regression analysis: NHANES 2007-2014.
Conclusions: The intake of calcium, folic acid and magnesium was negatively associated with blood glucose levels in individuals in different quantiles of FPG. Appropriate prevention and treatment strategies should be developed for people with different blood glucose levels. PMID: 31983911 [PubMed] (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - January 29, 2020 Category: Nutrition Tags: Food Nutr Res Source Type: research

Bacterial nanocellulose membranes loaded with vitamin B-based ionic liquids for dermal care applications
Publication date: Available online 22 January 2020Source: Journal of Molecular LiquidsAuthor(s): G. Chantereau, M. Sharma, A. Abednejad, C. Vilela, E.M. Costa, M. Veiga, F. Antunes, M.M. Pintado, G. Sèbe, V. Coma, M.G. Freire, C.S.R. Freire, A.J.D. SilvestreAbstractThe development of innovative bio-based skin care products has received an increase attention in the latter years. In the present work, the synthesis of original active principle ingredients based ionic liquids (ILs) with cholinium cation and vitamins B anions followed by their incorporation in bacterial nanocellulose (BC) membranes for topical applicatio...
Source: Journal of Molecular Liquids - January 23, 2020 Category: Molecular Biology Source Type: research

Elucidation of the biosynthetic pathway of vitamin B groups and potential secondary metabolite gene clusters via genome analysis of a marine bacterium Pseudoruegeria sp. M32A2M.
In this study, the genome of a marine bacterium, Pseudoruegeria sp. M32A2M, isolated from the south-eastern isles (GeoJe-Do) of South Korea, was sequenced and analyzed. A draft genome (91 scaffolds) of 5.5 Mb with a DNA G+C content of 62.4% was obtained. In total, 5,101 features were identified from gene annotation, and 4,927 genes were assigned to functional proteins. We also identified transcription core proteins, RNA polymerase subunits, and sigma factors. In addition, full flagella-related gene clusters involving the flagellar body, motor, regulator, and other accessory compartments were detected even though the genus ...
Source: Journal of Microbiology and Biotechnology - January 17, 2020 Category: Biotechnology Authors: Cho SH, Lee E, Ko SR, Jin S, Song Y, Ahn CY, Oh HM, Cho BK, Cho S Tags: J Microbiol Biotechnol Source Type: research

Folic acid ameliorates depression-like behaviour in a rat model of chronic unpredictable mild stress
Depression is characterized by significant and low mood. Classical antidepressants are still not adequate in treating depression because of undesirable side effects. Folic acid, a member of the vitamin B compl... (Source: BMC Neuroscience)
Source: BMC Neuroscience - January 15, 2020 Category: Neuroscience Authors: Yue Zhou, Yu Cong and Huan Liu Tags: Research article Source Type: research

Nutraceutical Potential and Processing Aspects of Oyster Mushrooms (Pleurotus Species)
Conclusion: Because of the occurrence of abundant nutritional ingredients and other bioactive components in P. ostreatus, they have a great scope as a potential source for the development of functional or specialty foods for value addition of deficient foods so as to alleviate the nutritional deficiency diseases from society. (Source: Current Nutrition and Food Science)
Source: Current Nutrition and Food Science - January 13, 2020 Category: Nutrition Source Type: research

Insulin autoimmune syndrome - time to remember.
Abstract Insulin autoimmune syndrome is characterized by spontaneous hypoglycemia, excessive serum insulin levels and insulin autoantibodies, which occur in the absence of exogenous insulin. It is especially seen with drugs containing sulfhydryl group. Alpha lipoic acid is a sulphydryl containing anti-oxidant used in the treatment of diabetic neuropathy. Apart from diabetic neuropathy, it is frequently used in many countries for non-neuropathic pain, anti-ageing and diet supplement. Although insulin autoimmune syndrome is frequently reported in the Asians due to its genetic predisposition, it is rarely seen in the...
Source: Endokrynologia Polska - January 7, 2020 Category: Endocrinology Authors: Okuroglu N, Sertbas M, Akkoz C, Sertbas Y, Sancak S, Ozdemir A Tags: Endokrynol Pol Source Type: research

Changes in Dietary Intake in Pregnant Women from Periconception to Pregnancy in the Japan Environment and Children ’s Study: A Nationwide Japanese Birth Cohort Study
ConclusionWe found that energy-adjusted intakes of calcium, vitamin A, and saturated fat increased from periconception to pregnancy, while intake of other nutrients did not increase. The percentage of women not meeting DRIs increased for water-soluble vitamins, saturated fat, and salt. (Source: Maternal and Child Health Journal)
Source: Maternal and Child Health Journal - January 1, 2020 Category: Health Management Source Type: research

Overall lack of replication of associations between dietary intake of folate and vitamin B-12 and DNA methylation in peripheral blood.
es GG PMID: 31907529 [PubMed - in process] (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - January 1, 2020 Category: Nutrition Authors: Dugué PA, Chamberlain JA, Bassett JK, Hodge AM, Brinkman MT, Joo JE, Jung CH, Wong EM, Makalic E, Schmidt DF, Hopper JL, Buchanan DD, English DR, Milne RL, Southey MC, Giles GG Tags: Am J Clin Nutr Source Type: research

Nutritional Deficiencies in Patients with Severe Obesity before Bariatric Surgery: What Should Be the Focus During the Preoperative Assessment?
Publication date: Available online 28 December 2019Source: Journal of the Academy of Nutrition and DieteticsAuthor(s): Tair Ben-Porat, Ram Weiss, Shiri Sherf-Dagan, Nour Nabulsi, Achinoam Maayani, Abed Khalaileh, Salayme Abed, Ronit Brodie, Rivki Harari, Yoav Mintz, Alon J. Pikarsky, Ram ElazaryAbstractBackgroundNutritional deficiencies are a well-recognized long-term complication following bariatric surgery. The presence of preoperative deficiencies has been shown to be predictive of postoperative deficiencies.ObjectiveThe aim of the study was to investigate the prevalence of micronutrient deficiency in a large sample of ...
Source: Journal of the Academy of Nutrition and Dietetics - December 30, 2019 Category: Nutrition Source Type: research

Dietary Intakes of Vitamin B-2 (Riboflavin), Vitamin B-6, and Vitamin B-12 and Ovarian Cycle Function among Premenopausal Women
ConclusionsHigher intakes of riboflavin were associated with a small decrease in serum estradiol among healthy, regularly menstruating women. Higher intakes of riboflavin and vitamin B-12 were associated with lower plasma homocysteine concentrations. Overall, riboflavin, vitamin B-6, and vitamin B-12 that are one-carbon nutrients do not appear to influence the ovarian cycle among premenopausal women. (Source: Journal of the Academy of Nutrition and Dietetics)
Source: Journal of the Academy of Nutrition and Dietetics - December 24, 2019 Category: Nutrition Source Type: research

Dietary Intakes of Vitamin B-2 (Riboflavin), Vitamin B-6, and Vitamin B-12 and Ovarian Cycle Function among Premenopausal Women
Riboflavin, vitamin B-6, and vitamin B-12 are key players in one-carbon metabolism as enzymatic cofactors, and deficiency of these nutrients may influence reproductive outcomes possibly through affecting reproductive hormones. (Source: Journal of the American Dietetic Association)
Source: Journal of the American Dietetic Association - December 23, 2019 Category: Nutrition Authors: Keewan Kim, James L. Mills, Kara A. Michels, Ellen N. Chaljub, Jean Wactawski-Wende, Torie C. Plowden, Sunni L. Mumford Tags: Research Source Type: research

Mucosal-associated invariant T cells restrict allergic airway inflammation
Asthma is a complicated airway inflammatory disorder that involves dysregulation of multiple adaptive and innate immune cell types. Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial vitamin B metabolites presented by MR1 but can function through both T-cell receptor –dependent and T-cell receptor–independent pathways.1,2 MAIT cells are abundant in healthy human individuals, accounting for a significant proportion of human CD8+ T cells. Recent studies have indicated that MAIT cells may be implicated in asthma. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - December 21, 2019 Category: Allergy & Immunology Authors: Longyun Ye, Jiexue Pan, Muhammad Asghar Pasha, Xiaofei Shen, Shanti S. D ’Souza, Ivan Ting Hin Fung, Yinna Wang, Bingnan Guo, Dale D Tang, Qi Yang Tags: Letter to the editor Source Type: research

Dietary Intakes of Vegetable Protein, Folate, and Vitamins B-6 and B-12 Are Partially Correlated with Physical Functioning of Dutch Older Adults Using Copula Graphical Models
ConclusionsWe determined that vegetable protein, vitamin B-6, folate, and vitamin B-12 intakes are partially correlated with improved functional outcome measurements in Dutch older adults. (Source: Journal of Nutrition)
Source: Journal of Nutrition - December 20, 2019 Category: Nutrition Source Type: research

Folate and vitamin B-12 deficiencies additively impaired memory function and disturbed the gut microbiota in amyloid- β infused rats.
Folate and vitamin B-12 deficiencies additively impaired memory function and disturbed the gut microbiota in amyloid-β infused rats. Int J Vitam Nutr Res. 2019 Dec 16;:1-13 Authors: Park S, Kang S, Sol Kim D Abstract Folate and vitamin B12(V-B12) deficiencies are associated with metabolic diseases that may impair memory function. We hypothesized that folate and V-B12 may differently alter mild cognitive impairment, glucose metabolism, and inflammation by modulating the gut microbiome in rats with Alzheimer's disease (AD)-like dementia. The hypothesis was examined in hippocampal amyloid-β inf...
Source: International Journal for Vitamin and Nutrition Research - December 18, 2019 Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research

Multiple serous pigment epithelial detachments in association with major weight loss: case report and review of the literature
Conclusion: Bilateral multiple serous PEDs may occur in the context of acute major weight loss and protein-rich diet. The precise pathogenesis remains to be elucidated. However, potential candidates include the protein-, mineral- and/or vitamin-related metabolism disturbing the pigment epithelium function. A predisposition for a central serous chorioretinopathy like response might have contributed. (Source: Retinal Cases and Brief Reports)
Source: Retinal Cases and Brief Reports - December 18, 2019 Category: Opthalmology Tags: Case Report Source Type: research