Vitamin B < sub > 12 < /sub > - a scoping review for Nordic Nutrition Recommendations 2023
Food Nutr Res. 2023 Nov 8;67. doi: 10.29219/fnr.v67.10257. eCollection 2023.ABSTRACTVitamin B12 (cobalamin) is essential for normal metabolic function, and even moderate deficiency of this vitamin has negative health effects. Vitamin B12 is found in animal foods, and as vegetarian diets are increasingly popular in Western countries, one might expect a higher prevalence of vitamin B12 deficiency in the Nordic population. Setting recommendations for vitamin B12 intake has proven to be difficult, as uptake of vitamin B12 varies substantially, the clinical deficiency symptoms are often diffuse, and there is no clear agreement ...
Source: Food and Nutrition Research - December 12, 2023 Category: Nutrition Authors: Anne-Lise Bj ørke-Monsen Vegard Lysne Source Type: research
Vitamin B < sub > 12 < /sub > -loaded chitosan-based nanoparticle-embedded polymeric nanofibers for sublingual and transdermal applications: Two alternative application routes for vitamin B < sub > 12 < /sub >
Int J Biol Macromol. 2023 Dec 6:128635. doi: 10.1016/j.ijbiomac.2023.128635. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a neurodegeneration type that is biologically recognizable via β-amyloid plaques and tau neurofibril tangles. Global estimation for the total count of individuals enduring AD will rise up to 131 million by 2050. Investigations suggested the existence of a direct proportion between the likelihood of AD occurrence and vitamin B12 (VB12) hypovitaminosis. Approved VB12 administrations, intramuscular and oral, each has serious defects broaching the demand for alternative routes. This work devel...
Source: International Journal of Biological Macromolecules - December 8, 2023 Category: Biochemistry Authors: Ece Guler Humeyra Betul Yekeler Gita Parviz Saliha Aydin Asima Asghar Murat Dogan Fakhera Ikram Deepak M Kalaskar Muhammet Emin Cam Source Type: research
Naturally nutrient rich (NNR) score and the risk of colorectal cancer: a case-control study
CONCLUSION: Low NNR scores may be linked to CRC. If confirmed by future longitudinal research, this result may help prevent CRC by recommending nutrient-rich diets.PMID:38050374 | DOI:10.1136/bmjgast-2023-001242 (Source: Cancer Control)
Source: Cancer Control - December 5, 2023 Category: Cancer & Oncology Authors: Naeemeh Hassanpour Ardekanizadeh Mahdi Mousavi Mele Saeideh Mohammadi Soheila Shekari Mobina Zeinalabedini Mohammad Masoumvand Seyedeh Hayedeh Mousavi Shalmani Seyed Ali Askarpour Maryam Gholamalizadeh Farhad Vahid Saeid Doaei Source Type: research
Glycerol as substrate and NADP < sup > + < /sup > -dependent glyceraldehyde-3-phosphate dehydrogenase enable higher production of 3-hydroxypropionic acid through the β-alanine pathway in E. Coli
Bioresour Technol. 2023 Dec 2:130142. doi: 10.1016/j.biortech.2023.130142. Online ahead of print.ABSTRACTMicrobial engineering is a promising way to produce3-HP using biorenewable substrates such as glycerol. However, theglycerol pathway to obtain 3-HPrequires vitamin B-12, which hinders its economic viability. The present work showed that 3-HP can be efficiently produced from glycerol through the β-alanine pathway. To develop a cell factory for this purpose, glycerol was evaluated as a substrate and showed more than two-fold improved 3-HP production compared to glucose. Next, the reducing power was modulated by overexpre...
Source: Bioresource Technology - December 4, 2023 Category: Biotechnology Authors: Raquel Salgado Batista Gabriel Luz Chaves Davi Benedito Oliveira Vitor Leonel Pantale ão Jos é Davi Dos Santos Neves Adilson Jos é da Silva Source Type: research
Glycerol as substrate and NADP < sup > + < /sup > -dependent glyceraldehyde-3-phosphate dehydrogenase enable higher production of 3-hydroxypropionic acid through the β-alanine pathway in E. Coli
Bioresour Technol. 2023 Dec 2:130142. doi: 10.1016/j.biortech.2023.130142. Online ahead of print.ABSTRACTMicrobial engineering is a promising way to produce3-HP using biorenewable substrates such as glycerol. However, theglycerol pathway to obtain 3-HPrequires vitamin B-12, which hinders its economic viability. The present work showed that 3-HP can be efficiently produced from glycerol through the β-alanine pathway. To develop a cell factory for this purpose, glycerol was evaluated as a substrate and showed more than two-fold improved 3-HP production compared to glucose. Next, the reducing power was modulated by overexpre...
Source: Bioresource Technology - December 4, 2023 Category: Biotechnology Authors: Raquel Salgado Batista Gabriel Luz Chaves Davi Benedito Oliveira Vitor Leonel Pantale ão Jos é Davi Dos Santos Neves Adilson Jos é da Silva Source Type: research
Bioavailability and daily requirement of vitamin B < sub > 12 < /sub > in adult humans: an observational study of its colonic absorption and daily excretion as measured by [ < sup > 13 < /sup > C]-cyanocobalamin kinetics
CONCLUSIONS: B12 is absorbed in the human colon. This observation confirms the potential contribution of the colon in daily B12 nutriture, and along with a possible lower requirement, could explain the absence of clinical deficiency in populations with marginal B12 intakes.TRIAL REGISTRATION NUMBER: This study was registered in Clinical Trials Registry of India (CTRI) with the registration number CTRI/2018/04/012957, available from https://ctri.nic.in/Clinicaltrials/showallp.php?mid1=49319&EncHid=&userName=029108.PMID:38044024 | DOI:10.1016/j.ajcnut.2023.08.020 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - December 3, 2023 Category: Nutrition Authors: Anura V Kurpad Roshni M Pasanna Shalini G Hegde Mallikarjun Patil Arpita Mukhopadhyay Harshpal S Sachdev Kishor G Bhat Ambily Sivadas Sarita Devi Source Type: research
Bioavailability and daily requirement of vitamin B < sub > 12 < /sub > in adult humans: an observational study of its colonic absorption and daily excretion as measured by [ < sup > 13 < /sup > C]-cyanocobalamin kinetics
CONCLUSIONS: B12 is absorbed in the human colon. This observation confirms the potential contribution of the colon in daily B12 nutriture, and along with a possible lower requirement, could explain the absence of clinical deficiency in populations with marginal B12 intakes.TRIAL REGISTRATION NUMBER: This study was registered in Clinical Trials Registry of India (CTRI) with the registration number CTRI/2018/04/012957, available from https://ctri.nic.in/Clinicaltrials/showallp.php?mid1=49319&EncHid=&userName=029108.PMID:38044024 | DOI:10.1016/j.ajcnut.2023.08.020 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - December 3, 2023 Category: Nutrition Authors: Anura V Kurpad Roshni M Pasanna Shalini G Hegde Mallikarjun Patil Arpita Mukhopadhyay Harshpal S Sachdev Kishor G Bhat Ambily Sivadas Sarita Devi Source Type: research
Bioavailability and daily requirement of vitamin B < sub > 12 < /sub > in adult humans: an observational study of its colonic absorption and daily excretion as measured by [ < sup > 13 < /sup > C]-cyanocobalamin kinetics
CONCLUSIONS: B12 is absorbed in the human colon. This observation confirms the potential contribution of the colon in daily B12 nutriture, and along with a possible lower requirement, could explain the absence of clinical deficiency in populations with marginal B12 intakes.TRIAL REGISTRATION NUMBER: This study was registered in Clinical Trials Registry of India (CTRI) with the registration number CTRI/2018/04/012957, available from https://ctri.nic.in/Clinicaltrials/showallp.php?mid1=49319&EncHid=&userName=029108.PMID:38044024 | DOI:10.1016/j.ajcnut.2023.08.020 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - December 3, 2023 Category: Nutrition Authors: Anura V Kurpad Roshni M Pasanna Shalini G Hegde Mallikarjun Patil Arpita Mukhopadhyay Harshpal S Sachdev Kishor G Bhat Ambily Sivadas Sarita Devi Source Type: research
Bioavailability and daily requirement of vitamin B < sub > 12 < /sub > in adult humans: an observational study of its colonic absorption and daily excretion as measured by [ < sup > 13 < /sup > C]-cyanocobalamin kinetics
CONCLUSIONS: B12 is absorbed in the human colon. This observation confirms the potential contribution of the colon in daily B12 nutriture, and along with a possible lower requirement, could explain the absence of clinical deficiency in populations with marginal B12 intakes.TRIAL REGISTRATION NUMBER: This study was registered in Clinical Trials Registry of India (CTRI) with the registration number CTRI/2018/04/012957, available from https://ctri.nic.in/Clinicaltrials/showallp.php?mid1=49319&EncHid=&userName=029108.PMID:38044024 | DOI:10.1016/j.ajcnut.2023.08.020 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - December 3, 2023 Category: Nutrition Authors: Anura V Kurpad Roshni M Pasanna Shalini G Hegde Mallikarjun Patil Arpita Mukhopadhyay Harshpal S Sachdev Kishor G Bhat Ambily Sivadas Sarita Devi Source Type: research
Bioavailability and daily requirement of vitamin B < sub > 12 < /sub > in adult humans: an observational study of its colonic absorption and daily excretion as measured by [ < sup > 13 < /sup > C]-cyanocobalamin kinetics
CONCLUSIONS: B12 is absorbed in the human colon. This observation confirms the potential contribution of the colon in daily B12 nutriture, and along with a possible lower requirement, could explain the absence of clinical deficiency in populations with marginal B12 intakes.TRIAL REGISTRATION NUMBER: This study was registered in Clinical Trials Registry of India (CTRI) with the registration number CTRI/2018/04/012957, available from https://ctri.nic.in/Clinicaltrials/showallp.php?mid1=49319&EncHid=&userName=029108.PMID:38044024 | DOI:10.1016/j.ajcnut.2023.08.020 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - December 3, 2023 Category: Nutrition Authors: Anura V Kurpad Roshni M Pasanna Shalini G Hegde Mallikarjun Patil Arpita Mukhopadhyay Harshpal S Sachdev Kishor G Bhat Ambily Sivadas Sarita Devi Source Type: research
Bioavailability and daily requirement of vitamin B < sub > 12 < /sub > in adult humans: an observational study of its colonic absorption and daily excretion as measured by [ < sup > 13 < /sup > C]-cyanocobalamin kinetics
CONCLUSIONS: B12 is absorbed in the human colon. This observation confirms the potential contribution of the colon in daily B12 nutriture, and along with a possible lower requirement, could explain the absence of clinical deficiency in populations with marginal B12 intakes.TRIAL REGISTRATION NUMBER: This study was registered in Clinical Trials Registry of India (CTRI) with the registration number CTRI/2018/04/012957, available from https://ctri.nic.in/Clinicaltrials/showallp.php?mid1=49319&EncHid=&userName=029108.PMID:38044024 | DOI:10.1016/j.ajcnut.2023.08.020 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - December 3, 2023 Category: Nutrition Authors: Anura V Kurpad Roshni M Pasanna Shalini G Hegde Mallikarjun Patil Arpita Mukhopadhyay Harshpal S Sachdev Kishor G Bhat Ambily Sivadas Sarita Devi Source Type: research
Bioavailability and daily requirement of vitamin B < sub > 12 < /sub > in adult humans: an observational study of its colonic absorption and daily excretion as measured by [ < sup > 13 < /sup > C]-cyanocobalamin kinetics
CONCLUSIONS: B12 is absorbed in the human colon. This observation confirms the potential contribution of the colon in daily B12 nutriture, and along with a possible lower requirement, could explain the absence of clinical deficiency in populations with marginal B12 intakes.TRIAL REGISTRATION NUMBER: This study was registered in Clinical Trials Registry of India (CTRI) with the registration number CTRI/2018/04/012957, available from https://ctri.nic.in/Clinicaltrials/showallp.php?mid1=49319&EncHid=&userName=029108.PMID:38044024 | DOI:10.1016/j.ajcnut.2023.08.020 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - December 3, 2023 Category: Nutrition Authors: Anura V Kurpad Roshni M Pasanna Shalini G Hegde Mallikarjun Patil Arpita Mukhopadhyay Harshpal S Sachdev Kishor G Bhat Ambily Sivadas Sarita Devi Source Type: research
Bioavailability and daily requirement of vitamin B < sub > 12 < /sub > in adult humans: an observational study of its colonic absorption and daily excretion as measured by [ < sup > 13 < /sup > C]-cyanocobalamin kinetics
CONCLUSIONS: B12 is absorbed in the human colon. This observation confirms the potential contribution of the colon in daily B12 nutriture, and along with a possible lower requirement, could explain the absence of clinical deficiency in populations with marginal B12 intakes.TRIAL REGISTRATION NUMBER: This study was registered in Clinical Trials Registry of India (CTRI) with the registration number CTRI/2018/04/012957, available from https://ctri.nic.in/Clinicaltrials/showallp.php?mid1=49319&EncHid=&userName=029108.PMID:38044024 | DOI:10.1016/j.ajcnut.2023.08.020 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - December 3, 2023 Category: Nutrition Authors: Anura V Kurpad Roshni M Pasanna Shalini G Hegde Mallikarjun Patil Arpita Mukhopadhyay Harshpal S Sachdev Kishor G Bhat Ambily Sivadas Sarita Devi Source Type: research
Treatment of refractory shock with vitamin B < sub > 12 < /sub > : A narrative review
Nutr Clin Pract. 2023 Nov 29. doi: 10.1002/ncp.11095. Online ahead of print.ABSTRACTHigh-dose vitamin B12 is a potential treatment for patients with vasodilatory shock that is refractory to other therapies. Vasodilatory shock is characterized by low blood pressure and low systemic vascular resistance. Nitric oxide and hydrogen sulfide, two potential targets of high-dose vitamin B12 given as hydroxocobalamin, facilitate this syndrome. This review explores the relationship between high-dose vitamin B12 and hemodynamic outcomes in adults with vasodilatory shock and provides an update on the literature since a 2019 review on t...
Source: Nutrition in Clinical Practice - November 29, 2023 Category: Nutrition Authors: Courtney Wedemire Hamed Samavat Melanie Newkirk Anna Parker Source Type: research
Treatment of refractory shock with vitamin B < sub > 12 < /sub > : A narrative review
Nutr Clin Pract. 2023 Nov 29. doi: 10.1002/ncp.11095. Online ahead of print.ABSTRACTHigh-dose vitamin B12 is a potential treatment for patients with vasodilatory shock that is refractory to other therapies. Vasodilatory shock is characterized by low blood pressure and low systemic vascular resistance. Nitric oxide and hydrogen sulfide, two potential targets of high-dose vitamin B12 given as hydroxocobalamin, facilitate this syndrome. This review explores the relationship between high-dose vitamin B12 and hemodynamic outcomes in adults with vasodilatory shock and provides an update on the literature since a 2019 review on t...
Source: Nutrition in Clinical Practice - November 29, 2023 Category: Nutrition Authors: Courtney Wedemire Hamed Samavat Melanie Newkirk Anna Parker Source Type: research
