Hepatic lipid accumulation is associated with multiple metabolic pathway alterations but not dyslipidemia and insulin resistance in central bearded dragons (Pogona vitticeps)
Am J Vet Res. 2024 Apr 13:1-10. doi: 10.2460/ajvr.23.12.0285. Online ahead of print.ABSTRACTOBJECTIVE: To investigate associations between hepatic fat accumulation, fibrosis, and plasma values of primary metabolites, biochemical measurands, insulin, and lipoproteins in bearded dragons.ANIMALS: 48 adult central bearded dragons (Pogona vitticeps).METHODS: Dragons were sedated with alfaxalone, and a blood sample was collected. Plasma was submitted for untargeted primary metabolomics using gas chromatography time-of-flight mass spectrometry, a biochemistry panel, and a lipoprotein panel determined by PAGE. Hepatic lipid conten...
Source: American Journal of Veterinary Research - April 9, 2024 Category: Veterinary Research Authors: Hugues Beaufr ère Lisa Pacumio Leonardo Susta Danielle Tarbert M élanie Ammersbach Kevin Keel Source Type: research
The virus is out of the barn: the emergence of HPAI as a pathogen of avian and mammalian wildlife around the globe
Am J Vet Res. 2024 Apr 13:1-7. doi: 10.2460/ajvr.24.01.0018. Online ahead of print.ABSTRACTHighly pathogenic avian influenza (HPAI) has persisted as a One Health threat whose current circulation and impact are addressed in the companion Currents in One Health by Puryear and Runstadler, JAVMA, March 2024. Highly pathogenic avian influenza emerged as a by-product of agricultural practices and adapted to endemic circulation in wild bird species. Over more than 20 years, continued evolution in a complex ecology involving multiple hosts has produced a lineage that expanded globally over the last 2 years. Understanding the conti...
Source: American Journal of Veterinary Research - April 9, 2024 Category: Veterinary Research Authors: Jonathan A Runstadler Wendy B Puryear Source Type: research
Faster perfusate instillation time results in more systemic leakage of amikacin sulfate when performing intravenous regional limb perfusion in horses
Am J Vet Res. 2024 Apr 13:1-6. doi: 10.2460/ajvr.24.02.0029. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate if a difference in synovial amikacin concentrations exists in the radiocarpal joint (RCJ) following different durations of instillation of an IV regional limb perfusion (IVRLP) perfusate.ANIMALS: 7 healthy horses.METHODS: Horses received 2 IVRLPs with 2 g amikacin diluted to 60 mL with 0.9% NaCl via the cephalic vein in a crossover study design with a wash-out period between procedures. Instillation of the perfusate was administered over a 1-minute (technique 1) and 5-minute (technique 5) period. Concentrations...
Source: American Journal of Veterinary Research - April 9, 2024 Category: Veterinary Research Authors: Laurel K Saldinger Isabelle Kilcoyne Jorge Nieto Source Type: research
Hepatic lipid accumulation is associated with multiple metabolic pathway alterations but not dyslipidemia and insulin resistance in central bearded dragons (Pogona vitticeps)
Am J Vet Res. 2024 Apr 13:1-10. doi: 10.2460/ajvr.23.12.0285. Online ahead of print.ABSTRACTOBJECTIVE: To investigate associations between hepatic fat accumulation, fibrosis, and plasma values of primary metabolites, biochemical measurands, insulin, and lipoproteins in bearded dragons.ANIMALS: 48 adult central bearded dragons (Pogona vitticeps).METHODS: Dragons were sedated with alfaxalone, and a blood sample was collected. Plasma was submitted for untargeted primary metabolomics using gas chromatography time-of-flight mass spectrometry, a biochemistry panel, and a lipoprotein panel determined by PAGE. Hepatic lipid conten...
Source: American Journal of Veterinary Research - April 9, 2024 Category: Veterinary Research Authors: Hugues Beaufr ère Lisa Pacumio Leonardo Susta Danielle Tarbert M élanie Ammersbach Kevin Keel Source Type: research
The virus is out of the barn: the emergence of HPAI as a pathogen of avian and mammalian wildlife around the globe
Am J Vet Res. 2024 Apr 13:1-7. doi: 10.2460/ajvr.24.01.0018. Online ahead of print.ABSTRACTHighly pathogenic avian influenza (HPAI) has persisted as a One Health threat whose current circulation and impact are addressed in the companion Currents in One Health by Puryear and Runstadler, JAVMA, March 2024. Highly pathogenic avian influenza emerged as a by-product of agricultural practices and adapted to endemic circulation in wild bird species. Over more than 20 years, continued evolution in a complex ecology involving multiple hosts has produced a lineage that expanded globally over the last 2 years. Understanding the conti...
Source: American Journal of Veterinary Research - April 9, 2024 Category: Veterinary Research Authors: Jonathan A Runstadler Wendy B Puryear Source Type: research
Faster perfusate instillation time results in more systemic leakage of amikacin sulfate when performing intravenous regional limb perfusion in horses
Am J Vet Res. 2024 Apr 13:1-6. doi: 10.2460/ajvr.24.02.0029. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate if a difference in synovial amikacin concentrations exists in the radiocarpal joint (RCJ) following different durations of instillation of an IV regional limb perfusion (IVRLP) perfusate.ANIMALS: 7 healthy horses.METHODS: Horses received 2 IVRLPs with 2 g amikacin diluted to 60 mL with 0.9% NaCl via the cephalic vein in a crossover study design with a wash-out period between procedures. Instillation of the perfusate was administered over a 1-minute (technique 1) and 5-minute (technique 5) period. Concentrations...
Source: American Journal of Veterinary Research - April 9, 2024 Category: Veterinary Research Authors: Laurel K Saldinger Isabelle Kilcoyne Jorge Nieto Source Type: research
Hepatic lipid accumulation is associated with multiple metabolic pathway alterations but not dyslipidemia and insulin resistance in central bearded dragons (Pogona vitticeps)
Am J Vet Res. 2024 Apr 13:1-10. doi: 10.2460/ajvr.23.12.0285. Online ahead of print.ABSTRACTOBJECTIVE: To investigate associations between hepatic fat accumulation, fibrosis, and plasma values of primary metabolites, biochemical measurands, insulin, and lipoproteins in bearded dragons.ANIMALS: 48 adult central bearded dragons (Pogona vitticeps).METHODS: Dragons were sedated with alfaxalone, and a blood sample was collected. Plasma was submitted for untargeted primary metabolomics using gas chromatography time-of-flight mass spectrometry, a biochemistry panel, and a lipoprotein panel determined by PAGE. Hepatic lipid conten...
Source: American Journal of Veterinary Research - April 9, 2024 Category: Veterinary Research Authors: Hugues Beaufr ère Lisa Pacumio Leonardo Susta Danielle Tarbert M élanie Ammersbach Kevin Keel Source Type: research
The virus is out of the barn: the emergence of HPAI as a pathogen of avian and mammalian wildlife around the globe
Am J Vet Res. 2024 Apr 13:1-7. doi: 10.2460/ajvr.24.01.0018. Online ahead of print.ABSTRACTHighly pathogenic avian influenza (HPAI) has persisted as a One Health threat whose current circulation and impact are addressed in the companion Currents in One Health by Puryear and Runstadler, JAVMA, May 2024. Highly pathogenic avian influenza emerged as a by-product of agricultural practices and adapted to endemic circulation in wild bird species. Over more than 20 years, continued evolution in a complex ecology involving multiple hosts has produced a lineage that expanded globally over the last 2 years. Understanding the continu...
Source: American Journal of Veterinary Research - April 9, 2024 Category: Veterinary Research Authors: Jonathan A Runstadler Wendy B Puryear Source Type: research
Faster perfusate instillation time results in more systemic leakage of amikacin sulfate when performing intravenous regional limb perfusion in horses
Am J Vet Res. 2024 Apr 13:1-6. doi: 10.2460/ajvr.24.02.0029. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate if a difference in synovial amikacin concentrations exists in the radiocarpal joint (RCJ) following different durations of instillation of an IV regional limb perfusion (IVRLP) perfusate.ANIMALS: 7 healthy horses.METHODS: Horses received 2 IVRLPs with 2 g amikacin diluted to 60 mL with 0.9% NaCl via the cephalic vein in a crossover study design with a wash-out period between procedures. Instillation of the perfusate was administered over a 1-minute (technique 1) and 5-minute (technique 5) period. Concentrations...
Source: American Journal of Veterinary Research - April 9, 2024 Category: Veterinary Research Authors: Laurel K Saldinger Isabelle Kilcoyne Jorge Nieto Source Type: research
Correction: Interleukin-22 facilitates the interferon- λ-mediated production of tripartite motif protein 25 to inhibit replication of duck viral hepatitis A virus type 1
(Source: Veterinary Research)
Source: Veterinary Research - April 9, 2024 Category: Veterinary Research Source Type: research
Emergence and genomic chion of Proteus mirabilis harboring blaNDM-1 in Korean companion dogs
AbstractProteus mirabilis is a commensal bacterium dwelling in the gastrointestinal (GI) tract of humans and animals. Although New Delhi metallo- β-lactamase 1 (NDM-1) producingP. mirabilis is emerging as a threat, its epidemiology in our society remains largely unknown. LHPm1, the firstP. mirabilis isolate harboring NDM-1, was detected from a companion dog that resides with a human owner. The whole-genome study revealed 20 different antimicrobial resistance (AMR) genes against various classes of antimicrobial agents, which corresponded to the MIC results. Genomic regions, including MDR genes, were identified with multipl...
Source: Veterinary Research - April 9, 2024 Category: Veterinary Research Source Type: research
Occludin and collagen IV degradation mediated by the T9SS effector SspA contributes to blood –brain barrier damage in ducks during Riemerella anatipestifer infection
In this study, we showed that obvious clinical symptoms, an increase in blood ‒brain barrier (BBB) permeability, and the accumulation of inflammatory cytokines occurred after intravenous infection with the Yb2 strain but not the mutant strain Yb2ΔsspA, indicating that Yb2 infection can lead to cerebrovascular dysfunction and that the type IX secretion system (T9SS) effecto r SspA plays a critical role in this pathological process. In addition, we showed that Yb2 infection led to rapid degradation of occludin (a tight junction protein) and collagen IV (a basement membrane protein), which contributed to endothelial barrie...
Source: Veterinary Research - April 9, 2024 Category: Veterinary Research Source Type: research
Serotype diversity and antimicrobial susceptibility profiles of Actinobacillus pleuropneumoniae isolated in Italian pig farms from 2015 to 2022
AbstractActinobacillus pleuropneumoniae (APP) is a bacterium frequently associated with porcine pleuropneumonia. The acute form of the disease is highly contagious and often fatal, resulting in significant economic losses for pig farmers. Serotype diversity and antimicrobial resistance (AMR) of APP strains circulating in north Italian farms from 2015 to 2022 were evaluated retrospectively to investigate APP epidemiology in the area. A total of 572 strains isolated from outbreaks occurring in 337 different swine farms were analysed. The majority of isolates belonged to serotypes 9/11 (39.2%) and 2 (28.1%) and serotype diver...
Source: Veterinary Research - April 9, 2024 Category: Veterinary Research Source Type: research
Bayesian approach for evaluation of lactation curve in cross bred cattle based on monthly and bimonthly test day milk yield
In this study Wood’s incomplete gamma function was fitted using Bayesian approach using m onthly (MTDY) and bimonthly test day (BTDY) yields. The lactation curve parameters thus obtained were used for prediction of FL305DMY. Efficiency of prediction based on monthly and bimonthly test day milk yield were compared using error of prediction. It was found to be 5.78% and 7.59% as root mean square error (RMSE) based on MTDY and BTDY respectively.The Breeding values of 97 Karan Fries sires were estimated using BLUP-AM based on actual and predicted FL305DMY thus obtained. The RMSE was calculated as the difference between estim...
Source: Tropical Animal Health and Production - April 9, 2024 Category: Veterinary Research Source Type: research
Molecular epidemiology of anaplasmosis in Indian dromedary camels
AbstractThe present study aimed to investigate the molecular epidemiology, risk factors, and haemato-biochemical changes in anaplasmosis in Indian dromedary camels. Blood samples collected from 103 camels were analysed using blood smear examination and semi-nested PCR based on the 16s rRNA gene to diagnose anaplasmosis. The prevalence of anaplasmosis was estimated to be 42.72% (95% CI: 33.59 –52.37) by PCR assay and 16.5% (95% CI: 10.47–24.95%) by blood smear examination. Phylogenetic analysis of six partial sequences of 16s rRNA gene obtained in the present study indicated the involvement of multipleAnaplasma species,...
Source: Veterinary Research Communications - April 9, 2024 Category: Veterinary Research Source Type: research
