The pharmacokinetics of single-dose oral atorvastatin and its metabolites support therapeutic use in cockatiels (Nymphicus hollandicus)
Am J Vet Res. 2024 Apr 19:1-7. doi: 10.2460/ajvr.24.03.0068. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the plasma concentrations and determine the pharmacokinetic parameters of atorvastatin and its primary active metabolites (para- and orthohydroxyatorvastatin) after administration of a single oral dose in cockatiels (Nymphicus hollandicus).ANIMALS: 14 adult cockatiels (7 male, 7 female) around 2 years of age.METHODS: A compounded oral suspension of atorvastatin 10 mg/mL made with an oral suspending agent and an oral sweetener was administered via oral gavage at 20 mg/kg to each bird. Blood samples were collecte...
Source: American Journal of Veterinary Research - April 16, 2024 Category: Veterinary Research Authors: Michaela Mitchell David Sanchez-Migallon Guzman Heather Knych Hugues Beaufr ère Source Type: research
Microvasculature of the suspensory ligament of the equine hind limb
Am J Vet Res. 2024 Apr 20:1-9. doi: 10.2460/ajvr.24.01.0019. Online ahead of print.ABSTRACTOBJECTIVE: To describe the microvascular anatomy of the equine hind limb suspensory ligament.ANIMALS: 18 hind limbs harvested from 9 adult horses euthanized for reasons unrelated to lameness.METHODS: A catheter was placed in the transected cranial tibial artery at the level of the mid-distal tibia for each hind limb and used to inject 120 to 150 mL of contrast medium (2 limbs) to identify principal vasculature using contrast-enhanced CT or India ink (11 limbs) to identify microvasculature using the Spalteholz tissue-clearing techniqu...
Source: American Journal of Veterinary Research - April 16, 2024 Category: Veterinary Research Authors: Megan R Williams Evan Crisman Brianne M Taylor Source Type: research
A lentivirus-vectored feline erythropoietin gene therapy strategy in tissue culture and rodent models for the potential treatment of chronic renal disease-associated anemia
Am J Vet Res. 2024 Apr 20:1-12. doi: 10.2460/ajvr.23.12.0280. Online ahead of print.ABSTRACTOBJECTIVE: The aim of this study was to assess the efficacy and safety of a third-generation lentivirus-based vector encoding the feline erythropoietin (EPO) (feEPO) gene in vitro and in rodent models in vivo. This vector incorporates a genetic mechanism to facilitate the termination of the therapeutic effect in the event of supraphysiologic polycythemia, the herpes simplex virus thymidine kinase (HSV-TK) "suicide gene."ANIMALS: CFRK cells and replication-defective lentiviral vectors encoding feEPO were used for in vitro experiments...
Source: American Journal of Veterinary Research - April 16, 2024 Category: Veterinary Research Authors: Sarah E Cook Diego Castillo Tatiana Wolf Chadwick Hillman Katherine Bauer Sonyia Williams Brian G Murphy Source Type: research
Measuring tissue oxygen saturation in the orad intestinal segment during equine colic surgery may aid in predicting the occurrence of postoperative ileus
Am J Vet Res. 2024 Apr 19:1-8. doi: 10.2460/ajvr.23.12.0286. Online ahead of print.ABSTRACTOBJECTIVE: To assess the histological injury and intestinal microperfusion measured by laser Doppler flowmetry and spectrophotometry (LDFS) of the small intestine orad to a strangulation during colic surgery.ANIMALS: Horses with naturally occurring small intestinal strangulations undergoing colic surgery were included.METHODS: In this prospective clinical trial, intestinal tissue oxygen saturation (tSO2) and tissue blood flow (tBF) were measured by LDFS orad to the strangulation following release of the strangulation (n = 18). The nu...
Source: American Journal of Veterinary Research - April 16, 2024 Category: Veterinary Research Authors: Nicole Verhaar Anna Marei Grages Fay J Sauer Tobias Geiger Wencke Reineking Marion Hewicker-Trautwein Florian Geburek Sabine B R K ästner Source Type: research
An approach to evaluating seasonal responses to acute toxicity of antibiotic nitrofurazone on periphytic ciliated protist communities in marine environments
Eur J Protistol. 2024 Apr 8;94:126081. doi: 10.1016/j.ejop.2024.126081. Online ahead of print.ABSTRACTPeriphytic protists including ciliates are the primary components of microbial communities in which they play a vital role in the progression of food webs by moving resources from lower to higher trophic levels. However, the toxic effects of veterinary antibiotics on periphytic protists across four seasons are minimally understood. Therefore, in this study, a 1-year survey was conducted with the antibiotic nitrofurazone (NFZ) applied at concentrations of 0.0, 1.5, 3.0, 6.0, and 12.0 mg/L. Samples of protist communities wer...
Source: European Journal of Protistology - April 16, 2024 Category: Microbiology Authors: Awais Ali Ning Wang Qiaoling Wang Guangjian Xu Henglong Xu Source Type: research
Association Between Household Location (Urban versus Rural) and Fundamental Care Provided to Domestic Dogs (Canis Familiaris) in Northern Ireland
In conclusion, the results of this study have shown a number of differences in basic care and perception of dogs kept in city locations and on farm locations. Further studies are required to understand the provision of health care and fulfilments of all welfare needs of the dogs kept on farms.PMID:38625531 | DOI:10.1007/978-3-031-54192-6_10 (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - April 16, 2024 Category: Research Authors: Violetta Naughton Teresa Grzelak Patrick J Naughton Source Type: research
Foot-and-mouth disease seroprevalence is higher in young female crossbred sheep and goats compared to their counterparts in the border area between Pakistan and Afghanistan
CONCLUSIONS: This study showed that FMD is highly prevalent in sheep and goats in the border areas of Pakistan and Afghanistan. Therefore, outbreak investigation teams should be arranged at the border level to develop FMD risk-based surveillance and control plans for small ruminants in order to mitigate infection risks.PMID:38626798 | DOI:10.2460/ajvr.23.12.0279 (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - April 16, 2024 Category: Veterinary Research Authors: Abdul Kabir Asghar A Kamboh Muhammad Abubakar Abdulkareem M Matar Kanwar Kumar Source Type: research
The pharmacokinetics of single-dose oral atorvastatin and its metabolites support therapeutic use in cockatiels (Nymphicus hollandicus)
Am J Vet Res. 2024 Apr 19:1-7. doi: 10.2460/ajvr.24.03.0068. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the plasma concentrations and determine the pharmacokinetic parameters of atorvastatin and its primary active metabolites (para- and orthohydroxyatorvastatin) after administration of a single oral dose in cockatiels (Nymphicus hollandicus).ANIMALS: 14 adult cockatiels (7 male, 7 female) around 2 years of age.METHODS: A compounded oral suspension of atorvastatin 10 mg/mL made with an oral suspending agent and an oral sweetener was administered via oral gavage at 20 mg/kg to each bird. Blood samples were collecte...
Source: American Journal of Veterinary Research - April 16, 2024 Category: Veterinary Research Authors: Michaela Mitchell David Sanchez-Migallon Guzman Heather Knych Hugues Beaufr ère Source Type: research
Microvasculature of the suspensory ligament of the equine hind limb
Am J Vet Res. 2024 Apr 20:1-9. doi: 10.2460/ajvr.24.01.0019. Online ahead of print.ABSTRACTOBJECTIVE: To describe the microvascular anatomy of the equine hind limb suspensory ligament.ANIMALS: 18 hind limbs harvested from 9 adult horses euthanized for reasons unrelated to lameness.METHODS: A catheter was placed in the transected cranial tibial artery at the level of the mid-distal tibia for each hind limb and used to inject 120 to 150 mL of contrast medium (2 limbs) to identify principal vasculature using contrast-enhanced CT or India ink (11 limbs) to identify microvasculature using the Spalteholz tissue-clearing techniqu...
Source: American Journal of Veterinary Research - April 16, 2024 Category: Veterinary Research Authors: Megan R Williams Evan Crisman Brianne M Taylor Source Type: research
A lentivirus-vectored feline erythropoietin gene therapy strategy in tissue culture and rodent models for the potential treatment of chronic renal disease-associated anemia
Am J Vet Res. 2024 Apr 20:1-12. doi: 10.2460/ajvr.23.12.0280. Online ahead of print.ABSTRACTOBJECTIVE: The aim of this study was to assess the efficacy and safety of a third-generation lentivirus-based vector encoding the feline erythropoietin (EPO) (feEPO) gene in vitro and in rodent models in vivo. This vector incorporates a genetic mechanism to facilitate the termination of the therapeutic effect in the event of supraphysiologic polycythemia, the herpes simplex virus thymidine kinase (HSV-TK) "suicide gene."ANIMALS: CFRK cells and replication-defective lentiviral vectors encoding feEPO were used for in vitro experiments...
Source: American Journal of Veterinary Research - April 16, 2024 Category: Veterinary Research Authors: Sarah E Cook Diego Castillo Tatiana Wolf Chadwick Hillman Katherine Bauer Sonyia Williams Brian G Murphy Source Type: research
Measuring tissue oxygen saturation in the orad intestinal segment during equine colic surgery may aid in predicting the occurrence of postoperative ileus
Am J Vet Res. 2024 Apr 19:1-8. doi: 10.2460/ajvr.23.12.0286. Online ahead of print.ABSTRACTOBJECTIVE: To assess the histological injury and intestinal microperfusion measured by laser Doppler flowmetry and spectrophotometry (LDFS) of the small intestine orad to a strangulation during colic surgery.ANIMALS: Horses with naturally occurring small intestinal strangulations undergoing colic surgery were included.METHODS: In this prospective clinical trial, intestinal tissue oxygen saturation (tSO2) and tissue blood flow (tBF) were measured by LDFS orad to the strangulation following release of the strangulation (n = 18). The nu...
Source: American Journal of Veterinary Research - April 16, 2024 Category: Veterinary Research Authors: Nicole Verhaar Anna Marei Grages Fay J Sauer Tobias Geiger Wencke Reineking Marion Hewicker-Trautwein Florian Geburek Sabine B R K ästner Source Type: research
Association Between Household Location (Urban versus Rural) and Fundamental Care Provided to Domestic Dogs (Canis Familiaris) in Northern Ireland
In conclusion, the results of this study have shown a number of differences in basic care and perception of dogs kept in city locations and on farm locations. Further studies are required to understand the provision of health care and fulfilments of all welfare needs of the dogs kept on farms.PMID:38625531 | DOI:10.1007/978-3-031-54192-6_10 (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - April 16, 2024 Category: Research Authors: Violetta Naughton Teresa Grzelak Patrick J Naughton Source Type: research
The multiple roles of viral 3Dpol protein in picornavirus infections
Volume 15, Issue 1, December 2024 . (Source: Virulence)
Source: Virulence - April 16, 2024 Category: Virology Authors: Zhenyu NieFengge ZhaiHan ZhangHaixue ZhengJingjing Peia State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, La Source Type: research
Flock level socio-economic and other associated risk factors for Peste des petits ruminants (PPR) exposure in sheep and goats in Madhya Pradesh state, India
AbstractTo effectively control and eradicate PPR, the comprehensive understanding of risk factors associated with PPR exposure is vital. Hence, this study investigated socioeconomic and other associated risk determinants for PPR exposure at flock level in sheep and goats in a non-vaccination programme implemented Madhya Pradesh state India. A total of 410 sheep and goat flocks, comprised mostly of goats but also some mixed flocks, were surveyed during 2016 using a multistage random sampling procedure. Further, 230 blood samples were also collected from the farmers-reported PPR affected flocks and sera were tested using c-E...
Source: Tropical Animal Health and Production - April 16, 2024 Category: Veterinary Research Source Type: research
