Evaluation of canine adipose-derived mesenchymal stem cells for neurological functional recovery in a rat model of traumatic brain injury
Traumatic brain injury (TBI) is a common condition in veterinary medicine that is difficult to manage.Veterinary regenerative therapy based on adipose mesenchymal stem cells seem to be an effective strategy fo... (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - March 18, 2024 Category: Veterinary Research Authors: Wenkang Jiang, Huina Luo, Mingming Zhao, Quanbao Fan, Cailing Ye, Xingying Li, Jing He, Jianyi Lai, Shi He, Wojun Chen, Weihang Xian, Shengfeng Chen, Zhisheng Chen, Dongsheng Li, Ruiai Chen and Bingyun Wang Tags: Research Source Type: research

The effect of selenium on the proliferation of bovine endometrial epithelial cells in a lipopolysaccharide-induced damage model
Endometritis is a common bovine postpartum disease. Rapid endometrial repair is beneficial for forming natural defense barriers and lets cows enter the next breeding cycle as soon as possible. Selenium (Se) is... (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - March 18, 2024 Category: Veterinary Research Authors: Hanqing Li, Heng Wang, Luying Cui, Kangjun Liu, Long Guo, Jianji Li and Junsheng Dong Tags: Research Source Type: research

Camel milk or silymarin could improve the negative effects that experimentally produced by aflatoxin B1 on rat ’s male reproductive system
Camel milk and silymarin have many different beneficial effects on several animal species. Meanwhile, Aflatoxins are mycotoxins with extraordinary potency that pose major health risks to several animal species... (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - March 18, 2024 Category: Veterinary Research Authors: Nahla H. Hassaneen, Shabaan A. Hemeda, Abeer F. El Nahas, Sabreen E. Fadl and Eman M. El-diasty Tags: Research Source Type: research

Dietary microalgal-fabricated selenium nanoparticles improve Nile tilapia biochemical indices, immune-related gene expression, and intestinal immunity
Feed supplements, including essential trace elements are believed to play an important role in augmenting fish immune response. In this context, selenium nanoparticles (SeNPs) in fish diets via a green biosynt... (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - March 18, 2024 Category: Veterinary Research Authors: Eman Zahran, Samia Elbahnaswy, Fatma Ahmed, Engy Risha, Abdallah Tageldein Mansour, Arwa sultan Alqahtani, Walaa Awadin and Mahmoud G. El Sebaei Tags: Research Source Type: research

Prophylactic activity of orally administered dry-heat-sterilized Acremonium egyptiacum against Trypanosoma congolense-induced animal African trypanosomosis
Acta Trop. 2024 Mar 15:107185. doi: 10.1016/j.actatropica.2024.107185. Online ahead of print.ABSTRACTAnimal African trypanosomosis (AAT) is an important global disease of livestock that causes economic losses of up to 4.5 billion US dollars per year. Thus, eliminating AAT in endemic countries will improve agricultural productivity and economic growth. To prevent AAT, vector control and the development of prophylactic drugs are crucial. Ascofuranone (AF) is a bioactive fungal compound with proven in vitro trypanocidal potency and in vivo treatment efficacy. However, the complex stereoselective synthesis of AF has prevented ...
Source: Acta Tropica - March 17, 2024 Category: Infectious Diseases Authors: Ai Yamazaki Yusuke Tanaka Kenichi Watanabe Mayu Sato Shin-Ichiro Kawazu Kiyoshi Kita Noboru Inoue Helena D Janse van Rensburg David D N'Da Keisuke Suganuma Source Type: research

High carriage of plasmid-mediated quinolone resistance (PMQR) genes by ESBL-producing and fluoroquinolone-resistant Escherichia coli recovered from animal waste dumps
CONCLUSIONS: This study showed that animal wastes disposed indiscriminately into dumps could be a budding 'hotspot' for multidrug resistant, ESBL-producing and fluoroquinolone-resistant E. coli carrying multiple genes encoding resistance to fluoroquinolone antibiotics.PMID:38491992 | DOI:10.1007/s11033-024-09228-8 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 16, 2024 Category: Molecular Biology Authors: Elizabeth Omokoshi Joel Olabisi Comfort Akinlabi Adedolapo Victoria Olaposi Temitayo Omotunde Olowomofe Abimbola Olumide Adekanmbi Source Type: research

High carriage of plasmid-mediated quinolone resistance (PMQR) genes by ESBL-producing and fluoroquinolone-resistant Escherichia coli recovered from animal waste dumps
CONCLUSIONS: This study showed that animal wastes disposed indiscriminately into dumps could be a budding 'hotspot' for multidrug resistant, ESBL-producing and fluoroquinolone-resistant E. coli carrying multiple genes encoding resistance to fluoroquinolone antibiotics.PMID:38491992 | DOI:10.1007/s11033-024-09228-8 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 16, 2024 Category: Molecular Biology Authors: Elizabeth Omokoshi Joel Olabisi Comfort Akinlabi Adedolapo Victoria Olaposi Temitayo Omotunde Olowomofe Abimbola Olumide Adekanmbi Source Type: research

Correction: Comparative analysis of  the interactions of different Streptococcus suis strains with monocytes, granulocytes and the complement system in porcine blood
(Source: Veterinary Research)
Source: Veterinary Research - March 16, 2024 Category: Veterinary Research Source Type: research

Pasteurella multocida activates Rassf1-Hippo-Yap pathway to induce pulmonary epithelial apoptosis
In this study, using unbiased RNA-seq analysis, we found that the evolutionarily conserved Hippo-Yap pathway was dysregulated afterP. multocida infection. Given the complexity ofP. multocida infection associated with lung injury and systemic inflammatory processes, we employed a combination of cell culture models, mouse models, and rabbit models to investigate the dynamics of the Hippo-Yap pathway duringP. multocida infection. Our findings reveal thatP. multocida infection activates the Hippo-Yap pathway both in vitro and in vivo, by upregulating the upstream factors p-Mst1/2, p-Lats1, and p-Yap, and downregulating the dow...
Source: Veterinary Research - March 16, 2024 Category: Veterinary Research Source Type: research

A matter of differentiation: equine enteroids as a model for the in vivo intestinal epithelium
AbstractEpithelial damage due to gastrointestinal disorders frequently causes severe disease in horses. To study the underlying pathophysiological processes, we aimed to establish equine jejunum and colon enteroids (eqJE, eqCE) mimicking the in vivo epithelium. Therefore, enteroids were cultivated in four different media for differentiation and subsequently characterized histomorphologically, on mRNA and on protein level in comparison to the native epithelium of the same donor horses to identify ideal culture conditions for an in vitro model system. With increasing enterocyte differentiation, the enteroids showed a reduced...
Source: Veterinary Research - March 16, 2024 Category: Veterinary Research Source Type: research

An equine iPSC-based phenotypic screening platform identifies pro- and anti-viral molecules against West Nile virus
AbstractOutbreaks of West Nile virus (WNV) occur periodically, affecting both human and equine populations. There are no vaccines for humans, and those commercialised for horses do not have sufficient coverage. Specific antiviral treatments do not exist. Many drug discovery studies have been conducted, but since rodent or primate cell lines are normally used, results cannot always be transposed to horses. There is thus a need to develop relevant equine cellular models. Here, we used induced pluripotent stem cells to develop a new in vitro model of WNV-infected equine brain cells suitable for microplate assay, and assessed ...
Source: Veterinary Research - March 16, 2024 Category: Veterinary Research Source Type: research

Construction of recombinant fluorescent LSDV for high-throughput screening of antiviral drugs
AbstractLumpy skin disease virus (LSDV) infection is a major socio-economic issue that seriously threatens the global cattle-farming industry. Here, a recombinant virus LSDV- ΔTK/EGFP, expressing enhanced green fluorescent protein (EGFP), was constructed with a homologous recombination system and applied to the high-throughput screening of antiviral drugs. LSDV-ΔTK/EGFP replicates in various kidney cell lines, consistent with wild-type LSDV. The cytopathic effect, vira l particle morphology, and growth performance of LSDV-ΔTK/EGFP are consistent with those of wild-type LSDV. High-throughput screening allowed to identify...
Source: Veterinary Research - March 16, 2024 Category: Veterinary Research Source Type: research

Ultrasensitive and visual detection of Feline herpesvirus type-1 and Feline calicivirus using one-tube dRPA-Cas12a/Cas13a assay
Feline herpesvirus type 1 (FHV) and Feline calicivirus (FCV) are the primary co-infecting pathogens that cause upper respiratory tract disease in cats. However, there are currently no visual detection assays a... (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - March 16, 2024 Category: Veterinary Research Authors: Fumei Jiang, Yunjia Liu, Xiaonong Yang, Yan Li and Jian Huang Tags: Research Source Type: research

Effect of transporting Oreochromis niloticus in water with and without sodium chloride on skin morphology and some immunity-related genes expression
The aim of this study was to examine the effects of salt addition on the skin gene expression of Mucin, Antimicrobial peptides, cortisol, and glucose in Oreochromis niloticus after 5-hour transportation in wat... (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - March 16, 2024 Category: Veterinary Research Authors: Heba Naeim Sadek Hana, Mohamed Abd El Aziz Ahmed Abd El Galil, Mohamed Abd Allah Mousa, Rasha S. B. El-Lateif and Arafah M. Emam Tags: Research Source Type: research

Canine peer review, stolen toxins, and more stories you might have missed this week
How did a single-celled yeast evolve to be as tough as wood? Could your next paper be reviewed by a dog? And is “biological sex” really a useful category for scientific research? Check out the answers below in some of our favorite selections from Science ’s daily newsletter, Science Adviser . Autonomous swimming microbots make a tiny splash Tiny robots that swim through our blood to deliver drugs or hunt down pathogens have been a staple of science fiction for decades. Although still distant, that vision came a step closer to reality last week, when electrical engi...
Source: Science of Aging Knowledge Environment - March 15, 2024 Category: Geriatrics Source Type: research