Prevalence and molecular characterization of Trichomonas gallinae from pigeons in Anhui, China
This study aimed to investigate the prevalence and genotypes of T. gallinae in Anhui Province, China. A total of 1612 oropharyngeal swab samples were collected from pigeon farms in Anhui Province to determine the prevalence of T. gallinae infection. The results revealed 565 (35.1%) positive samples of T. gallinae. Significant differences in infection rates were observed among different regions and age groups. Furthermore, the ITS1/5.8 S/ITS2 region was amplified, sequenced, and subjected to phylogenetic analysis. Genotypes A and B of T. gallinae were identified, and genotype B was the dominant genotype in Anhui Province. T...
Source: Comparative immunology, microbiology and infectious diseases. - March 14, 2024 Category: Allergy & Immunology Authors: Yilei Zhang Zhenxiao Lu Zhenzhen Liu Yuhan Zhou Guodong Xiao Ayanniyi Olalekan Opeyemi Sihua Jin Yongsheng Li Tao Liu Qiong Wu Xingdong Sun Qianming Xu Qingxun Zhang Congshan Yang Source Type: research
Vaginal dysbiosis seems associated with hrHPV infection in women attending the Dutch Cervical Cancer Screening Program
In conclusion, vaginal dysbiosis seems associated with hrHPV infection in women attending the Dutch Cervical Cancer Screening Program. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - March 13, 2024 Category: Microbiology Source Type: research
Exploring novel pyrazole-nitroimidazole hybrids: Synthesis and antiprotozoal activity against the human pathogen trichomonas vaginalis
In this study, we synthesized ten pyrazole-nitroimidazoles 1(a-j) and 4-nitro-1-(hydroxyethyl)-1H-imidazole 2, an analog of metronidazole (MTZ), and assessed their trichomonacidal and cytotoxic effects. All compounds 1(a-j) and 2 exhibited IC50 values ≤ 20 μM and ≤ 41 μM, after 24 h and 48 h, respectively. Compounds 1d (IC50 5.3 μM), 1e (IC50 4.8 μM), and 1i (IC50 5.2 μM) exhibited potencies equivalent to MTZ (IC50 4.9 μM), the reference drug, after 24 h. Notably, compound 1i showed high anti-trichomonas activity after 24 h (IC50 5.2 μM) and 48 h (IC50 2.1 μM). Additionally, all compounds demonstrated either no...
Source: Bioorganic and Medicinal Chemistry - March 10, 2024 Category: Chemistry Authors: Rafaela Corr êa Silva Anna De Freitas Bruno Vicente Victor Midlej Maur ício Silva Dos Santos Source Type: research
Exploring novel pyrazole-nitroimidazole hybrids: Synthesis and antiprotozoal activity against the human pathogen trichomonas vaginalis
In this study, we synthesized ten pyrazole-nitroimidazoles 1(a-j) and 4-nitro-1-(hydroxyethyl)-1H-imidazole 2, an analog of metronidazole (MTZ), and assessed their trichomonacidal and cytotoxic effects. All compounds 1(a-j) and 2 exhibited IC50 values ≤ 20 μM and ≤ 41 μM, after 24 h and 48 h, respectively. Compounds 1d (IC50 5.3 μM), 1e (IC50 4.8 μM), and 1i (IC50 5.2 μM) exhibited potencies equivalent to MTZ (IC50 4.9 μM), the reference drug, after 24 h. Notably, compound 1i showed high anti-trichomonas activity after 24 h (IC50 5.2 μM) and 48 h (IC50 2.1 μM). Additionally, all compounds demonstrated either no...
Source: Bioorganic and Medicinal Chemistry - March 10, 2024 Category: Chemistry Authors: Rafaela Corr êa Silva Anna De Freitas Bruno Vicente Victor Midlej Maur ício Silva Dos Santos Source Type: research
Exploring novel pyrazole-nitroimidazole hybrids: Synthesis and antiprotozoal activity against the human pathogen trichomonas vaginalis
In this study, we synthesized ten pyrazole-nitroimidazoles 1(a-j) and 4-nitro-1-(hydroxyethyl)-1H-imidazole 2, an analog of metronidazole (MTZ), and assessed their trichomonacidal and cytotoxic effects. All compounds 1(a-j) and 2 exhibited IC50 values ≤ 20 μM and ≤ 41 μM, after 24 h and 48 h, respectively. Compounds 1d (IC50 5.3 μM), 1e (IC50 4.8 μM), and 1i (IC50 5.2 μM) exhibited potencies equivalent to MTZ (IC50 4.9 μM), the reference drug, after 24 h. Notably, compound 1i showed high anti-trichomonas activity after 24 h (IC50 5.2 μM) and 48 h (IC50 2.1 μM). Additionally, all compounds demonstrated either no...
Source: Bioorganic and Medicinal Chemistry - March 10, 2024 Category: Chemistry Authors: Rafaela Corr êa Silva Anna De Freitas Bruno Vicente Victor Midlej Maur ício Silva Dos Santos Source Type: research
Exploring novel pyrazole-nitroimidazole hybrids: Synthesis and antiprotozoal activity against the human pathogen trichomonas vaginalis
In this study, we synthesized ten pyrazole-nitroimidazoles 1(a-j) and 4-nitro-1-(hydroxyethyl)-1H-imidazole 2, an analog of metronidazole (MTZ), and assessed their trichomonacidal and cytotoxic effects. All compounds 1(a-j) and 2 exhibited IC50 values ≤ 20 μM and ≤ 41 μM, after 24 h and 48 h, respectively. Compounds 1d (IC50 5.3 μM), 1e (IC50 4.8 μM), and 1i (IC50 5.2 μM) exhibited potencies equivalent to MTZ (IC50 4.9 μM), the reference drug, after 24 h. Notably, compound 1i showed high anti-trichomonas activity after 24 h (IC50 5.2 μM) and 48 h (IC50 2.1 μM). Additionally, all compounds demonstrated either no...
Source: Bioorganic and Medicinal Chemistry - March 10, 2024 Category: Chemistry Authors: Rafaela Corr êa Silva Anna De Freitas Bruno Vicente Victor Midlej Maur ício Silva Dos Santos Source Type: research
Exploring novel pyrazole-nitroimidazole hybrids: Synthesis and antiprotozoal activity against the human pathogen trichomonas vaginalis
In this study, we synthesized ten pyrazole-nitroimidazoles 1(a-j) and 4-nitro-1-(hydroxyethyl)-1H-imidazole 2, an analog of metronidazole (MTZ), and assessed their trichomonacidal and cytotoxic effects. All compounds 1(a-j) and 2 exhibited IC50 values ≤ 20 μM and ≤ 41 μM, after 24 h and 48 h, respectively. Compounds 1d (IC50 5.3 μM), 1e (IC50 4.8 μM), and 1i (IC50 5.2 μM) exhibited potencies equivalent to MTZ (IC50 4.9 μM), the reference drug, after 24 h. Notably, compound 1i showed high anti-trichomonas activity after 24 h (IC50 5.2 μM) and 48 h (IC50 2.1 μM). Additionally, all compounds demonstrated either no...
Source: Bioorganic and Medicinal Chemistry - March 10, 2024 Category: Chemistry Authors: Rafaela Corr êa Silva Anna De Freitas Bruno Vicente Victor Midlej Maur ício Silva Dos Santos Source Type: research
Quercetin as a Promising Antiprotozoan Phytochemical: Current Knowledge and Future Research Avenues
Biomed Res Int. 2024 Feb 29;2024:7632408. doi: 10.1155/2024/7632408. eCollection 2024.ABSTRACTDespite tremendous advances in the prevention and treatment of infectious diseases, only few antiparasitic drugs have been developed to date. Protozoan infections such as malaria, leishmaniasis, and trypanosomiasis continue to exact an enormous toll on public health worldwide, underscoring the need to discover novel antiprotozoan drugs. Recently, there has been an explosion of research into the antiprotozoan properties of quercetin, one of the most abundant flavonoids in the human diet. In this review, we tried to consolidate the ...
Source: Cell Research - March 8, 2024 Category: Cytology Authors: Hamed Memariani Mojtaba Memariani Abdolmajid Ghasemian Source Type: research
Quercetin as a Promising Antiprotozoan Phytochemical: Current Knowledge and Future Research Avenues
Biomed Res Int. 2024 Feb 29;2024:7632408. doi: 10.1155/2024/7632408. eCollection 2024.ABSTRACTDespite tremendous advances in the prevention and treatment of infectious diseases, only few antiparasitic drugs have been developed to date. Protozoan infections such as malaria, leishmaniasis, and trypanosomiasis continue to exact an enormous toll on public health worldwide, underscoring the need to discover novel antiprotozoan drugs. Recently, there has been an explosion of research into the antiprotozoan properties of quercetin, one of the most abundant flavonoids in the human diet. In this review, we tried to consolidate the ...
Source: Biomed Res - March 8, 2024 Category: Research Authors: Hamed Memariani Mojtaba Memariani Abdolmajid Ghasemian Source Type: research
Quercetin as a Promising Antiprotozoan Phytochemical: Current Knowledge and Future Research Avenues
Biomed Res Int. 2024 Feb 29;2024:7632408. doi: 10.1155/2024/7632408. eCollection 2024.ABSTRACTDespite tremendous advances in the prevention and treatment of infectious diseases, only few antiparasitic drugs have been developed to date. Protozoan infections such as malaria, leishmaniasis, and trypanosomiasis continue to exact an enormous toll on public health worldwide, underscoring the need to discover novel antiprotozoan drugs. Recently, there has been an explosion of research into the antiprotozoan properties of quercetin, one of the most abundant flavonoids in the human diet. In this review, we tried to consolidate the ...
Source: Biomed Res - March 8, 2024 Category: Research Authors: Hamed Memariani Mojtaba Memariani Abdolmajid Ghasemian Source Type: research
Anti- < em > Trichomonas vaginalis < /em > Activity of Marine Ascidians (Tunicates; Ascidiacea) from the Bushehr Province, Iran
CONCLUSION: The ethanolic fraction containing phenol-2,4-bis (1,1-dimethylethyl), which has a potent lethality effect on T. vaginalis, may be considered as an antiparasite drug candidate.PMID:38449363 | DOI:10.4274/tpd.galenos.2023.96658 (Source: Turkish Society for Parasitology)
Source: Turkish Society for Parasitology - March 7, 2024 Category: Parasitology Authors: Hamideh Malekhayati Afshar Bargahi Soleiman Khorami Mohsen Khataminejad Moradali Fouladvand Source Type: research
Unconventional features in the transcription and processing of spliceosomal small nuclear RNAs in the protozoan parasite Trichomonas vaginalis
In conclusion, transcription and processing of spliceosomal snRNAs in T. vaginalis deviate considerably from the conventional rules of other eukaryotes.PMID:38452964 | DOI:10.1016/j.ijpara.2024.03.001 (Source: International Journal for Parasitology)
Source: International Journal for Parasitology - March 7, 2024 Category: Parasitology Authors: Augusto Simoes-Barbosa Jully Pinheiro Source Type: research
Anti- < em > Trichomonas vaginalis < /em > Activity of Marine Ascidians (Tunicates; Ascidiacea) from the Bushehr Province, Iran
CONCLUSION: The ethanolic fraction containing phenol-2,4-bis (1,1-dimethylethyl), which has a potent lethality effect on T. vaginalis, may be considered as an antiparasite drug candidate.PMID:38449363 | DOI:10.4274/tpd.galenos.2023.96658 (Source: Turkish Society for Parasitology)
Source: Turkish Society for Parasitology - March 7, 2024 Category: Parasitology Authors: Hamideh Malekhayati Afshar Bargahi Soleiman Khorami Mohsen Khataminejad Moradali Fouladvand Source Type: research
Unconventional features in the transcription and processing of spliceosomal small nuclear RNAs in the protozoan parasite Trichomonas vaginalis
In conclusion, transcription and processing of spliceosomal snRNAs in T. vaginalis deviate considerably from the conventional rules of other eukaryotes.PMID:38452964 | DOI:10.1016/j.ijpara.2024.03.001 (Source: International Journal for Parasitology)
Source: International Journal for Parasitology - March 7, 2024 Category: Parasitology Authors: Augusto Simoes-Barbosa Jully Pinheiro Source Type: research
Anti- < em > Trichomonas vaginalis < /em > Activity of Marine Ascidians (Tunicates; Ascidiacea) from the Bushehr Province, Iran
CONCLUSION: The ethanolic fraction containing phenol-2,4-bis (1,1-dimethylethyl), which has a potent lethality effect on T. vaginalis, may be considered as an antiparasite drug candidate.PMID:38449363 | DOI:10.4274/tpd.galenos.2023.96658 (Source: Turkish Society for Parasitology)
Source: Turkish Society for Parasitology - March 7, 2024 Category: Parasitology Authors: Hamideh Malekhayati Afshar Bargahi Soleiman Khorami Mohsen Khataminejad Moradali Fouladvand Source Type: research
