Cytogenetic Abnormalities Do Not Affect Prognosis in Pediatric CML
Chromosomal abnormalities such as a variant t(9;22) translocation do not appear to have significant prognostic impact on children with chronic myeloid leukemia. (Source: CancerNetwork)
Source: CancerNetwork - May 22, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Chronic Myeloid Leukemia Hematologic Malignancies News Source Type: news
Tetraspanin microdomains control localized protein kinase C signaling in B cells
Activation of B cells by the binding of antigens to the B cell receptor (BCR) requires the protein kinase C (PKC) family member PKCβ. Because PKCs must translocate to the plasma membrane to become activated, we investigated the mechanisms regulating their spatial distribution in mouse and human B cells. Through live-cell imaging, we showed that BCR-stimulated production of the second messenger diacylglycerol (DAG) resulted in the translocation of PKCβ from the cytosol to plasma membrane regions containing the tetraspanin protein CD53. CD53 was specifically enriched at sites of BCR signaling, suggesting that BCR-d...
Source: Signal Transduction Knowledge Environment - May 9, 2017 Category: Science Authors: Zuidscherwoude, M., Dunlock, V.-M. E., van den Bogaart, G., van Deventer, S. J., van der Schaaf, A., van Oostrum, J., Goedhart, J., In 't Hout, J., Hämmerling, G. J., Tanaka, S., Nadler, A., Schultz, C., Wright, M. D., Adjobo-Hermans, M. J. W., va Tags: STKE Research Articles Source Type: news
Research questions effectiveness of translocation conservation method
A DNA study of endangered greater prairie chickens in Illinois indicates that supplementing the dwindling population with birds from out of state did not improve genetic diversity. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 22, 2017 Category: Science Source Type: news
[Research Article] Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking
An inflammation-associated kinase also stimulates glucose uptake through plasma membrane translocation of GLUT4 in response to insulin. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 21, 2017 Category: Science Authors: Maeran Uhm, Merlijn Bazuine, Peng Zhao, Shian-Huey Chiang, Tingting Xiong, Sheelarani Karunanithi, Louise Chang, Alan R. Saltiel Source Type: news
Abnormal development of the brain in an intractable disease, thanatophoric dysplasia
In this study, by combining ferrets, whose brain is rather similar to that of humans, and unique technique developed by the present researchers, neuronal translocation along radial glial fibers to the cerebral cortex during fetal brain development has been discovered to be aberrant, which suggests the cause underlying TD. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 17, 2017 Category: Science Source Type: news
Abnormal development of the brain in an intractable disease, thanatophoric dysplasia
In this study, by combining ferrets, whose brain is rather similar to that of humans, and unique technique developed by the present researchers, neuronal translocation along radial glial fibers to the cerebral cortex during fetal brain development has been discovered to be aberrant, which suggests the cause underlying TD. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 17, 2017 Category: Global & Universal Source Type: news
[Perspective] Hematopoietic stem cells gone rogue
Cardiovascular disease is considered to be an aging-related disease and is the leading cause of death in the elderly in developed countries (1). As of 2013, 65% of deaths attributed to cardiovascular disease occurred among patients 75 years and older. A hallmark of aging is the accumulation of somatic DNA mutations in proliferative tissue. Although somatic mutations in the hematopoietic (blood cell) system are frequently observed in patients with hematological cancers, there is also a close correlation between hematopoietic somatic mutations and increased incidence of diabetes, atherosclerosis, and cardiovascular disease-r...
Source: ScienceNOW - February 23, 2017 Category: Science Authors: Yanfang Peipei Zhu Tags: Cardiovascular Disease Source Type: news
Targeted sequencing of FKBP5 in suicide attempters with bipolar disorder - Breen ME, Gaynor SC, Monson ET, de Klerk K, Parsons MG, Braun TA, DeLuca AP, Zandi PP, Potash JB, Willour VL.
FKBP5 is a critical component of the Hypothalamic-Pituitary-Adrenal (HPA) axis, a system which regulates our response to stress. It forms part of a complex of chaperones, which inhibits binding of cortisol and glucocorticoid receptor translocation to the n... (Source: SafetyLit)
Source: SafetyLit - January 5, 2017 Category: Global & Universal Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
[Editors' Choice] NIK sends mitochondria to the periphery
The kinase NIK promotes tumor cell invasion by stimulating the translocation of mitochondria to the cell periphery. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - January 3, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news
[Research Article] The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor
The kinase AXL promotes cetuximab resistance by promoting the nuclear accumulation of EGFR. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - January 3, 2017 Category: Science Authors: Toni M. Brand, Mari Iida, Kelsey L. Corrigan, Cara M. Braverman, John P. Coan, Bailey G. Flanigan, Andrew P. Stein, Ravi Salgia, Jana Rolff, Randall J. Kimple, Deric L. Wheeler Source Type: news
[Perspective] Spying on the neighbors' pool
The structure and properties of the proton in water are of fundamental importance in many areas of chemistry and biology. The high mobility of the proton in an aqueous solution is understood in terms of its “hopping” between neighboring water molecules, as suggested by the two-century-old Grotthuss mechanism. The barrier for this process intimately depends on the proton's surrounding environment, which is manifested by the connectivity of the immediate hydrogen-bonding network as well as its dynamics caused by thermal fluctuations. On page 1131 of this issue, Wolke et al. (1) shed new light on the role that the proton'...
Source: ScienceNOW - December 1, 2016 Category: Science Authors: Sotiris S. Xantheas Tags: Chemical Physics Source Type: news
[Research Article] A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
Inhibition or genetic deletion of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) is protective against toxic insults in many organ systems. The molecular mechanisms underlying PARP-1–dependent cell death involve release of mitochondrial apoptosis-inducing factor (AIF) and its translocation to the nucleus, which results in chromatinolysis. We identified macrophage migration inhibitory factor (MIF) as a PARP-1–dependent AIF-associated nuclease (PAAN). AIF was required for recruitment of MIF to the nucleus, where MIF cleaves genomic DNA into large fragments. Depletion of MIF, disruption of the AIF-MIF interaction, or mutati...
Source: ScienceNOW - October 6, 2016 Category: Science Authors: Yingfei Wang Source Type: news
Critical But Overlooked: ICU Patients' Gut Bacteria
Paul Wischmeyer
Our bodies are full of bacteria, and when we get sick, those microbial populations change. Hospitals monitor patients' bloodwork and vitals, so why not track the makeup of their microbiomes too? Paul Wischmeyer and his collaborators are conducting research that could allow them to do just that, opening the door for microbiome diagnostic indicators and probiotic measures to restore patients' normal bacterial signatures. We asked him about the research, and what he's learned so far.
This text was edited for length. Read the full interview on ResearchGate News.
ResearchGate: How did you first get involve...
Source: Science - The Huffington Post - September 6, 2016 Category: Science Source Type: news
OriGene's ALK UltraMAB® Antibody (OTI1A4) Outperform D5F3...
Recent Studies Validate High performance and Accurate Results for OriGene's UltraMAB® OTI1A4 as an Effective Screening Tool for ALK Translocation in Lung Adenocarcinomas(PRWeb April 14, 2016)Read the full story at http://www.prweb.com/releases/2016/04/prweb13344220.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - April 15, 2016 Category: Pharmaceuticals Source Type: news
[Report] Activation of proto-oncogenes by disruption of chromosome neighborhoods
Oncogenes are activated through well-known chromosomal alterations such as gene fusion, translocation, and focal amplification. In light of recent evidence that the control of key genes depends on chromosome structures called insulated neighborhoods, we investigated whether proto-oncogenes occur within these structures and whether oncogene activation can occur via disruption of insulated neighborhood boundaries in cancer cells. We mapped insulated neighborhoods in T cell acute lymphoblastic leukemia (T-ALL) and found that tumor cell genomes contain recurrent microdeletions that eliminate the boundary sites of insulated nei...
Source: ScienceNOW - March 24, 2016 Category: Science Authors: Denes Hnisz Source Type: news
