Fight Aging! Newsletter, January 3rd 2022
In this study, we showed that the iPaD (inducing Plagl2 and anti-Dyrk1a) lentivirus substantially rejuvenated the proliferative and neurogenic potential of NSCs in the aged brain. Clonal analysis by a sparse labeling approach as well as transcriptome analysis indicated that iPaD can rejuvenate aged NSCs (19-21 mo of age) to a level comparable with those at 1 or 2 months of age and successfully improved cognition of aged mice.
Once rejuvenated and activated by iPaD, aged dormant NSCs can generate, on average, 4.9 neurons but very few astrocytes in 3-week tracing. Furthermore, these activated NSCs were maintained for ...
Source: Fight Aging! - January 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2021: Progress Towards the Treatment of Aging as a Medical Condition
Well, here we are again, at the end of another pandemic year, a year older and - hopefully - a year wiser and more knowledgeable. I said all that really needs to be said on the topic of COVID-19 as an age-related condition at the end of last year. We might hope that, given widespread vaccination, the pandemic will become a topic of diminishing importance as the year ahead progresses, even given the present round of variants, fears, and reintroduction of restrictions.
Advocacy for Aging Research
Have we finally made significant progress in convincing the world that aging is the cause of age-related disease, th...
Source: Fight Aging! - December 31, 2021 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated.
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity
Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - December 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Adult Disruption of Growth Hormone Receptor in Mice Produces Improved Health and Longevity
Genetic engineering of mouse lineages to produce life-long disruption of growth hormone metabolism, either growth hormone itself or growth hormone receptor, extends life. Animals are smaller, more challenged in maintaining body temperature, have more fat tissue, yet enhanced insulin sensitivity, and exhibit as much as a 70% longer life span. The present record for engineered mouse longevity has been held since 2003 by growth hormone receptor knockout (GHRKO) mice. That this record still stands in 2021 might be taken as a sign that the research and development community are not yet trying hard enough to produce therapies ca...
Source: Fight Aging! - December 2, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Machine Learning Can Make Lab Testing More Precise
An analysis of over 2 billion lab test results suggests a deep learning model can help create personalized reference ranges, which in turn would enable clinicians to monitor health and disease better.Paul Cerrato, MA, senior research analyst and communications specialist, Mayo Clinic Platform and John Halamka, M.D., president, Mayo Clinic Platform, wrote this article.Almost every patient has blood drawn to measure a variety of metabolic markers. Typically, test results come back as a numeric or text value accompanied by a reference range which represents normal values. If total serum cholesterol level is below 200 mg/dl or...
Source: Life as a Healthcare CIO - October 21, 2021 Category: Information Technology Source Type: blogs
Six guidelines to navigate the Aduhelm controversy and (hopefully) help patients with Mild Cognitive Impairment and early-stage Alzheimer ’s Disease
The approval of a controversial new drug for Alzheimer’s disease, Aduhelm, is shining a spotlight on mild cognitive impairment — problems with memory, attention, language or other cognitive tasks that exceed changes expected with normal aging.
After initially indicating that Aduhelm could be prescribed to anyone with dementia, the Food and Drug Administration now specifies that the prescription drug be given to individuals with mild cognitive impairment or early-stage Alzheimer’s, the groups in which the medication was studied.
Yet this narrower recommendation raises questions. What does a diagnosis of mild cognitive...
Source: SharpBrains - October 13, 2021 Category: Neuroscience Authors: Kaiser Health News Tags: Brain/ Mental Health Aduhelm Alzheimer’s Disease attention-problems brain bleeding brain swelling cognitive problems dementia dementia specialists early-stage Alzheimer’s Food and Drug Administration language problems memory pr Source Type: blogs
Fight Aging! Newsletter, September 13th 2021
In this study, mature DCs (mDCs), generated from the GM-CSF and IL-4 induced bone marrow cells, were intravenously injected into wild-type mice. Three days later, assays showed that the mDCs were indeed able to return to the thymus. Homing DCs have been mainly reported to deplete thymocytes and induce tolerance. However, medullary TECs (mTECs) play a crucial role in inducing immune tolerance. Thus, we evaluated whether the mDCs homing into the thymus led to TECs depletion. We cocultured mDCs with mTEC1 cells and found that the mDCs induced the apoptosis and inhibited the proliferation of mTEC1 cells. These effects were onl...
Source: Fight Aging! - September 12, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Quantifying the Effects of a Five Day Fast for Comparison with Fasting Mimicking and Calorie Restriction
One of the more interesting developments of recent years in work on the beneficial effects of calorie restriction in humans is the establishment of an optimal boundary of reduced calorie intake. Can one obtain near all the benefits of fasting by eating a little, and how much is "a little" in this context? That question led to the fasting mimicking diet, supported by evidence for "a little" to be something like 750 calories per day for an averagely sized human, when considering a five day fast or low-calorie diet. As researchers note here, improvements in many metabolic parameters are not very different when considering fas...
Source: Fight Aging! - September 9, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Protein and Brain Health: What to Know
In this study of over five hundred seniors, those who consumed 120 grams of protein daily had lower levels of amyloid-beta than those whose daily intake was only fifty-four grams.
But that’s not all. Another study of 920 seniors showed that those who follow a high-protein diet, along with plenty of leafy greens and healthy fats, also had a decreased risk of dementia and improved cognitive function.
Unfortunately, it’s not entirely clear how protein influences the level of amyloid-beta in the brain. Some believe it’s the effects of a high-protein diet for lowering blood pressure and improving heart health. In ge...
Source: PickTheBrain | Motivation and Self Improvement - August 15, 2021 Category: Consumer Health News Authors: Nicole McCray Tags: diet featured health and fitness self-improvement brain health protein Source Type: blogs
AI and Multispectral Photoacoustic Imaging to Diagnose Thyroid Cancer
This study is significant in that it is the first to acquire photoacoustic images of thyroid nodules and classify malignant nodules using machine learning,” said Chulhong Kim, a researcher involved in the study, in a Pohang press release. “In addition to minimizing unnecessary biopsies in thyroid cancer patients, this technique can also be applied to a variety of other cancers, including breast cancer.”
“The ultrasonic device based on photoacoustic imaging will be helpful in effectively diagnosing thyroid cancer commonly found during health checkups and in reducing the number of biopsies,” ...
Source: Medgadget - July 13, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Oncology Radiology Source Type: blogs
Why “Radiopharmaceutical” Should be Part of your Healthcare Vocabulary
By JAY T. RIPTON
Not to sound too alarmist, but the radiopharmaceutical industry is on the verge of an explosion. But don’t worry; it’s not the type of explosion one often associates with nuclear materials… I love those movies too! It’s the beginning of a new wave of innovation for the diagnosis and treatment of certain cancers and other diseases.
This new radiopharmaceutical boom quite literally has the life sciences industry in a nuclear arms race of sorts, as companies like Y-mAbs, Novartis and others are pushing through clinical trials for the next blockbuster for the treatment and detection of hard-t...
Source: The Health Care Blog - June 14, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice jay t ripton nuclear medicine radiation oncology radiopharmaceuticals Source Type: blogs
6 Ways Our Bodies Try to Tell Us Something is Wrong
Your body is a pretty incredible specimen, if you think about it. So many different systems work in tandem to keep you alive and well.
Still, things can go wrong — and a machine as finely tuned as the human body has its ways of telling you that it needs your attention. Some are quite obvious, and you’ve probably experienced them. But sometimes, the message is much more subtle.
Here are six of the more unexpected ways your body might be telling you that something’s up — and what each sign means for you and your health.
1. Your Eyes Have Gone Dry
Normally, your eyes would stay lubricated with yo...
Source: PickTheBrain | Motivation and Self Improvement - June 3, 2021 Category: Consumer Health News Authors: Kara Reynolds Tags: featured health and fitness self-improvement mental health rest Source Type: blogs
Pumping Iron: The Heavy Lifting Iron Does in Our Bodies
Our blood appears red for the same reason the planet Mars does: iron. The element may bring to mind cast-iron pans, wrought-iron fences, or ancient iron tools, but it’s also essential to life on Earth. All living organisms, from humans to bacteria, need iron. It’s crucial for many processes in the human body, including oxygen transport, muscle function, proper growth, cell health, and the production of several hormones.
Iron is the reason both our blood and the planet Mars appear red. The element also makes up the majority of Earth’s core and generates the planet’s magnetic field. Credit: Compound Interest....
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - May 5, 2021 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Cellular Processes Proteins Source Type: blogs
Fight Aging! Newsletter, March 29th 2021
Discussion of Systemic Inflammation and its Contribution to Dementia
Fisetin Reduces D-Galactose Induced Cognitive Loss in Mice
Reprogramming Cancer Cells into Normal Somatic Cells
Considering Longevity Medicine and the Education of Physicians
Researchers Generate Thyroid Organoids Capable of Restoring Function in Mice
In Search of Transcriptional Signatures of Aging
A Pace of Aging Biomarker Correlates with Manifestations of Aging
Targeting Tissues with Extracellular Vesicles
Calorie Restriction Slows Aging of the Gut Microbiome in Mice
Mitochondrial DNA Heteroplasmy in the Aging Heart
Evidence...
Source: Fight Aging! - March 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
