Metaphyseal trauma of the lower extremities in major orthopedic surgery as an independent risk factor for deep vein thrombosis
ConclusionMetaphyseal bone trauma in the hip and knee major orthopedic surgery is an independent risk factor for deep vein thrombosis. (Source: European Journal of Orthopaedic Surgery and Traumatology)
Source: European Journal of Orthopaedic Surgery and Traumatology - May 23, 2024 Category: Orthopaedics Source Type: research
Structure and pharmacokinetics/pharmacodynamics of the anticoagulant tetradecasaccharide oHG-14 as an intrinsic tenase inhibitor
The intrinsic tenase complex (iXase) is an attractive antithrombotic target to treat or prevent pathological thrombosis with negligible bleeding risk. Fucosylated glycosaminoglycan (FG) is a promising anticoagulant by inhibiting iXase. A depolymerized FG (dHG-5) as an anticoagulant has been approved for clinical trials. Given that dHG-5 is a multi-component drug candidate consisting of a homologous series of oligosaccharides, it is difficult to predict a clear pharmacokinetics. Here, as a major oligosaccharide component, the tetradecasaccharide (oHG-14) was purified from dHG-5 and its structure was defined as L-Fuc3S4S- α...
Source: Thrombosis Research - May 23, 2024 Category: Hematology Authors: Taocui Zhang, Lisha Lin, Lin Ren, Huifang Sun, Weili Wang, Shuang Liu, Shanni Li, Chuang Xiao, Na Gao, Jinhua Zhao Tags: Full Length Article Source Type: research
Translating proof-of-concept for platelet slip into improved antithrombotic therapeutic regimens
Platelets. 2024 Dec;35(1):2353582. doi: 10.1080/09537104.2024.2353582. Epub 2024 May 22.ABSTRACTPlatelets are central to thrombosis. Research at the intersection of biological and physical sciences provides proof-of-concept for shear rate-dependent platelet slip at vascular stenosis and near device surfaces. Platelet slip extends the observed biological "slip-bonds" to the boundary of functional gliding without contact. As a result, there is diminished engagement of the coagulation cascade by platelets at these surfaces. Comprehending platelet slip would more precisely direct antithrombotic regimens for different shear env...
Source: Platelets - May 22, 2024 Category: Hematology Authors: Scott J Denardo Pavlos P Vlachos Brett A Meyers Reza Babakhani-Galangashi Lin Wang Zejin Gao James E Tcheng Source Type: research
Comparison of Efficacy between Pemafibrate and Omega-3-Acid Ethyl Ester in the Liver: the PORTRAIT Study
CONCLUSIONS: Pemafibrate is recommended over omega-3-acid ethyl ester for lipid management and MASLD treatment in patients with hypertriglyceridemia complicated by MASLD. The study results may contribute to the development of future treatment strategies for patients with MASLD/MASH.PMID:38777770 | DOI:10.5551/jat.64896 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 22, 2024 Category: Cardiology Authors: Yoshio Sumida Hidenori Toyoda Satoshi Yasuda Satoshi Kimoto Kazumasa Sakamoto Yukiomi Nakade Kiyoaki Ito Takeshi Osonoi Masashi Yoneda Source Type: research
Translating proof-of-concept for platelet slip into improved antithrombotic therapeutic regimens
Platelets. 2024 Dec;35(1):2353582. doi: 10.1080/09537104.2024.2353582. Epub 2024 May 22.ABSTRACTPlatelets are central to thrombosis. Research at the intersection of biological and physical sciences provides proof-of-concept for shear rate-dependent platelet slip at vascular stenosis and near device surfaces. Platelet slip extends the observed biological "slip-bonds" to the boundary of functional gliding without contact. As a result, there is diminished engagement of the coagulation cascade by platelets at these surfaces. Comprehending platelet slip would more precisely direct antithrombotic regimens for different shear env...
Source: Platelets - May 22, 2024 Category: Hematology Authors: Scott J Denardo Pavlos P Vlachos Brett A Meyers Reza Babakhani-Galangashi Lin Wang Zejin Gao James E Tcheng Source Type: research
Comparison of Efficacy between Pemafibrate and Omega-3-Acid Ethyl Ester in the Liver: the PORTRAIT Study
CONCLUSIONS: Pemafibrate is recommended over omega-3-acid ethyl ester for lipid management and MASLD treatment in patients with hypertriglyceridemia complicated by MASLD. The study results may contribute to the development of future treatment strategies for patients with MASLD/MASH.PMID:38777770 | DOI:10.5551/jat.64896 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 22, 2024 Category: Cardiology Authors: Yoshio Sumida Hidenori Toyoda Satoshi Yasuda Satoshi Kimoto Kazumasa Sakamoto Yukiomi Nakade Kiyoaki Ito Takeshi Osonoi Masashi Yoneda Source Type: research
Translating proof-of-concept for platelet slip into improved antithrombotic therapeutic regimens
Platelets. 2024 Dec;35(1):2353582. doi: 10.1080/09537104.2024.2353582. Epub 2024 May 22.ABSTRACTPlatelets are central to thrombosis. Research at the intersection of biological and physical sciences provides proof-of-concept for shear rate-dependent platelet slip at vascular stenosis and near device surfaces. Platelet slip extends the observed biological "slip-bonds" to the boundary of functional gliding without contact. As a result, there is diminished engagement of the coagulation cascade by platelets at these surfaces. Comprehending platelet slip would more precisely direct antithrombotic regimens for different shear env...
Source: Platelets - May 22, 2024 Category: Hematology Authors: Scott J Denardo Pavlos P Vlachos Brett A Meyers Reza Babakhani-Galangashi Lin Wang Zejin Gao James E Tcheng Source Type: research
Outcomes with treatment interventions for clot-in-transit in patients with pulmonary embolism: a meta-analysis
CONCLUSIONS: In this meta-analysis of patients with CIT and PE, the highest mortality was observed with AC alone, followed by surgical thrombectomy, CBT, and ST therapy. However, there remains a need for randomized clinical trial data to determine the best treatment.PMID:38776476 | DOI:10.25270/jic/24.00089 (Source: The Journal of Invasive Cardiology)
Source: The Journal of Invasive Cardiology - May 22, 2024 Category: Cardiology Authors: Muhammad Haisum Maqsood Robert S Zhang David M Zlotnick Sahil A Parikh Sripal Bangalore Source Type: research
Comparison of Efficacy between Pemafibrate and Omega-3-Acid Ethyl Ester in the Liver: the PORTRAIT Study
CONCLUSIONS: Pemafibrate is recommended over omega-3-acid ethyl ester for lipid management and MASLD treatment in patients with hypertriglyceridemia complicated by MASLD. The study results may contribute to the development of future treatment strategies for patients with MASLD/MASH.PMID:38777770 | DOI:10.5551/jat.64896 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 22, 2024 Category: Cardiology Authors: Yoshio Sumida Hidenori Toyoda Satoshi Yasuda Satoshi Kimoto Kazumasa Sakamoto Yukiomi Nakade Kiyoaki Ito Takeshi Osonoi Masashi Yoneda Source Type: research
Antidote-controlled DNA aptamer modulates human factor IXa activity
Bioorg Chem. 2024 May 19;148:107463. doi: 10.1016/j.bioorg.2024.107463. Online ahead of print.ABSTRACTThrombosis leads to elevated mortality rates and substantial medical expenses worldwide. Human factor IXa (HFIXa) protease is pivotal in tissue factor (TF)-mediated thrombin generation, and represents a promising target for anticoagulant therapy. We herein isolated novel DNA aptamers that specifically bind to HFIXa through systematic evolution of ligands by exponential enrichment (SELEX) method. We identified two distinct aptamers, seq 5 and seq 11, which demonstrated high binding affinity to HFIXa (Kd = 74.07 ± 2.53 nM, ...
Source: Bioorganic Chemistry - May 22, 2024 Category: Chemistry Authors: Liang Fang Jin Jin Zhe Zhang Shuang Yu Cheng Tian Fukang Luo Mengfei Long Hua Zuo Shifeng Lou Source Type: research
Dehydration in cerebral venous sinus thrombosis
CONCLUSION: High levels of USG, especially USG >1.013, were more common in patients with CVST. Dehydration-related indices could not characterize CVST and were not associated with CVST severity and prognosis.PMID:38775183 | PMC:PMC11110100 | DOI:10.1111/cns.14760 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 22, 2024 Category: Neuroscience Authors: Jiayue Ding Duo Lan Xiaoming Zhang Xiangyu Li Yanli Duan Xiaobing Tian Zhangyuan Liao Xuanye Yue Ming Zou Ran Meng Source Type: research
Translating proof-of-concept for platelet slip into improved antithrombotic therapeutic regimens
Platelets. 2024 Dec;35(1):2353582. doi: 10.1080/09537104.2024.2353582. Epub 2024 May 22.ABSTRACTPlatelets are central to thrombosis. Research at the intersection of biological and physical sciences provides proof-of-concept for shear rate-dependent platelet slip at vascular stenosis and near device surfaces. Platelet slip extends the observed biological "slip-bonds" to the boundary of functional gliding without contact. As a result, there is diminished engagement of the coagulation cascade by platelets at these surfaces. Comprehending platelet slip would more precisely direct antithrombotic regimens for different shear env...
Source: Platelets - May 22, 2024 Category: Hematology Authors: Scott J Denardo Pavlos P Vlachos Brett A Meyers Reza Babakhani-Galangashi Lin Wang Zejin Gao James E Tcheng Source Type: research
Gelsolin regulates receptor-mediated and fluid-phase endocytosis in platelets
CONCLUSION: Our study demonstrates that Gsn plays a key role in the uptake of bioactive mediators by platelets.PMID:38777258 | DOI:10.1016/j.jtha.2024.05.010 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - May 22, 2024 Category: Hematology Authors: Manoj Paul Felix Hong Herv é Falet Hugh Kim Source Type: research
Fibrinogen binding to histones in circulation protects against adverse cellular and clinical outcomes
CONCLUSION: Fibrinogen buffers the cytotoxic properties of circulating histones. Detection and monitoring of circulating histones and histones:fibrinogen ratios will identify critically ill patients at highest risk of adverse outcomes who might benefit from anti-histone therapy.PMID:38777257 | DOI:10.1016/j.jtha.2024.05.009 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - May 22, 2024 Category: Hematology Authors: Julien M Toh Jun Yong Simon T Abrams Lijun Wang Jeremy Schofield Steven Lane Amy Cilia La Corte Susan S Wang Robert As Ari ëns Helen Philippou Jianfeng Xie Weiping Yu Guozheng Wang Cheng-Hock Toh Source Type: research
Comparison of Efficacy between Pemafibrate and Omega-3-Acid Ethyl Ester in the Liver: the PORTRAIT Study
CONCLUSIONS: Pemafibrate is recommended over omega-3-acid ethyl ester for lipid management and MASLD treatment in patients with hypertriglyceridemia complicated by MASLD. The study results may contribute to the development of future treatment strategies for patients with MASLD/MASH.PMID:38777770 | DOI:10.5551/jat.64896 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 22, 2024 Category: Cardiology Authors: Yoshio Sumida Hidenori Toyoda Satoshi Yasuda Satoshi Kimoto Kazumasa Sakamoto Yukiomi Nakade Kiyoaki Ito Takeshi Osonoi Masashi Yoneda Source Type: research
