Prospective Observational Evaluation of Fixed Combination Calcipotriol/Betamethasone Aerosol Foam (Enstilar ®) in the Management of Psoriasis with Scalp Involvement in Everyday Clinical Practice (the CAPITIS Study)
Conclusion: This study demonstrated the effectiveness, rapid onset of action, good tolerability, and good safety profile of the Cal/BD aerosol foam in patients with scalp psoriasis treated in a real-world setting.Dermatology (Source: Dermatology)
Source: Dermatology - January 30, 2023 Category: Dermatology Source Type: research
New options to manage epidermolysis bullosa
Wounds. 2022 Dec;34(12):297-299.ABSTRACTRDEB is a genetic skin disorder involving COL7A1, the gene encoding C7, which is a component of the fibers anchoring the epidermis to the dermis. Affected patients (about 1.35 per million persons in the United States) experience lifelong painful itching, blistering, fibrosis, impaired healing, and scarring, with increased likelihood of infection and cancer. RCT involving those affected by RDEB are rare with limited sample sizes due to the low prevalence of this genetic disorder. Treatment with topical or systemic agents has not consistently improved patient outcomes. Therapies focuse...
Source: Wounds - January 11, 2023 Category: General Medicine Authors: Laura Bolton Source Type: research
[ASAP] Novel Synergistic Approach: Tazarotene-Calcipotriol-Loaded-PVA/PVP-Nanofibers Incorporated in Hydrogel Film for Management and Treatment of Psoriasis
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.2c00713 (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - January 11, 2023 Category: Drugs & Pharmacology Authors: Sunita Thakur, Md Meraj Anjum, Shweta Jaiswal, Anand Kumar, Payal Deepak, Sneha Anand, Sanjay Singh, and Paruvathanahalli Siddalingam Rajinikanth Source Type: research
Expert Consensus on Real-World Use and Consumption Patterns of a Fixed-Dose Combination Foam for Psoriasis as a Reactive Management (RM) and Proactive Management (PAM) Regimen
ConclusionThis modified-Delphi study confirms that prescription of RM or PAM, with Cal/BD foam, is largely driven by patient-related factors and patient involvement is key to optimise outcomes. Real-world experiences captured in this study suggest that a PAM regimen does not increase overall consumption, and thus costs per patient for payers and prescribers, in comparison to RM. (Source: Advances in Therapy)
Source: Advances in Therapy - January 10, 2023 Category: Drugs & Pharmacology Source Type: research
Dissolvable microneedles for transdermal drug delivery showing skin pentation and modified drug release
In this study the depot effect and skin penetration of an innovative dissolvable MN patch was assessed by insertion in ex vivo human skin and in vivo using minipigs. The MN patches are based on biodegradable polymers and the active pharmaceutical ingredients calcipotriol (Calci) and betamethasone-17-21-dipropionate (BDP) used to treat psoriasis. Using computed tomography (CT) and coherent anti-Stokes Raman scattering (CARS) microscopy it was possible to visualize the skin penetration and follow the morphology of the MN as function of time in the skin. The depot effect was assessed by studying the modified in vitro release ...
Source: European Journal of Pharmaceutical Sciences - January 9, 2023 Category: Drugs & Pharmacology Authors: Irina Iachina Andr é H Eriksson Malene Bertelsen Karsten Petersson J örgen Jansson Pernille Kemp Karen M Engell Jonathan R Brewer Kim T Nielsen Source Type: research
Dissolvable microneedles for transdermal drug delivery showing skin pentation and modified drug release
In this study the depot effect and skin penetration of an innovative dissolvable MN patch was assessed by insertion in ex vivo human skin and in vivo using minipigs. The MN patches are based on biodegradable polymers and the active pharmaceutical ingredients calcipotriol (Calci) and betamethasone-17-21-dipropionate (BDP) used to treat psoriasis. Using computed tomography (CT) and coherent anti-Stokes Raman scattering (CARS) microscopy it was possible to visualize the skin penetration and follow the morphology of the MN as function of time in the skin. The depot effect was assessed by studying the modified in vitro release ...
Source: European Journal of Pharmaceutical Sciences - January 9, 2023 Category: Drugs & Pharmacology Authors: Irina Iachina Andr é H Eriksson Malene Bertelsen Karsten Petersson J örgen Jansson Pernille Kemp Karen M Engell Jonathan R Brewer Kim T Nielsen Source Type: research
Dissolvable microneedles for transdermal drug delivery showing skin pentation and modified drug release
In this study the depot effect and skin penetration of an innovative dissolvable MN patch was assessed by insertion in ex vivo human skin and in vivo using minipigs. The MN patches are based on biodegradable polymers and the active pharmaceutical ingredients calcipotriol (Calci) and betamethasone-17-21-dipropionate (BDP) used to treat psoriasis. Using computed tomography (CT) and coherent anti-Stokes Raman scattering (CARS) microscopy it was possible to visualize the skin penetration and follow the morphology of the MN as function of time in the skin. The depot effect was assessed by studying the modified in vitro release ...
Source: European Journal of Pharmaceutical Sciences - January 9, 2023 Category: Drugs & Pharmacology Authors: Irina Iachina Andr é H Eriksson Malene Bertelsen Karsten Petersson J örgen Jansson Pernille Kemp Karen M Engell Jonathan R Brewer Kim T Nielsen Source Type: research
Supersaturation as a Galenic Concept for Improving the Cutaneous Bioavailability of Drugs in Topical Therapy
AbstractThe essential force that allows an epicutaneously applied drug to penetrate the skin is mediated by diffusion. The physicochemical properties of the skin tissue at the site of application and the concentration gradient of the dissolved drug between the vehicle and the stratum corneum are decisive here. One way to specifically improve these diffusion conditions is to use supersaturation. This uses the physical principle of the difference between the solubility curve and precipitation curve (Ostwald-Miers range). During the conversion of the application vehicle into the segregation vehicle, supersaturation of the dis...
Source: Dermatology and Therapy - December 21, 2022 Category: Dermatology Source Type: research
Prevention of Skin Cancers With Topical Calcipotriol and Fluorouracil in Patients With Xeroderma Pigmentosum
This case report describes treatment regimens with topical calcipotriol plus fluorouracil for 2 patients with xeroderma pigmentosum. (Source: JAMA Dermatology)
Source: JAMA Dermatology - December 21, 2022 Category: Dermatology Source Type: research
Supersaturation as a Galenic Concept for Improving the Cutaneous Bioavailability of Drugs in Topical Therapy
AbstractThe essential force that allows an epicutaneously applied drug to penetrate the skin is mediated by diffusion. The physicochemical properties of the skin tissue at the site of application and the concentration gradient of the dissolved drug between the vehicle and the stratum corneum are decisive here. One way to specifically improve these diffusion conditions is to use supersaturation. This uses the physical principle of the difference between the solubility curve and precipitation curve (Ostwald-Miers range). During the conversion of the application vehicle into the segregation vehicle, supersaturation of the dis...
Source: Dermatology and Therapy - December 21, 2022 Category: Dermatology Source Type: research
Breast Milk ‐Derived Limosilactobacillus reuteri Prevents Atopic Dermatitis in Mice via Activating Retinol Absorption and Metabolism in Peyer's Patches
ConclusionsFn041 induces anti-AD immune responses directly by promoting the absorption and metabolism of retinol in Peyer's patches, and plays an indirect role by strengthening the mucosal barrier and increasing the abundance of specific anti-AD bacteria in the cecum. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - December 8, 2022 Category: Food Science Authors: Ce Qi,
Huayu Tu,
Yuning Zhao,
Jingbo Zhou,
Jie Chen,
Haiting Hu,
Renqiang Yu,
Jin Sun Tags: Research Article Source Type: research
