Matching-Adjusted Indirect Comparison of Long-Term Efficacy and Safety Outcomes for Calcipotriol Plus Betamethasone Dipropionate Foam Versus Halobetasol Proprionate Plus Tazarotene Lotion in the Treatment of Plaque Psoriasis
ConclusionsCal/BD aerosol foam demonstrated significantly greater efficacy than HP/Taz lotion, and had a more favorable safety profile, compared with HP/Taz lotion, for up to 52 weeks. Proactive Cal/BD foam maintenance therapy and reactive use of Cal/BD foam following relapse both had significant advantages over HP/Taz lotion. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - October 12, 2022 Category: Dermatology Source Type: research
Therapeutic escalation in a case of nevoid hyperkeratosis of the areola and the nipple
We described the case of a 26-year-old woman with bilateral nevoid hyperkeratosis of the NAC. Several lines of treatment have been used with varying efficacy: conservative (calcipotriol and local retinoids), semi-conservative (CO2 laser) and surgical (excision and total skin graft). The final result is very satisfactory and without recurrence at 1 year follow-up.PMID:36114083 | DOI:10.1016/j.anplas.2022.08.004 (Source: Annales de Chirurgie)
Source: Annales de Chirurgie - September 16, 2022 Category: Surgery Authors: T de La âge de Meux V Pinsolle A Michot Y B élaroussi J Fray Source Type: research
Therapeutic escalation in a case of nevoid hyperkeratosis of the areola and the nipple
We described the case of a 26-year-old woman with bilateral nevoid hyperkeratosis of the NAC. Several lines of treatment have been used with varying efficacy: conservative (calcipotriol and local retinoids), semi-conservative (CO2 laser) and surgical (excision and total skin graft). The final result is very satisfactory and without recurrence at 1 year follow-up.PMID:36114083 | DOI:10.1016/j.anplas.2022.08.004 (Source: Annales de Chirurgie Plastique et Esthetique)
Source: Annales de Chirurgie Plastique et Esthetique - September 16, 2022 Category: Cosmetic Surgery Authors: T de La âge de Meux V Pinsolle A Michot Y B élaroussi J Fray Source Type: research
Therapeutic escalation in a case of nevoid hyperkeratosis of the areola and the nipple
We described the case of a 26-year-old woman with bilateral nevoid hyperkeratosis of the NAC. Several lines of treatment have been used with varying efficacy: conservative (calcipotriol and local retinoids), semi-conservative (CO2 laser) and surgical (excision and total skin graft). The final result is very satisfactory and without recurrence at 1 year follow-up.PMID:36114083 | DOI:10.1016/j.anplas.2022.08.004 (Source: Annales de Chirurgie)
Source: Annales de Chirurgie - September 16, 2022 Category: Surgery Authors: T de La âge de Meux V Pinsolle A Michot Y B élaroussi J Fray Source Type: research
Therapeutic escalation in a case of nevoid hyperkeratosis of the areola and the nipple
We described the case of a 26-year-old woman with bilateral nevoid hyperkeratosis of the NAC. Several lines of treatment have been used with varying efficacy: conservative (calcipotriol and local retinoids), semi-conservative (CO2 laser) and surgical (excision and total skin graft). The final result is very satisfactory and without recurrence at 1 year follow-up.PMID:36114083 | DOI:10.1016/j.anplas.2022.08.004 (Source: Annales de Chirurgie Plastique et Esthetique)
Source: Annales de Chirurgie Plastique et Esthetique - September 16, 2022 Category: Cosmetic Surgery Authors: T de La âge de Meux V Pinsolle A Michot Y B élaroussi J Fray Source Type: research
Therapeutic escalation in a case of nevoid hyperkeratosis of the areola and the nipple
We described the case of a 26-year-old woman with bilateral nevoid hyperkeratosis of the NAC. Several lines of treatment have been used with varying efficacy: conservative (calcipotriol and local retinoids), semi-conservative (CO2 laser) and surgical (excision and total skin graft). The final result is very satisfactory and without recurrence at 1 year follow-up.PMID:36114083 | DOI:10.1016/j.anplas.2022.08.004 (Source: Annales de Chirurgie)
Source: Annales de Chirurgie - September 16, 2022 Category: Surgery Authors: T de La âge de Meux V Pinsolle A Michot Y B élaroussi J Fray Source Type: research
An anchored matching-adjusted indirect comparison of fixed-dose combination calcipotriol and betamethasone dipropionate (Cal/BDP) cream versus Cal/BDP foam for the treatment of psoriasis
CONCLUSIONS: Cal/BDP cream and Cal/BDP foam have equivalent efficacy and HRQoL (measured in DLQI) outcomes when used for the topical treatment of plaque psoriasis at their recommended treatment durations. Comparison of treatment satisfaction assessments after 1 week of treatment, demonstrated that patients find Cal/BDP cream to be more convenient than foam.PMID:36036596 | DOI:10.1080/09546634.2022.2116924 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 29, 2022 Category: Dermatology Authors: Anthony Bewley Erin Barker Hannah Baker Will Green Brooke Avey Aina Pi-Blanque Jordi Galv án Paw Trebbien Morten Praestegaard Source Type: research
Calcipotriol, a synthetic Vitamin D analog, promotes antitumor immunity via CD4+T-dependent CTL/NK cell activation
Biomed Pharmacother. 2022 Aug 19;154:113553. doi: 10.1016/j.biopha.2022.113553. Online ahead of print.ABSTRACTTo overcome the hurdles of immunotherapy, we investigated whether calcipotriol, a synthetic vitamin D analog, could overcome the immune evasion of glioblastoma multiforme (GBM) by modulating immune responses and the immunosuppressive tumor microenvironment. Administration of calcipotriol considerably reduced tumor growth. Both in vivo and in vitro studies revealed that CD8+T and natural killer (NK) cell gene signatures were enriched and activated, producing high levels of IFN-γ and granzyme B. In contrast, regulat...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 22, 2022 Category: Drugs & Pharmacology Authors: Hyungsin Kim Jeongsoo Kim Jason K Sa Byung-Kyu Ryu Kyung-Jae Park Jiyoung Kim Hyojeong Ha Yejin Park Min Hwa Shin Jungwon Kim Hyemin Lee Daham Kim Kyunghye Lee Byunghyun Jang Kyung-Mi Lee Shin-Hyuk Kang Source Type: research
Calcipotriol, a synthetic Vitamin D analog, promotes antitumor immunity via CD4+T-dependent CTL/NK cell activation
Biomed Pharmacother. 2022 Aug 19;154:113553. doi: 10.1016/j.biopha.2022.113553. Online ahead of print.ABSTRACTTo overcome the hurdles of immunotherapy, we investigated whether calcipotriol, a synthetic vitamin D analog, could overcome the immune evasion of glioblastoma multiforme (GBM) by modulating immune responses and the immunosuppressive tumor microenvironment. Administration of calcipotriol considerably reduced tumor growth. Both in vivo and in vitro studies revealed that CD8+T and natural killer (NK) cell gene signatures were enriched and activated, producing high levels of IFN-γ and granzyme B. In contrast, regulat...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 22, 2022 Category: Drugs & Pharmacology Authors: Hyungsin Kim Jeongsoo Kim Jason K Sa Byung-Kyu Ryu Kyung-Jae Park Jiyoung Kim Hyojeong Ha Yejin Park Min Hwa Shin Jungwon Kim Hyemin Lee Daham Kim Kyunghye Lee Byunghyun Jang Kyung-Mi Lee Shin-Hyuk Kang Source Type: research
Calcipotriol, a synthetic Vitamin D analog, promotes antitumor immunity via CD4+T-dependent CTL/NK cell activation
Biomed Pharmacother. 2022 Aug 19;154:113553. doi: 10.1016/j.biopha.2022.113553. Online ahead of print.ABSTRACTTo overcome the hurdles of immunotherapy, we investigated whether calcipotriol, a synthetic vitamin D analog, could overcome the immune evasion of glioblastoma multiforme (GBM) by modulating immune responses and the immunosuppressive tumor microenvironment. Administration of calcipotriol considerably reduced tumor growth. Both in vivo and in vitro studies revealed that CD8+T and natural killer (NK) cell gene signatures were enriched and activated, producing high levels of IFN-γ and granzyme B. In contrast, regulat...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 22, 2022 Category: Drugs & Pharmacology Authors: Hyungsin Kim Jeongsoo Kim Jason K Sa Byung-Kyu Ryu Kyung-Jae Park Jiyoung Kim Hyojeong Ha Yejin Park Min Hwa Shin Jungwon Kim Hyemin Lee Daham Kim Kyunghye Lee Byunghyun Jang Kyung-Mi Lee Shin-Hyuk Kang Source Type: research
Efficacy of Calcipotriol/Betamethasone Dipropionate Fixed-Combination Aerosol Foam in the Treatment of Localized Scalp Psoriasis: A Real-Life Case Series from Switzerland
ConclusionOur case series confirms that Cal/BD foam is a rapid, effective, and convenient treatment for localized scalp psoriasis in a nonselected real-world patient cohort refractory to TCS or other local treatments. Clear application instructions are crucial for treatment success and cosmetic acceptance, however. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 20, 2022 Category: Dermatology Source Type: research
Hyaluronic Acid Filler Injection for Localized Scleroderma - Case Report and Review of Literature on Filler Injections for Localized Scleroderma
CONCLUSION: Hyaluronic acid filler can be used safely in cases of stable localized scleroderma with facial atrophies. It is an effective, minimally invasive treatment with minimal downtime. It is extremely important to inject fillers only in stable cases of localized morphea. This modality of treatment should be considered for a larger trial in patients with similar disfigurements.PMID:35983128 | PMC:PMC9379108 | DOI:10.2147/CCID.S356641 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - August 19, 2022 Category: Dermatology Authors: Jaishree Sharad Source Type: research
