Neutrophil recruitment by CD4 tissue-resident memory T cells induces chronic recurrent inflammation in atopic dermatitis
CONCLUSIONS: We have established a novel, chronic recurrent mouse model for investigating TRM cells in AD. Our findings demonstrate that CD4+TRM cells in the skin mediate early flare-up response during AD recurrence and influence the chronic recurrent inflammation of AD by recruiting neutrophils. Targeting CD4+TRM cells may represent a promising approach for the treatment of chronic recurrent inflammation in AD.PMID:37832861 | DOI:10.1016/j.clim.2023.109805 (Source: Clinical Immunology)
Source: Clinical Immunology - October 13, 2023 Category: Allergy & Immunology Authors: Chunjiao Zheng Ting Cao Chengbin Ye Ying Zou Source Type: research
Calcipotriol suppresses GPX4-mediated ferroptosis in OA chondrocytes by blocking the TGF- β1 pathway
In this study, western blotting, quantitative reverse-transcription polymerase chain reaction, and immunofluorescence analysis were performed to elucidate the molecular mechanisms by which calcipotriol alleviates chondrocyte ferroptosis. The effect of calcipotriol on reactive oxygen species and lipid peroxidation levels in chondrocytes was assessed using dihydroethidium staining and the fluorescent dye BODIPY. To replicate OA, the destabilized medial meniscus model was employed, followed by the injection of calcipotriol into the knee articular cavity. Morphological analysis was conducted through hematoxylin and eosin stain...
Source: Cytokine - October 2, 2023 Category: Molecular Biology Authors: Zhicheng Yang Wei Jiang Chenwei Xiong JingJing Shang Yong Huang Xindie Zhou Su Zhang Source Type: research
Transcriptional signature of islet neogenesis-associated protein peptide-treated rat pancreatic islets reveals induction of novel long non-coding RNAs
ConclusionsOur results reveal the transcriptional program that could explain the enhancement of INGAP-PP-mediated physiological effects on β-cell mass and function. We identified novel lncRNAs that are induced by INGAP-PP in rat islets, some of which are selectively expressed in pancreatic β-cells and downregulated by IL1β treatment of INS-1 cells. Our results suggest a relevant function for Ri-lnc1 in β-cells. These findings are expected to provide the basis for a deeper understanding of islet translational results from rodents to humans, with the ultimate goal of designing new therapies for people with diabetes. (Sou...
Source: Frontiers in Endocrinology - September 29, 2023 Category: Endocrinology Source Type: research
Calcipotriol and Betamethasone Dipropionate Cream Based on PAD Technology for the Treatment of Plaque Psoriasis: A Narrative Review
This article aims to summarize the most relevant published evidence about CAL/BDP PAD-cream and its underlying PAD Technology. The PAD Technology enables CAL and BDP stability in an aqueous cream through a multimolecular shell structure, as well as it increases the penetration of both active ingredients into the epidermis and dermis. This technology also demonstrated to increase the cosmetic acceptability and to provide the desirable sensory properties for a topical psoriasis treatment. Two phase III clinical trials have been conducted so far with CAL/BDP PAD-cream. Findings from both trials revealed high efficacy with a f...
Source: Dermatology and Therapy - September 23, 2023 Category: Dermatology Source Type: research
Topical Calcipotriol Plus Imiquimod Immunotherapy for Nonkeratinocyte Skin Cancers
In this study, we demonstrate that topical TSLP cytokine inducers-calcipotriol and retinoic acid-synergize with IMQ to activate CD4+ T-cell immunity against nonkeratinocyte cutaneous malignancies. Topical calcipotriol plus IMQ treatment reduced breast tumor growth compared with calcipotriol or IMQ alone (P < 0.0001). Calcipotriol plus IMQ-mediated tumor suppression was associated with significant infiltration of CD4+ effector T cells in the tumor microenvironment. Notably, topical calcipotriol plus IMQ immunotherapy enabled immune checkpoint blockade therapy to effectively control immunologically cold breast tumors, whi...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Marjan Azin Kenneth H Ngo Jennet Hojanazarova Shadmehr Demehri Source Type: research
Comparison of the efficacy of tacrolimus 0.1% ointment vs calcipotriol/betamethasone in combination with NBUVB in treatment of vitiligo
Conclusions: Although both combinations are efficacious, they did not significantly differ in efficacy at three and six months follow-up points.Clinical trial registration: The study was registered at clinicaltrials.gov (NCT04440371).PMID:37644869 | DOI:10.1080/09546634.2023.2252119 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 30, 2023 Category: Dermatology Authors: Diala Alshiyab Firas Al-Qarqaz Saleh Ba-Shammakh Abdulqudos Al-Fakih Aya Altawalbeh Safa' Alsheyab Danyah Sarakbi Jihan Muhaidat Source Type: research
The therapeutic effect of glycyrrhizic acid compound ointment on imiquimod-induced psoriasis-like disease in mice
by Yanwen Zhang, Qian Wang, Shuangyong Sun, Lingyan Jiang
Glycyrrhetinic acid, a drug with anti-inflammatory effects, enhanced the activity of antipsoriatic efficacy. In this research, an ointment with glycyrrhetinic acid was prepaired as the major component and several other herbal monomers (astilbin, osthole, and momordin Ic) have antipsoriatic activit y as minor components. Then an Imiquimod-induced psoriasis-like mouse model was established and the damaged skin condition of the administered group, the changes in the spleen index and the secretion of inflammatory factors in mouse skin were observed. Calcipotriol ointme...
Source: PLoS One - August 29, 2023 Category: Biomedical Science Authors: Yanwen Zhang Source Type: research
Potential biomarkers for psoriasis topical treatment by in-depth serum proteomics
CONCLUSION: In this work, we analyzed the response to topical sequential therapy and finally identified four biomarkers. Additionally, we found that topical sequential therapy may alleviate psoriasis by regulating lipid metabolism and modulating the immune response by affecting the complement activation process.PMID:37621164 | DOI:10.1080/09546634.2023.2248318 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 25, 2023 Category: Dermatology Authors: Jingwen Cui Xiaomei Zhang Jingwen Deng Yuhong Yan Danni Yao Hao Deng Jingjie Yu Shuyan Ye Ling Han Xiaobo Yu Chuanjian Lu Source Type: research
