ROS-sensitive calcipotriol nano-micelles prepared by methoxypolyethylene glycol (mPEG) - modified polymer for the treatment of psoriasis
In this study, a ROS-sensitive material methoxypolyethylene glycol-thioether-thiol (mPEG-SS) was synthesized using mPEG as the parent structure with sulfide structural modification. An mPEG-SS-calcipotriol (mPEG-SS-CPT, PSC) nano-micelle percutaneous delivery system was prepared by encapsulating CPT. A small animal imaging system was used to study PSC's the ROS-sensitive drug release process. It is shown that endogenous ROS mainly affects PSC and releases drugs. Finally, the therapeutic effect of PSC on psoriasis was explored by animal experiments. Ultimately, it ameliorates imiquimod-induced psoriasis-like inflammation. O...
Source: Drug Delivery - June 24, 2022 Category: Drugs & Pharmacology Authors: Yulin Hua Tiantian Chang Kun Jiang Jinhong Wang Xiaodong Cui Min Cheng Fang Yan Bo Song Yuzhen Wang Source Type: research
Calcipotriol abrogates cancer-associated fibroblast-derived IL-8-mediated oxaliplatin resistance in gastric cancer cells via blocking PI3K/Akt signaling
In this study we first conducted immunohistochemistry analysis on tissue microarrays including 88 pairs of GC and normal mucosa samples, and provided clinical evidence that VDR was mainly expressed in gastric mucous cells but almost invisible in CAFs, and VDR expression was negatively correlated with malignant clinical phenotype and advanced stages, low VDR expression confers to poor overall survival rate of patients with GC. In a co-culture system of primary CAFs and cancer cells, we showed that treatment of HGC-27 and AGS GC cells with VDR ligand calcipotriol (Cal, 500 nM) significantly inhibited CAF-induced oxaliplatin ...
Source: Acta Pharmacologica Sinica - June 8, 2022 Category: Drugs & Pharmacology Authors: Zhen-Xiong Zhao Yan-Qiu Zhang Hui Sun Zi-Qi Chen Jin-Jia Chang Xin Wang Xu Wang Cong Tan Shu-Juan Ni Wei-Wei Weng Meng Zhang Lei Wang Dan Huang Yun Feng Wei-Qi Sheng Mi-Die Xu Source Type: research
Calcipotriol abrogates cancer-associated fibroblast-derived IL-8-mediated oxaliplatin resistance in gastric cancer cells via blocking PI3K/Akt signaling
In this study we first conducted immunohistochemistry analysis on tissue microarrays including 88 pairs of GC and normal mucosa samples, and provided clinical evidence that VDR was mainly expressed in gastric mucous cells but almost invisible in CAFs, and VDR expression was negatively correlated with malignant clinical phenotype and advanced stages, low VDR expression confers to poor overall survival rate of patients with GC. In a co-culture system of primary CAFs and cancer cells, we showed that treatment of HGC-27 and AGS GC cells with VDR ligand calcipotriol (Cal, 500 nM) significantly inhibited CAF-induced oxaliplatin ...
Source: Acta Pharmacologica Sinica - June 8, 2022 Category: Drugs & Pharmacology Authors: Zhen-Xiong Zhao Yan-Qiu Zhang Hui Sun Zi-Qi Chen Jin-Jia Chang Xin Wang Xu Wang Cong Tan Shu-Juan Ni Wei-Wei Weng Meng Zhang Lei Wang Dan Huang Yun Feng Wei-Qi Sheng Mi-Die Xu Source Type: research
Calcipotriol abrogates cancer-associated fibroblast-derived IL-8-mediated oxaliplatin resistance in gastric cancer cells via blocking PI3K/Akt signaling
Acta Pharmacologica Sinica, Published online: 08 June 2022; doi:10.1038/s41401-022-00927-1Calcipotriol abrogates cancer-associated fibroblast-derived IL-8-mediated oxaliplatin resistance in gastric cancer cells via blocking PI3K/Akt signaling (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - June 8, 2022 Category: Drugs & Pharmacology Authors: Zhen-xiong Zhao Yan-qiu Zhang Hui Sun Zi-qi Chen Jin-jia Chang Xin Wang Xu Wang Cong Tan Shu-juan Ni Wei-wei Weng Meng Zhang Lei Wang Dan Huang Yun Feng Wei-qi Sheng Mi-die Xu Source Type: research
Efficacy, quality of life and treatment satisfaction: an indirect comparison of calcipotriol/betamethasone dipropionate cream versus foam for treatment of psoriasis
Conclusions: Indirect comparison analyses showed that Cal/BDP cream significantly improves treatment satisfaction and tends to improve QoL versus foam. Cal/BDP cream is on par with foam on efficacy.PMID:35575759 | DOI:10.1080/03007995.2022.2078099 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 16, 2022 Category: Research Authors: Adam Reich Johan Selmer Jordi Galv án Paw Trebbien Aina Pi-Blanque Anne Dan ø Sandra Elkjaer Stallknecht Anthony Bewley Source Type: research
Not something to sit on: A case of senile gluteal dermatosis responding to calcipotriol ointment
Australas J Dermatol. 2022 May 4. doi: 10.1111/ajd.13863. Online ahead of print.NO ABSTRACTPMID:35510336 | DOI:10.1111/ajd.13863 (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - May 5, 2022 Category: Dermatology Authors: Xiaotian Wu Wei-Sheng Chong Source Type: research
Not something to sit on: A case of senile gluteal dermatosis responding to calcipotriol ointment
Australas J Dermatol. 2022 May 4. doi: 10.1111/ajd.13863. Online ahead of print.NO ABSTRACTPMID:35510336 | DOI:10.1111/ajd.13863 (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - May 5, 2022 Category: Dermatology Authors: Xiaotian Wu Wei-Sheng Chong Source Type: research
An ultrasensitive UHPLC-ESI-MS/MS method augmented with a controlled microwave derivatization reaction for quantitation of vitamin D3 and its major metabolites in COVID-19 patients
Talanta. 2022 Apr 22;246:123497. doi: 10.1016/j.talanta.2022.123497. Online ahead of print.ABSTRACTIt is established that vitamin D deficiency is correlated with the disease severity in COVID-19 patients. However, the reliable and sensitive quantitation of vitamin D3 (D3) and its metabolites remains a difficult challenge. Herein, a novel ultrasensitive and reliable UHPLC-ESI-MS/MS method was developed and validated for the quantitation of D3 and its major metabolites in COVID-19 patients. The mass spectral sensitivity was augmented via controlled microwave-assisted derivatization reaction (CMDR) with 2-nitrosopyridine (Pyr...
Source: Talanta - April 29, 2022 Category: Chemistry Authors: Sameh A Ahmed Hani M J Khojah Sultan S Al-Thagfan Yaser M Alahmadi Yasser A Mohammed Source Type: research
An ultrasensitive UHPLC-ESI-MS/MS method augmented with a controlled microwave derivatization reaction for quantitation of vitamin D3 and its major metabolites in COVID-19 patients
Talanta. 2022 Apr 22;246:123497. doi: 10.1016/j.talanta.2022.123497. Online ahead of print.ABSTRACTIt is established that vitamin D deficiency is correlated with the disease severity in COVID-19 patients. However, the reliable and sensitive quantitation of vitamin D3 (D3) and its metabolites remains a difficult challenge. Herein, a novel ultrasensitive and reliable UHPLC-ESI-MS/MS method was developed and validated for the quantitation of D3 and its major metabolites in COVID-19 patients. The mass spectral sensitivity was augmented via controlled microwave-assisted derivatization reaction (CMDR) with 2-nitrosopyridine (Pyr...
Source: Talanta - April 29, 2022 Category: Chemistry Authors: Sameh A Ahmed Hani M J Khojah Sultan S Al-Thagfan Yaser M Alahmadi Yasser A Mohammed Source Type: research
Vitamin D analogs combined with different types of phototherapy in the treatment of vitiligo: A systematic review of randomized trials and within-patient studies
CONCLUSIONS: The current evidence suggests that the additional use of topical calcipotriol or tacalcitol to NB-UVB may increase the treatment effect of vitiligo, and the effect of tacalcitol is greater than that of calcipotriol. None of the vitamin D analogs were found to enhance the efficacy of PUVA or EL for vitiligo.PMID:35468365 | DOI:10.1016/j.intimp.2022.108789 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 25, 2022 Category: Allergy & Immunology Authors: Xiaowu Liu Ziqian Yao Yanchun Wang Luyu Chai Xu Zhou Source Type: research
Vitamin D analogs combined with different types of phototherapy in the treatment of vitiligo: A systematic review of randomized trials and within-patient studies
CONCLUSIONS: The current evidence suggests that the additional use of topical calcipotriol or tacalcitol to NB-UVB may increase the treatment effect of vitiligo, and the effect of tacalcitol is greater than that of calcipotriol. None of the vitamin D analogs were found to enhance the efficacy of PUVA or EL for vitiligo.PMID:35468365 | DOI:10.1016/j.intimp.2022.108789 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 25, 2022 Category: Allergy & Immunology Authors: Xiaowu Liu Ziqian Yao Yanchun Wang Luyu Chai Xu Zhou Source Type: research
Vitamin D analogs combined with different types of phototherapy in the treatment of vitiligo: A systematic review of randomized trials and within-patient studies
CONCLUSIONS: The current evidence suggests that the additional use of topical calcipotriol or tacalcitol to NB-UVB may increase the treatment effect of vitiligo, and the effect of tacalcitol is greater than that of calcipotriol. None of the vitamin D analogs were found to enhance the efficacy of PUVA or EL for vitiligo.PMID:35468365 | DOI:10.1016/j.intimp.2022.108789 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 25, 2022 Category: Allergy & Immunology Authors: Xiaowu Liu Ziqian Yao Yanchun Wang Luyu Chai Xu Zhou Source Type: research
