Imbalanced insulin substrate-1 and insulin substrate-2 signaling trigger hepatic steatosis in vitamin D deficient rats: 8-methoxypsoralen, a vitamin D receptor ligand with a promising anti-steatotic action
In this study, we induced VD deficiency by feeding Female Sprague-Dawley rats a VD deficient (VDD) Diet and studied the hepatic changes associated with VD deficiency. Simultaneously, we provided the VDD rats with VD or 8-methoxy psoralen (8-MOP), a suggested vitamin D receptor agonist, to test the reversibility of the hepatic changes. VDD Rats developed borderline non-alcoholic steatohepatitis (NASH) with considerable elevation in hepatic triglycerides, total cholesterol, and malondialdehyde.Furthermore, VD deficiency induced the expression of crucial enzymes and transcription factors involved in denovo lipogenesis, which ...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - February 10, 2020 Category: Lipidology Source Type: research

Sensitivity of Different In Vitro Performance Tests and Their In Vivo Relevance for Calcipotriol/Betamethasone Ointment
AbstractPurposeWe compared results ofin vitro performance testing with results of therapeutic equivalence study for calcipotriol/betamethasone ointment, to evaluate their sensitivity andin vivo relevance.MethodsDifferentin vitro methods were used to evaluate drug release and permeation from the test and reference ointment. Moreover, 444 psoriasis patients were randomized in the therapeutic equivalence study and the parameters of efficacy and safety were compared within vitro results.ResultsIn vitro release and permeation rate of calcipotriol and betamethasone from the test formulation was higher than from the reference pro...
Source: Pharmaceutical Research - February 10, 2020 Category: Drugs & Pharmacology Source Type: research

Calcipotriol/betamethasone dipropionate aerosol foam for the treatment of psoriasis vulgaris: a review of real-world evidence (RWE).
Conclusion: The results from real-world studies undertaken in diverse healthcare systems reinforce the positive findings reported in RCTs with Cal/BD aerosol foam in patients with psoriasis. PMID: 31986945 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 30, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Cost per PASI-75 responder of calcipotriol plus betamethasone dipropionate cutaneous foam versus non-biologic systemic therapies for the treatment of plaque psoriasis in seven European countries.
Conclusions: Driven by its lower costs and high response rates, Cal/BD foam is likely to be a cost-effective option over the short-term in the investigated psoriasis population. PMID: 31940225 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 16, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Kinetics versus statistics in the analysis of therapeutic effects of mometasone and calcipotriol for the treatment of alopecia areata
Jonghoon Kang, Erin KangInternational Journal of Trichology 2019 11(6):256-257 (Source: International Journal of Trichology)
Source: International Journal of Trichology - January 14, 2020 Category: Dermatology Authors: Jonghoon Kang Erin Kang Source Type: research

Patient and Physician Satisfaction with Calcipotriol and Betamethasone Dipropionate Aerosol Foam in the Treatment of Plaque Psoriasis on the Body
Publication date: Available online 24 October 2019Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): M. Velasco, D. González-Fernández, M. Rodriguez-Martín, M. Sánchez-Regaña, S. Pérez-Barrio (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - October 24, 2019 Category: Dermatology Source Type: research

Vitamin D and alopecia areata: possible roles in pathogenesis and potential implications for therapy.
This article reviews the current literature and discusses the possible roles of vitamin D in the pathogenesis of alopecia areata in the context of (1) loss of immune privilege in hair follicle, (2) autoreactive effector T cells and mast cells, (3) nature killer group 2 member d-positive cytotoxic T cells, (4) Janus kinase/signal transducers and activators of transcriptional signaling pathway, (5) regulatory T cells, (6) immune checkpoints, and (7) oxidative stress, which are believed to play important roles in autoimmunity in AA. This paper provides new insights into research directions to elucidate the exact mechanisms of...
Source: American Journal of Translational Research - October 23, 2019 Category: Research Tags: Am J Transl Res Source Type: research

Calcipotriol Plus Betamethasone Dipropionate Aerosol Foam For Scalp Psoriasis.
This article presents real-world experience of the effectiveness of calcipotriol (50 µg/g)/betamethasone dipropionate (0.5 mg/g) (Cal/BD) aerosol foam formulation in three cases of scalp psoriasis, and briefly reviews the literature relating to Cal/BD topical therapy in adults with scalp psoriasis. Patients had long histories of scalp psoriasis and reported negative impacts on their lives (e.g. clothing choices, psychological well-being, employment status). Previous treatments had provided inadequate or only temporary relief. Cal/BD aerosol foam relieved itching in the first few days and was associated with visible i...
Source: Clinical, Cosmetic and Investigational Dermatology - October 2, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Erosive pustular dermatosis of the scalp: challenges and solutions.
Authors: Starace M, Alessandrini A, Baraldi C, Piraccini BM Abstract Erosive pustular dermatosis of the scalp is a rare chronic inflammatory disorder defined. It usually affects elderly people and is characterized by extensive pustular lesions, erosions, and crusts located on the scalp. The pathogenesis of this disease is not completely understood, but a known predisposing factor is skin trauma. Autoimmune disorders including rheumatoid arthritis, autoimmune hepatitis, Hashimoto thyroiditis, and Takayasu aortitis are associated diseases reported. The clinical examination reveals erythema, erosions, crusts, follicul...
Source: Clinical, Cosmetic and Investigational Dermatology - October 2, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

387 Ex Vivo Visualization and Extended Drug Release from a Dissolvable Microarray
The aim of the study was to investigate a dissolvable microarray (MA) patch in terms of skin insertion and drug release in ex vivo human skin for 6 days and in vivo using minipigs for 4 days. The patches contain polymeric, microscopic arrays composed of a fast dissolving drug-free backing layer and slowly dissolving drug containing tips. The calcipotriol and betamethasone dipropionate (BDP) is encapsulated in the tip and delivered in a pain-free and minimally invasive manner by micro-perforation of the stratum corneum with 500 μm long microneedles. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - September 1, 2019 Category: Dermatology Authors: K. Troensegaard Nielsen, A. Huss Eriksson, M. Funch Carlsen, K. Engell, J. Jansson, K. Petersson, M. R øpke, P. Kemp Tags: Innate Immunity and Inflammation Source Type: research

Combination of yeast-based in  vitro screens with high-performance thin-layer chromatography as a novel tool for the detection of hormonal and dioxin-like compounds.
Combination of yeast-based in vitro screens with high-performance thin-layer chromatography as a novel tool for the detection of hormonal and dioxin-like compounds. Anal Chim Acta. 2019 Nov 12;1081:218-230 Authors: Riegraf C, Reifferscheid G, Belkin S, Moscovici L, Shakibai D, Hollert H, Buchinger S Abstract The combination of classic in vitro bioassays with high-performance thin-layer chromatography (HPTLC) is a promising technique to directly link chemical analysis of contaminants to their potential adverse biological effects. With respect to endocrine disruption, much work is focused on e...
Source: Analytica Chimica Acta - August 28, 2019 Category: Chemistry Authors: Riegraf C, Reifferscheid G, Belkin S, Moscovici L, Shakibai D, Hollert H, Buchinger S Tags: Anal Chim Acta Source Type: research

A Review of Topical Corticosteroid Foams
Authors: Payne J, Habet KA, Pona A, Feldman SR Abstract BACKGROUND: Topical corticosteroids are efficacious treatment options for multiple dermatoses. However, ointments and cream corticosteroid vehicles can be cumbersome to patients and may act as a barrier to adherence. Foam vehicles may be preferred by some patients. OBJECTIVE: To evaluate the efficacy and safety of topical corticosteroid foams. METHODS: A literature review was conducted using the keywords “clobetasol,” “betamethasone,” “propionate,” “valerate,” “topical,” “foam,” “v...
Source: Journal of Drugs in Dermatology - August 20, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Betamethasone dipropionate/calcipotriol
(Source: Reactions Weekly)
Source: Reactions Weekly - August 1, 2019 Category: Drugs & Pharmacology Source Type: research

Patient and Physician Satisfaction with Calcipotriol and Betamethasone Dipropionate Aerosol Foam in the Treatment of Plaque Psoriasis on the Body.
CONCLUSION: Both patients and physicians expressed high satisfaction with the use of Cal/BD aerosol foam for the treatment of plaque psoriasis on the body. PMID: 31256797 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - June 27, 2019 Category: Dermatology Authors: Velasco M, González-Fernández D, Rodriguez-Martín M, Sánchez-Regaña M, Pérez-Barrio S Tags: Actas Dermosifiliogr Source Type: research

Topical calcipotriol vs narrowband ultraviolet B in treatment of alopecia areata: a randomized-controlled trial
The objectives of this study are to compare the efficacy of topical calcipotriol vs narrow band ultraviolet B phototherapy (NB-UVB) in the treatment of alopecia areata and its correlation with serum vitamin D3 levels. A randomized-controlled trial has been conducted on 60 patients with scalp alopecia areata randomized into four groups; topical calcipotriol, NB-UVB, both and placebo. All patients were evaluated by assessment of severity of alopecia areata by severity of alopecia tool (SALT) score at baseline and 3  months after treatment and vitamin D3 levels at baseline and after 3  months. SALT score and vitamin...
Source: Archives of Dermatological Research - June 24, 2019 Category: Dermatology Source Type: research

Comparative study of efficacy of topical mometasone with calcipotriol versus mometasone alone in the treatment of alopecia areata
Conclusion: We found that adding topical calcipotriol 0.005% ointment with topical mometasone 0.1% cream has higher efficacy than topical mometasone alone, in the treatment of alopecia areata. (Source: International Journal of Trichology)
Source: International Journal of Trichology - June 12, 2019 Category: Dermatology Authors: Mahtab Alam Syed Suhail Amin Mohammad Adil Tasleem Arif Fatima Tuz Zahra Iti Varshney Source Type: research

Expanded Table: Some Drugs for Psoriasis (online only)
Date: June 17, 2019 Issue #:  1574Summary:  View the Expanded Table: Some Drugs for Psoriasis (Source: The Medical Letter)
Source: The Medical Letter - June 10, 2019 Category: Drugs & Pharmacology Authors: admin Tags: Acitretin Adalimumab Amjevita apremilast Betamethasone Brenzys brodalumab Calcipotriene calcipotriol Calcitriol Certolizumab Cimzia Cosentyx Cyclosporine Cyltezo Dovobet Dovonex Duobril Enbrel Enstilar Erelzi Etan Source Type: research

Risankizumab (Skyrizi) for Psoriasis
Date: June 3, 2019 Issue #:  1573Summary:  The FDA has approved the interleukin (IL)-23 antagonist risankizumab-rzaa (Skyrizi– Abbvie) for treatment of moderate to severe plaque psoriasis in adults. Risankizumab is the third IL-23 antagonist to be approved for this indication; guselkumab(Tremfya) and tildrakizumab(Ilumya) were approved earlier. (Source: The Medical Letter)
Source: The Medical Letter - May 15, 2019 Category: Drugs & Pharmacology Authors: admin Tags: Acitretin Adalimumab apremilast brodalumab Calcipotriene calcipotriol Certolizumab Cimzia corticosteroids Cosentyx Cyclosporine Dovonex Enbrel Etanercept guselkumab Humira Ilumya Inflectra Infliximab ixekizumab Meth Source Type: research

679 Pharmacological validation of a mouse model of atopic dermatitis induced by topical calcipotriol
Atopic dermatitis (AD) is the most common inflammatory skin disease. Malfunction of the epidermal barrier, along with an immune dysregulation play a major role in its onset. AD patients ’ keratinocytes produce thymic stromal lymphopoietin (TSLP), a cytokine that indirectly induces the differentiation of T lymphocytes towards a Th2 phenotype. In addition, overexpression of TSLP in mouse keratinocytes induces the onset of AD-like clinical signs and inflammation. TSLP expression can be induced in mouse skin by repeated topical application of calcipotriol, a synthetic vitamin D3 analogue. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 20, 2019 Category: Dermatology Authors: A. Gavalda, L. Casals-Diaz, R. Martinez, A. Blanco, N. Godessart Tags: Pharmacology and Drug Development Source Type: research

Drugs for Psoriasis
Date: June 17, 2019 Issue #:  1574Summary:  Mild to moderate psoriasis can be treated with topical drugs or with phototherapy. Patients with moderate to severe disease generally require systemic therapy. (Source: The Medical Letter)
Source: The Medical Letter - April 3, 2019 Category: Drugs & Pharmacology Authors: admin Tags: Acitretin Adalimumab Amjevita apremilast Betamethasone Brenzys brodalumab Calcipotriene calcipotriol Calcitriol Certolizumab Cimzia Cosentyx Cyclosporine Cyltezo Dovobet Dovonex Duobril Elidel Enbrel Enstilar Erel Source Type: research

Psoriasis and skin pain: real-life effectiveness of calcipotriol plus betamethasone dipropionate in aerosol foam formulation.
Abstract BACKGROUND/OBJECTIVE: Although 40% of psoriasis patients reported skin pain, this symptom is often underestimated. A new formula of calcipotriol plus betamethasone dipropionate (Cal/BD) has been recently approved for psoriasis treatment. Therefore, we aimed to evaluate the efficacy of Cal/BD aerosol foam on skin pain of patients with plaque psoriasis. METHODS: A real-life 4 weeks prospective, open study on Cal/BD aerosol foam (not compared to vehicle or emollient cream) was performed in adult psoriasis patients attending three Dermatology units located in Campania region, Italy, between March and Oct...
Source: Pain Physician - February 15, 2019 Category: Anesthesiology Authors: Gallo L, Megna M, Cirillo T, Caterino P, Lodi G, Mozzillo R, Dente V, Balato A Tags: J Eur Acad Dermatol Venereol Source Type: research

Update on Topical Treatments for Psoriasis: The Role of Calcipotriol Plus Betamethasone Dipropionate Aerosol Foam
Publication date: Available online 16 January 2019Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): L. Puig, G. CarreteroAbstractTopical agents are the first-line treatment for mild and moderate psoriasis, but factors such as frequency of administration, organoleptic properties, and the limited short term results can reduce treatment adherence and effectiveness.Innovations in topical treatments are linked not only to the discovery of new molecules, but also to the reformulation of existing active ingredients based on improvements to administration, organoleptic properties, bioavailability, and ease of ...
Source: Actas Dermo-Sifiliograficas - January 17, 2019 Category: Dermatology Source Type: research

A Cost-utility Analysis of Calcipotriol/betamethasone Dipropionate Aerosol Foam versus Ointment for the Topical Treatment of Psoriasis Vulgaris in Sweden.
In conclusion, Cal/BD foam was predicted to be more cost-effective than Cal/BD ointment in the treatment of psoriasis vulgaris. PMID: 30628631 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - January 9, 2019 Category: Dermatology Authors: Duvetorp A, Levin LÅ, Engerstedt Mattsson E, Ryttig L Tags: Acta Derm Venereol Source Type: research

Comparing the Efficacy of Triamcinolone Acetonide Iontophoresis versus Topical Calcipotriol/Betamethasone Dipropionate in Treating Nail Psoriasis: A Bilateral Controlled Clinical Trial.
Conclusion: Monthly TI has an equal efficacy compared to daily topical calcipotriol/betamethasone dipropionate. It can be used as a safe, easy, and compliant treatment for nail psoriasis. This study is registered under IRCT2017050233778N1. PMID: 30584420 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - December 27, 2018 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Vasoconstrictor potency of fixed-dose combination calcipotriol (50 μg/g) and betamethasone dipropionate (0.5 mg/g) cutaneous foam versus other topical corticosteroids used to treat psoriasis vulgaris.
Vasoconstrictor potency of fixed-dose combination calcipotriol (50 μg/g) and betamethasone dipropionate (0.5 mg/g) cutaneous foam versus other topical corticosteroids used to treat psoriasis vulgaris. J Dermatolog Treat. 2018 Dec 24;:1-22 Authors: Queille-Roussel C, Nielsen J, Lacour JP Abstract BACKGROUND: It is important to determine the vasoconstrictor potencies of topical corticosteroids used to treat psoriasis to ensure appropriate clinical use. OBJECTIVE: To compare the vasoconstrictive potencies of fixed-dose combination calcipotriol (50 μg/g) and betamethasone dipropionate (0.5...
Source: Journal of Dermatological Treatment - December 26, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Pharmacokinetics of intra-articular vitamin D analogue calcipotriol in sheep and metabolism in human synovial and mesenchymal stromal cells
Publication date: Available online 15 December 2018Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Jere Huovinen, Maija Haj Hussain, Markus Niemelä, Sakari Laaksonen, Hanna-Marja Voipio, Juha Jyrkäs, Janne Mannila, Toni Lassila, Ari Tolonen, Sanna Turunen, Ulrich Bergmann, Petri Lehenkari, Johanna A. HuhtakangasAbstractCalcipotriol (MC903) is a side chain analogue of the biologically active 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. Due to its anti-inflammatory and anti-proliferative effects on stromal cells, calcipotriol is a promising candidate for the local treatment of arthritis. In t...
Source: The Journal of Steroid Biochemistry and Molecular Biology - December 16, 2018 Category: Biochemistry Source Type: research

Calcipotriol plus betamethasone dipropionate aerosol foam versus apremilast, methotrexate, acitretin, or fumaric acid esters for the treatment of plaque psoriasis: A matching ‐adjusted indirect comparison
AbstractBackgroundPlaque psoriasis has significant impact on patients ’ quality of life. Topical therapy is considered the treatment mainstay for mild‐to‐moderate disease according to guidelines. Calcipotriol/betamethasone dipropionate (Cal/BD) [0.005%/0.05%] aerosol foam is indicated for psoriasis vulgaris treatment in adults. Cal/BD foam trials demonstrated im proved efficacy and similar safety in this population. Psoriasis treatment is complicated by the broad range of disease presentation, variability, and therapeutic options; particularly decisions on transition from topical to non‐biologic systemic treatm...
Source: Journal of the European Academy of Dermatology and Venereology - November 25, 2018 Category: Dermatology Authors: A. Bewley, N.H. Shear, P.G. Calzavara ‐Pinton, J.B. Hansen, M.E. Nyeland, J. Signorovitch Tags: Original Article Source Type: research

Stimulation of the Proliferation of Mouse and Human Definitive Erythroid Progenitors By Activation of the Vitamin D Receptor Transcription Factor
How the proliferation of erythroid progenitors is regulated is still now well understood. We found, using a computational analysis, that the vitamin D receptor (Vdr) nuclear hormone receptor transcription factor gene is expressed in the fetal and adult (definitive) but not the embryonic (primitive) stage of mouse erythroid ontogeny. Vdr is transcribed in definitive erythroid (EryD) progenitors and was downregulated during their maturation. VDR transcription factor activation by its ligand vitamin D3 (1,25(OH)2D3) results in conformational changes that stabilize the protein and induce its translocation into the nucleus, whe...
Source: Blood - November 21, 2018 Category: Hematology Authors: Baron, M. H., Barminko, J. H., Reinholt, B. M., Narla, M. Tags: 101. Red Cells and Erythropoiesis, Structure and Function, Metabolism, and Survival, Excluding Iron: Poster I Source Type: research

Calcipotriol/betamethasone dipropionate aerosol foam for the treatment of psoriasis vulgaris: case series and review of the literature.
Authors: Pinter A, Thormann H, Angeletti F, Jalili A Abstract An aerosol foam formulation of a once-daily, fixed-dose combination of a synthetic vitamin D3 analog/synthetic corticosteroid (calcipotriol [Cal] 50 µg/g and betamethasone dipropionate [BD] 0.5 mg/g) has recently been introduced for the topical treatment of plaque psoriasis in adults. Data from several sources - randomized controlled trials, case reports (as highlighted in this review), and real-world evidence (RWE) - underscore the considerable and rapid clinical response, effectiveness, and favorable safety and tolerability of Cal/BD aerosol foam...
Source: Clinical, Cosmetic and Investigational Dermatology - October 24, 2018 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Calcipotriol ‐assisted vs. conventional MAL‐PDT in actinic keratosis
British Journal of Dermatology,Volume 179, Issue 4, Page e171-e171, October 2018. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - October 15, 2018 Category: Dermatology Authors: L. Torezan, B. Grinblat, M. Haedersdal, N. Valente, C. Festa ‐Neto, R.M. Szeimies Source Type: research

Effectiveness of topical calcipotriol (0.005%) ointment with or without narrowband ultraviolet B phototherapy in patients with alopecia areata: a randomized evaluator-blinded placebo-controlled trial
Source: Journal of the Egyptian Womens Dermatologic Society - September 1, 2018 Category: Dermatology Tags: Original articles Source Type: research

Therapeutic equivalence of two formulations of calcipotriol –betamethasone ointment: a multicentre, randomized, double‐blind study in adult patients with chronic plaque psoriasis
British Journal of Dermatology, EarlyView. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - August 16, 2018 Category: Dermatology Authors: N. Habjanic , R. Koytchev , R. Yankova , M. Kerec ‐Kos , D. Grabnar‐Peklar Source Type: research

Use of topical antipsoriatic drugs in Denmark: A nationwide drug utilization study.
CONCLUSION: The study provides further evidence that the use of topical antipsoriatic drugs shows considerable heterogeneity over time, regional practices and differences between patients. This article is protected by copyright. All rights reserved. PMID: 30098007 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 11, 2018 Category: Dermatology Authors: Svendsen MT, Ernst MT, Andersen KE, Andersen F, Johannessen H, Pottegård A Tags: Br J Dermatol Source Type: research

Alternate treatment of alopecia areata with the use of calcipotriol: A prospective study in children versus adults
Introduction: Alopecia areata (AA) is a common and chronic inflammatory condition that presents as nonscarring patches of alopecia and is known to affect any hair bearing area. Mild to moderate AA is notable for its spontaneous recovery, and no treatment known to modify its course. Vitamin D receptors are expressed on the root sheath of hair follicles and reduced 1,25-dihydroxyvitamin D3 receptor expression has been demonstrated in AA patients. Very few studies have, however, demonstrated the efficacy of topical calcipotriol in alopecia areata. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

Porokeratosis ptychotropica: A differential diagnosis for “psoriasis” of the gluteal region
A 51-year-old man presented with an 8-year history of a well demarcated erythematous scaly plaque on the buttocks, extending into the natal cleft. Initial skin biopsy was reported as showing features of psoriasis. Treatment with topical calcipotriol, acitretin, UVB and intralesional triamcinolone were ineffective. Repeat biopsies taken from two different areas showed neutrophilic collections within the stratum corneum and a psoriasiform pattern of hyperplasia supporting the initial diagnosis of psoriasis. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

Calcipotriol/betamethasone ointment compared to narrow ‐band UVB in plaque psoriasis: first clinical and ultrasonographic study
International Journal of Dermatology, EarlyView. (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - August 2, 2018 Category: Dermatology Authors: Adriana Pola ńska MD, PhD , Tomasz Gaura MD , Monika Bowszyc‐Dmochowska MD, PhD , Agnieszka Osmola‐Mańkowska MD, PhD , Karolina Olek‐Hrab MD, PhD , Zygmunt Adamski MD, PhD , Ryszard Żaba MD, PhD , Aleksandra Dańczak‐Pazdrowska M Source Type: research

Update on Topical Treatments for Psoriasis: The Role of Calcipotriol Plus Betamethasone Dipropionate Aerosol Foam.
Abstract Topical agents are the first-line treatment for mild and moderate psoriasis, but factors such as frequency of administration, organoleptic properties, and the limited short term results can reduce treatment adherence and effectiveness. Innovations in topical treatments are linked not only to the discovery of new molecules, but also to the reformulation of existing active ingredients based on improvements to administration, organoleptic properties, bioavailability, and ease of use. Calcipotriol and betamethasone dipropionate aerosol foam is a new formulation in which the active ingredients are dissolved in...
Source: Actas Dermo-Sifiliograficas - July 18, 2018 Category: Dermatology Authors: Puig L, Carretero G Tags: Actas Dermosifiliogr Source Type: research

Evaluation of the efficacy of transdermal drug delivery of calcipotriol plus betamethasone versus tacrolimus in the treatment of vitiligo
Journal of Cosmetic Dermatology, EarlyView. (Source: Journal of Cosmetic Dermatology)
Source: Journal of Cosmetic Dermatology - July 16, 2018 Category: Dermatology Authors: Zeinab A. Ibrahim MD , Ghada F. Hassan MD , Hoda Y. Elgendy MBBCH , Hanan A. Al ‐shenawy MD Source Type: research

Differential modulation of hepatitis C virus replication and innate immune pathways by synthetic calcitriol-analogs
ConclusionCalcipotriol induces local structure rearrangements in VDR that could possibly translate into a superior clinical potential to execute important non-classical vitamin D effects such as inhibition of HCV replication.Graphical abstract (Source: The Journal of Steroid Biochemistry and Molecular Biology)
Source: The Journal of Steroid Biochemistry and Molecular Biology - July 11, 2018 Category: Biochemistry Source Type: research

Morphea in Childhood: An Update
Publication date: May 2018Source: Actas Dermo-Sifiliográficas (English Edition), Volume 109, Issue 4Author(s): B. Aranegui, J. Jiménez-ReyesAbstractMorphea is an inflammatory, fibrosing skin disorder. When it occurs in childhood, it is also known as juvenile localized scleroderma. It is more common in girls and typically appears around the age of 5 to 7 years. According to a recent classification system, morphea is divided into 5 types: circumscribed (plaque), linear, generalized, pansclerotic, and mixed. Approximately 40% of patients present extracutaneous manifestations. Childhood morphea is treated with ph...
Source: Actas Dermo-Sifiliograficas - July 10, 2018 Category: Dermatology Source Type: research

Differential modulation of hepatitis C virus replication and innate immune pathways by synthetic calcitriol-analogs
ConclusionCalcipotriol induces local structure rearrangements in VDR that could possibly translate into a superior clinical potential to execute important non-classical vitamin D effects such as inhibition of HCV replication.Graphical abstract (Source: The Journal of Steroid Biochemistry and Molecular Biology)
Source: The Journal of Steroid Biochemistry and Molecular Biology - July 6, 2018 Category: Biochemistry Source Type: research

Morphea in Childhood: An Update
Publication date: May 2018Source: Actas Dermo-Sifiliográficas (English Edition), Volume 109, Issue 4Author(s): B. Aranegui, J. Jiménez-ReyesAbstractMorphea is an inflammatory, fibrosing skin disorder. When it occurs in childhood, it is also known as juvenile localized scleroderma. It is more common in girls and typically appears around the age of 5 to 7 years. According to a recent classification system, morphea is divided into 5 types: circumscribed (plaque), linear, generalized, pansclerotic, and mixed. Approximately 40% of patients present extracutaneous manifestations. Childhood morphea is treated with ph...
Source: Actas Dermo-Sifiliograficas - July 5, 2018 Category: Dermatology Source Type: research

Therapeutic equivalence of two formulations of calcipotriol ‐betamethasone ointment: a multi‐centre, randomized, double‐blind study in adult patients with chronic plaque psoriasis
British Journal of Dermatology,Volume 0, Issue ja, -Not available-. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - June 26, 2018 Category: Dermatology Authors: N Habjanic , R Koytchev , R Yankova , M Kerec ‐Kos , D Grabnar‐Peklar Source Type: research

Therapeutic equivalence of two formulations of calcipotriol-betamethasone ointment: a multi-centre, randomized, double-blind study in adult patients with chronic plaque psoriasis.
This article is protected by copyright. All rights reserved. PMID: 29945295 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 26, 2018 Category: Dermatology Authors: Habjanic N, Koytchev R, Yankova R, Kerec-Kos M, Grabnar-Peklar D Tags: Br J Dermatol Source Type: research

Differential modulation of hepatitis C virus replication and innate immune pathways by synthetic calcitriol-analogs
Conclusion Calcipotriol induces local structure rearrangements in VDR that could possibly translate into a superior clinical potential to execute important non-classical vitamin D effects such as inhibition of HCV replication. Graphical abstract (Source: The Journal of Steroid Biochemistry and Molecular Biology)
Source: The Journal of Steroid Biochemistry and Molecular Biology - June 8, 2018 Category: Biochemistry Source Type: research

Improvement in facial discoid dermatosis with calcipotriol/betamethasone ointment and low ‐dose acitretin
Clinical and Experimental Dermatology, EarlyView. (Source: Clinical And Experimental Dermatology)
Source: Clinical And Experimental Dermatology - May 17, 2018 Category: Dermatology Authors: M. Bohdanowicz , J. G. DeKoven Source Type: research

Differential effects of phototherapy, adalimumab and betamethasone –calcipotriol on effector and regulatory T cells in psoriasis
British Journal of Dermatology, EarlyView. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - April 27, 2018 Category: Dermatology Authors: I.S. Kotb , B.J. Lewis , R.N. Barker , A.D. Ormerod Source Type: research

Vitamin D Analogues Tacalcitol and Calcipotriol Inhibit Proliferation and Migration of T98G Human Glioblastoma Cells
Basic&Clinical Pharmacology&Toxicology, EarlyView. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - April 25, 2018 Category: Drugs & Pharmacology Authors: Ida Emanuelsson , Kjell Wikvall , Tomas Friman , Maria Norlin Source Type: research