The impact of regular aspirin use on aneurysm recanalization rates after endovascular coiling
CONCLUSIONS: Regular use of aspirin appears to be associated with reduced rates of aneurysm recanalization after endovascular coiling. However, caution is advised in interpretation of these results given the retrospective nature of this study. Further randomized controlled trials are needed to confirm these findings.PMID:38608309 | DOI:10.3171/2024.1.JNS232726 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 12, 2024 Category: Neurosurgery Authors: Basel Musmar Samantha E Spellicy Jihad Abdelgadir Stevie Kraljic Ali Zomorodi David M Hasan Source Type: research
LAMC1 attenuates neuronal apoptosis via FAK/PI3K/AKT signaling pathway after subarachnoid hemorrhage
CONCLUSION: Exogenous LAMC1 treatment improved neurological deficits after SAH in rats, and attenuated neuronal apoptosis in both in vitro and in vivo SAH models, at least partially through the FAK/PI3K/AKT pathway.PMID:38609046 | DOI:10.1016/j.expneurol.2024.114776 (Source: Experimental Neurology)
Source: Experimental Neurology - April 12, 2024 Category: Neurology Authors: Qiaowei Wu Kaikun Yuan Yanting Yao Jinbiao Yao Jiang Shao Yuxiao Meng Pei Wu Huaizhang Shi Source Type: research
The impact of regular aspirin use on aneurysm recanalization rates after endovascular coiling
CONCLUSIONS: Regular use of aspirin appears to be associated with reduced rates of aneurysm recanalization after endovascular coiling. However, caution is advised in interpretation of these results given the retrospective nature of this study. Further randomized controlled trials are needed to confirm these findings.PMID:38608309 | DOI:10.3171/2024.1.JNS232726 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 12, 2024 Category: Neurosurgery Authors: Basel Musmar Samantha E Spellicy Jihad Abdelgadir Stevie Kraljic Ali Zomorodi David M Hasan Source Type: research
p97 inhibits integrated stress response-induced neuronal apoptosis after subarachnoid hemorrhage in mice by enhancing proteasome function
Exp Neurol. 2024 Apr 10:114778. doi: 10.1016/j.expneurol.2024.114778. Online ahead of print.ABSTRACTNeuronal apoptosis is a common pathological change in early brain injury after subarachnoid hemorrhage (SAH), and it is closely associated with neurological deficits. According to previous research, p97 exhibits a remarkable anti-cardiomyocyte apoptosis effect. p97 is a critical molecule in the growth and development of the nervous system. However, it remains unknown whether p97 can exert an anti-neuronal apoptosis effect in SAH. In the present study, we examined the role of p97 in neuronal apoptosis induced after SAH and in...
Source: Experimental Neurology - April 12, 2024 Category: Neurology Authors: Wenping Cheng Boyang Wei Wenchao Liu Lei Jin Shenquan Guo Mingxiang Ding Yanchao Liu Haiyan Fan Ran Li Xin Zhang Xuying He Xifeng Li Chuanzhi Duan Source Type: research
The impact of regular aspirin use on aneurysm recanalization rates after endovascular coiling
CONCLUSIONS: Regular use of aspirin appears to be associated with reduced rates of aneurysm recanalization after endovascular coiling. However, caution is advised in interpretation of these results given the retrospective nature of this study. Further randomized controlled trials are needed to confirm these findings.PMID:38608309 | DOI:10.3171/2024.1.JNS232726 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 12, 2024 Category: Neurosurgery Authors: Basel Musmar Samantha E Spellicy Jihad Abdelgadir Stevie Kraljic Ali Zomorodi David M Hasan Source Type: research
One-year survival of aneurysmal subarachnoid hemorrhage after airplane transatlantic transfer – a monocenter retrospective study
Aneurysmal subarachnoid hemorrhage (aSAH) is preferentially treated by prompt endovascular coiling, which is not available in Guadeloupe. Subsequently, patients are transferred to Paris, France mainland, by co... (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - April 12, 2024 Category: Anesthesiology Authors: Fr édéric Martino, Antoine Fleuri, Nicolas Engrand, Amélie Rolle, Michel Piotin, Michel Carles, Delphine Delta, Laurent Do, Adrien Pons, Patrick Portecop, Mathys Sitcharn, Marc Valette, Laurent Camous, Jean-David Pommier and Alexandre Demoule Tags: Research Source Type: research
Isolated Traumatic Subarachnoid Hemorrhage on Head Computed Tomography Scan May Not Be Isolated: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study (TRACK-TBI) Study
Journal of Neurotrauma, Ahead of Print. (Source: Journal of Neurotrauma)
Source: Journal of Neurotrauma - April 11, 2024 Category: Neurology Authors: John K. Yue Esther L. Yuh Mahmoud M. Elguindy Xiaoying Sun Thomas A. van Essen Hansen Deng Patrick J. Belton Gabriela G. Satris Justin C. Wong Alex B. Valadka Frederick K. Korley Claudia S. Robertson Michael A. McCrea Murray B. Stein Ramon Diaz-Arrastia K Source Type: research
Three Pillars of Recovery After Aneurysmal Subarachnoid Hemorrhage: A Narrative Review
AbstractAneurysmal subarachnoid hemorrhage (aSAH) is a devastating neurologic disease with high mortality and disability. There have been global improvements in survival, which has contributed to the prevalence of patients living with long-term sequelae related to this disease. The focus of active research has traditionally centered on acute treatment to reduce mortality, but now there is a great need to study the course of short- and long-term recovery in these patients. In this narrative review, we aim to describe the core pillars in the preservation of cerebral function, prevention of complications, the recent literatur...
Source: Translational Stroke Research - April 11, 2024 Category: Neurology Source Type: research
Correction to tumor necrosis factor receptor ‐associated factor 6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress
(Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 10, 2024 Category: Neuroscience Tags: CORRECTION Source Type: research
Differential DNA methylation associated with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a systematic review
AbstractRecent studies suggest that differential DNA methylation could play a role in the mechanism of cerebral vasospasm (CVS) and delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). Considering the significance of this matter and a lack of effective prophylaxis against DCI, we aim to summarize the current state of knowledge regarding their associations with DNA methylation and identify the gaps for a future trial. PubMed MEDLINE, Scopus, and Web of Science were searched by two authors in three waves for relevant DNA methylation association studies in DCI after aSAH. PRISMA checklist was follo...
Source: Neurosurgical Review - April 10, 2024 Category: Neurosurgery Source Type: research
Contemporary management of aneurysmal subarachnoid haemorrhage. An update for the intensivist
AbstractAneurysmal subarachnoid haemorrhage (aSAH) is a rare yet profoundly debilitating condition associated with high global case fatality and morbidity rates. The key determinants of functional outcome include early brain injury, rebleeding of the ruptured aneurysm and delayed cerebral ischaemia. The only effective way to reduce the risk of rebleeding is to secure the ruptured aneurysm quickly. Prompt diagnosis, transfer to specialized centers, and meticulous management in the intensive care unit (ICU) significantly improved the prognosis of aSAH. Recently, multimodality monitoring with specific interventions to correct...
Source: Intensive Care Medicine - April 10, 2024 Category: Intensive Care Source Type: research
Mesenchymal Stem Cell-Derived Extracellular Vesicles Alleviate Brain Damage Following Subarachnoid Hemorrhage via the Interaction of miR-140-5p and HDAC7
This study highlights the potential of MSC-EV-miR-140-5p in mitigating SAH-induced neuroinflammation and brain injury, providing a foundation for developing MSC-EV-based treatments for SAH. (Source: Molecular Neurobiology)
Source: Molecular Neurobiology - April 9, 2024 Category: Neurology Source Type: research
Temperature Control in Acute Brain Injury: An Update
Semin Neurol DOI: 10.1055/s-0044-1785647Temperature control in severe acute brain injury (SABI) is a key component of acute management. This manuscript delves into the complex role of temperature management in SABI, encompassing conditions like traumatic brain injury (TBI), acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), aneurysmal subarachnoid hemorrhage (aSAH), and hypoxemic/ischemic brain injury following cardiac arrest. Fever is a common complication in SABI and is linked to worse neurological outcomes due to increased inflammatory responses and intracranial pressure (ICP). Temperature management, particul...
Source: Seminars in Neurology - April 9, 2024 Category: Neurology Authors: Lin, Victor Tian, Cindy Wahlster, Sarah Castillo-Pinto, Carlos Mainali, Shraddha Johnson, Nicholas J. Tags: Review Article Source Type: research
Hemorrhage Volume Drives Early Brain Injury and Outcome in Poor-Grade Aneurysmal SAH [NEUROVASCULAR/STROKE IMAGING]
CONCLUSIONS:
Global intracranial hemorrhage volume plays a pivotal role in global cerebral edema development and emerged as an independent predictor of both mortality and long-term clinical outcome. Aging emerged as a reducing predictor in the relationship between global intracranial hemorrhage volume and global cerebral edema. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - April 8, 2024 Category: Radiology Authors: Panni, P., Simionato, F., Cao, R., Pedicelli, A., Marchese, E., Caricato, A., Alexandre, A., Feletti, A., Testa, M., Zanatta, P., Gitti, N., Piva, S., Mardighian, D., Semeraro, V., Nardin, G., Lozupone, E., Paiano, G., Picetti, E., Montanaro, V., Petranca Tags: NEUROVASCULAR/STROKE IMAGING Source Type: research
Correction to: Gas6 Promotes Microglia Efferocytosis and Suppresses Inflammation Through Activating Axl/Rac1 Signaling in Subarachnoid Hemorrhage Mice
(Source: Translational Stroke Research)
Source: Translational Stroke Research - April 8, 2024 Category: Neurology Source Type: research
