Deep learning-based quantification of total bleeding volume and its association with complications, disability, and death in patients with aneurysmal subarachnoid hemorrhage
CONCLUSIONS: Elevated TBV is associated with a greater risk of hydrocephalus, rebleeding, death, and poor prognosis.PMID:38552240 | DOI:10.3171/2024.1.JNS232280 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 29, 2024 Category: Neurosurgery Authors: Ping Hu Yanze Wu Tengfeng Yan Lei Shu Feng Liu Bing Xiao Minhua Ye Miaojing Wu Shigang Lv Xingen Zhu Source Type: research
NAD-Dependent Protein Deacetylase Sirtuin-1 Mediated Mitophagy Regulates Early Brain Injury After Subarachnoid Hemorrhage
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - March 28, 2024 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
Safety and efficacy of magnesium-rich artificial cerebrospinal fluid for subarachnoid hemorrhage
ConclusionUsing MACSF as an irrigation fluid for aneurysm clipping can significantly improve the 90-day prognosis of patients with aSAH, which may be related to the reduced incidence of CVS.Clinical trial registrationhttps://www.clinicaltrials.gov, identifier NCT04358445. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 28, 2024 Category: Neurology Source Type: research
Validation of prognostic stroke scores — comments on “Evaluation of FRESH scores in predicting outcome and quality of life after aneurysmal subarachnoid haemorrhage in a European patient cohort”
(Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - March 28, 2024 Category: Neurosurgery Source Type: research
Huperzine A ameliorates neurological deficits after spontaneous subarachnoid hemorrhage through endothelial cell pyroptosis inhibition
In this study, Evans blue assay, TUNEL staining, immunofluorescence, western blot analysis, and ELISA are conducted. We find that Huperzine A can improve neurological deficits and inhibit the apoptosis of nerve cells in SAH rats. Huperzine A treatment can improve the upregulation of brain water content, damage of blood-brain barrier, fibrinogen and matrix metalloprotein 9 expressions and the downregulation of ZO-1 and occludin expressions induced by SAH. Huperzine A inhibit the expressions of proteins involved in pyroptosis in endothelial cells in SAH rats. The increase in MDA content and decrease in SOD activity in SAH ra...
Source: Acta Biochimica et Biophysica Sinica - March 26, 2024 Category: Biochemistry Authors: Qiang Hu Rong Zhang Xiaoqiao Dong Dingbo Yang Wenhua Yu Quan Du Source Type: research
Huperzine A ameliorates neurological deficits after spontaneous subarachnoid hemorrhage through endothelial cell pyroptosis inhibition
In this study, Evans blue assay, TUNEL staining, immunofluorescence, western blot analysis, and ELISA are conducted. We find that Huperzine A can improve neurological deficits and inhibit the apoptosis of nerve cells in SAH rats. Huperzine A treatment can improve the upregulation of brain water content, damage of blood-brain barrier, fibrinogen and matrix metalloprotein 9 expressions and the downregulation of ZO-1 and occludin expressions induced by SAH. Huperzine A inhibit the expressions of proteins involved in pyroptosis in endothelial cells in SAH rats. The increase in MDA content and decrease in SOD activity in SAH ra...
Source: Acta Biochimica et Biophysica Sinica - March 26, 2024 Category: Biochemistry Authors: Qiang Hu Rong Zhang Xiaoqiao Dong Dingbo Yang Wenhua Yu Quan Du Source Type: research
Impact of early follow-up CT in the conservative management of traumatic brain injury on surgical decision making: A retrospective, single-center analysis with special respect to coagulopathy
ConclusionEarly routine follow-up CT does neither anticipate imminent neurological deterioration nor impact surgical decision making. A substantial number of patients with initially stable follow-up imaging need delayed surgery due to conservative treatment failure. If patients can be monitored clinically, surgical decision making depends on clinical status. Patients with coagulopathy do not present with larger lesions, but show a higher ratio of drastic increase in SDH in contrast to contusions. (Source: European Journal of Trauma and Emergency Surgery)
Source: European Journal of Trauma and Emergency Surgery - March 26, 2024 Category: Emergency Medicine Source Type: research
Elevated troponin levels as a predictor of mortality in patients with acute stroke: a systematic review and meta-analysis
ConclusionElevated troponin levels can serve as a promising predictive marker for both in-hospital and last follow-up mortality in AIS and SAH patients but not in ICH patients. Further prospective studies are needed to validate our findings along with exploring the preventive management of mortality in acute stroke settings. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 25, 2024 Category: Neurology Source Type: research
Causal Relationships Between Gut Microbiota, Inflammatory Cells/Proteins, and Subarachnoid Hemorrhage: A Multi-omics Bidirectional Mendelian Randomization Study and Meta-analysis
This study combined various omics approaches with Mendelian randomization analysis, including MR-IVW, MR Egger, MR weight median, and MR weight mode, to generate preliminary results. It also employed reverse Mendelian randomization, treating SAH as the exposure. Finally, a meta -analysis was conducted to summarize these findings. The study found positive correlations between SAH and both GBPA-Pyridoxal 5 phosphate biosynthesis I (OR=1.48, 95% CI, 1.04–2.12) and GBPA-glucose biosynthesis I (OR=0.68, 95% CI, 0.52–0.90). Increased levels of urokinase-type plasma activator were also associated with SAH (OR=1.17, 95% CI, 1....
Source: Molecular Neurobiology - March 25, 2024 Category: Neurology Source Type: research
Tat-NR2B9c attenuates oxidative stress via inhibition of PSD95-NR2B-nNOS complex after subarachnoid hemorrhage in rats
Neuropharmacology. 2024 Mar 21:109905. doi: 10.1016/j.neuropharm.2024.109905. Online ahead of print.ABSTRACTOxidative stress plays important roles in the pathogenesis of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Tat-NR2B9c has shown efficacy as a neuroprotective agent in several studies. Here, we identified the neuroprotective role of Tat-NR2B9c after SAH and its related mechanisms. The results showed that Tat-NR2B9c treatment attenuated oxidative stress, therefore alleviated neuronal apoptosis and neurological deficits after SAH. Tat-NR2B9c treatment could alleviate mitochondrial vacuolization induced ...
Source: Neuropharmacology - March 23, 2024 Category: Drugs & Pharmacology Authors: Haocheng Zhang Longbiao Xu Yezhao He Zeyu Zhang Jiahao Zhang Qian Yu Yibo Liu Xiaoyu Wang Anke Zhang Kaikai Wang Yuanjian Fang Sheng Chen Source Type: research
Tat-NR2B9c attenuates oxidative stress via inhibition of PSD95-NR2B-nNOS complex after subarachnoid hemorrhage in rats
Neuropharmacology. 2024 Mar 21:109905. doi: 10.1016/j.neuropharm.2024.109905. Online ahead of print.ABSTRACTOxidative stress plays important roles in the pathogenesis of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Tat-NR2B9c has shown efficacy as a neuroprotective agent in several studies. Here, we identified the neuroprotective role of Tat-NR2B9c after SAH and its related mechanisms. The results showed that Tat-NR2B9c treatment attenuated oxidative stress, therefore alleviated neuronal apoptosis and neurological deficits after SAH. Tat-NR2B9c treatment could alleviate mitochondrial vacuolization induced ...
Source: Neuropharmacology - March 23, 2024 Category: Drugs & Pharmacology Authors: Haocheng Zhang Longbiao Xu Yezhao He Zeyu Zhang Jiahao Zhang Qian Yu Yibo Liu Xiaoyu Wang Anke Zhang Kaikai Wang Yuanjian Fang Sheng Chen Source Type: research
Corrigendum: Clinical value of serum complement component 1q levels in the prognostic analysis of aneurysmal subarachnoid hemorrhage: a prospective cohort study
(Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 22, 2024 Category: Neurology Source Type: research
Association between serum creatinine and 30 days all-cause mortality in critically ill patients with non-traumatic subarachnoid hemorrhage: analysis of the MIMIC-IV database
ConclusionCreatinine emerges as a significant biomarker, closely associated with heightened in-hospital mortality in individuals suffering from SAH. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 21, 2024 Category: Neurology Source Type: research
Early prediction of ventricular peritoneal shunt dependency in aneurysmal subarachnoid haemorrhage patients by recurrent neural network-based machine learning using routine intensive care unit data
AbstractAneurysmal subarachnoid haemorrhage (aSAH) can lead to complications such as acute hydrocephalic congestion. Treatment of this acute condition often includes establishing an external ventricular drainage (EVD). However, chronic hydrocephalus develops in some patients, who then require placement of a permanent ventriculoperitoneal (VP) shunt. The aim of this study was to employ recurrent neural network (RNN)-based machine learning techniques to identify patients who require VP shunt placement at an early stage. This retrospective single-centre study included all patients who were diagnosed with aSAH and treated in t...
Source: Journal of Clinical Monitoring and Computing - March 21, 2024 Category: Information Technology Source Type: research
