GSE223261 Autonomous transposons tune their sequences to ensure somatic suppression [polyA_HeLa]
Contributors : Ibrahim A Ilik ; Petar Gla žar ; Tugce AktasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTransposable elements (TEs) are a major constituent of human genes, occupying approximately half of the intronic space. During pre-mRNA synthesis, intron Łic TEs are transcribed along with their host genes but rarely contribute to the final mRNA product as they are spliced out together with the intron and rapidly degraded. Paradoxically, TEs are an abundant source of RNA-processing signals through which they can create new introns (Huff et al. 2016) , and functional (Cosby et...
Source: GEO: Gene Expression Omnibus - January 8, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE223262 Autonomous transposons tune their sequences to ensure somatic suppression [polyA_S2]
Contributors : Ibrahim A Ilik ; Petar Gla žar ; Tugce AktasSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterTransposable elements (TEs) are a major constituent of human genes, occupying approximately half of the intronic space. During pre-mRNA synthesis, intron Łic TEs are transcribed along with their host genes but rarely contribute to the final mRNA product as they are spliced out together with the intron and rapidly degraded. Paradoxically, TEs are an abundant source of RNA-processing signals through which they can create new introns (Huff et al. 2016) , and functiona...
Source: GEO: Gene Expression Omnibus - January 8, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Drosophila melanogaster Source Type: research
GSE244699 Autonomous transposons tune their sequences to ensure somatic suppression [SAFKD_1H4_DHX9_FLASH]
Contributors : Ibrahim A Ilik ; Petar Gla žar ; Tugce AktasSeries Type : OtherOrganism : Homo sapiensTransposable elements (TEs) are a major constituent of human genes, occupying approximately half of the intronic space. During pre-mRNA synthesis, intronic TEs are transcribed along with their host genes but rarely contribute to the final mRNA product as they are spliced out together with the intron and rapidly degraded. Paradoxically, TEs are an abundant source of RNA-processing signals through which they can create new introns (Huff et al. 2016), and functional (Cosby et al. 2021) or non-functional chimeric transcripts...
Source: GEO: Gene Expression Omnibus - January 8, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
GSE244701 Autonomous transposons tune their sequences to ensure somatic suppression [directRNA_HEK293]
Contributors : Ibrahim A Ilik ; Petar Gla žar ; Tugce AktasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTransposable elements (TEs) are a major constituent of human genes, occupying approximately half of the intronic space. During pre-mRNA synthesis, intron Łic TEs are transcribed along with their host genes but rarely contribute to the final mRNA product as they are spliced out together with the intron and rapidly degraded. Paradoxically, TEs are an abundant source of RNA-processing signals through which they can create new introns (Huff et al. 2016) , and functional (Cosby et...
Source: GEO: Gene Expression Omnibus - January 8, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE244708 Autonomous transposons tune their sequences to ensure somatic suppression [polyA_HCT116]
Contributors : Ibrahim A Ilik ; Petar Gla žar ; Tugce AktasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTransposable elements (TEs) are a major constituent of human genes, occupying approximately half of the intronic space. During pre-mRNA synthesis, intron Łic TEs are transcribed along with their host genes but rarely contribute to the final mRNA product as they are spliced out together with the intron and rapidly degraded. Paradoxically, TEs are an abundant source of RNA-processing signals through which they can create new introns (Huff et al. 2016) , and functional (Cosby et...
Source: GEO: Gene Expression Omnibus - January 8, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE244711 Autonomous transposons tune their sequences to ensure somatic suppression [totalRNA_HEK293_fractionation]
Contributors : Ibrahim A Ilik ; Petar Gla žar ; Tugce AktasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTransposable elements (TEs) are a major constituent of human genes, occupying approximately half of the intronic space. During pre-mRNA synthesis, intronic TEs are transcribed along with their host genes but rarely contribute to the final mRNA product as they are spliced out together with the intron and rapidly degraded. Paradoxically, TEs are an abundant source of RNA-processing signals through which they can create new introns (Huff et al. 2016), and functional (Cosby et al....
Source: GEO: Gene Expression Omnibus - January 8, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Intraoperative Radiation Therapy Delivered by Brachytherapy in Breast Cancer: An Interim Analysis of a Phase 2 Trial
CONCLUSION: Acknowledging the short median follow-up time at interim analysis, our initial results indicate that delivering IORT through HDR brachytherapy in carefully selected breast cancer patients is feasible and oncological safe so far. A long-term follow-up is essential to confirm the initial results.PMID:38185607 | DOI:10.1016/j.clbc.2023.12.006 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 7, 2024 Category: Cancer & Oncology Authors: Åsa Wickberg Clara Prag Antonis Valachis Leif Karlsson Bengt Johansson Source Type: research
Intraoperative Radiation Therapy Delivered by Brachytherapy in Breast Cancer: An Interim Analysis of a Phase 2 Trial
CONCLUSION: Acknowledging the short median follow-up time at interim analysis, our initial results indicate that delivering IORT through HDR brachytherapy in carefully selected breast cancer patients is feasible and oncological safe so far. A long-term follow-up is essential to confirm the initial results.PMID:38185607 | DOI:10.1016/j.clbc.2023.12.006 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 7, 2024 Category: Cancer & Oncology Authors: Åsa Wickberg Clara Prag Antonis Valachis Leif Karlsson Bengt Johansson Source Type: research
Genes, Vol. 15, Pages 73: Estimation of Genetic Diversity and Number of Unique Genotypes of Cassava Germplasm from Burkina Faso Using Microsatellite Markers
This study was carried out to assess the genetic diversity and the number of unique multilocus genotypes (MLGs) in a cassava collection in Burkina Faso. To achieve this objective, 130 cassava accessions were genotyped using 32 simple sequence repeat (SSR) markers. The results revealed that among these markers, twelve (12) were highly informative, with polymorphic information content (PIC) values greater than 0.50; twelve (12) were moderately informative, with PIC values ranging between 0.25 and 0.50; and eight (8) were not very informative, with PIC values lower than 0.25. A moderate level of genetic diversity was found fo...
Source: Genes - January 5, 2024 Category: Genetics & Stem Cells Authors: Monique Soro Serge Marie Felicien Wend-Pagnagd é Zida Koussao Som é Fid èle Tiendrébéogo Daniel H. Otron Justin S. Pita James B. N éya Daouda Kon é Tags: Article Source Type: research
GSE230176 The hagfish genome and the evolution of vertebrates
Contributors : Ferdinand Marletaz ; Oleg Simakov ; Dan RokhsarSeries Type : Expression profiling by high throughput sequencingOrganism : Eptatretus atamiAs the only surviving lineages of jawless fishes, hagfishes and lampreys provide a critical window into early vertebrate evolution. Here, we investigate the complex history, timing, and functional role of genome-wide duplications in vertebrates in the light of a chromosome-scale genome of the brown hagfish Eptatretus atami. Using robust chromosome-scale (paralogon-based) phylogenetic methods, we confirm the monophyly of cyclostomes, document an auto-tetraploidization (1...
Source: GEO: Gene Expression Omnibus - January 4, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Eptatretus atami Source Type: research
936 Testing transcriptional regulatory pathway in early-onset FGR using patient-specific human trophoblast stem cells
Human Trophoblast stem cells (hTSC) are an excellent model system to understand trophoblast development during human pregnancy. However, most of previously studied hTSCs were established from 1st trimester placentas, which limits evaluation of mechanisms underlying development of early-onset FGR. We hypothesize that a defect in trophoblast progenitor self-renewal and differentiation can result in a pathologic pregnancy, such as FGR. Components of Hippo signaling pathway are essential for optimization of trophoblast progenitor self-renewal. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: Juliana Bakk, Soumen Paul, Soma Ray, Marc Parrish Source Type: research
Assessment of seasonal variability of PM, BC and UFP levels at a highway toll stations and their associated health risks
Environ Res. 2023 Dec 29:118028. doi: 10.1016/j.envres.2023.118028. Online ahead of print.ABSTRACTAs a part of their occupation, workers at toll stations are exposed to traffic emissions during the working shift, which sometimes stretches to 12 h. To assess the exposure and subsequent health risk of these workers, a study was performed on a highway toll station in India. PM1, PM2.5, PM10, BC and UFP concentration were determined inside a toll collectors' cabin and outside in a free-flowing traffic section (125 m from the toll cabin). The concentrations varied in the following range: PM1 (40.69-226.13 μg m-3), PM2.5 (49.71...
Source: Environmental Research - December 31, 2023 Category: Environmental Health Authors: None Nazneen Aditya Kumar Patra Soma Sekhara Rao Kolluru Penchala Abhishek Sachidanand Kumar Namrata Mishra Naragam Bhanu Sree Samrat Santra Ravish Dubey Source Type: research
Quantitative analysis of microglia morphological changes in the hypothalamus of chronically stressed rats
Brain Res Bull. 2023 Dec 21:110861. doi: 10.1016/j.brainresbull.2023.110861. Online ahead of print.ABSTRACTBased on the successful establishment of a rat model of chronic restraint stress, we used multiple algorithms to quantify the morphological changes of rat hypothalamic microglia from various perspectives, providing a pathomorphological basis for the subsequent study of molecular mechanisms of hypothalamic stress injury, such as neuroinflammation. To verify the successful establishment of the chronic stress model, an enzyme-linked immunosorbent assay was performed to detect serum glucocorticoid levels. Microglia labele...
Source: Brain Research - December 23, 2023 Category: Neurology Authors: Ke Chen Xin Qi Lin-Lin Zhu Mei-Li Li Bin Cong Ying-Min Li Source Type: research
Quantitative analysis of microglia morphological changes in the hypothalamus of chronically stressed rats
Brain Res Bull. 2023 Dec 21:110861. doi: 10.1016/j.brainresbull.2023.110861. Online ahead of print.ABSTRACTBased on the successful establishment of a rat model of chronic restraint stress, we used multiple algorithms to quantify the morphological changes of rat hypothalamic microglia from various perspectives, providing a pathomorphological basis for the subsequent study of molecular mechanisms of hypothalamic stress injury, such as neuroinflammation. To verify the successful establishment of the chronic stress model, an enzyme-linked immunosorbent assay was performed to detect serum glucocorticoid levels. Microglia labele...
Source: Brain Research Bulletin - December 23, 2023 Category: Neurology Authors: Ke Chen Xin Qi Lin-Lin Zhu Mei-Li Li Bin Cong Ying-Min Li Source Type: research
Quantitative analysis of microglia morphological changes in the hypothalamus of chronically stressed rats
Brain Res Bull. 2023 Dec 21;206:110861. doi: 10.1016/j.brainresbull.2023.110861. Online ahead of print.ABSTRACTBased on the successful establishment of a rat model of chronic restraint stress, we used multiple algorithms to quantify the morphological changes of rat hypothalamic microglia from various perspectives, providing a pathomorphological basis for the subsequent study of molecular mechanisms of hypothalamic stress injury, such as neuroinflammation. To verify the successful establishment of the chronic stress model, an enzyme-linked immunosorbent assay was performed to detect serum glucocorticoid levels. Microglia la...
Source: Brain Research - December 23, 2023 Category: Neurology Authors: Ke Chen Xin Qi Lin-Lin Zhu Mei-Li Li Bin Cong Ying-Min Li Source Type: research
